ライフサイエンスコーパス: ring-closing metathesis

1 chain is possible using cross metathesis or ring closing metathesis.

2 n, to some extent, undergo an intramolecular ring closing metathesis.

3 ondensation, (ii) ether synthesis, and (iii) ring closing metathesis.

4 Tsuji-Trost allylic amination reaction and a ring-closing metathesis.

5 or aminohydroxylation protocols followed by ring-closing metathesis.

6 ometallic addition, and a Z-selective alkene ring-closing metathesis.

7 oyl-protected carbocyclic bis-allyl ureas by ring-closing metathesis.

8 onic acid-controlled Z-selective macrocyclic ring-closing metathesis.

9 carbon macrocyclic ring system was formed by ring-closing metathesis.

10 yclononene substructure could be realized by ring-closing metathesis.

11 as the five-membered ring was formed through ring-closing metathesis.

12 d six-membered cyclic phosphonates using the ring-closing metathesis.

13 ared from optically pure acyclic acetals via ring-closing metathesis.

14 y eight-membered-ring intermediate employing ring-closing metathesis.

15 formation of an unsaturated lactone through ring-closing metathesis.

16 ed to a single phenanthrene target by way of ring-closing metathesis.

17 turn a Myers reductive coupling followed by ring-closing metathesis.

18 ysts used to promote CO(2) hydrogenation and ring-closing metathesis.

19 ) alkylidene catalyst for deconstruction via ring-closing metathesis.

20 aining bulky dendrons via sequential cascade ring-closing metathesis.

21 center, and the lactone moiety was formed by ring-closing metathesis.

22 ring stapled peptide by means of macrocyclic ring-closing metathesis.

23 homoallylglycine building blocks followed by ring-closing metathesis.

24 n metathesis, including cross-metathesis and ring-closing metathesis.

25 d by homodimerization, cross metathesis, and ring-closing metathesis.

26 cycle was realized by a highly (E)-selective ring-closing metathesis (35 --> 37).

27 ophilic addition to an N-acyl iminium ion, a ring-closing metathesis, a diastereoselective hydroborat

28 ree important types of metathesis reactions: ring-closing metathesis, alkene dimerization, and alkene

29 ropic [1,3]-shift followed by a second enyne ring-closing metathesis allowed the formation of a highl

30 e base and the carbocyclic sugar moiety, via ring-closing metathesis, allowed for a facial selective

31 the C4' stereocenter, and a highly efficient ring-closing metathesis-allylic oxidation sequence to fo

32 atalyst was shown to catalyze various olefin ring closing metathesis and hydrosilylation reactions in

33 -membered macrocyclic lactone was formed via ring closing metathesis and subsequent chemoselective re

34 Other key steps include a ring-closing metathesis and a selective olefin oxidation

35 The application in sequence of ring-closing metathesis and an intramolecular Heck react

36 otal synthesis of chatenaytrienin-2 based on ring-closing metathesis and C(sp)-C(sp(3)) Sonogashira c

37 With the advent of ruthenium-catalyzed ring-closing metathesis and copper-catalyzed alkyne-azid

38 etic macrocycles has been accomplished using ring-closing metathesis and enyne tandem cross-metathesi

39 The C-Glc Ser was available by a ring-closing metathesis and hydroalkoxylation route.

40 ic macromonomers was demonstrated using both ring-closing metathesis and macrolactonization reactions

41 The combination of ring-closing metathesis and Pd-catalyzed, silicon-assist

42 The enyne ring-closing metathesis and relay metathesis provides th

43 esis of the eight-membered analogues involve ring-closing metathesis and Sharpless asymmetric dihydro

44 ment of a strategy consisting of allylsilane ring-closing metathesis and subsequent S(E)' electrophil

45 loped a robust macrocyclization method using ring-closing metathesis and synthesized a 45,000-compoun

46 use of ruthenium catalysts, first in azepine ring-closing metathesis and then in alkene isomerization

47 hese products served as substrates for enyne ring-closing metathesis and, consequently, as precursors

48 re discussed based on asymmetric allylation, ring closing metathesis, and aldol reactions.

