ライフサイエンスコーパス: ring-closing

1 zolidine-1,1-dioxides by an enantioselective ring-closing 1,5-C-H amination of sulfamoyl azides.

2 ig iodoetherification enabled regioselective ring-closing alkene metatheses to afford the 5- as well

3 s aldol reaction conjoined with a relay-type ring-closing alkene metathesis is reported.

4 Ring-closing alkene metathesis of allylsilanes provides

5 of a highly enolizable beta-keto-lactone, a ring closing alkyne metathesis and a modified Stille cou

6 neous molybdenum(VI) catalyst was applied to ring closing alkyne metathesis and cyclooligomerization

7 Ring-closing alkyne metathesis allowed a 13-membered cyc

8 quired macrocyclic precursor was prepared by ring-closing alkyne metathesis followed by trans-hydrost

9 rmediate and macrocyclization using Furstner ring-closing alkyne metathesis.

10 sequence involving ring closing-ring opening-ring closing and cross metathesis (RC-RO-RC-CM) occurred

11 ility of in situ imine formation followed by ring-closing, but support instead hydrogen-bond assisted

12 An enantioselective ring-closing C(sp(3) )-H amination of 2-azidoacetamides

13 m has been proposed involving a ring-opening-ring-closing cascade followed by a 1,3-indole migration

14 methylene aziridine promotes a ring-opening/ring-closing cascade that efficiently transfers chiralit

15 by a deprotection and intramolecular double ring-closing condensation reaction.

16 sirine, including the first application of a ring-closing copper(I)/TEMPO aerobic oxidation to the py

17 The key step, a ring-closing dienyne metathesis (RCDEYM) reaction, has b

18 ism is proposed that involves a ring-opening/ring-closing (Dimroth) rearrangement.

19 ial one-pot two-directional cross-metathesis/ring-closing double aza-Michael process.

20 and is often used in organic synthesis as a ring-closing effect.

21 on the use of the Stewart Grubbs catalyst in ring closing enyne metatheses.

22 The ring closing enyne metathesis of substrates with proparg

23 tions, followed by a ruthenium(II)-catalyzed ring closing enyne metathesis reaction.

24 In the presence of the Grubbs II catalyst, ring-closing enyne metathesis of the PK cycloaddition pr

25 ting the same starting dipeptide to a direct ring-closing enyne metathesis or an ethylene-mediated cr

26 a base-catalyzed alkynyl silane alcoholysis/ring-closing enyne metathesis sequence for facile constr

27 minobutyric acid (P-A1-Daba), converting the ring-closing ester bond to an amide bond.

28 Replacing the ring-closing ester bond with an amide bond had little or

29 (DABA), or serine, effectively replacing the ring-closing ester bond with an amide linkage or with a

30 arting furoindole followed by a ring-opening/ring-closing event affording 2-spirocyclopentane-1,2-dih

31 rocyclic ring opening, and 6pi-electrocyclic ring-closing events, constitutes a robust method for pro

32 Methodology for the ring-closing iodoamination of bishomoallylic amines foll

33 try of the observed products, a ring-opening/ring-closing mechanism is proposed and supported by the

34 hly efficient in macrocyclizations involving ring-closing metatheses (RCM), whereas the complex featu

35 ng the unsubstituted parent, was accessed by ring-closing metatheses of alpha,alpha-diallylacetonitri

36 Ring-closing metatheses provide efficient access to the

37 Asymmetric ring closing metathesis (ARCM) of a challenging class of

38 m of precatalyst and PAG was capable of both ring closing metathesis (RCM) and ring opening metathesi

39 erivatives based on selective alkylation and ring closing metathesis (RCM) by exploiting the four pos

40 In all cases, ring closing metathesis (RCM) depolymerization of the PC

41 ,Arg(4),d-Ala(8)]dynorphin A(1-11)-NH(2)) by ring closing metathesis (RCM) involving tyrosine(O-allyl

42 eactions of COE and norbornadiene (NBD), and ring closing metathesis (RCM) reactions of diethyl diall

43 synthesized through an asymmetric allylation/ring closing metathesis (RCM) sequence.

