ライフサイエンスコーパス: ring finger

1 r), or type 3 (index finger shorter than the ring finger).

2 left eye, chest, left ring finger, and right ring finger.

3 fold increase in affinity between the E2 and RING finger.

4 reased ubiquitylation by Ube2g2 and the gp78 RING finger.

5 the ubiquitination activity of its cytosolic RING finger.

6 all nodule on the volar surface of his right ring finger.

7 tes for ubiquitin-activating enzyme (E1) and RING fingers.

8 ng to understand how deficiency of Mahogunin RING finger 1 (MGRN1) affects cell viability, we uncover

9 TRIM63 encoding Muscle RING Finger 1 (MuRF1) maintains muscle protein homeostas

10 e in muscle atrophy F-box (MAFbx) and muscle RING finger 1 (MuRF1) mRNA expression, but did significa

11 ophy, likely because of repression of muscle RING finger 1 (MuRF1), a proatrophic FOXO1 target gene.

12 Deletion of muscle RING finger 1 (MuRF1), an E3 ubiquitin ligase, leads to

13 he E3 ligase atrogenes, atrogin-1 and muscle ring finger 1 (MuRF1), mediate muscle protein breakdown

14 rg275Trp, is located in the highly conserved RING finger 1 domain of PARK2, which encodes an E3 ubiqu

15 Human UHRF1 (ubiquitin-like PHD and RING finger 1) functions to maintain CpG DNA methylation

16 s, mRNA levels of ubiquitin, muscle-specific ring finger 1, and atrogin-1/muscle atrophy F-box were l

17 Expression of muscle RING-finger 1 (MuRF1), a ubiquitin ligase, is markedly i

18 phenomenon by which the E3 ligase mahogunin ring finger-1 (MGRN1) translocates to the nucleus in an

19 , as mRNA expression of the atrogenes muscle RING finger-1 (MuRF1) and atrogin-1 were 1.2- and 1.3-fo

20 g muscle atrophy-associated genes for muscle ring finger-1 (MuRF1) and atrogin1 were measured.

21 ttractin, Atrn/mg) and mahoganoid (Mahogunin Ring Finger-1, Mgrn1/md) are mutations epistatic to A(y)

22 ation of the ubiquitin ligase, MuRF1 (muscle ring finger-1; R(2)=0.91; P=0.003) and a molecular profi

23 d muscle-enriched E3 ubiquitin ligase muscle RING-finger-1 (MuRF1) expression, which may involve prot

24 The E3 ligase RING finger 168 (RNF168), mutated in the human radiosens

25 thermore, increased levels of K63 and muscle RING finger 2 (MuRF2) protein could also be important en

26 E3 ubiquitin ligases RING finger 43/zinc and RING finger 3 (RNF43/ZNRF3).

27 e transmembrane E3 ubiquitin ligase zinc and ring finger 3 (ZNRF3) and its homologue ring finger 43 (

28 gulated by the E3 ubiquitin ligases zinc and ring finger 3 (ZNRF3) and ring finger protein 43 (RNF43)

29 o stabilize the membrane-associated zinc and ring finger 3 (ZNRF3).

30 embrane E3 ubiquitin ligases ZNRF3 (zinc and ring finger 3) and RNF43 (ring finger protein 43) antago

31 we show that the noncanonical Polycomb group RING finger 3/5 (PCGF3/5)-PRC1 complex initiates recruit

32 and ring finger 3 (ZNRF3) and its homologue ring finger 43 (RNF43) are negative feedback regulators

33 Ubiquitin E3 ligase ring finger 43 (RNF43) has been suggested as a negative

34 ) and the transmembrane E3 ubiquitin ligases RING finger 43/zinc and RING finger 3 (RNF43/ZNRF3).