49 acrocyclic PIs were designed, synthesized by ring-closing metathesis, and evaluated alongside with 10

50 blishes the stereochemistry of the product), ring-closing metathesis, and simple functional group con

51 Here, a ring-closing metathesis approach is utilized to synthesi

52 ment of an iterative reductive aromatization/ring-closing metathesis approach.

53 3C7 in 81% yield, using a threading-followed-ring-closing-metathesis approach.

54 Asymmetric ring closing metathesis (ARCM) of a challenging class of

55 carbenes and their application to asymmetric ring-closing metathesis (ARCM) are reported.

56 The Mo-catalyzed asymmetric ring-closing metathesis (ARCM) of various achiral triene

57 The first examples of catalytic asymmetric ring-closing metathesis (ARCM) reactions of enol ethers

58 OM transformations that occur in tandem with ring-closing metathesis are described.

59 16-epi-luffarin L (2) by a silicon-tethered ring closing metathesis as a key step has been achieved.

60 -membered macrocycle has been synthesized by ring closing metathesis as a synthetic application.

61 ed macrocyclic dienediyne was achieved using ring-closing metathesis as a key step.

62 ermolecular Pauson-Khand cycloaddition and a ring-closing metathesis as key bond-forming transformati

63 employing ring-rearrangement metathesis and ring-closing metathesis as key steps.

64 errier rearrangement, Grignard addition, and ring-closing metathesis as key steps.

65 ablish the E,Z-diene part, an ester-tethered ring-closing metathesis/base-induced eliminative ring op

66 We initially investigated a ring-closing metathesis based synthetic strategy to form

67 A ring-closing metathesis-based strategy has allowed acces

68 idine fragment are depicted, both relying on ring-closing metathesis but differing in the substitutio

69 solution would entail catalytic macrocyclic ring-closing metathesis, but these transformations requi

70 productive and hidden degenerate pathways of ring-closing metathesis by focusing on one individual ca

71 Ring-closing metathesis can be performed on the N-protec

72 pyl ketenethioacetal, (2) an efficient enyne ring-closing metathesis cascade reaction in a challengin

73 y performing a domino cross enyne metathesis/ring-closing metathesis (CEYM/RCM) in the presence of st

74 -trisubstituted furan and features efficient ring-closing metathesis chemistry made possible through

75 amolecular oxa-Michael reaction, E-selective ring-closing metathesis, De Brabander's esterification,

76 ion of a higher-order dimethylcuprate upon a ring-closing metathesis-derived alpha,beta-unsaturated v

77 Iron(III)-catalyzed carbonyl-olefin ring-closing metathesis employs reactivity not typically

78 into C-ribosides 29a,b via the Ru-catalyzed ring-closing metathesis, followed by a diastereoselectiv

79 The new sequence is an alternative to the ring-closing metathesis for the synthesis of carbohydrat

80 ase-an artificial metalloenzyme designed for ring-closing metathesis-for whole-cell biocatalysis.

81 ess, the alternative approach was based on a ring-closing metathesis from the corresponding N-allyl-s

82 Interestingly, the ring-closing metathesis generates a new eight-membered r

83 In the second stage of the tandem strategy, ring-closing metathesis generates the nitrogen heterocyc

84 termediates in the catalytic carbonyl-olefin ring-closing metathesis has been obtained.

85 The aromatizing ring-closing metathesis has been shown to take place ins

86 owed by a conjugate addition-elimination and ring-closing metathesis, has been developed.

87 de reduction, and (iii) a template-supported ring-closing metathesis/hydrolysis sequence.

88 nthesis include (i) macrocycle formation via ring-closing metathesis, (ii) macrocyclic substrate-cont

89 onveniently protected d-glyceraldehyde, (ii) ring-closing metathesis, (iii) debenzylative cycloetheri

90 Conformational restriction by ring-closing metathesis increased the specificity of res

91 cyclic ring system via alcohol oxidation and ring-closing metathesis is also described.

