ライフサイエンスコーパス: risk

1 act of a healthy lifestyle in mitigating CHD risk.

2 d four main pathways that contribute to SVAS risk.

3 ight into the lifetime impact of SVD genetic risk.

4 outcompete other HSCs and increase leukemia risk.

5 cy of tools to identify persons at increased risk.

6 n end products) strongly associate with ARDS risk.

7 pe expression profiles with specific disease risk.

8 ptor binding in tandem pose greater pandemic risk.

9 iants, some of which may not increase cancer risk.

10 crease operative difficulty and complication risk.

11 ations in individuals at high cardiovascular risk.

12 ) scenarios reflective of endogenous CR-POPF risk.

13 ple stents were characterized by the highest risk.

14 e postoperative outcomes, as well as suicide risk.

15 nd act as intermediate biomarkers of disease risk.

16 associated with a variety of serious health risks.

17 and a broad range of adverse cardiovascular risks.

18 ent, especially in the presence of competing risks.

19 s triggering environmental and public health risks.

20 -day mortality than use of placebo (relative risk, 0.19; 95% CI, 0.05 to 0.75), whereas later treatme

21 ic factors and assessed it in the context of risk-adapted therapy for young patients with NRSTS.

22 Risk-adjusted mortality declined with increasing dischar

23 First, cancer risk after antireflux surgery was compared to the expect

24 94.89, P < 0.001), but a 62% lower mortality risk (aHR: 0.310.380.46, P < 0.001) beyond this.

25 Patients with DAP1 risk allele exhibit significantly higher autoantibody ti

26 athway transcripts, indicating that the DAP1 risk allele mediates enhanced autophagy, leading to the

27 re (GRS) constructed as the sum of inherited risk alleles, weighted by allelic effects established in

28 rs in most age-groups, with highest relative risks among 20-39 year-olds (respective aRRs 1.79, 2.33,

29 n diabetes and variables associated with CRC risk and ADR.

30 are identified that contribute to both LOAD risk and age at onset of LOAD.

31 sk score to detect genetic influences on GBA risk and age at onset.

32 lipids as cholesterol-independent markers of risk and even future targets for optimizing cardiovascul

33 We assessed risk and incidence rate of documented SARS-CoV-2 reinfec

34 ins can cause death in individuals from both risk and non-risk groups, including young adults.

35 mining chronic obstructive pulmonary disease risk and severity is controversial.Objectives: To compre

36 ession may alter smoking-related lung cancer risk and tissue damage from other inhaled toxins.

37 em inhibitors in SARS-CoV-2 may outweigh the risks and at the very least should not be withheld.

38 ake the largest known contribution to autism risk, and correlate with paternal age at the time of con

39 quarters among families who are the most at risk, and factors including the openings of some schools

40 thy in patients of African ancestry and high-risk APOL1 genotype infected with SARS-CoV-2 have emerge

41 ogic mortality were compared using competing risks approaches.

42 This outcome has important implications for risk assessment and the migratory success of monarchs in

43 e for the identification, and the hazard and risk assessment of these thyroid hormone disrupting chem

44 hypothesized that this approach improves BPD risk assessment, particularly in extremely premature inf

45 ng, and reduction of any potential infection risk associated with FcRn inhibition, in addition to hig

46 Risk-averse behaviours, such as standing on 'safe' block

47 disaggregate patients within RCTs to define risk-based variation in benefit, and an "effect-modeling

48 ed anxiety symptoms in combination with high-risk biological factors such as APOEepsilon4 and subcort

49 from 285 mothers enrolled in a high-allergy-risk birth cohort, the Melbourne Atopy Cohort Study.

50 egarding nephrogenic systemic fibrosis (NSF) risk, but there are few if any unconfounded cases of NSF

51 arly significant because it puts patients at risk by reducing the capacity of nurses to provide high

52 ACC risks by Hounsfield density were 0%, 0.5%, and 6.3% for

53 Quality Improvement Program (NSQIP) Surgical Risk Calculator (SRC) and a 5-factor NSQIP-derived frail

54 This risk calculator might be useful for triage of patients t

55 e levels measured in the general population, risks cannot be ruled out due to the potential for popul

56 al-molecular correlates stratified pLGG into risk categories.

