ライフサイエンスコーパス: risk allele

1 .04] per 1000euro/mo increase and additional risk allele).

2 etabolite being increased in carriers of the risk allele.

3 occurs on haplotypes carrying the rs9834970 risk allele.

4 ncomycin with and without the identified HLA risk allele.

5 o understand the functional impact of the at-risk allele.

6 rrelated with the level of expression of the risk allele.

7 for incident coronary events per additional risk allele.

8 zophrenic patients carrying the rs6039769 at-risk allele.

9 tion than those from individuals without the risk allele.

10 res, and were more likely to carry the MUC5B risk allele.

11 creased in carriers of the TM6SF2 rs58542926 risk allele.

12 ed DNA methylation more effectively than the risk allele.

13 way regulation in patients carrying specific risk alleles.

14 f the odds ratio multiplied by the number of risk alleles.

15 resilience in carriers of disease-associated risk alleles.

16 nificantly lower in kidneys of subjects with risk alleles.

17 ls exclusively from subjects carrying asthma-risk alleles.

18 n, especially in patients homozygous for the risk alleles.

19 tant contributions from both common and rare risk alleles.

20 ence likely carry a greater burden of common risk alleles.

21 potentially identify new cancer-predisposing risk alleles.

22 s triggering disease in interaction with the risk alleles.

23 holesterol (TC) were created as the count of risk alleles.

24 ARMS2 risk alleles (1 vs. 0: HR, 2.72, CI, 1.58-4.70; 2 vs. 0:

25 increased frequency of the rs10455872-G LPA risk allele (15.1% vs. 8.8%; p < 0.05).

26 abolites were positively associated with the risk allele (17-58% increase/allele copy, P = 0.046-0.00

27 Most SCZ risk alleles (61 of 75, 81%) were associated with poorer

28 oorer cognitive performance, whereas most BD risk alleles (9 of 12, 75%) were associated with better

29 eta=-0.11 micromol/L per genetic risk scores risk allele; 95% confidence interval, -0.188 to -0.033;

30 The risk allele A in rs7175922 (CYP19A1) was significantly a

31 d the risk for DILI among those with the HLA risk alleles A*02:01 and DRB1*15:01.

32 Homozygotes for the PSC disease risk allele (AA) showed significantly lower CD28 mRNA ex

33 GPS) was generated by summing BMI-increasing risk alleles across the genome.

34 chizophrenia that involves a large number of risk alleles across the whole range of population freque

35 Individuals carrying the rs7090445-C risk allele also have reduced ARID5B expression.

36 a cell function, and many with HLA+ diabetes risk alleles also had monogenic diabetes variants, indic

37 t of the association between the rs9277378*A risk allele and NKTCL susceptibility (OR 2.38, p value f

38 whether an association exists between APOL1 risk alleles and cardiovascular disease (CVD) that is in

39 ARMS2 risk alleles and higher GRS were associated with the pre

40 , to our knowledge, to identify specific CAD risk alleles and potential genetic factors contributing

41 correlation between coronary artery disease risk alleles and repressed expression of these genes.

42 observations from genetically defined autism risk alleles and rodent model, these findings suggest a

43 Apolipoprotein L-1 (APOL1) high-risk alleles and the glutathione-S-transferase-mu1 (GSTM

44 M transcript produced primarily by the "LOAD-risk" allele and a shorter CD33m isoform lacking the sia

45 y differences in response inhibition between risk-allele and non-risk allele carriers in children suf

46 .02] per 1000euro/mo increase and additional risk allele) and for incident coronary events (hazard ra

47 he identification of human leukocyte antigen risk alleles, and drug-induced proliferation of lymphocy

48 When adjusting for age, sex, ARMS2 and CFH risk alleles, and examination phase, the ox-LDL at the b

49 e expression in mouse models harboring major risk alleles, and strengthen the connection between chan

50 tations can be expected to share some common risk alleles, and therefore pathophysiological mechanism

51 These APOL1 kidney risk alleles are a rare example of genetic variants that

52 We demonstrated that type 2 diabetes risk alleles are associated with decreased ADCY5 express

53 APOL1 risk alleles are associated with higher SBP and earlier

54 Autosomal recessive LRBA risk alleles are associated with severe, early-onset aut

55 need to keep questioning if weighted sums of risk alleles are measuring what we think they are in the

56 ar, multifactorial relationship in which HLA risk alleles are one factor.

