ライフサイエンスコーパス: ripple

1 ic propagating Ca(2+) release events (Ca(2+) ripples).

2 s responded more consistently from ripple to ripple.

3 uced hierarchical coupling with spindles and ripples.

4 mechanism may involve hippocampal sharp-wave ripples.

5 rongest and the most consistent during awake ripples.

6 ipples, but increased around spindle-coupled ripples.

7 een thalamocortical spindles and hippocampal ripples.

8 pleats, folds, blisters, and liquid crystal ripples.

9 es such as theta oscillations and sharp-wave ripples.

10 states like theta oscillations or sharp-wave ripples.

11 ally analyzed for spikes, spike ripples, and ripples.

12 coupling of slow oscillations, spindles, and ripples.

13 ns, theta bursts, and hippocampal sharp-wave ripples.

14 ns during sleep, concurrent with hippocampal ripples.

15 tical delta waves and hippocampal sharp-wave ripples.

16 s of identified CA1 pyramidal neurons during ripples.

17 mechanism keeping most neurons silent during ripples.

18 ing long-duration compared to short-duration ripples.

19 a higher occurrence of ripples than of fast ripples.

20 t lines, making them unlike terrestrial wind ripples.

21 ripple rates that were higher than those of ripples.

22 is enhanced during long-duration hippocampal ripples.

23 l as HPC sequences present during sharp-wave ripples.

24 epilepsy group (n = 26, 46%), mean rates of ripples (0.3 vs 0.09 / minute, p < 0.0001) and spike rip

25 (0.3 vs 0.09 / minute, p < 0.0001) and spike ripples (0.6 vs 0.06 / minute, p < 0.05) were significan

26 predictive value (area under the curve [AUC](ripples) = 0.88).

27 primary cortical areas, displayed localized ripple (100 to 150 hertz) oscillations during sleep, con

28 high-frequency field potential oscillations (ripples, 100-260 Hz) superimposed on a slower SPW.

29 often that the rest of the network channels (ripples: 13 of 27 [48%] versus 65 of 262 [25%]; p = 0.01

30 ciated delta (0.5-4 Hz), theta (4-12 Hz) and ripple (150-250 Hz) oscillations; and (2) stabilization

31 s, together with superimposed high-frequency ripples(2), propagate to the entire neighbouring pallial

32 (p < 0.001), and interictal spikes with fast ripples (250-500Hz) (p < 0.001) were lower in PV-ChR2 th

33 [48%] versus 65 of 262 [25%]; p = 0.01; fast ripples: 8 of 9 [89%] versus 17 of 40 [43%]; p = 0.002);

34 Ripples (80-200Hz) occurring outside of interictal spike

35 Ripples (80-250 Hz) were automatically detected during S

36 ided into fast ripples (FRs; 250-500 Hz) and ripples (80-250 Hz), and spikes in pre- and postresectio

37 NIFICANCE STATEMENT Disruption of sharp-wave ripples, a characteristic hippocampal rhythm coordinated

38 coordinated interactions between hippocampal ripple activity and ACC neural firings.

39 ow ACC activity is influenced by hippocampal ripple activity during sleep.

40 ity of ACC neurons are activated just before ripple activity during the sleep state, but not during t

41 layed a further activation immediately after ripple activity.

42 showed increased activity before hippocampal ripple activity; moreover, a subpopulation (17%) display

43 Moreover, the number of ripples after learning predicts subsequent memory perfor

44 ke ripple events') are easier to detect than ripples alone and have greater pathological significance

45 t field exposure may induce unique membrane "rippling" along with nanoscale pores on A549 cells.

46 on of ACC neurons correlated positively with ripple amplitude, and the same neurons were excited upon

47 The degree of MD modulation correlated with ripple amplitude, differed across behavioral states, and

48 1000 events of each class (spike, RonS, ripple and baseline) were selected from the candidates i

49 HFOs in ripple and fast ripple frequency ranges were evaluated i

50 SW occurrence rates, ripple frequencies, and ripple and sharp wave (SW) amplitudes were increased in

51 rony of neural populations during periods of ripple and theta instances.

52 These cells display sharp wave ripple and theta modulation, spatial firing fields, and

53 Importantly, sharp-wave ripples and associated activation appear to regulate act

54 es was similar to short-duration spontaneous ripples and contained little spatial information.