44 and, consequently, the kinetic model of the ring closing metathesis (RCM), enabling a further increa

45 h a suitable side chain tether introduced by ring closing metathesis (RCM).

46 atalyst was shown to catalyze various olefin ring closing metathesis and hydrosilylation reactions in

47 -membered macrocyclic lactone was formed via ring closing metathesis and subsequent chemoselective re

48 16-epi-luffarin L (2) by a silicon-tethered ring closing metathesis as a key step has been achieved.

49 rate that their synthesis can be achieved by ring closing metathesis of readily accessible precursors

50 ermally mediated Overman rearrangement and a ring closing metathesis reaction of allylic trichloroace

51 diene derivatives that were subjected to the ring closing metathesis reaction to furnish the gem-difl

52 The synthesis relied on an acylation-ring closing metathesis sequence.

53 re the result of a tandem cycloisomerization-ring closing metathesis sequence.

54 ed a cascade Takai-Utimoto ester olefination/ring closing metathesis to construct ring Y, a hydroxydi

55 used benzofuran and 2) a cascade ene-yne-ene ring closing metathesis to forge the tetracyclic morphin

56 that ultimately was subjected to diene-diene ring closing metathesis to form the macrocycle.

57 ement of a functionalized allyl bromide, and ring closing metathesis to obtain the macrolactone.

58 h the Grb7-SH2 domain, both before and after ring closing metathesis to show that the closed staple i

59 Ring closing metathesis using difluorinated 1,7-enyne ca

60 re discussed based on asymmetric allylation, ring closing metathesis, and aldol reactions.

61 ondensation, (ii) ether synthesis, and (iii) ring closing metathesis.

62 carbenes and their application to asymmetric ring-closing metathesis (ARCM) are reported.

63 y performing a domino cross enyne metathesis/ring-closing metathesis (CEYM/RCM) in the presence of st

64 idemniserinolipid B utilizing a ketalization/ring-closing metathesis (K/RCM) strategy is described.

65 sterification, Friedel-Crafts acylation, and ring-closing metathesis (or cross metathesis).

66 e and terminal arylalkynes followed by enyne ring-closing metathesis (RCM) and Heck cyclization affor

67 The feasibility of ring-closing metathesis (RCM) as a synthetic entry to 10

68 action, followed by Fischer indolization and ring-closing metathesis (RCM) as key steps.

69 -11)NH(2) analogues on solid phase utilizing ring-closing metathesis (RCM) between the side chains of

70 rresponding alcohols, smoothly underwent the ring-closing metathesis (RCM) by using Hoveyda-Grubbs II

71 and titanium assisted cross-metathesis (CM)/ring-closing metathesis (RCM) cascade has been used to s

72 It allows us to design a transvinylation/ring-closing metathesis (RCM) cascade reaction leading t

73 Ring-closing metathesis (RCM) catalyzed by a second-gene

74 orochrysophaentin A enabled by a Z-selective ring-closing metathesis (RCM) cyclization followed by an

75 tituted piperidinone D-rings were formed via ring-closing metathesis (RCM) followed by a 1,4-addition

76 To this end, the catalytic process known as ring-closing metathesis (RCM) has allowed access to coun

77 Catalytic ring-closing metathesis (RCM) is a widely used method fo

78 enation, acryloylation, and Ru(II)-catalyzed ring-closing metathesis (RCM) led to the formation of th

79 embedded bicyclic lactone, and an efficient ring-closing metathesis (RCM) reaction to generate the m

80 de and monoaryloxide complexes promote enyne ring-closing metathesis (RCM) reactions, affording the c

81 iency in mediating cross metathesis (CM) and ring-closing metathesis (RCM) reactions, little is known

82 bond formations, one etherification, and one ring-closing metathesis (RCM) step, using readily availa

83 C1-C21 bond and the second approach using a ring-closing metathesis (RCM) strategy to form the C10-C

84 A phosphate tether-mediated ring-closing metathesis (RCM) study to the synthesis of

85 centerpiece of the strategy is a sequential ring-closing metathesis (RCM) that forms an unsaturated

86 F3.Et2O-mediated Et3SiH reduction and olefin ring-closing metathesis (RCM) using Ru(II) catalysts.

87 Ring-closing metathesis (RCM) was employed to join carbo

88 struction of the central macrolide employing ring-closing metathesis (RCM), followed by selective pro

89 ghly efficient and selective for macrocyclic ring-closing metathesis (RCM).