35 ealed that p47 interacts with polycomb group ring finger 5 (PCGF5) protein, Src protein tyrosine kina

36 ARF binding protein 1 (GGA1), polycomb group ring finger 5 (PCGF5), actin gamma 1 (ACTG1), and unc-13

37 show that the PRC1 component polycomb group ring finger 6 (Pcgf6) is required to maintain embryonic

38 show that Arabidopsis (Arabidopsis thaliana) RING Finger ABA-Related1 (RFA1) and RFA4 E3 ubiquitin li

39 D14, proteasome subunit beta type 1 (PSMB1), ring finger and CCCH-type domain 1 (RC3H1), and tumor pr

40 lization with ICP0 was dependent on the ICP0 RING finger and did not occur when proteasome activity w

41 The PLR-1 RING finger and protease-associated (PA) domain are esse

42 CD2AP.Cbl-3/c complex required a functional ring finger and TKB domain in Cbl-3/c.

43 Ring finger and WD domain 2 (RFWD2, also termed COP1) is

44 RING finger and WD repeat domain 3 (RFWD3) was initially

45 We identify cellular E3 ubiquitin ligase ring-finger and CHY zinc-finger domain-containing 1 (RCH

46 RNF183 is a ubiquitin ligase containing RING-finger and transmembrane domains, and its expressio

47 ation dose at 4 sites: left eye, chest, left ring finger, and right ring finger.

48 Surprisingly, both the zinc knuckle and the RING finger are needed for RNA-binding activity.

49 thylated CpG via its conserved SRA (SET- and RING finger-associated) domain.

50 horax (SET) and really interesting new gene (RING) finger-associated (SRA) protein domain is conserve

51 SET and RING-finger-associated (SRA) domain is involved in estab

52 /p16(INK4a) and BMI1 proto-oncogene polycomb ring finger (BMI1), with the latter limiting expression

53 MDM2 via its C-terminal RING finger can bind to the Basic region of ATF3 and med

54 ng interacting proteins or in the C-terminal RING finger catalytic domain.

55 rotein ICP0 is an E3 ubiquitin ligase of the RING finger class that degrades several cellular protein

56 e 1 (HSV-1) is an E3 ubiquitin ligase of the RING finger class that is required for efficient lytic i

57 XB3 is a RING finger-containing E3 ubiquitin ligase that has been

58 ponsive genes1 (HOS1) locus, which encodes a RING finger-containing E3 ubiquitin ligase.

59 based overexpression screen and identified a Ring-finger-containing protein, RNF34, as a specific E3

60 onstrate that Bmi1 interacts with Gata6 in a Ring finger-dependent manner to confer protection agains

61 ly, UBE2D1 (UbcH5a) and UBE2E1 (UbcH6), in a RING finger-dependent manner.

62 owing gluing, with the representation of the ring finger (digit 4) shifted towards the little finger

63 rophobic pocket can be regulated through the RING finger domain and that increases in pocket affinity

64 We demonstrate that disruption of the ORF61p RING finger domain by amino acid substitution (Cys19Gly)

65 of 49 patients; all of these cases harbored RING finger domain c-Cbl mutations.

66 tin-like (UBL) domain, a zinc knuckle, and a RING finger domain characteristic of some ubiquitin liga

67 in the outer mitochondrial membrane with its RING finger domain facing the cytoplasm.

68 polymerase-associated domain in PolH and the RING finger domain in Pirh2.

69 hemical analyses further show that the yBre1 RING finger domain is essential for H2B ubiquitylation b

70 dition, we demonstrate that an intact ORF61p RING finger domain is necessary for E3 ubiquitin ligase

71 nfection, (v) ICP0 carrying mutations in the RING finger domain is stable both early and late in infe

72 key function of ICP0 that requires an intact RING finger domain is that of an ubiquitin E3 ligase: IC

73 In contrast, the C381A Ring finger domain mutant functions like WT c-Cbl.

74 ues required for the interaction between the RING finger domain of ICP0 and UBE2D1, and we report tha

75 t (i) consistent with previous findings, the RING finger domain of ICP0 is required for the activatio

76 etion of ICP0 or mutations in the N-terminal RING finger domain of ICP0 results in the absence of ICP

77 The RING finger domain of ICP0 was required for degradation

78 main (CRD) of frizzled and the intracellular RING finger domain of RNF43.

79 The RING finger domain of Yvh1, but not its phosphatase doma

80 Mutations in the Cbl family RING finger domain or linker sequence constitute importa

81 hat single point mutations in the human MDM2 RING finger domain prevent the interaction of MDM2 with

82 heckpoint with Forkhead-associated (FHA) and RING finger domain protein (CHFR), an E3 ubiquitin ligas

83 The central region of Pirh2 harbors a RING finger domain that is critical for its ubiquitin li

84 domain of p53, and (iii) a C-terminal C2H2C4 RING finger domain that is required for E2 enzyme-bindin

85 otein interactions via its TRAF domain and a RING finger domain that possesses non-conventional E3 ub