55 g learning are "replayed" during hippocampal ripples and contribute to the consolidation of episodic

56 eased the coupling of hippocampal sharp wave ripples and cortical spindles, and these learning-induce

57 However, both ripples and fast ripples were observed with higher rates

58 = 0.002); channels with the highest rates of ripples and fast ripples were resected in a similar prop

59 For both ripples and fast ripples, first source channels were res

60 g the crystallization of foam, which creates ripples and fluctuations on the surface of the 2D crysta

61 ges are due to the shrouded object or to the ripples and folds of the overlying cloth.

62 ally, selectively influencing high-frequency ripples and low-frequency theta events, respectively.

63 ment of epilepsy better than spikes or spike ripples and might be useful biomarkers in the estimation

64 Yet it is unclear whether ripples and other hippocampal neural events influence en

65 Inhibition of CA3 activity suppressed ripples and replays in CA1 regardless of behavioral stat

66 mory neural network for detection of spikes, ripples and ripples-on-spikes (RonS).

67 used objective techniques to quantify spike ripples and test whether this biomarker predicts seizure

68 Here, we document the appearance of ripples and wrinkles in biofilms grown from three specie

69 EGs were visually analyzed for spikes, spike ripples, and ripples.

70 exploration, elevated their association with ripples, and showed increased bursting and temporal coac

71 campal replay occurs during local sharp-wave ripples, and the associated neocortical replay tends to

72 p-the thalamo-cortical spindles, hippocampal ripples, and the cortical slow oscillations-is thought t

73 hich in the hippocampus associated with fast ripples, and which was replicated in a computational mod

74 aired rats to examine age-related changes in ripple architecture, ripple-triggered spike variance, an

75 These data provide evidence that spike ripples are a specific non-invasive biomarker for seizur

76 Sharp-wave ripples are brief ( approximately 70 ms) high-frequency

77 Ripples are high-frequency oscillations associated with

78 We discovered that long-duration ripples are increased in situations demanding memory in

79 Our study predicts that ripples are not persistent oscillations but result from

80 The ripples are shown to be continually present during all 1

81 tertrough intervals of individually detected ripples are slower, and the rate of SPW-R generation is

82 Furthermore, posterior hippocampal spindle ripples are tightly coupled to posterior parietal locati

83 This reactivation occurred in ripple-associated awake replay of place cell sequences e

84 In particular, hippocampal sharp-wave ripple-associated neural activation is important for thi

85 The pattern of standing ripples at half the vibrating frequency that results fro

86 rather, it is correlated with the structural ripples at mesoscopic length scale and associated flexoe

87 tructures is the cause for the nucleation of ripples at the edges that grow towards the center of the

88 In DS mice, peak ripple-band power is shifted to lower frequencies, avera

89 We compared the rate of spike ripples between children with epilepsy and healthy contr

90 se data provide direct evidence that coupled ripples between the MTL and association cortex may under

91 high-frequency (>80 Hz) oscillations called ripples-both during sleep [9, 10] and awake deliberative

92 Thus, MECIII input to CA1 is crucial for ripple bursts and long-range replays specifically in qui

93 state, but roles of neural inputs to CA1 in ripple bursts and replays are unknown.

94 Here we show that ripple bursts in CA1 and medial entorhinal cortex (MEC)

95 CIII input to CA1 during quiet awake reduced ripple bursts in CA1 and restricted the spatial coverage

96 Chains of ripples (ripple bursts) in CA1 have been reported to co-occur wit

97 ring rate decreased around spindle-uncoupled ripples, but increased around spindle-coupled ripples.

98 ic increase in the DMN fMRI signal following ripples, but not following other hippocampal electrophys

99 find increases in ongoing DMN activity after ripples, but not in other RSNs.

100 h seizure-free decreased the odds of a spike ripple by a factor of 0.66 [95% confidence interval (0.4

101 Prolongation of spontaneously occurring ripples by optogenetic stimulation, but not randomly ind

102 Finally, multiple spindle ripples can recur within a second, whereas SWRs are sepa

103 e p-bits, and we present results for a 4-bit ripple carry adder with 48 p-bits and a 4-bit multiplier

104 y reducing gamma oscillations and sharp wave ripples, changes associated with a decrease in extinctio

105 The coupling between PGO waves and ripples, classically associated with distinct sleep stag

106 inter-SPW interval timing between SPW-Rs in ripple clusters.