90 erein an uncaging reaction that results from ring-closing metathesis (RCM).

91 metathesis involving ring-opening metathesis-ring-closing metathesis (ROM-RCM) of a bicyclo[2.2.2]oct

92 l 2-allyl-4-fluorophenyl auxiliary for relay ring-closing metathesis (RRCM) was developed, which incr

93 n reaction pathways (ring-opening metathesis/ring-closing metathesis [ROM/RCM] cascade vs ring-closin

94 ropic [1,3]-shift followed by a second enyne ring-closing metathesis allowed the formation of a highl

95 Other key steps include a ring-closing metathesis and a selective olefin oxidation

96 The application in sequence of ring-closing metathesis and an intramolecular Heck react

97 otal synthesis of chatenaytrienin-2 based on ring-closing metathesis and C(sp)-C(sp(3)) Sonogashira c

98 With the advent of ruthenium-catalyzed ring-closing metathesis and copper-catalyzed alkyne-azid

99 The C-Glc Ser was available by a ring-closing metathesis and hydroalkoxylation route.

100 ic macromonomers was demonstrated using both ring-closing metathesis and macrolactonization reactions

101 The enyne ring-closing metathesis and relay metathesis provides th

102 esis of the eight-membered analogues involve ring-closing metathesis and Sharpless asymmetric dihydro

103 ment of a strategy consisting of allylsilane ring-closing metathesis and subsequent S(E)' electrophil

104 loped a robust macrocyclization method using ring-closing metathesis and synthesized a 45,000-compoun

105 ment of an iterative reductive aromatization/ring-closing metathesis approach.

106 ed macrocyclic dienediyne was achieved using ring-closing metathesis as a key step.

107 errier rearrangement, Grignard addition, and ring-closing metathesis as key steps.

108 employing ring-rearrangement metathesis and ring-closing metathesis as key steps.

109 idine fragment are depicted, both relying on ring-closing metathesis but differing in the substitutio

110 pyl ketenethioacetal, (2) an efficient enyne ring-closing metathesis cascade reaction in a challengin

111 Iron(III)-catalyzed carbonyl-olefin ring-closing metathesis employs reactivity not typically

112 ess, the alternative approach was based on a ring-closing metathesis from the corresponding N-allyl-s

113 In the second stage of the tandem strategy, ring-closing metathesis generates the nitrogen heterocyc

114 termediates in the catalytic carbonyl-olefin ring-closing metathesis has been obtained.

115 The aromatizing ring-closing metathesis has been shown to take place ins

116 cyclic ring system via alcohol oxidation and ring-closing metathesis is also described.

117 and macrocyclic nitrogen heterocycles using ring-closing metathesis is described.

118 l boronic esters and homoallylic alcohols by ring-closing metathesis is reported.

119 However, a sequential enyne ring-closing metathesis of a diyne moiety and metallotro

120 A key catalytic ring-closing metathesis of an achiral triene is used to

121 stituted monobenzofused 1,4-azaborines using ring-closing metathesis of an enamine-containing diene a

122 as 25 ppm can lead to 100% conversion in the ring-closing metathesis of diethyl diallylmalonate.

123 friendly alternative to either the classical ring-closing metathesis of N-homoallyl-unsaturated amide

124 benzo[b]phosphole-1-oxide, itself derived by ring-closing metathesis of phenylstyrylvinylphosphine ox

125 acids derivatives, are readily prepared via ring-closing metathesis of sulfinimine-derived N-sulfiny

126 15-membered macrocyclic PIs were prepared by ring-closing metathesis of the corresponding linear PIs.