57 rect evidence demonstrating that these APOL1 risk alleles are pathogenic is still lacking because the

58 AD and MD and to determine whether polygenic risk alleles are shared with neuropsychiatric traits or

59 The burden of schizophrenia risk alleles, as indexed by a polygenic risk score (PRS)

60 ypes, were enriched for common schizophrenia risk alleles, as well as rare loss-of-function and de no

61 cated in intron 3 of VLDLR; rs3780181-A is a risk allele associated (P <= 2 x 10-9) with increased TC

62 tive trait locus (eQTL) for IFITM3, with the risk allele associated with lower mRNA expression.

63 or evening preference, and MTNR1B rs10830963 risk allele associated with type 2 diabetes and HbA(1c)

64 s with IBD, particularly in those with CARD9 risk alleles associated with IBD.

65 We identified individuals with risk alleles associated with NASH-fibrosis: rs738409C>G

66 interest, we hypothesized that summation of risk-allele-associated gene expression, namely a transcr

67 ated mapping to a B-cell super-enhancer, and risk allele association with decreased enhancer activity

68 This study assessed the APOL1 risk alleles' association with blood pressure traits in

69 APOL1 risk alleles' association with blood pressure-related tr

70 The risk allele at rs56048322 affects splicing of PTPN22, re

71 The diabetes risk allele at TCF7L2 was associated with a stronger eff

72 showed colocalized associations between the risk allele at the IL6 lead variant and higher eosinophi

73 The risk allele at the NAV1 lead variant colocalized with hi

74 We identified 138 individuals with risk alleles at 15 STR disease loci.

75 lder siblings among carriers of known asthma risk alleles at 17q21 (e.g., rs8076131) (adjusted odds r

76 Rare homozygous carriers of the risk alleles at both loci are predicted to have 3.3-3.7

77 Finally, we show that risk alleles at rs11203203 and rs80054410, two T1D-assoc

78 Children with risk alleles at the 17q21 genetic locus who wheeze durin

79 Common psychiatric risk alleles at the NT5C2 locus reduce expression of thi

80 tinoic acid treatment and by the presence of risk alleles at the Pitx2 locus.

81 t cohort, we also showed that the numbers of risk alleles at these loci are negatively correlated wit

82 A high burden of disease risk alleles at these loci was associated with earlier a

83 ations systematically replaced the inherited risk alleles (at MPL) or duplicated them to the homologo

84 asing) associations among 11 type 2 diabetes risk alleles (at P < 0.05).

85 The Crohn's disease risk allele ATG16L1 T300A results in abnormal Paneth cel

86 ression quantitative trait loci effects, the risk allele being associated with lower lymphocytic expr

87 s been postulated that individuals who carry risk alleles but are unaffected are at some reproductive

88 podocyte-specific expression of either APOL1 risk allele, but not of the G0 allele, develop functiona

89 Our results suggest that the T2DM risk allele C is associated with higher islet zinc level

90 In addition, we found an association of CRC-risk allele C of rs7198799 with elevated transcript leve

91 bilical vein endothelial cells (HUVECs), the risk allele "C" is associated with lower expression of t

92 provide mechanistic insights into how CHRNA3 risk alleles can increase the risk of tobacco dependence

93 CTCF binding in promoter-binding assays, and risk allele carriage diminished transcriptional correlat

94 Importantly, MDMs from rs1517352 C IBD risk allele carriers demonstrated increased TLR4-, IFN-g

95 Finally, in the PPMI cohort, TMEM106B risk allele carriers demonstrated more rapid longitudina

96 pendent subject groups demonstrated that T2D-risk allele carriers displayed reduced levels of STARD10

97 ponse inhibition between risk-allele and non-risk allele carriers in children suffering from ADHD and

98 ted expression of these lncRNAs and c-myc in risk allele carriers may explain their greater susceptib

99 using functional magnetic resonance imaging, risk allele carriers of rs17689918 showed aberrant diffe

100 Our findings suggest that MTNR1B risk allele carriers who carry out shift work or have mo

101 ncreased transepidermal water loss (TEWL) in risk allele carriers.