57 Risk characterization analysis showed that although in v

58 Patients at clinical high-risk (CHR) for psychosis show elevations in [(18)F]DOPA

59 Our findings show that the known high-risk CNVs are not only associated with schizophrenia and

60 RMST may offer a complementary risk communication tool for AF in clinical practice.

61 nits) after resuscitation had 3-times higher risk compared to those who remained negative (21.8% vs 8

62 t pregnancy, particularly in attenuating the risk conferred by maternal asthma on childhood asthma or

63 associated with increased prevalence of high-risk coronary plaque and risk of cardiovascular events.

64 Improved understanding of these risks could meaningfully improve long-term care of patie

65 In the Coronary Artery Disease Risk Development in Young Adults study, a cohort of blac

66 assessed using a stratified Mantel-Haenszel risk difference, with non-inferiority declared if the lo

67 to a traditional risk factor model improved risk discrimination and reclassification for CHD but not

68 However, in some high-risk districts in Africa, a 95% coverage may be required

69 Enemy-risk effects, often referred to as non-consumptive effec

70 prevention of CVD introduced the concept of risk-enhancing factors that are specific to women and ar

71 merican Heart Association 2013 pooled cohort risk equation.

72 ent ketoacidosis, and enables individualized risk estimates for better prevention trial selection.

73 Alcohol intake >30 g/day yielded increased risk estimates for mortality compared to lifetime abstai

74 rsimonious risk model improved perioperative risk estimation.

75 ant should be offered individualized genetic risk evaluation, counseling, and genetic testing.

76 intestine and mitigate the particular health risks faced by individuals receiving sex steroid treatme

77 We applied the model to data on risk factor distribution from a variety of sources to pr

78 t underlie microvascular aging, the greatest risk factor for cerebrovascular disease and its subseque

79 dentified as potentially the most modifiable risk factor for dementia.

80 rs of infection were injection drug use as a risk factor for HIV acquisition (aOR, 2.2; 95% CI, 1.3-3

81 Obesity is a major modifiable risk factor for pancreatic ductal adenocarcinoma (PDAC),

82 interaction has been proposed as a potential risk factor in patients treated with RAAS inhibitors.

83 Adding CAC to a traditional risk factor model improved risk discrimination and recla

84 les to infer the causal effect of a specific risk factor on an outcome.

85 counterfactual that Russia had the Norwegian risk factor profile, the absolute age-standardized CVD m

86 VDA was noted with increasing frequency as a risk factor.

87 tory diet trial and for a pragmatic multiple risk-factor intervention, one designed by Institute staf

88 dependent of socio-demographics and vascular risk factors (body mass index, smoking, diabetes mellitu

89 Variation in risk factors across host-disease pairs suggests that eit

90 We discovered HLA risk factors and four non-HLA susceptibility loci in VPS

91 d relationship existed between the number of risk factors and subsequent mortality.

92 experiencing homelessness (PEH) to identify risk factors and support control measures.

93 Individuals with stroke risk factors but without AF were recruited from the gene

94 e for infectious, environmental, and genetic risk factors described.

95 Accounting for traditional risk factors did not eliminate the Black excess in combi

96 years for women; however, not all lifestyle risk factors equally correlated with life expectancy, wi

97 sleep are increasingly prevalent modifiable risk factors for cardiovascular disease.

98 egative but have villous atrophy and genetic risk factors for celiac disease must undergo endoscopic

99 Statistically significant risk factors for developing colon pathology include toba

100 Risk factors for early transient rhinitis involve a comb

101 SPs seem to act synergistically with CCT as risk factors for glaucoma progression.

102 Previous work has established that risk factors for lead exposure include race/ethnicity, p

103 mmon environmental exposures are independent risk factors for radiologic abnormalities.

104 multivariable logistic regression analysis, risk factors for severe infection included pre-existing

105 with chronic complications, and obesity were risk factors in most age-groups, with highest relative r

106 be related to poorer long-term monitoring of risk factors in nonwhite groups.