127 )amide to tert-butyl sorbate was followed by ring-closing metathesis of the resultant N-alkenyl beta-

128 opane to make two rings, and group-selective ring-closing metathesis of the resulting divinylcyclopen

129 increase macrocyclization selectivity in the ring-closing metathesis of various dienes at elevated su

130 ve been prepared via two key steps involving ring-closing metathesis of vinyl chlorides and regiosele

131 vity are highlighted by cross metathesis and ring-closing metathesis on diverse peptide substrates.

132 Ru-catalyzed ring-closing metathesis performed on the diallylated aro

133 lkenylamide containing peptides, prepared as ring-closing metathesis precursors, showed that the high

134 -amino acid derivatives could be accessed by ring-closing metathesis presenting a viable strategy to

135 studies include development of an efficient ring-closing metathesis procedure to prepare macrocyclic

136 y such initiating neophylidenes in promoting ring-closing metathesis processes, are disclosed.

137 y is one reason why many cross-metathesis or ring-closing metathesis processes, which are reversible

138 f this arrangement through esterification or ring-closing metathesis produces the closed-knot complex

139 ing reactions include Nazarov cyclization, a ring-closing metathesis promoted with complete diastereo

140 n and a highly chemo- and diastereoselective ring-closing metathesis protocol for the formation of th

141 A high-performing ring-closing metathesis protocol has been achieved by si

142 Ring-closing metathesis provided access to a twelve-memb

143 ctrophilic alpha-chloro sulfide, and last by ring-closing metathesis reaction as the key steps.

144 rbon bond is enabled by a microwave-assisted ring-closing metathesis reaction between two terminal ol

145 c approach highlights a remarkably efficient ring-closing metathesis reaction catalyzed by Nolan ruth

146 icient molybdenum-catalyzed enantioselective ring-closing metathesis reaction for the desymmetrizatio

147 Overman rearrangement and a Ru(II)-catalyzed ring-closing metathesis reaction has been developed for

148 discovery of an efficient and selective bis ring-closing metathesis reaction leading to peptides bea

149 ombination of Ichikawa's rearrangement and a ring-closing metathesis reaction of allyl carbamates is

150 e we demonstrate a catalytic carbonyl-olefin ring-closing metathesis reaction that uses iron, an Eart

151 ion to build ring E and a diastereoselective ring-closing metathesis reaction to construct ring D.

152 e key intermediates, as well as Ru-catalyzed ring-closing metathesis reaction to construct the key tr

153 ved from D-glucose, followed by a sequential ring-closing metathesis reaction using Grubbs catalysts,

154 NMR studies confirmed that the ring-closing metathesis reaction yielded a single produc

155 action, an Overman rearrangement reaction, a ring-closing metathesis reaction, and an amination react

156 ic attack of a hindered tertiary alkoxide, a ring-closing metathesis reaction, and the Diels-Alder cy

157 The synthesis features a challenging ring-closing metathesis reaction, followed by eliminatio

158 aldols, Yamaguchi esterification, and Grubbs ring-closing metathesis reaction.

159 which is advantageously synthesized using a ring-closing metathesis reaction.

160 actical approach based on esterification and ring-closing metathesis reaction.

161 is are surveyed, with particular emphasis on ring-closing metathesis reactions and annulation reactio

162 yclizations of bis(vinyl boronate esters) or ring-closing metathesis reactions followed by complexati

163 ment of Lewis acid-catalyzed carbonyl-olefin ring-closing metathesis reactions for aliphatic ketones.

164 A study of the ring-closing metathesis reactions of two bis(enynes) is

165 Olefin cross- and ring-closing metathesis reactions run in the presence of

166 alyst-controlled stereoselective macrocyclic ring-closing metathesis reactions that generate Z-enoate

167 hesis include diastereoselective Nazarov and ring-closing metathesis reactions, and a highly efficien

168 catalyst modification necessary) to perform ring-closing metathesis reactions, generating 14- to 21-

169 trategy using intramolecular Diels-Alder and ring-closing metathesis reactions.