107 ponsive units exhibited increased sharp-wave ripple co-activation during the taste delivery session a

108 ed spindle co-occurrence and frontal spindle-ripple co-occurrence, eventually resulting in increased

109 We show that human hippocampal sharpwave ripples co-occur with all varieties of cortical sleep wa

110 Recent studies have demonstrated that ripples co-occurring with epileptiform discharges ('spik

111 essed around hippocampal ripples, except for ripples co-occurring with sleep spindles, when the MD ac

112 icity and positive predictive value of spike ripples compared to spikes (P = 0.016 and P = 0.006, res

113 Sharp wave-ripple complexes (SWRs) are hippocampal network phenomen

114 etworks, including alterations in sharp wave-ripple complexes.

115 tical communication, as indicated by spindle/ripple coupling, may contribute to selectivity and relia

116 The incidence of sharp wave ripples decreased but the surviving ripples were associa

117 re, an external input, mimicking hippocampal ripples, delivered to the cortical network results in in

118 h young rats, the rate of ripple occurrence (ripple density) is reduced in aged rats during postbehav

119 istent results using a fully automated spike ripple detector, including comparison with an automated

120 TF mutations induce rippling downstream effects by simultaneously altering t

121 terneurons dynamically constrains individual ripple duration.

122 ustrum suppress the production of sharp-wave ripples during slow-wave sleep in a unilateral or bilate

123 Among epilepsy subjects with spike ripples, each month seizure-free decreased the odds of a

124 selected for during viral evolution or are a ripple effect from the primary function.

125 ial community following infection also has a ripple effect on the host regulation of cecum-associated

126 ndromes, indicating that there are molecular ripple effects of the changes in X chromosome dosage.

127 osphere, they are paradoxically analogous to ripples emerging on granular beds submitted to viscous s

128 SIGNIFICANCE STATEMENT Hippocampal sharpwave ripples, essential for memory consolidation, mark when h

129 Hippocampal replay during sharp-wave ripple events (SWRs) is thought to drive memory consolid

130 f the hippocampus is dominated by sharp wave-ripple events (SWRs), which have been shown to be import

131 Sharp-wave ripple events generated in the hippocampus have been imp

132 We conclude that scalp spike ripple events identify disease and track with seizure ri

133 e a mismatch in timing across the SO-spindle-ripple events that are associated with memory consolidat

134 single-unit activity surrounding sharp-wave ripple events were examined in the CA1 region of the hip

135 curring with epileptiform discharges ('spike ripple events') are easier to detect than ripples alone

136 campal input, such as mediated by sharp wave-ripple events, cortical slow oscillations, and synaptic

137 x (NC) time-locked to individual hippocampal ripple events.

138 o a shorter distance corresponding to single ripple events.

139 triple coupling of slow oscillation-spindle-ripple events.

140 as transiently suppressed around hippocampal ripples, except for ripples co-occurring with sleep spin

141 For ripples, first source channels were found in a higher pr

142 For both ripples and fast ripples, first source channels were resected more often

143 ar hydrogen at catalytically active graphene ripples, followed by adsorbed atoms flipping to the othe

144 ependent memory tasks, DSW occurrence rates, ripple frequencies, and ripple and sharp wave (SW) ampli

145 hat Scn1a haploinsufficiency slows intrinsic ripple frequency and reduces the rate of SPW-R occurrenc

146 Second, mean ripple frequency during prebehavior and postbehavior res

147 rp-wave ripple occurrence and slows internal ripple frequency in vivo and a simple in silico model de

148 HFOs in ripple and fast ripple frequency ranges were evaluated in both condition

149 ced sodium conductance is sufficient to slow ripple frequency, and stimulation with a modeled SPW dem

150 Instead, they suggest that ripple-frequency excitation leading inhibition shapes in

151 : detection of interictal ripples (Rs), fast ripples (FRs), and VHFOs; resective surgery; and at leas

152 rospectively, marked HFOs, divided into fast ripples (FRs; 250-500 Hz) and ripples (80-250 Hz), and s

153 dy proposes a novel mechanism of hippocampal ripple generation consistent with a broad range of exper

154 ChR2 group (p < 0.01), whereas isolated fast ripples had lower rates (p < 0.01).

155 dly suppressed during hippocampal sharp-wave ripples, had a low burst incidence, and several of them

156 ortical spindles, and hippocampal sharp-wave ripples has convincingly been shown to be a key element

157 y in NREM sleep during hippocampal sharpwave ripples (HC-SWRs), correlated with neocortical graphoele

158 net excitatory input to CA1, while the post-ripple hyperpolarization varies proportionately.