92 uencing the diastereochemical outcome of the ring-closing metathesis is also presented, revealing tha

93 The utility of the Mo-catalyzed AROM/ring-closing metathesis is demonstrated through an enant

94 and macrocyclic nitrogen heterocycles using ring-closing metathesis is described.

95 yl moieties followed by a diastereoselective ring-closing metathesis is described.

96 l boronic esters and homoallylic alcohols by ring-closing metathesis is reported.

97 ng a tethered olefinic site followed by RCM (ring-closing metathesis) is described.

98 de novo from l-ethyl lactate through tandem ring-closing metathesis-isomerization sequence, undergoe

99 idemniserinolipid B utilizing a ketalization/ring-closing metathesis (K/RCM) strategy is described.

100 arting materials and key Wittig olefination, ring-closing metathesis, Lindlar reduction, and C(sp)-C(

101 e two elaborate fragments, and a challenging ring-closing metathesis macrocyclization with an unusual

102 ylenation of these compounds was followed by ring-closing metathesis, mediated by the Schrock molybde

103 Ring-closing metathesis-mediated incorporation of an int

104 The first catalytic asymmetric ring-closing metathesis method for the synthesis of N-co

105 rate that their synthesis can be achieved by ring closing metathesis of readily accessible precursors

106 Ring-closing metathesis of 5a-f afforded functionalized

107 However, a sequential enyne ring-closing metathesis of a diyne moiety and metallotro

108 A key catalytic ring-closing metathesis of an achiral triene is used to

109 stituted monobenzofused 1,4-azaborines using ring-closing metathesis of an enamine-containing diene a

110 Attempts to effect ring-closing metathesis of dienes 37, 38, and 46 were un

111 as 25 ppm can lead to 100% conversion in the ring-closing metathesis of diethyl diallylmalonate.

112 The ring-closing metathesis of enediynes induces a facile me

113 friendly alternative to either the classical ring-closing metathesis of N-homoallyl-unsaturated amide

114 benzo[b]phosphole-1-oxide, itself derived by ring-closing metathesis of phenylstyrylvinylphosphine ox

115 acids derivatives, are readily prepared via ring-closing metathesis of sulfinimine-derived N-sulfiny

116 15-membered macrocyclic PIs were prepared by ring-closing metathesis of the corresponding linear PIs.

117 ystem 5 has been developed that features the ring-closing metathesis of the enyne 45 to construct the

118 )amide to tert-butyl sorbate was followed by ring-closing metathesis of the resultant N-alkenyl beta-

119 opane to make two rings, and group-selective ring-closing metathesis of the resulting divinylcyclopen

120 increase macrocyclization selectivity in the ring-closing metathesis of various dienes at elevated su

121 ve been prepared via two key steps involving ring-closing metathesis of vinyl chlorides and regiosele

122 ization step was achieved using a sequential ring-closing metathesis/olefin isomerization reaction.

123 ed through a reaction sequence that included ring-closing metathesis on acrylate esters of the homoal

124 Ring-opening/ring-closing metathesis on cyclobutene-containing substr

125 vity are highlighted by cross metathesis and ring-closing metathesis on diverse peptide substrates.

126 sterification, Friedel-Crafts acylation, and ring-closing metathesis (or cross metathesis).

127 Olefin-cross metathesis, ring-closing metathesis, palladium-catalyzed Meinwald re

128 loped via asymmetric alkoxyallylboration and ring-closing metathesis pathways.

129 Ru-catalyzed ring-closing metathesis performed on the diallylated aro

130 lkenylamide containing peptides, prepared as ring-closing metathesis precursors, showed that the high

131 -amino acid derivatives could be accessed by ring-closing metathesis presenting a viable strategy to

132 studies include development of an efficient ring-closing metathesis procedure to prepare macrocyclic

133 y such initiating neophylidenes in promoting ring-closing metathesis processes, are disclosed.