170 ctrocyclization sequence and others based on ring-closing metathesis reactions.

171 Iron(III)-catalyzed carbonyl-olefin ring-closing metathesis represents a new approach toward

172 d dihydropyran rings was constructed via the ring-closing metathesis route.

173 an ambitious one-pot alkyne cross-metathesis/ring-closing metathesis self-assembly process.

174 ates by a Suzuki coupling-Wittig olefination-ring-closing metathesis sequence allowed a convergent an

175 A ring-closing metathesis served for construction of the s

176 catalysts initiate the key enantioselective ring-closing metathesis step in the total synthesis of q

177 t the piperidine core and a silicon-tethered ring-closing metathesis strategy to install the Z exocyc

178 A highly efficient, Z-selective ring-closing metathesis system for the formation of macr

179 yclic core of Vaniprevir (MK-7009) utilizing ring-closing metathesis technology.

180 de pyrrolide (MAP) complex and a macrocyclic ring-closing metathesis that affords a trisubstituted al

181 rization/Claisen rearrangement cascade and a ring-closing metathesis that allows access to a variety

182 d a relatively rare application of catalytic ring-closing metathesis to access an 11-membered ring st

183 and 10 (obtained from D-ribose) followed by ring-closing metathesis to afford enol ether 8, whose el

184 The isomerization can be combined with ring-closing metathesis to afford the synthesis of exocy

185 Use was also made of ring-closing metathesis to bring about the conversion of

186 trategically forge the C1-C2 bond, and (3) a ring-closing metathesis to build the bridging bicyclo[4.

187 o alcohol functionality of conduramine E and ring-closing metathesis to construct its carbocyclic cor

188 d assemble the diazatricycloundecane core, a ring-closing metathesis to construct the 13-membered rin

189 riate allyl bromide provides a precursor for ring-closing metathesis to deliver the oxepinochromone r

190 e aldol reaction provided a diene useful for ring-closing metathesis to form an oxonene, which was ul

191 y substituted cyclobutanols; (ii) the use of ring-closing metathesis to form the pendant five-membere

192 Our convergent route features an adventurous ring-closing metathesis to form the requisite trisubstit

193 terically encumbered tetrahydropyran ring, a ring-closing metathesis to generate the C(4a-13-20a) mac

194 e previously reported that the employment of ring-closing metathesis to introduce a single all-hydroc

195 Additional key steps include ring-closing metathesis to prepare the D-ring and Bosch-

196 turally occurring monoterpene myrcene (1) by ring-closing metathesis using Grubbs second generation c

197 Ring-closing metathesis was a key reaction used to form

198 An E-selective ring-closing metathesis was used to access the 10-member

199 Ring-closing metathesis was used to construct the strain

200 tereoselective Grignard reaction followed by ring-closing metathesis was used.

201 phosphonate derived from (S)-lactic acid and ring-closing metathesis were the key reactions during th

202 1]tridecenes were synthesized by E-selective ring-closing metathesis where their absolute stereochemi

203 In particular, ring-closing metathesis with the Hoveyda-Grubbs catalyst

204 onveniently protected d-glyceraldehyde, (ii) ring-closing metathesis, (iii) debenzylative cycloetheri

205 ophilic addition to an N-acyl iminium ion, a ring-closing metathesis, a diastereoselective hydroborat

206 e base and the carbocyclic sugar moiety, via ring-closing metathesis, allowed for a facial selective

207 acrocyclic PIs were designed, synthesized by ring-closing metathesis, and evaluated alongside with 10

208 blishes the stereochemistry of the product), ring-closing metathesis, and simple functional group con

209 amolecular oxa-Michael reaction, E-selective ring-closing metathesis, De Brabander's esterification,

210 into C-ribosides 29a,b via the Ru-catalyzed ring-closing metathesis, followed by a diastereoselectiv

211 arting materials and key Wittig olefination, ring-closing metathesis, Lindlar reduction, and C(sp)-C(

212 Olefin-cross metathesis, ring-closing metathesis, palladium-catalyzed Meinwald re

213 an ethylene-mediated cross-enyne metathesis/ring-closing metathesis, respectively.