159 hereby adsorbates are carried by propagating ripples in a motion similar to surfing.

160 2.5% for spikes in one patient and 81.9% for ripples in another patient).

161 We found that sharpwave ripples in different parts of the hippocampus usually oc

162 d, significant changes in characteristics of ripples in older animals that could impact consolidation

163 We evaluated spike ripples in scalp EEG recordings from a prospective cohor

164 evidence for the existence of quasi-periodic ripples in the F-region electron content at high latitud

165 thought to originate from periodic nanoscale ripples in the graphene sheet, which enhance puckering a

166 oscillation in the neocortex and sharp wave-ripples in the hippocampus, these alternations are often

167 , these modes are altered, forming potential ripples in the local density of states, due to intrinsic

168 trieval, and this replay was associated with ripples in the medial temporal lobe.

169 ecreased rates of interictal spikes and fast ripples in this MTLE model.

170 tal evidence supports the role of sharp-wave ripples in transferring hippocampal information to the n

171 induced defect coalescence and to long range rippling in graphene.

172 enetic stimulation, but not randomly induced ripples, increased memory during maze learning.

173 s, the MD neural activity around hippocampal ripples, indicators of memory replay and hippocampal-cor

174 revolution in the field of genomics that has rippled into many branches of the life and physical scie

175 ctivity suppression during spindle-uncoupled ripples is favorable for memory replay, as it reduces in

176 that the subthreshold depolarization during ripples is uncorrelated with the net excitatory input to

177 frustration associated with an isotropic to rippled lamellar liquid-crystal transition.

178 scale (mm to m) sedimentary structures (e.g. ripple lamination, cross-bedding) have received a great

179 d can trigger propagating microscopic Ca(2+) ripples, larger macroscopic Ca(2+) waves, and EADs.

180 subnetworks of principal neurons compared to ripple-like events, increased the sparsity of network ac

181 son to control animals we could classify as 'ripple-like' or 'pHFO'.

182 Ripple mapping (RM) displays every electrogram deflectio

183 Ripple mapping (RM) is an alternative approach to activa

184 Ablation was performed along all identified ripple mapping conducting channels (median 18 lesions) a

185 apped in 3 patients and colocated within the ripple mapping conducting channels identified.

186 Ripple mapping displays every deflection of an electrogr

187 ty suppression at times of spindle-uncoupled ripples may be favorable for memory replay, as it reduce

188 acteristics of posterior hippocampal spindle ripples may support a related function in humans.

189 al cortex plays a key role in organizing the ripple-mediated information transfer during non-rapid ey

190 nd ripple networks in all patients, and fast ripple networks in 9.

191 We found ripple networks in all patients, and fast ripple network

192 The peak amplitudes of ripples observed are in excellent agreement with the exp

193 First, compared with young rats, the rate of ripple occurrence (ripple density) is reduced in aged ra

194 on in DS mice reduces hippocampal sharp-wave ripple occurrence and slows internal ripple frequency in

195 s impact nearly all organisms on Earth, with ripples of influence in agriculture, health, and biogeoc

196 our foreheads to crinkly plant leaves, from ripples on plastic-wrapped objects to the protein film o

197 y) are separated by ~5 s on average, whereas ripples on successive SSR peaks are separated by only ~8

198 eflected in the pulse repetition rate and in ripples on the frequency spectrum but not in the number

199 network for detection of spikes, ripples and ripples-on-spikes (RonS).

200 th the MD activity suppression preceding the ripple onset for 0.41 +/- 0.04 s (range, 0.01-0.95 s).

201 in ripple-spindle coupling without affecting ripple or spindle incidence.

202 The percentage of resected FRs, ripples, or spikes in pre-ECoG did not predict outcome.

203 e tuned to a narrower range of phases of the ripple oscillation relative to young animals.