107 Cerebrovascular risk factors increase the likelihood of dementia in olde

108 This study determined the incidence and risk factors of obesity among pediatric solid-organ tran

109 of transferring hospitals, and determine the risk factors of transfer and mortality in IHT patients.

110 T cells compared with patients who had fewer risk factors, but these cells showed impaired IFN-gamma

111 d are associated with cardiovascular disease risk factors, HsCRP and Ox-LDL.

112 useful information to the available clinical risk factors.

113 vely, 0, 1, 2, or >=3 guidelines-recommended risk factors.

114 in 300 m of the home and all cardiometabolic risk factors.

115 ions in PCOS should focus on women with high-risk features rather than all women with PCOS.

116 High-risk features were defined by bulky tumors, variant hist

117 02, 2.72, P = .04), perceived kidney disease risk following donation (aOR, 1.68; 95% CI, 1.03, 2.73,

118 Genetic risk for a disease in the population may be represented

119 avirus-2 (SARS-CoV-2) infection increase the risk for acute nonischemic myocardial injury and acute m

120 e at strategies to better identify people at risk for AKI and to develop new approaches to improve AK

121 was associated with significantly increased risk for all-cause death (adjusted hazard ratio for mode

122 , wherein a multivariable model predicts the risk for an outcome and is applied to disaggregate patie

123 tment, may help identify individuals most at risk for developing chronic PTSD in the aftermath of tra

124 retinopathy appearing to carry a heightened risk for each outcome.

125 ith increased risk of ESKD, with the highest risk for heart failure (hazard ratio, 11.40; 95% confide

126 zation for HFpEF identifies patients at high risk for near-term clinical progression.

127 ration of GERD in identifying individuals at risk for neoplastic BE.

128 stoma has been associated with a significant risk for recurrence, extraocular spread, and systemic me

129 functional mechanisms in persons at familial risk for schizophrenia.

130 ibution from a variety of sources to project risk for the general adult population across 477 US citi

131 in women, who have a notable increase in the risk for this disease after menopause and typically deve

132 ttraumatic stress disorder (PTSD) may inform risk for this disorder.

133 h rate of dialysis mortality are at a higher risk for transplant failure compared with patients with

134 Remarkably high risks for second in situ squamous cell carcinoma of the

135 asing, research regarding possible long-term risks for users and their offspring is needed.

136 h reduction of an inflammatory bowel disease risk gene ATG16L1 and Paneth cell lysozymes in patients

137 osophila Tao kinase, the ortholog of the ASD risk gene Taok2, as a regulator of dendritic arborizatio

138 ts, mostly in cancer (40%) and cardiac (27%) risk genes.

139 f high MELD patients transplanted with "high-risk" grafts.

140 Cannabis use by risk group interactions were observed in the striatum an

141 intervention improves outcomes in this high-risk group.

142 death in individuals from both risk and non-risk groups, including young adults.

143 e confirmed highly variable estimates within risk groups, necessitating an individualized approach to

144 3 for favorable-, intermediate-, and adverse-risk groups, respectively (P < .001).

145 rvival (OS) differed significantly among ELN risk groups, with estimated 5-year OS probabilities of 0

146 s individually have small effects on disease risk, GWAS provide a powerful opportunity to explore pat

147 Both complications and preoperative patient risk have been shown to increase costs following surgery

148 ology, with an increasing occurrence of high-risk ICI-related myocarditis.

149 y AGE restriction, may reduce cardiovascular risk in CKD, but this requires testing in prospective ra

150 years, participating in the Atherosclerosis Risk in Communities (ARIC) study and 2390 participating

151 aseline (1996-1998) from the Atherosclerosis Risk in Communities study, we quantified the association

152 ion of genes associated with type 2 diabetes risk in genome-wide association studies.

153 o muscles types and indicating no additional risk in the consumption of dark muscle.

154 ireflux surgery was compared to the expected risk in the corresponding background population by calcu

155 e set was significantly associated with ADHD risk in the discovery and replication data sets.