134 y is one reason why many cross-metathesis or ring-closing metathesis processes, which are reversible

135 f this arrangement through esterification or ring-closing metathesis produces the closed-knot complex

136 ing reactions include Nazarov cyclization, a ring-closing metathesis promoted with complete diastereo

137 n and a highly chemo- and diastereoselective ring-closing metathesis protocol for the formation of th

138 A high-performing ring-closing metathesis protocol has been achieved by si

139 Ring-closing metathesis provided access to a twelve-memb

140 m of precatalyst and PAG was capable of both ring closing metathesis (RCM) and ring opening metathesi

141 erivatives based on selective alkylation and ring closing metathesis (RCM) by exploiting the four pos

142 In all cases, ring closing metathesis (RCM) depolymerization of the PC

143 ,Arg(4),d-Ala(8)]dynorphin A(1-11)-NH(2)) by ring closing metathesis (RCM) involving tyrosine(O-allyl

144 Ring closing metathesis (RCM) of the diene 42 using Cl2(

145 eactions of COE and norbornadiene (NBD), and ring closing metathesis (RCM) reactions of diethyl diall

146 synthesized through an asymmetric allylation/ring closing metathesis (RCM) sequence.

147 ied out through the use of an esterification-ring closing metathesis (RCM) strategy.

148 and, consequently, the kinetic model of the ring closing metathesis (RCM), enabling a further increa

149 h a suitable side chain tether introduced by ring closing metathesis (RCM).

150 e and terminal arylalkynes followed by enyne ring-closing metathesis (RCM) and Heck cyclization affor

151 The feasibility of ring-closing metathesis (RCM) as a synthetic entry to 10

152 action, followed by Fischer indolization and ring-closing metathesis (RCM) as key steps.

153 -11)NH(2) analogues on solid phase utilizing ring-closing metathesis (RCM) between the side chains of

154 rresponding alcohols, smoothly underwent the ring-closing metathesis (RCM) by using Hoveyda-Grubbs II

155 and titanium assisted cross-metathesis (CM)/ring-closing metathesis (RCM) cascade has been used to s

156 It allows us to design a transvinylation/ring-closing metathesis (RCM) cascade reaction leading t

157 Ring-closing metathesis (RCM) catalyzed by a second-gene

158 orochrysophaentin A enabled by a Z-selective ring-closing metathesis (RCM) cyclization followed by an

159 tituted piperidinone D-rings were formed via ring-closing metathesis (RCM) followed by a 1,4-addition

160 generate the three stereogenic centers and a ring-closing metathesis (RCM) for the formation of the m

161 To this end, the catalytic process known as ring-closing metathesis (RCM) has allowed access to coun

162 opening metathesis polymerization (ROMP) and ring-closing metathesis (RCM) have been investigated.

163 Catalytic ring-closing metathesis (RCM) is a widely used method fo

164 enation, acryloylation, and Ru(II)-catalyzed ring-closing metathesis (RCM) led to the formation of th

165 gue (5) were synthesized in good yield using ring-closing metathesis (RCM) methods.

166 We have demonstrated that the ring-closing metathesis (RCM) provides [17]ddEpoB or [18

167 = 3, 2) has been developed that involves the ring-closing metathesis (RCM) reaction of cis-2,6-dialke

168 embedded bicyclic lactone, and an efficient ring-closing metathesis (RCM) reaction to generate the m

169 ydrides 8-11 are further derivatized via the ring-closing metathesis (RCM) reaction to yield amino ac

170 on of allylic hydroxyl group followed by the ring-closing metathesis (RCM) reaction with Grubbs catal

171 oups was synthesized, cross-linked using the ring-closing metathesis (RCM) reaction, and the core was

172 (M06, M06L, and PM6) on intermediates in the ring-closing metathesis (RCM) reactions in the synthesis

173 de and monoaryloxide complexes promote enyne ring-closing metathesis (RCM) reactions, affording the c