204 Given the connection between ripple oscillations and memory consolidation, we investi

205 on, we investigated whether the structure of ripple oscillations and ripple-triggered patterns of sin

206 We examine here whether these ripple oscillations are altered over the course of the l

207 s in the medial prefrontal cortex (mPFC) and ripple oscillations in the hippocampus is thought to und

208 We found that ripple oscillations in the human cortex reflect underlyi

209 roencephalographic recordings, we found that ripple oscillations were dynamically coupled between the

210 lamo-cortical sleep spindles and hippocampal ripple oscillations.

211 tion leading inhibition shapes intracellular ripple oscillations.

212 ltered morphology compared to WT EBs, with a rippled outer surface and a smaller size due to decrease

213 tures, including Laws (capture edges, waves, ripple patterns) and CoLIAGe (capture disease heterogene

214 ikely represent metastable precursors of the ripple phase that vanished at increased temperatures.

215 approximately as many spindle ripples (SSR: ripples phase-locked to local spindles).

216 nd a coexistence of Lalpha and either gel or ripple phases.

217 of children with a first unprovoked seizure, ripples predict the development of epilepsy better than

218 hippocampus also produces SWRs, but spindle ripples predominate in posterior.

219 ese results support the proposition that the ripples propagate from the solar wind to the F-region, a

220 de, brief bursts of fast oscillations in the ripple range have been identified in the scalp EEG as a

221 a content-selective increase in hippocampal ripple rate emerging 1 to 2 seconds prior to recall even

222 Spike ripple rate was higher in subjects with active epilepsy

223 d a hypersynchronous onset pattern with fast ripple rates that were higher than those of ripples.

224 Ripple rates were negatively correlated to days passing

225 wer in the different frequency bands and the ripple rates were then compared between STW and control

226 of contextual emotional memory occurs during ripple-reactivation of hippocampus-amygdala circuits.

227 Prolonged ripples recruited new neurons that represented either ar

228 elationship with human hippocampal sharpwave ripples remains unclear.

229 ctivation of hippocampal cells in sharp-wave/ripples represent inferred relationships that include re

230 Ca(2+) ripples resemble Ca(2+) waves in terms of local propagat

231 Chains of ripples (ripple bursts) in CA1 have been reported to co-

232 These findings suggest that ripple-ripple coupling supports hippocampal-association

233 th surgical outcome: detection of interictal ripples (Rs), fast ripples (FRs), and VHFOs; resective s

234 Of those 3 markers, ripples showed the best predictive value (area under the

235 The duration of ripples shows a skewed distribution with a minority of l

236 wever, whether learning-induced increases in ripple-spindle coupling are necessary for successful mem

237 nsistent with the hypothesized importance of ripple-spindle coupling in memory consolidation, post-tr

238 that contextual fear conditioning increased ripple-spindle coupling in mice.

239 les, and these learning-induced increases in ripple-spindle coupling were blocked when oligodendrogen

240 eliminated this learning-induced increase in ripple-spindle coupling without affecting ripple or spin

241 In order to decouple ripple-spindle oscillations, here we chemogenetically in

242 Because sharp wave-ripples (SPW-R) orchestrate both retrospective and prosp

243 vations peaked during hippocampal sharp wave-ripples (SPW-Rs) and involved a subgroup of BLA cells po

244 high frequency activity known as sharp wave ripples (SPW-Rs) facilitate communication between the hi

245 Hippocampal sharp wave ripples (SPW-Rs) have been hypothesized as a mechanism f

246 mnemonic functions of hippocampal sharp wave ripples (SPW-Rs) have been studied extensively.

247 IEDs) in mice with TLE as well as sharp-wave ripples (SPW-Rs) in healthy mice, and find that abGCs an

248 atial memory requires hippocampal sharp-wave ripples (SPW-Rs), which consist of high-frequency field

249 r forward or reverse modes during sharp wave-ripples (SPW-Rs).

250 n increase in post-learning sleep sharp-wave ripple (SPWR) density and reduced time locking of learni

251 also generates approximately as many spindle ripples (SSR: ripples phase-locked to local spindles).

252 sing pure tones and broadband dynamic moving ripple stimuli, to examine properties of functional inte

253 d or younger) identifies potential wind-drag ripple stratification formed under a thin atmosphere.