86 n addition, DIAP2 also requires a functional RING finger domain to block cell death and target drICE

87 ICP0 has a RING finger domain with E3 ubiquitin ligase activity tha

88 TRIM37 contains a RING finger domain, a hallmark of E3 ubiquitin ligases,

89 diate these processes, it requires its C3HC4 RING finger domain, a tertiary structural fold that is c

90 tyrosine kinase binding domain, a catalytic RING finger domain, and a C-terminal proline-rich domain

91 is reduced by MKRN3 mutations affecting the RING finger domain, and that these mutations compromised

92 ubiquitinase activity of MKRN3 required its RING finger domain, in order to repress the promoter act

93 the ubiquitin ligase ubiquitin-like PHD and RING finger domain-containing protein 1 (UHRF1) and its

94 omain (PHD) of UHRF1 (ubiquitin-like PHD and RING finger domain-containing protein 1) operates as a f

95 Specifically, we identified a RING finger domain-containing protein, RINCK (for RING-f

96 TRIM21 is a RING finger domain-containing ubiquitin E3 ligase whose

97 components requires BRCA1's BRCT but not the ring finger domain.

98 on of similarity between these proteins is a RING finger domain.

99 i-spanning membrane protein with a cytosolic RING finger domain.

100 Flag-gp78), but not Flag-gp78 mutated in its RING-finger domain (Flag-RINGmut) with deficient ubiquit

101 Deletion of the enzyme's N-terminal RING-finger domain almost completely abolishes fiber for

102 Ubiquitination of lysines in Hrd1's RING-finger domain is required for substrate retrotransl

103 protein family, which contain a cluster of a RING-finger domain, a B box/coiled-coil domain and a SPR

104 indicates that checkpoint with forkhead and ring finger domains (CHFR), a recently identified mitoti

105 is required for ubiquitin-like with PHD and RING finger domains 1 (UHRF1) E3 ubiquitin ligase activi

106 or ubiquitin-like protein containing PHD and RING finger domains 1 (uhrf1) in zebrafish leads to a re

107 Ubiquitin-like with PHD and RING finger domains 1 (UHRF1) is an essential regulator

108 or ubiquitin-like with plant homeodomain and RING finger domains 1 (Uhrf1) is essential for maintenan

109 Ubiquitin-like, containing PHD and RING finger domains 1 (uhrf1) is regulated at the transc

110 mutations in the ubiquitin-like with PHD and ring finger domains 1 (uhrf1) or DNA methyltransferase 1

111 DNMT1) and ubiquitin-like containing PHD and RING finger domains 1 (UHRF1) proteins.

112 n ligase UHRF1 (Ubiquitin-like, with PHD and RING finger domains 1) directly participates in the inte

113 UHRF1 (ubiquitin-like, containing PHD and RING finger domains 1) has a well-established role in ep

114 port that UHRF1 (ubiquitin-like with PHD and RING finger domains 1) interacts with TIP60 both in vitr

115 UHRF1 (ubiquitin-like, containing PHD and RING finger domains 1) is a multi-domain protein associa

116 UHRF1 (ubiquitin-like, containing PHD and RING finger domains 1) is required for maintenance methy

117 E3 ligase UHRF1 (ubiquitin-like with PHD and RING finger domains 1), which is commonly upregulated in

118 by Uhrf1 (Ubiquitin-like, Containing PHD and RING Finger Domains 1).

119 e identified the ubiquitin-like with PHD and ring finger domains 2 (UHRF2) gene as an important media

120 As a result, the juxtaposition of PA and RING finger domains across a lipid bilayer facilitates t

121 ructural and functional asymmetry of dimeric RING finger domains may be a general feature of E3 ligas

122 effect by targeting cysteine residues in the RING finger domains of histone E3 ubiquitin ligase, ther

123 und that arsenite could bind directly to the RING finger domains of RNF20 and RNF40 in vitro and in c

124 The ubiquitin-like, containing PHD and RING finger domains protein 1 (UHRF1) is essential for m

125 UHRF1 (ubiquitin-like, containing PHD and RING finger domains, 1) recruits DNMT1 to hemimethylated

126 olecular adaptor ubiquitin-like with PHD and RING finger domains-1 (UHRF1), was measured in human HCC

127 CULLIN (CUL)4-associated factor in a Cullin4-RING Finger E3 Ligase (CRL4) that mediates light-depende

128 The RING finger E3 ligase GRAIL is thought to selectively fu

129 se-6-phosphate dehydrogenase and ER-anchored RING finger E3 ligase in the activation of unfolded prot