156 Fracture risk increased with increasing eczema severity, with the

157 Taking excess mortality risk into consideration, this reduction in the number of

158 Ri) should not be used in high-immunological risk kidney transplant recipients due to a perceived inc

159 ate indicator of their diagnosis, status, or risk level, this initial triage process is inaccurate, w

160 t3b were enriched for kidney disease genetic risk loci.

161 ce supports that addressing these modifiable risks may be effective for primary and secondary AF prev

162 of subjective assessment with a parsimonious risk model improved perioperative risk estimation.

163 categories of predictive HTE approaches: a "risk-modeling" approach, wherein a multivariable model p

164 phase clinical trials in children with high-risk MYCN-driven disease, with limited ability to evalua

165 Patients with anemia and lower-risk myelodysplastic syndromes in whom erythropoiesis-st

166 galization without adequate knowledge of the risks necessitate the characterization of the billions o

167 mechanism (TMM) on clinical outcomes in high-risk neuroblastoma, we integrated the C-circle assay [a

168 = 0.002) were inversely associated with ICH risk, no significant associations were found for HDL and

169 Tocilizumab significantly reduced the risk of a subsequent NMOSD relapse compared with azathio

170 The possible increased risk of acute cerebrovascular disease in patients with d

171 hat ATG, as compared to IL2RA, may lower the risk of acute rejection without increasing hepatic compl

172 n fit a longitudinal joint model to estimate risk of advanced neoplasia at each subsequent examinatio

173 ment 1 (HTRA1) are associated with increased risk of age-related macular degeneration (AMD) and disea

174 s ADH1B*1: OR, 0.96; P = .036) and a reduced risk of an NAFLD activity score of 4 or higher (ADH1B*2:

175 or synthetic therapeutics that decrease the risk of autoimmune, metabolic, neoplastic, and infectiou

176 nisation of Care methods were used to assess risk of bias for the glycemic outcome and to prepare a s

177 th von Willebrand disease, have an increased risk of bleeding during pregnancy and delivery.

178 No significant difference in the risk of cardiovascular death was observed for patients w

179 diabetes (T2D) is associated with increased risk of cardiovascular disease (CVD).

180 prevalence of high-risk coronary plaque and risk of cardiovascular events.

181 te of orotracheal intubation and reduces the risk of complications when compared with direct laryngos

182 TLR10/1/6 locus appear to be linked with the risk of contracting a bloodstream infection.

183 athy is significantly associated with future risk of CVA, MI, CHF, and death, with higher degrees of

184 We estimated the 10-year predicted risk of CVD using the American College of Cardiology/Ame

185 In this study, we observed an increased risk of CVDs associated with glucocorticoid dose intake

186 ed to ADH1B*1, was associated with a reduced risk of definite NASH (ADH1B*2: OR, 0.80; P < .01 vs ADH

187 of risk variables works best for predicting risk of dementia in LMICs is needed.

188 ations, support a twofold increased relative risk of diabetes compared with the general population.

189 <0.001) both were positively associated with risk of diabetes, whereas scores of glycosylceramides, l

190 having an SFA base) were not associated with risk of diabetes.

191 hat, acting alone and in combination, confer risk of disease.

192 Physicians should be aware of the risk of dry eye after ptosis surgery and discuss dry eye

193 scular disease was associated with increased risk of ESKD, with the highest risk for heart failure (h

194 independently associated with a 23% reduced risk of functional dependence at 3 months after onset (R

195 Deterioration in eyes with or at risk of glaucomatous visual field loss was "detected" if

196 of EM CD8(+) T cells associated with reduced risk of graft failure.

197 After the first year, the risk of Guillain-Barre was not increased.

198 We investigated the risk of having thoracic and abdominal aortic sizes in th

199 lucose cotransporter 2 inhibitors reduce the risk of heart failure hospitalization and cardiovascular

200 In the most adjusted Cox models, the risk of HF was 39% and 62% lower among moderate fit (ter

201 n WC was significantly associated with lower risk of HF with preserved EF but not HF with reduced EF.