102 nhibitor sildenafil compared with homozygous risk allele carriers.

103 eta1 upregulation in the vasculature of 9p21 risk allele carriers.

104 that such treatment may prevent CHD in 1q25 risk allele carriers.

105 Among rs1333049 risk-allele carriers (CC+GC), the incidence of MI was re

106 ression of the human APOL1 G1 and G2 disease risk alleles caused near-complete lethality in D. melano

107 pattern of differential injury by the APOL1 risk alleles compared with the nonrisk alleles across ev

108 ebral vasculature is a mechanism by which AD risk alleles confer susceptibility.

109 gether, these data suggest that rs11708067-A risk allele contributes to type 2 diabetes by disrupting

110 nucleotide polymorphisms on stroke risk per risk allele, corresponding to a one allele increase in t

111 The risk allele count (genetic load) exhibits an acceleratin

112 (PRS) for cases and controls by summing the risk allele counts for the variants weighted by their na

113 find that KIF3A SNP rs11740584 and rs2299007 risk alleles create cytosine-phosphate-guanine sites, wh

114 In conclusion, GSTM1 null and APOL1 high-risk alleles deleteriously affect CKD progression among

115 Furthermore, the risk allele disrupts a CpG site that undergoes different

116 espite this, many individuals expressing HLA risk alleles do not develop hypersensitivity when expose

117 se the majority of individuals who carry HLA risk alleles do not develop hypersensitivity, other para

118 CFH and ARMS2 risk alleles do not modify the response to the AREDS2 nu

119 aled an association between Brugada syndrome risk allele dosage and HEY2 expression (beta=+0.159; P=0

120 e, as well as a positive association between risk-allele dosage and symptom severity, whereas neuroty

121 ward circuit as a function of increased OXTR risk-allele dosage, as well as a positive association be

122 ocusing on how connectivity varies with OXTR risk-allele dosage.

123 In addition, the putative risk alleles, DRB1*15:01 and DQB1*06:02, are associated

124 The inclusion of genetic risk alleles (either singly or as a composite genetic ri

125 Patients with DAP1 risk allele exhibit significantly higher autoantibody ti

126 usion, abstinent smokers with the withdrawal risk allele experienced greater alleviation of their urg

127 e secondary structure of the paRNA, with the risk allele facilitating the assembly of the microRNA-gu

128 FL in the nasal sector with each copy of the risk allele for both the SIX1 (rs10483727) and SIX6 (rs3

129 ards longer lifespan in individuals with the risk allele for depressive symptoms in men (odds ratio (

130 ns only with the GRSBMI and GRSComplete [per risk allele for each soft drink serving per day: 0.05 cm

131 The previously reported risk allele for FMD (rs9349379-A) was associated with a

132 Carriers of the risk allele for rs74315329 were identified using whole-g

133 pollution were stronger in carriers of fewer risk alleles for atopic eczema.

134 Children with risk alleles for both genes were at higher risk for EoE

135 Mean age decreased with the number of risk alleles for CFH (P < .001), ARMS2 (P < .001), and C

136 We sought risk alleles for clozapine-associated neutropenia in a s

137 d DNA sequence variants that colocalize with risk alleles for common diseases can expose disease-asso

138 rosis (FAM13A and DSP) but that had opposite risk alleles for COPD.

139 for each individual by summing the number of risk alleles for each SNP weighted by the respective eff

140 ity explained by known common low penetrance risk alleles for EOC.

141 ormed to compare the 2 groups and identified risk alleles for IVIG resistance.

142 dies have thus far indicated five genes with risk alleles for LATE-NC: GRN, TMEM106B, ABCC9, KCNMB2,

143 Second, although the strongest genetic risk alleles for NAFLD (ie, the 148Met allele in PNPLA3

144 ate experimental proof of causality of these risk alleles for renal disease.