130 s, MAF=up to 0.78%) in RNF186, a single-exon ring finger E3 ligase with strong colonic expression, pr

131 a new mechanism in which an uncharacterized RING finger E3 ligase, PPP1R11, directly ubiquitinates T

132 ates that Vpx recruits SAMHD1 to the Cullin4-Ring Finger E3 ubiquitin ligase (CRL4) by facilitating a

133 Although BBS11/TRIM32 represents a RING finger E3 ubiquitin ligase also involved in heredit

134 We identify SIAH2, a RING finger E3 ubiquitin ligase associated with the cell

135 The RBCC/TRIM family RING finger E3 ubiquitin ligase Nrdp1 mediates the ubiqu

136 Our previous studies indicate that the RING finger E3 ubiquitin ligase Nrdp1, a protein lost in

137 We identified the RING finger E3 ubiquitin ligase PIR2/Rnf144b as a direct

138 ed phosphoproteomics, we have identified the RING finger E3 ubiquitin ligase RNF157 as a target at th

139 The RING finger E3 ubiquitin ligase Siah2 is implicated in c

140 TMEM129 is an unconventional C4C4-type RING finger E3 ubiquitin ligase that resides within a co

141 Roquin-1, a RING finger E3 ubiquitin ligase, functions as a modulato

142 Here, we found that Pirh2, a RING finger E3 ubiquitin ligase, promotes the proteasome

143 ma-associated herpesvirus (KSHV) encodes two RING finger E3 ubiquitin ligases (MIR1 and MIR2) that me

144 ed the entire inventory of membrane-spanning RING finger E3 ubiquitin ligases localized to the ER.

145 Core histones can be ubiquitinated by RING finger E3 ubiquitin ligases, among which the RNF20-

146 suggest arsenite as a general inhibitor for RING finger E3 ubiquitin ligases.

147 RING-finger E3 ligases are instrumental in the regulatio

148 old unrelated to previously observed HECT or RING-finger E3 ligases.

149 in-proteasome pathway involving the IBR-type RING-finger E3 ubiquitin ligase IBRDC2, and genetic corr

150 COP1 is a Ring-Finger E3 ubiquitin ligase that is involved in plan

151 We report that IBRDC2, an IBR-type RING-finger E3 ubiquitin ligase, regulates the levels of

152 an ubiquitinated protein and targeted by the RING-finger E3 ubiquitin-protein ligase constitutive pho

153 3s tested including multimeric and monomeric Ring finger E3s (MuRF1, Siah2, Parkin, APC, and SCF(beta

154 on observed when Ube2g2 is paired with other RING finger E3s.

155 are associated with zinc finger (C3HC4-type RING finger) family protein and AOX1A (alternative oxida

156 proteasomal degradation depending on c-Cbl's RING finger function.

157 PCGF1 encodes one of six human Polycomb RING finger homologs that are linked to transcriptional

158 ed that these amino acid changes in the RLIM RING finger impaired RLIM ubiquitin ligase activity.

159 ereby allosteric effects on an E2 enhance E2-RING finger interactions and, consequently, ubiquitylati

160 in kinase and that an ICP0 with mutations in RING finger is stable.

161 ul4B), a scaffolding component of the Cullin ring finger ligase family of ubiquitin E3 ligases.

162 e residues makes it highly probable that the RING finger-like domain coordinates two zinc ions, analy

163 BBP6) plays a facilitating role, through its RING finger-like domain, in the ubiquitination of p53 by

164 f whom who have pathogenic variants in RLIM (RING finger LIM domain-interacting protein).

165 ng Rnf12 encoding the ubiquitin ligase RLIM (RING finger LIM-domain-interacting protein).

166 LANA on the stability and activity of RLIM (RING finger LIM-domain-interacting protein, encoded by t

167 biquitin ligase really interesting new gene (RING) finger LIM domain-interacting protein (RLIM)/RING

168 These data suggest that RING finger-mediated p53 inhibition and MDMX interaction

169 nteraction could be mapped to the C-terminal RING finger motif of RNF217.

170 tudied subunit in Smc5/6, contains a SP-like-RING finger motif on the C-terminus and was identified a

171 within the kinase domain and an intact MEKK1 RING finger motif.