202 d CM interventions are effective in reducing risk of HIV and sequelae of injection and other drug use

203 tion of SSBs is associated with an increased risk of hyperuricemia in Mexican adults, but diet soft d

204 eloped PREDICT scoring tools for stratifying risk of IE, and the need for undergoing a TEE, among cas

205 o women and are associated with an increased risk of incident atherosclerotic CVD in women.

206 tched with patients in refractory arrest (at risk of intra-arrest transport) at that same time (unexp

207 meters is potentially useful to stratify the risk of LI after SOT.

208 The risk of lymph node involvement was calculated using the

209 an follow-up of 30 months, women had a lower risk of MACE (9.5% vs. 11.2%; adjusted hazard ratio: 0.7

210 Higher doses of NAC reduced risk of macular loci sensitivity loss in RP.

211 eripheral artery disease (PAD) have a higher risk of major adverse cardiovascular events (MACE) compa

212 ith dense breasts have an increased lifetime risk of malignancy that has been attributed to a higher

213 ing to HSC depletion and dysfunction and the risk of malignant transformation over time.

214 places axons crossing this region at greater risk of mechanical damage during brain tissue deformatio

215 Because small chromosomes would be at risk of missegregation if recombination were randomly di

216 be a criterion for selecting elderly PLWH at risk of MM.

217 ients with acute kidney injury (AKI) and the risk of mortality is high, especially if renal replaceme

218 ed with no device, was associated with lower risk of mortality, all-cause hospital admission, and int

219 analysis, the Pocket PATH group showed lower risk of nonadherence to lifestyle requirements (diet/exe

220 and quality are associated with an increased risk of obesity and related metabolic disorders, but the

221 nd cocaine use, select co-usage elevated the risk of oral disease.

222 th rifampicin and efavirenz, thus increasing risk of ovulation.

223 imilar cohorts of infants showed an elevated risk of persistent stunting from 12 through 24 months wi

224 ing environmental quality result in a higher risk of population quasi-extinction, regardless of summe

225 The risk of postoperative constipation was higher with PN vs

226 alve replacement (TPVR) is associated with a risk of procedural serious adverse events (SAE) and expo

227 Evaluating the risk of progression using naive CD4+ T-cells was predict

228 ixed results on the role of margin status in risk of recurrence after surgical resection.

229 The lowest risk of recurrence among those with precipitants occurre

230 events after cancer diagnosis had increased risk of recurrence and cancer-specific death.

231 nial stenosis was perceived to convey a high risk of recurrent stroke, but two previous trials (SAMMP

232 lant recipients due to a perceived increased risk of rejection.

233 uvant dabrafenib plus trametinib reduced the risk of relapse versus placebo in patients with resected

234 als with major decreases in LOS had a higher risk of severe adverse events [1.22 (1.11-1.34)] and dea

235 Globally, the risk of severe outcomes associated with COVID-19 has con

236 to usual care, PSM significantly reduced the risk of stroke (risk ratio [RR] 0.24, 95% CI 0.08-0.68).

237 software developers and users to reduce the risk of such errors.

238 These results highlight the impending risk of sudden and severe biodiversity losses from clima

239 iomyopathy and a low- or intermediate 5-year risk of sudden cardiac death underwent cardiac magnetic

240 Coprimary endpoints were risk of the composite outcome of blood transfusion or de

241 e asked 15 clinicians to assess the relative risk of the subpopulation defined by each rule compared

242 association between preexisting LA-DRVs and risk of virological failure whereas 14/25 (56.0%) did no

243 The purpose of this study was to define the risk of, and associations with, SAE and high-dose radiat

244 en higher physical activity levels and lower risks of breast cancer and colorectal cancer.

245 egrated health care setting, we examined the risks of CRC and related death by baseline colonoscopy a

246 We observed no long-term increased risks of dementia, Alzheimer's disease, Parkinson's dise

247 eas benzodiazepines were linked to increased risks of dementia.

248 reme aviation is accompanied by ever-present risks of hypobaric hypoxia and decompression sickness.

249 scores were associated with higher relative risks of neonatal death and greater absolute rate differ

250 Absolute 10-year risks of outcomes were as follows: HF: 3.18% (95% confid

251 lergen-specific analyses suggested increased risks of sensitization to birch (odds ratio [OR] = 1.12

252 ver time and whether such transition affects risks of subtypes of CVD in Chinese adults.