145 ntially complex molecular etiology, in which risk alleles for schizophrenia generate epigenetic alter

146 Numerous risk alleles for systemic lupus erythematosus (SLE) have

147 o be negatively associated with the maternal risk alleles for the alpha5 nicotinic acetylcholine rece

148 ide association studies (GWAS) have revealed risk alleles for ulcerative colitis (UC).

149 results, nor did evaluation of the number of risk alleles formed by the two SNPs.

150 Furthermore, a comparison of risk allele frequencies and genetic risk scores suggeste

151 However, higher risk allele frequencies and population-attributable risk

152 vs non-DS ALL case-case analyses, comparing risk allele frequencies at these and other established s

153 4, between the genes LINC01142 and METTL11B (risk allele frequency = 8.1%; odds ratio [OR]: 1.26; p =

154 he fundamental statistical trade-off between risk allele frequency and odds ratio.

155 Risk allele frequency in whites (0.43) was greater than

156 ive disease model with 100% penetrance and a risk allele frequency of 5%.

157 cluded an association between the rs2007044 (risk allele G) within CACNA1C and poorer working memory

158 ry 2 copies of the apolipoprotein L1 (APOL1) risk alleles G1 or G2, which are associated with 1.5- to

159 ld type allele (G0) or the predominant APOL1 risk allele (G1) in different tissues.

160 othesis that APOL1 (G0) preserves, but APOL1 risk alleles (G1 and G2) disrupt APOL1-miR193a axis in D

161 Further, enhancer with the risk allele gains response to androgen stimulation by re

162 In contrast, the rs59892895*C risk allele had a frequency of less than 0.1% in individ

163 Carriers of the risk allele had reduced numbers of CD8(+) T cells in the

164 th normal kidney function at baseline with 2 risk alleles had slightly higher risk of developing coro

165 In conclusion, blacks with two APOL1 risk alleles had the highest risk for albuminuria and eG

166 isposition to keloid formation, and a keloid risk allele has been reported in the gene locus for the

167 identified and the work in identifying rare risk alleles has only just begun.

168 haracter because humans carrying the ADAMTS9 risk allele have decreased expression of mitochondrial m

169 esting that carriers of the reduced migraine risk allele have reduced sensitivity to cold stimuli and

170 that individuals with more diabetes genetic risk alleles have a higher risk of developing DR.

171 Although several at-risk alleles have been identified, they do not completel

172 Such autoimmune risk alleles have recurrently evolved at the DANGEROUS M

173 y artery disease compared with those with no risk alleles (hazard ratio, 1.11 [95% CI, 1.01-1.21]; P=

174 participants, 3941 (13%) carried the 2 APOL1 risk allele high-risk genotype.

175 four SNPs, carriers of two copies of the T2D risk allele (homozygous genotype) had significantly smal

176 score, we find increased polygenic burden of risk alleles identified by GWAS in multiplex vitiligo ca

177 The majority of common risk alleles identified for neuropsychiatric disorders r

178 The risk alleles impair glucose-induced insulin secretion an

179 expression being slightly biased toward the risk allele in heterozygotes.

180 ar metabolic traits associated with the 1q25 risk allele in HUVECs, including impairments of the gamm

181 The risk allele in MTARC1 was associated with higher levels

182 18) explore the consequences of this genetic risk allele in NEDD4 for inflammation in the skin and fo

183 thinner RNFL was found with each copy of the risk allele in rs33912345 with a decrease trend observed

184 significantly thinned with each copy of the risk allele in SIX1/SIX6.

185 als matched for the genotype of a common T2D-risk allele in SLC30A8, p.Arg325.

186 A functional risk allele in the MET promoter, enriched in subgroups o

187 In addition to known risk alleles in 349 brains (23.9% of 1461 undergoing exo

188 indicating an increased penetrance of CDKN2A risk alleles in children with DS.

189 Risk alleles in PNPLA3 and HSD17B13 were both associated

190 ignificant RNFL thinning in each copy of the risk alleles in SIX1/SIX6 in the eyes of younger individ

191 We sought to identify risk alleles in the first genome-wide association study

192 e disorder as well as the persistence of its risk alleles in the modern human genome.