172 Muscle ring finger (MuRF)1 is a muscle-specific protein implica

173 Here, we show that CD4(+) T cells from Cbl-b RING finger mutant knockin or Cbl-b-deficient mice show

174 Using the c-Cbl RING finger mutant mouse as a model of a myeloproliferat

175 by the similarity between Cbl-b(-/-) and its RING finger mutant NKT cells.

176 i) in cells infected with both wild type and RING finger mutant only the wild-type ICP0 is rapidly de

177 A RING finger mutant RLIM is resistant to LANA-mediated de

178 1H, a linker region mutant, and CBL-C384R, a RING finger mutant, lead to enhanced GM-CSF signaling.

179 and gp78, but not its functionally inactive RING-finger mutant, resulted in enhanced CYP3A4 loss gre

180 Our study indicates that CBL linker and RING finger mutants lead to enhanced GM-CSF signaling du

181 Furthermore, we show that RING finger mutants that are unable to interact with UBE

182 RING finger mutants were unable to reactivate transcript

183 The RING finger nuclear factor RNF168 is required for recrui

184 erved cysteine residue in the C(3)HC(4) zinc RING finger of bICP0 has dramatic effects on the growth

185 The C(3)HC(4) zinc RING finger of bICP0 is crucial for activating viral tra

186 tion (51st amino acid) in the C(3)HC(4) zinc RING finger of bICP0.

187 le amino acid mutation in the C(3)HC(4) zinc RING finger of bICP0.

188 e mutations are in the linker region and the RING finger of CBL, leading to a loss of E3 ligase activ

189 Here, we warmed the index and ring fingers of each hand while cooling the middle finge

190 of ROR1 inhibited expression of the polycomb ring-finger oncogene, Bmi-1, and other genes associated

191 vein, viruses that have mutations in ICP0's RING finger or are deleted for the gene are sensitive to

192 n (Ub)-protein conjugates formed by purified ring-finger or U-box E3s with the E2, UbcH5, resist degr

193 g finger), type 2 (index finger equal to the ring finger), or type 3 (index finger shorter than the r

194 like with 4 mbt domains 2 and polycomb group ring finger (Pcgf) 2/ Pcgf5, displayed antagonistic regu

195 how that the expansion of the Polycomb Group RING Finger (PCGF) protein family, an essential step for

196 protein docking complex PEX13-PEX14 and the (RING)-finger peroxin PEX2.

197 ha2 isoform is necessary for muscle-specific ring finger protein 1 (MuRF1) up-regulation and myofiber

198 Muscle RING finger protein 1 (MuRF1), a muscle-specific ubiquit

199 the proteins of the Polycomb complex is the Ring finger protein 1 (RING1).

200 ubiquitin E3 ligase, PIR1 (PP2CA interacting RING finger protein 1), that interacted with PP2CA.

201 a-light-chain-enhancer of activated B cells, RING finger protein 10, and SH3 and multiple ankyrin rep

202 WWP1 forms a protein complex with RING finger protein 11 (RNF11), a negative regulator of

203 We identify RING finger protein 113A (RNF113A) as the E3 ligase resp

204 finger LIM domain-interacting protein (RLIM)/RING finger protein 12 (Rnf12), which serves as a major

205 We identify a unique cofactor, RING finger protein 126 (RNF126), verify its interaction

206 ranscriptionally represses the expression of RING finger protein 144A (RNF144A), an uncharacterized g

207 identify a poorly characterized RBR protein, Ring Finger protein 144A (RNF144A), as the first, to our

208 igases, we identified a RING-type E3 ligase, ring finger protein 186 (RNF186), that critically mediat

209 nd nitrosylation of, the epigenetic modifier ring finger protein 1A (RING1A) as assessed by immunosta

210 (EZH2), suppressor of zeste 12 (SUZ12), and ring finger protein 2 (RNF2) from (and concomitant recru

211 w that monoubiquitination of H2AX induced by RING finger protein 2 (RNF2) is required for the recruit

212 eric protein complex with prohibitin and the ring finger protein 2 (RNF2).

213 analysis identified the E3 ubiquitin ligases ring finger protein 20 (RNF20) and RNF40, factors that i

214 identify the histone H2B E3 ubiquitin ligase ring finger protein 20 (RNF20) as an additional chromati

215 of histone H3 at Lys4 and Lys79 by targeting ring finger protein 20 (RNF20) for proteasomal degradati

216 ubiquitin-specific peptidase 22 (Usp22) and ring finger protein 20 (Rnf20).