253 dates who accepted had a brief perioperative risk period within the first month posttransplant (adjus

254 being used to rule out infection among high-risk persons, such as exposed inpatients and health care

255 sion could potentially explain breast cancer risk phenotypes.

256 effective in preventing T2D; however, the at-risk pool is large, and a clinically meaningful metric f

257 G to detect asymptomatic paroxysmal AF in at-risk populations (such as those with cryptogenic stroke)

258 osure prophylaxis (PrEP) regimens among high-risk populations, including men who have sex with men (M

259 ondrug reward are linked and together form a risk profile for drug use or abuse, particularly in youn

260 demilitarize police would have the downside risks proposed by proponents of military transfers.

261 l anticoagulation enrolled in the Evolut Low Risk randomized trial underwent computed tomographic ima

262 We meta-analysed the risk ratio (RR) for major vascular events (a composite o

263 SM significantly reduced the risk of stroke (risk ratio [RR] 0.24, 95% CI 0.08-0.68).

264 ng from 12 through 24 months with a relative risk ratio of 1.51 (95% CI 1.21, 1.88).

265 ement of heroin-seeking in high- but not low-risk rats.

266 In patients at increased cardiovascular risk receiving metformin-based background therapy, speci

267 e ability to accurately identify patients at risk remains limited despite decades of clinical researc

268 the SOC arm (34%, 18/53; P < .001; relative risk [RR] 2.48, 95% CI 1.54-3.95), and the proportion of

269 as associated with lymphadenopathy (relative risk [RR]: 1.7; 95% confidence interval [CI]: 1.2, 2.4;

270 e EBL was assessed using 20 3-factor fistula risk score (FRS) scenarios reflective of endogenous CR-P

271 e population may be represented as a genetic risk score (GRS) constructed as the sum of inherited ris

272 A polygenic risk score (PRS) derived from genome-wide association st

273 nce kernel association testing and polygenic risk score (PRS) methods to examine rare and common vari

274 ecent Parkinson's disease-associated genetic risk score to detect genetic influences on GBA risk and

275 accuracy of a previously validated polygenic risk score was assessed among 4847 adults of white Europ

276 We examined the association of the risk score with plasma markers of liver disease and with

277 tly higher content quality score and a lower risk score, and was less likely to recommend MC use in g

278 Genetic risk scores were not associated with cardiovascular even

279 lyses were used to estimate summary relative risks (SRRs) and 95% confidence intervals (CIs).

280 We developed a risk stratification system from known prognostic factors

281 arge, and a clinically meaningful metric for risk stratification to guide interventions remains a cha

282 necessitating an individualized approach to risk stratification.

283 o correct for intravascular deficits in high-risk surgical patients is either effective or safe.

284 We generated individualised risk tables for patients with cancer, considering age, s

285 In this review, we place risk taking within existing models of information proces

286 entification of individuals with the highest risk that may require supportive treatment.

287 a substantial proportion of their hereditary risk, they do not, from a genetic perspective, simply re

288 sociated with higher driving simulator crash risk, though mechanisms explaining this relationship rem

289 intain a diverse natural reservoir, posing a risk to humans through the occasional emergence of novel

290 , research suggests that up to two-thirds at risk to inherit LS don't participate.

291 ng cause of mortality worldwide, with higher risks to develop pulmonary infections, including Aspergi

292 eatinine and cystatin C) and ACR with cancer risk using Cox regression models adjusted for potential

293 efining what number and which combination of risk variables works best for predicting risk of dementi

294 Genetic risk variants strongly associated with expression of SNX

295 Aggregated WMH risk variants were associated with altered white matter

296 ic neurons are enriched for neuropsychiatric risk variants, particularly those associated with schizo

297 The increased risk was unrelated to AF and inserted mechanical valves.

298 Improved OS and lower relapse risk were observed following TBI plus etoposide compared

299 roups characterized by an enhanced infection risk will be challenged by the virus.

300 This approach to quantifying reactivation risks will enable evaluations of the potential impacts o