193 se HCM patients commonly have low penetrance risk alleles in TNNT2 or TNNI3 but exhibit few clinicall

194 tions that duplicate or remove the inherited risk alleles, including large-effect rare variants at NB

195 d that the common IBD-associated rs1517352 C risk allele increased both STAT1 and STAT4 expression in

196 nd ABHD8, and luciferase assays indicate six risk alleles increased transactivation of the ADHD8 prom

197 a transcriptional silencer for CDC42 and the risk allele increases expression of CDC42.

198 DNA-nuclear protein interactions, where the risk allele is associated with increased SLC4A7 expressi

199 We demonstrate that the risk allele is less efficient in repressing miR-196a-5p

200 tly, the dosage of the rs17594362/rs12429256 risk allele is positively correlated with the expression

201 Finally, the rs7090445-C risk allele is preferentially retained in HD-ALL blasts

202 st that a larger burden of AD common genetic risk alleles is associated with attenuated cerebrovascul

203 t demonstration that the expression of APOL1 risk alleles is causal for altered podocyte function and

204 logical perspective and that the concept of "risk allele" is highly context dependent, changing with

205 who were informed that they carried the FTO risk allele (level 3 AT/AA carriers) than in the nonpers

206 ing and immunoblotting demonstrated that the risk allele locally conferred reduced expression of SEL1

207 athway transcripts, indicating that the DAP1 risk allele mediates enhanced autophagy, leading to the

208 lleles, n=176), and low-risk black (zero/one risk allele, n=1154).

209 e white (n=1700), high-risk black (two APOL1 risk alleles, n=176), and low-risk black (zero/one risk

210 We found that the risk alleles occur in two non-reference haplotypes in HC

211 xpressed in subjects homozygous for the high-risk allele of lead SNP rs60131261 than subjects homozyg

212 ven in those individuals that carry the high-risk allele of rs1061170 (Y402H).

213 r large HDL particle numbers, such that each risk allele of the genetic risk scores was associated wi

214 derived neural progenitor cells carrying the risk allele of the single nucleotide polymorphism (SNP),

215 d from the percentage of the carriers of the risk allele of the variant who had high IOP (ocular hype

216 Carrying increasing numbers of at-risk alleles of 31 SNPs confers a higher risk of being n

217 GRS was computed by summing the number of at-risk alleles of tagging SNPs.

218 sion of ESR1, RMND1 and CCDC170, whereas the risk alleles of the strongest candidates for the remaini

219 The risk alleles of these SNPs were proved to be associated

220 Retreatment was associated with T(risk) allele of ARMS2 A69S (P = 2.0 x 10(-4); hazard rat

221 ; hazard ratio: 2.18:95%CI: 1.47-3.24) and C(risk) allele of CFH rs1329428 (P = 2.0 x 10(-3); hazard

222 aplotype (Chr1-prot-del) on Chr1 without any risk alleles on Chr10.

223 rs investigated the influence of psychiatric risk alleles on early-onset mental health trajectories a

224 st this hypothesis, isolating the effects of risk alleles on fecundity from the effects that are cont

225 emonstrate the overall enrichment of disease risk alleles on gene regulatory regions, they are not de

226 iduals with the growing number (>/=8) of the risk alleles on gout associated loci.

227 estigate the effect of atopic eczema-related risk alleles on this association.

228 transcription factor TCF7L2 to the rs6983267 risk allele over the non-risk.

229 0.227; interaction between treatment and the risk-allele P=0.016).

230 f IL-12p70 in patients with pSS carrying the risk allele (P = .016).

231 0131261 than subjects homozygous for the low-risk allele (P = 0.006).

232 association with MDS did not differ by Y204H risk allele (P = 0.89).

233 iated with higher GRS (P < 0.0001) and ARMS2 risk alleles (P < 0.0001) and, at a nominal level, with

234 P < 0.0001) and, at a nominal level, with C3 risk alleles (P = 0.04) and CFH risk alleles (P = 0.048

235 vel, with C3 risk alleles (P = 0.04) and CFH risk alleles (P = 0.048 for homozygotes).