217 ressing role via its interaction with RNF20 (ring finger protein 20) in shaping chromatin landscape a

218 eotide polymorphism within the gene encoding RING finger protein 207 (RNF207) and the QT interval.

219 o6 (anocatmin 6; chromosome 15), and Rnf220 (Ring finger protein 220; chromosome 4) were considered c

220 s a major stimulator of puberty, and makorin RING finger protein 3 (MKRN3) as an inhibitory signal th

221 f43 (RING finger protein 43) and Znrf3 (zinc/RING finger protein 3) (RZ) are two closely related tran

222 Ring finger protein 4 (RNF4) is a SUMO-targeted ubiquiti

223 Keap1 but contained modified Nrf2 as well as RING finger protein 4 (RNF4), a poly-SUMO-specific E3 ub

224 AT1 phosphorylation, we went on to show that RING finger protein 4 depletion stabilizes PML and is co

225 t recruitment of E3 ubiquitin-protein ligase RING finger protein 4 resulted in ubiquitin-mediated deg

226 the SUMO-targeted ubiquitin E3 ligase, RNF4 (RING finger protein 4) (1).

227 Here we show that RNF4 (RING finger protein 4), a SUMO-dependent ubiquitin E3-li

228 at SUMO3 is important for the recruitment of RING finger protein 4, a poly-SUMO-dependent E3 ubiquiti

229 onjugating enzyme UBC9-mediated SUMOylation, RING finger protein 4-mediated (RNF4-mediated) polyubiqu

230 ng platform for ubiquitin E3 ligases such as ring finger protein 4.

231 We also found that the ring finger protein 41 (RNF41) as an E3 ligase ubiquitin

232 n ligases zinc and ring finger 3 (ZNRF3) and ring finger protein 43 (RNF43), which are disrupted in c

233 Rnf43 (RING finger protein 43) and Znrf3 (zinc/RING finger prot

234 es ZNRF3 (zinc and ring finger 3) and RNF43 (ring finger protein 43) antagonize Wnt signaling by prom

235 he TRP120-interacting protein polycomb group ring finger protein 5 (PCGF5) to the inclusion, indicati

236 phospho-MDC1) or E3 ubiquitin-protein ligase ring finger protein 8 (RNF8), two factors involved in DS

237 The E3 ubiquitin ligase RNF8 (RING finger protein 8) is a pivotal enzyme for DNA repai

238 Moreover, we have found that RNF8 (ring finger protein 8), an E3 ubiquitin ligase, regulate

239 Human RNF217 codes for a highly conserved RING finger protein and is mainly expressed in testis an

240 region that is predicted to contact the ROC1 RING finger protein by structural studies.

241 n ligase comprised of the cullin Rtt101, the RING finger protein Hrt1, and the adaptor protein Mms1.

242 In this regard we show that TRAF2, a RING finger protein implicated in ubiquitylation, select

243 We demonstrate that RING finger protein MSL2 in the MOF-MSL complex is a his

244 o heterodimers of either Cullin 2 (Cul2) and RING finger protein Rbx1 or Cullin 5 (Cul5) and Rbx2.

245 Using this strategy, we identified the RING finger protein RNF181 as an interactor of CARD11, a

246 The RING finger protein Z has been identified as the driving

247 We have identified a RING finger protein, AO7/RNF25, as a ubiquitin ligase fo

248 lister encodes a RING finger protein, LISTERIN, which functions as an E3

249 We identified a conserved transmembrane RING finger protein, PLR-1, that governs the response to

250 proof-of-concept study in a muscle-specific ring finger protein-1 (MuRF-1) knockout mouse model, we

251 Osteoblast depletion of the atrogene muscle ring finger protein-1 (MuRF1) protected against gluco- a

252 d, whereas the expression of muscle-specific RING finger protein-1 and atrogin-1, muscle atrophy mark

253 p-based cloning revealed that SIS3 encodes a RING finger protein.

254 strate-targeting subunit, Skp1, and the ROC1 RING finger protein.