174 iency in mediating cross metathesis (CM) and ring-closing metathesis (RCM) reactions, little is known

175 nger [2 + 2] ketene-imine cycloaddition, and ring-closing metathesis (RCM) reactions, the synthesis w

176 A concise, (Z)-selective ring-closing metathesis (RCM) route to the 14-membered c

177 A tandem cross metathesis (CM)--ring-closing metathesis (RCM) sequence to form cyclic si

178 bond formations, one etherification, and one ring-closing metathesis (RCM) step, using readily availa

179 C1-C21 bond and the second approach using a ring-closing metathesis (RCM) strategy to form the C10-C

180 ied out through the use of an esterification-ring-closing metathesis (RCM) strategy.

181 A phosphate tether-mediated ring-closing metathesis (RCM) study to the synthesis of

182 centerpiece of the strategy is a sequential ring-closing metathesis (RCM) that forms an unsaturated

183 lyldiphenylphosphonate esters and subsequent ring-closing metathesis (RCM) to access P-chiral P-heter

184 ntheses involve cobalt-complexation-promoted ring-closing metathesis (RCM) to generate ynolides, foll

185 F3.Et2O-mediated Et3SiH reduction and olefin ring-closing metathesis (RCM) using Ru(II) catalysts.

186 Ring-closing metathesis (RCM) was employed to join carbo

187 struction of the central macrolide employing ring-closing metathesis (RCM), followed by selective pro

188 ghly efficient and selective for macrocyclic ring-closing metathesis (RCM).

189 erein an uncaging reaction that results from ring-closing metathesis (RCM).

190 nocrystal were globally cross-linked through ring-closing metathesis (RCM).

191 A tandem ruthenium-catalyzed olefin ring-closing metathesis (RCM)/Kharasch addition allows f

192 addition were observed to undergo efficient ring-closing-metathesis (RCM) reaction in the presence o

193 ermally mediated Overman rearrangement and a ring closing metathesis reaction of allylic trichloroace

194 diene derivatives that were subjected to the ring closing metathesis reaction to furnish the gem-difl

195 A Grubbs' ring closing metathesis reaction was utilized to close t

196 ctrophilic alpha-chloro sulfide, and last by ring-closing metathesis reaction as the key steps.

197 rbon bond is enabled by a microwave-assisted ring-closing metathesis reaction between two terminal ol

198 c approach highlights a remarkably efficient ring-closing metathesis reaction catalyzed by Nolan ruth

199 constraint is incorporated using either the ring-closing metathesis reaction catalyzed by the first

200 d-generation approach, a tandem ring-opening/ring-closing metathesis reaction effected an overall [2.

201 icient molybdenum-catalyzed enantioselective ring-closing metathesis reaction for the desymmetrizatio

202 yclic nucleosides, have been developed via a ring-closing metathesis reaction from d-ribose in eight

203 Overman rearrangement and a Ru(II)-catalyzed ring-closing metathesis reaction has been developed for

204 discovery of an efficient and selective bis ring-closing metathesis reaction leading to peptides bea

205 ombination of Ichikawa's rearrangement and a ring-closing metathesis reaction of allyl carbamates is

206 e we demonstrate a catalytic carbonyl-olefin ring-closing metathesis reaction that uses iron, an Eart

207 ion to build ring E and a diastereoselective ring-closing metathesis reaction to construct ring D.

208 e key intermediates, as well as Ru-catalyzed ring-closing metathesis reaction to construct the key tr

209 centers adjacent to the ether linkage and a ring-closing metathesis reaction to construct the nine-m

210 A key step in the synthesis was a ring-closing metathesis reaction to prepare the macrocyc

211 ved from D-glucose, followed by a sequential ring-closing metathesis reaction using Grubbs catalysts,

212 and octadendron macromolecules underwent the ring-closing metathesis reaction using Grubbs' Type I ca

213 NMR studies confirmed that the ring-closing metathesis reaction yielded a single produc

214 action, an Overman rearrangement reaction, a ring-closing metathesis reaction, and an amination react

215 ic attack of a hindered tertiary alkoxide, a ring-closing metathesis reaction, and the Diels-Alder cy

216 The synthesis features a challenging ring-closing metathesis reaction, followed by eliminatio

217 which is advantageously synthesized using a ring-closing metathesis reaction.