254 on is correlated with hippocampal sharp wave ripple (SWR) density, cortical delta waves (DWs), cortic

255 aptic and spiking activity during sharp wave ripple (SWR) events in early amyloid pathology and revea

256 Hippocampal sharp-wave ripple (SWR) events occur during both behavior (awake SW

257 A prevalent model is that sharp-wave ripples (SWR) arise 'spontaneously' in CA3 and propagate

258 Sharp-wave ripples (SWRs) are high-frequency local field potential

259 Hippocampal sharp-wave ripples (SWRs) constitute one of the most synchronized a

260 eurons replay waking events during sharpwave ripples (SWRs) in NREM sleep, facilitating memory transf

261 IGNIFICANCE STATEMENT Hippocampal sharp-wave ripples (SWRs) occur both in the awake state during beha

262 ace cell activity associated with sharp-wave ripples (SWRs) reflects predominantly stationary locatio

263 p, the human hippocampus generates sharpwave ripples (SWRs) similar to those which in rodents mark me

264 l task and focused on hippocampal sharp-wave ripples (SWRs) to identify times of memory reactivation

265 sic LFP events of the CA1 region, sharp-wave ripples (SWRs), are induced by CA3 activity and consider

266 s of AD, there are disruptions to sharp wave ripples (SWRs), hippocampal population events with a cri

267 ions in the hippocampus, known as sharp-wave ripples (SWRs), synchronise the firing behaviour of grou

268 incidences of sleep spindles and sharp-wave ripples (SWRs), typically associated with cortical plast

269 In contrast, during sharp-wave ripples (SWRs), when representations of experience are t

270 onsolidation crucially depends on sharp-wave ripples (SWRs), which are local field potential (LFP) pa

271 h reactivation is observed during sharp-wave ripples (SWRs)-synchronous oscillatory electrical events

272 nergic activity, and modulated at sharp wave ripples (SWRs).

273 e snippets occur primarily during sharp-wave-ripples (SWRs).

274 ribution to non-REM oscillations (sharp-wave ripples, SWRs; slow/delta; spindles), we recorded units

275 were associated with a higher occurrence of ripples than of fast ripples.

276 could be a pathogenic epicenter anatomically rippling throughout the nervous system.

277 ged animals responded more consistently from ripple to ripple.

278 her the structure of ripple oscillations and ripple-triggered patterns of single-unit activity are al

279 age-related changes in ripple architecture, ripple-triggered spike variance, and spike-phase coheren

280 We found that sharpwave ripples typically occur after certain types of cortical

281 r as cortex emerges from inactivity, spindle ripples typically occur at peak cortical activity.

282 detected in 23 of 40 patients and ultrafast ripples (UFRs; 1,000-2,000Hz) in almost half of investig

283 ed in-plane strain through the nucleation of ripples under both tensile and compressive loading condi

284 curacy of the presence of at least one spike ripple versus a classic spike event to identify group, w

285 Interictal very fast ripples (VFRs; 500-1,000Hz) were detected in 23 of 40 pa

286 ike content of the optogenetically prolonged ripples was biased by the ongoing, naturally initiated n

287 The optimal threshold for ripples was calculated to be >= 0.125 / minute with a se

288 The neuronal content of randomly induced ripples was similar to short-duration spontaneous ripple

289 Coupling between hippocampal and neocortical ripples was strengthened during sleep following learning

290 crease in high-frequency activity, including ripples, was observed concomitantly, involving the senso

291 equent) spatiotemporal summation into Ca(2+) ripples/waves.

292 arp wave ripples decreased but the surviving ripples were associated with stronger population firing

293 Moreover, hippocampal sharp-wave ripples were disrupted, which may have further contribut

294 Linear stability analysis suggested that the ripples were Kelvin-Helmholtz Instabilities.

295 Coupled ripples were more pronounced during successful verbal me

296 However, both ripples and fast ripples were observed with higher rates, higher relative

297 s with the highest rates of ripples and fast ripples were resected in a similar proportion.

298 pocampal-neocortical spindle coupling around ripples, with directionality analyses indicating an infl

299 ansiently (0.76 +/- 0.06 s) decreased around ripples, with the MD activity suppression preceding the

300 spontaneous spindles in nesting hippocampal ripples within their excitable troughs, stimulation in-p