255 The Really Interesting New Gene (RING) Finger Protein 4 (RNF4) represents a class of ubiq

256 effectors (fold-change messenger RNA: muscle RING-finger protein 1 = 5.7, atrogin-1 = 2.8; caspase-3

257 Muscle-specific ubiquitin ligases (muscle RING-finger protein 1 and atrogin-1), caspase-3 activity

258 dotoxemia, proinflammatory cytokines, muscle RING-finger protein 1, and atrogin-1 were not significan

259 utations in MKRN3, the gene encoding makorin RING-finger protein 3, in 5 of the 15 families; both sex

260 dependent kinase 7 (CDK7), Cyclin H, and the RING-finger protein MAT1 form the heterotrimeric CDK-act

261 The RING-finger protein PAR-2 becomes enriched on the poster

262 finger domain-containing protein, RINCK (for RING-finger protein that interacts with C kinase) from a

263 ble to phosphorylate TdRF1 in vitro, and the RING-finger protein WHEAT VIVIPAROUS-INTERACTING PROTEIN

264 eta1) signaling and repression of the muscle ring-finger protein-1 (MURF1)-mediated ubiquitylation of

265 ternally imprinted gene encoding the makorin RING-finger protein-3, has recently emerged as putative

266 nteracts with CUL3 independent of a bridging RING-finger protein; and (iv) can engage the neddylated

267 RING finger proteins constitute the large majority of ub

268 es by regulating the association between the RING finger proteins HEI10 and RNF212 and components of

269 naling and reveal roles for mutations in the RING finger proteins in cancer.

270 alphaherpesviruses also express ICP0-related RING finger proteins, but these have limited homology ou

271 tes and members of the Zip3/RNF212 family of RING finger proteins, which in turn stabilize MutSgamma.

272 Several ring between ring fingers (RBR) -domain proteins, such as Parkin and

273 iquitin ligases, members of the RING between RING fingers (RBR)-type RSL1/RFA family, are key regulat

274 100 by the ubiquitin ligase expressed by the RING finger (RF), and it blocks silencing of viral DNA m

275 BMI1 consists of a ring finger (RF), helix-turn-helix-turn-helix-turn (HT),

276 The human RING finger (RNF) E3 ubiquitin ligases, RNF8 and RNF168,

277 ery of ubiquitin, E1-like, E2-like and small-RING finger (srfp) protein components in the Aigarchaeot

278 P100) subunits, flanked by two copies of the RING finger subunit, FANCL.

279 sub-complex including the cullin domain and RING finger subunits Apc2 and Apc11, respectively, and a

280 further observe that restoration of Nrdp1, a RING finger type E3 ubiquitin ligase whose suppression i

281 fied as type 1 (index finger longer than the ring finger), type 2 (index finger equal to the ring fin

282 e these rearrangements and find that COP1, a RING-finger-type ubiquitin E3 ligase, is required for de

283 active beta-catenin in the Wnt-on phase by a RING finger ubiquitin E3 ligase, Casitas B-lineage lymph

284 d to anergy in lymphocytes), a transmembrane RING finger ubiquitin E3 ligase, initially described as

285 ed that the endoplasmic reticulum-associated RING finger ubiquitin ligase gp78 can mediate the preass

286 ~11.7 kb downstream of the gene encoding the RING finger ubiquitin ligase rififylin (RFFL) and variab

287 Proteomic analysis revealed that RNF8, a RING finger ubiquitin ligase that plays an important rol

288 The activity of RING finger ubiquitin ligases (E3) is dependent on their

289 highlight the function of two transmembrane RING finger ubiquitin ligases in modulating Wnt signalin

290 tylation of the surrounding chromatin by the RING finger ubiquitin ligases RNF8 and RNF168.

291 Cbl is a member of a family of RING finger ubiquitin ligases that negatively regulate s

292 gases (CRLs) constitute the largest group of RING finger ubiquitin ligases.

293 e Saccharomyces cerevisiae protein Asr1 is a RING finger ubiquitin-ligase that binds directly to RNA

294 ig-1 and Insig-2 bind another membrane-bound RING-finger ubiquitin ligase called Trc8.

295 yubiquitination activity in complex with the RING-finger ubiquitin ligase TRAF6 and the downstream NF

296 not Insig-2, recruits gp78, a membrane-bound RING-finger ubiquitin ligase.

297 We stimulated the index, middle, and ring fingers when the middle finger either was or was no

298 he most prominent of which appears to be the RING finger, which confers E3 ubiquitin ligase activity.

299 ratings pressed onto the stationary index or ring finger, with auditory feedback provided to signal c

300 The arenavirus small RING finger Z protein has been shown to be the main driv