218 actical approach based on esterification and ring-closing metathesis reaction.

219 laced by a carbon-carbon bond derived from a ring-closing metathesis reaction.

220 ficant influence on the E:Z ratio during the ring-closing metathesis reaction.

221 aldols, Yamaguchi esterification, and Grubbs ring-closing metathesis reaction.

222 is are surveyed, with particular emphasis on ring-closing metathesis reactions and annulation reactio

223 yclizations of bis(vinyl boronate esters) or ring-closing metathesis reactions followed by complexati

224 ment of Lewis acid-catalyzed carbonyl-olefin ring-closing metathesis reactions for aliphatic ketones.

225 We describe how our investigations of ring-closing metathesis reactions in epothilone settings

226 lass pellets used in a sequence of catalytic ring-closing metathesis reactions mediated by various su

227 A study of the ring-closing metathesis reactions of two bis(enynes) is

228 Olefin cross- and ring-closing metathesis reactions run in the presence of

229 alyst-controlled stereoselective macrocyclic ring-closing metathesis reactions that generate Z-enoate

230 Two ring-closing metathesis reactions were then used to form

231 hesis include diastereoselective Nazarov and ring-closing metathesis reactions, and a highly efficien

232 catalyst modification necessary) to perform ring-closing metathesis reactions, generating 14- to 21-

233 trategy using intramolecular Diels-Alder and ring-closing metathesis reactions.

234 ctrocyclization sequence and others based on ring-closing metathesis reactions.

235 metathesis and enyne tandem cross-metathesis-ring-closing metathesis reactions.

236 Of these, ring-closing metathesis represented by the conversion of

237 Iron(III)-catalyzed carbonyl-olefin ring-closing metathesis represents a new approach toward

238 an ethylene-mediated cross-enyne metathesis/ring-closing metathesis, respectively.

239 After protection of the amine, a ring-closing metathesis results in a multifunctional eig

240 ring-closing metathesis [ROM/RCM] cascade vs ring-closing metathesis/ring-opening metathesis [RCM/ROM

241 metathesis involving ring-opening metathesis-ring-closing metathesis (ROM-RCM) of a bicyclo[2.2.2]oct

242 n reaction pathways (ring-opening metathesis/ring-closing metathesis [ROM/RCM] cascade vs ring-closin

243 d dihydropyran rings was constructed via the ring-closing metathesis route.

244 l 2-allyl-4-fluorophenyl auxiliary for relay ring-closing metathesis (RRCM) was developed, which incr

245 an ambitious one-pot alkyne cross-metathesis/ring-closing metathesis self-assembly process.

246 The synthesis relied on an acylation-ring closing metathesis sequence.

247 re the result of a tandem cycloisomerization-ring closing metathesis sequence.

248 ates by a Suzuki coupling-Wittig olefination-ring-closing metathesis sequence allowed a convergent an

249 n amide coupling/Michael addition/allylation/ring-closing metathesis sequence which allowed the intro

250 ield, respectively, via a novel ketalization/ring-closing metathesis sequence.

251 A ring-closing metathesis served for construction of the s

252 is diene unit was accomplished with a tandem ring-closing metathesis/silicon-assisted intramolecular

253 catalysts initiate the key enantioselective ring-closing metathesis step in the total synthesis of q

254 The synthesis hinges on an asymmetric aldol-ring closing metathesis strategy to construct the five-m

255 Here we introduce a ring-closing metathesis strategy for synthesis of trisub

256 A convergent ring-closing metathesis strategy has been employed for t

257 t the piperidine core and a silicon-tethered ring-closing metathesis strategy to install the Z exocyc

258 A highly efficient, Z-selective ring-closing metathesis system for the formation of macr

259 yclic core of Vaniprevir (MK-7009) utilizing ring-closing metathesis technology.