214 d-catalyzed Suzuki coupling and Ru-catalyzed ring-closing metathesis, thus representing a practical m

215 is inclusion complex was subjected to olefin ring-closing metathesis, which was observed to proceed u

216 the C4' stereocenter, and a highly efficient ring-closing metathesis-allylic oxidation sequence to fo

217 A ring-closing metathesis-based strategy has allowed acces

218 de novo from l-ethyl lactate through tandem ring-closing metathesis-isomerization sequence, undergoe

219 Ring-closing metathesis-mediated incorporation of an int

220 homoallylglycine building blocks followed by ring-closing metathesis.

221 n metathesis, including cross-metathesis and ring-closing metathesis.

222 d by homodimerization, cross metathesis, and ring-closing metathesis.

223 Tsuji-Trost allylic amination reaction and a ring-closing metathesis.

224 or aminohydroxylation protocols followed by ring-closing metathesis.

225 ometallic addition, and a Z-selective alkene ring-closing metathesis.

226 oyl-protected carbocyclic bis-allyl ureas by ring-closing metathesis.

227 onic acid-controlled Z-selective macrocyclic ring-closing metathesis.

228 carbon macrocyclic ring system was formed by ring-closing metathesis.

229 yclononene substructure could be realized by ring-closing metathesis.

230 as the five-membered ring was formed through ring-closing metathesis.

231 d six-membered cyclic phosphonates using the ring-closing metathesis.

232 ed to a single phenanthrene target by way of ring-closing metathesis.

233 center, and the lactone moiety was formed by ring-closing metathesis.

234 ring stapled peptide by means of macrocyclic ring-closing metathesis.

235 ablish the E,Z-diene part, an ester-tethered ring-closing metathesis/base-induced eliminative ring op

236 ization step was achieved using a sequential ring-closing metathesis/olefin isomerization reaction.

237 ring-closing metathesis [ROM/RCM] cascade vs ring-closing metathesis/ring-opening metathesis [RCM/ROM

238 addition were observed to undergo efficient ring-closing-metathesis (RCM) reaction in the presence o

239 oselectivity and diversity generation at the ring-closing moiety became dominant over the last years.

240 Net conrotatory ring closing occurred in 5.0 +/- 0.5% of the released tr

241 hitecture in high yield ( 75%) via efficient ring closing of rationally designed metallosupramolecula

242 methylene compound to the aryne followed by ring closing of the adduct.

243 s-1,4-diacetoxy-2-butene and the macrocyclic ring-closing of a 14-membered lactone.

244 mark olefin metathesis reactions such as the ring-closing of diethyldiallyl and diethylallylmethallyl

245 xhibiting pseudo-first-order kinetics in the ring-closing of diethyldiallyl malonate.

246 c ring-opening of cyclobutene, electrocyclic ring-closing of Z-hexatriene, the [1,5]-H shift in Z-pen

247 g ratio between symmetry-allowed disrotatory ring closing (of which the trapped diradicaloid structur

248 ition to a tert-butanesulfinyl aldimine, and ring closing olefin metathesis as key steps.

249 thyl, alpha-alkenyl amino acids and (ii) the ring-closing olefin metathesis (RCM) of the resulting re

250 The syntheses of these macrocycles feature ring-closing olefin metathesis (RCM) reactions catalyzed

251 Ring-closing olefin metathesis (RCM) then affords the cl

252 om [(ArylNCH2CH2)3N]Mo(NB(C6F5)3) with PMe3, ring-closing olefin metathesis (RCM) was employed to joi

253 t joining of the overhand knot end groups by ring-closing olefin metathesis affords a single enantiom

254 yl acetal rearrangement were synthesized via ring-closing olefin metathesis of bis(allyoxy)methyl der

255 c polymer backbone using ruthenium-catalyzed ring-closing olefin metathesis to afford a molecular cha

256 the all-carbon quaternary stereocenter and a ring-closing olefin metathesis to concomitantly form the

257 The ligand strands can be cyclized by ring-closing olefin metathesis to form a molecular trefo

258 nd:metal complexes is covalently captured by ring-closing olefin metathesis to form topologically chi

259 ith other stabilization chemistries, such as ring-closing olefin metathesis, to stabilize loop, turn,

260 iron(II), or cobalt(II) cations, followed by ring-closing olefin metathesis.