260 de pyrrolide (MAP) complex and a macrocyclic ring-closing metathesis that affords a trisubstituted al

261 rization/Claisen rearrangement cascade and a ring-closing metathesis that allows access to a variety

262 d-catalyzed Suzuki coupling and Ru-catalyzed ring-closing metathesis, thus representing a practical m

263 ogram directed to the possible adaptation of ring closing metathesis to a total synthesis of vinigrol

264 ed a cascade Takai-Utimoto ester olefination/ring closing metathesis to construct ring Y, a hydroxydi

265 used benzofuran and 2) a cascade ene-yne-ene ring closing metathesis to forge the tetracyclic morphin

266 that ultimately was subjected to diene-diene ring closing metathesis to form the macrocycle.

267 ement of a functionalized allyl bromide, and ring closing metathesis to obtain the macrolactone.

268 h the Grb7-SH2 domain, both before and after ring closing metathesis to show that the closed staple i

269 d a relatively rare application of catalytic ring-closing metathesis to access an 11-membered ring st

270 and 10 (obtained from D-ribose) followed by ring-closing metathesis to afford enol ether 8, whose el

271 The isomerization can be combined with ring-closing metathesis to afford the synthesis of exocy

272 Use was also made of ring-closing metathesis to bring about the conversion of

273 trategically forge the C1-C2 bond, and (3) a ring-closing metathesis to build the bridging bicyclo[4.

274 o alcohol functionality of conduramine E and ring-closing metathesis to construct its carbocyclic cor

275 d assemble the diazatricycloundecane core, a ring-closing metathesis to construct the 13-membered rin

276 absolute configuration of the pseudosugar, a ring-closing metathesis to construct the pseudosugar rin

277 riate allyl bromide provides a precursor for ring-closing metathesis to deliver the oxepinochromone r

278 e aldol reaction provided a diene useful for ring-closing metathesis to form an oxonene, which was ul

279 y substituted cyclobutanols; (ii) the use of ring-closing metathesis to form the pendant five-membere

280 Our convergent route features an adventurous ring-closing metathesis to form the requisite trisubstit

281 hylvinylsilane and subjected to Mo-catalyzed ring-closing metathesis to form unsaturated siloxanes.

282 terically encumbered tetrahydropyran ring, a ring-closing metathesis to generate the C(4a-13-20a) mac

283 glycinol derivatives was followed by Grubbs' ring-closing metathesis to generate the key lactam inter

284 e previously reported that the employment of ring-closing metathesis to introduce a single all-hydroc

285 lin I (2), highlighted by the application of ring-closing metathesis to macrolide formation.

286 Additional key steps include ring-closing metathesis to prepare the D-ring and Bosch-

287 functionalized aminodienes, which underwent ring-closing metathesis to provide chiral C5-C6 disubsti

288 Ring closing metathesis using difluorinated 1,7-enyne ca

289 turally occurring monoterpene myrcene (1) by ring-closing metathesis using Grubbs second generation c

290 Ring-closing metathesis using the Schrock inverted quest

291 ar analogue, which shows minimal activity in ring-closing metathesis, V/SiO(2) is a productive cataly

292 Ring-closing metathesis was a key reaction used to form

293 An E-selective ring-closing metathesis was used to access the 10-member

294 Ring-closing metathesis was used to construct the strain

295 tereoselective Grignard reaction followed by ring-closing metathesis was used.

296 phosphonate derived from (S)-lactic acid and ring-closing metathesis were the key reactions during th

297 1]tridecenes were synthesized by E-selective ring-closing metathesis where their absolute stereochemi

298 is inclusion complex was subjected to olefin ring-closing metathesis, which was observed to proceed u

299 lidinones 15 and 51, respectively, underwent ring-closing metathesis with Grubbs's catalyst to give a

300 In particular, ring-closing metathesis with the Hoveyda-Grubbs catalyst