261 bsequent covalent capture of the catenane by ring-closing olefin metathesis.

262 een synthesized based on macrocyclization by ring-closing olefin metathesis.

263 cked molecular architectures are produced by ring-closing olefin metathesis.

264 c2]daisy-chain dimer via ruthenium-catalyzed ring-closing olefin metathesis.

265 substituents synthesized by alkyne coupling/ring closing or palladium-catalyzed ipso-arylation chemi

266 and beta-amino acid residues to template the ring-closing process.

267 ditions followed by several ring-opening and ring-closing processes.

268 rominated tetralone motif was generated in a ring-closing protocol.

269 of 7e (R(1) = NMe2, R(2) = H) for which the ring-closing quantum yield increased 10-fold upon switch

270 The yields of the ring closing reaction highly depend on the metal (Cu or

271 e synthesized using an oxidative Glaser-type ring closing reaction.

272 ins why additional base does not lead to the ring-closing reaction as observed with 2-chloro-5-nitrop

273 method is based on the Lewis acid-catalyzed ring-closing reaction between substituted orthoesters an

274 A succeeding methanolysis and concomitant ring-closing reaction gives the tetrazinanone.

275 easily undergoes an endocyclic, sigmatropic ring-closing reaction to form the final 2H-chromene prod

276 in which the cyclopentane ring is formed by ring closing reactions (C=C and C-C formation) and metho

277 nyltellurophene (3) were synthesized through ring closing reactions of 1,4-substituted butadiyne.

278 upling reactions, and (3) the development of ring closing reactions to form the desired macrocyclic p

279 e transition states for the ring-opening and ring-closing reactions, and both transition states contr

280 E-selective cross-metathesis and macrocyclic ring-closing reactions, where E-butene serves as the met

281 sive in the observed outcome of irreversible ring-closing reactions.

282 e acid-catalyzed or spontaneous ring-opening-ring-closing rearrangement to yield fused polyheterocycl

283 ynthesis route featuring an iterative double ring-closing reductive amination reaction.

284 A tandem metathesis sequence involving ring closing-ring opening-ring closing and cross metathe

285 hesis of main-chain polymers through radical ring-closing/ring-opening cascade polymerization is repo

286 sulfide or allylic sulfone motifs enabled a ring-closing/ring-opening cascade reaction that provides

287 hloride in the presence of 4-DMAP allows the ring-closing step under mild conditions.

288 - and exo-cyclic fragments formed during the ring-closing step, which stands as a distinctive and use

289 early cycloadditions and alkyne couplings as ring-closing steps to very recent 3d metal-catalyzed mac

290 result from two consecutive ring-opening and ring-closing steps.

291 e using an "open and shut" (ring-opening and ring-closing) strategy.

292 on, in cis-stilbene it leads to an ultrafast ring-closing to form 4a,4b-dihydrophenanthrene.

293 that, after intersystem crossing, undergoes ring-closing to form the desired product.

294 Ring-closing to prepare the cyclic macromonomers was dem

295 , but support instead hydrogen-bond assisted ring-closing to prodrugs.

296 ated to be 6.9 from the pH dependence of its ring-closing to the pyrimidopurinone derivative 1.

297 s proposed based on relative energies of the ring-closing transition structures.

298 on state) and symmetry-forbidden conrotatory ring closing (whose transition state is nearby) can be i

299 ive nucleophilic addition and intramolecular ring-closing with dihalo electrophiles.

300 e and the first one ever of a macrolide by a ring-closing Wittig olefination of a stabilized phosphor