236 ogenic CNVs carry an excess burden of common risk alleles (P=2.25 x 10(-17)) defined from a genome-wi

237 Risk alleles positively correlate with ORMDL3 (orosomuco

238 The risk allele predicted higher transcriptional levels of P

239 dated human leukocyte antigen (HLA)-DR*03:01 risk allele predicted increased risk of adverse outcome

240 nd sexual abuse in interaction with an FKBP5 risk allele previously associated with vulnerability to

241 who are heterozygous or homozygous for this risk allele produce significantly higher levels of IL-12

242 tients who are homozygous for cardiovascular-risk alleles (R/R cardiomyocytes) or from healthy indivi

243 n four separate enhancer elements, and their risk alleles reduce expression of ESR1, RMND1 and CCDC17

244 ly interacts with the NTN4 promoter, and the risk allele reduced NTN4 promoter activity.

245 the transcription factor SPDEF whereas, non-risk alleles remain non-responsive.

246 In one such example, T2D risk alleles residing in a muscle stretch/super enhancer

247 k for MI was determined by counting the 9p21 risk alleles; results were provided to each participant

248 tently demonstrated that the 1q42.1 melanoma risk allele (rs3219090[G]) is correlated with higher PAR

249 decreased in subjects with the 17q21 asthma-risk alleles rs7216389 and rs8076131.

250 sues, such as the correlation between asthma risk allele, rs7216389-T and Gasdermin-B (GSDMB) in plac

251 When in trans with the RET intron 1 enhancer risk allele, rs9282834 increases the risk of HSCR from 1

252 major mood disorders; subjects carrying the risk allele showed impaired cognitive abilities, increas

253 preadipocyte cells and that the rs3780181-A risk allele showed significantly less enhancer activity

254 us (P0.05), with BD subjects carrying the T (risk) allele showing decreased fractional anisotropy com

255 Here we show that risk alleles spanning multiple genes across the 10q24.32

256 zed the cross-sectional association of APOL1 risk allele status with lipid traits and 115 cardiovascu

257 The primary exposure was APOL1 risk allele status.

258 The risk allele ('T') is associated with higher expression o

259 sequencing captures low-frequency functional risk alleles that are missed by SNP array-based studies.

260 rstanding of the biological functions of the risk alleles that have been identified, although Parkins

261 bly, within and across independent loci, T2D risk alleles that overlap with RFX footprints uniformly

262 associated with genetic risk (schizophrenia risk alleles), the subsequent course of emotional proble

263 Using an integrative analysis of RA risk alleles, the transcriptome and methylome in RA FLS,

264 ntribute to the persistence of schizophrenia risk alleles, these results indicate that the negative s

265 atients with the chromosome 9p21.3 rs1333049 risk allele together with high fasting insulin levels be

266 C2 expression associated with the homozygous risk allele (TT) of rs9517723 could induce overactivatio

267 erally constructed as weighted sum scores of risk alleles using effect sizes from genome-wide associa

268 nsmembrane and coiled-coil domains 1 (TMCO1) risk alleles using Kaplan-Meier and Cox proportional haz

269 The apolipoprotein E (APOE) risk allele (varepsilon4) is associated with higher tota

270 The effect size of one risk allele was 1.4 +/- 0.3 vs. 2.2 +/- 0.44 kg/m(2) in

271 Consistent with these findings, the risk allele was also associated with decreased glutathio

272 The disease-risk allele was also associated with up-regulated humora

273 The ARMS2 risk allele was associated significantly with progressio

274 15 SNPs showed that each additional average risk allele was associated with a 0.073 SDS (SE 0.011, P

275 Each copy of the rs59892895*C risk allele was associated with increased risk of primar

276 The risk allele was found to have decreased IRF3 binding and

277 hat represent COA-specific risk factors, the risk allele was more common in COA- than in AOA-affected

278 The CFH risk allele was not associated with AMD progression.

279 The rs59892895*C risk allele was present at appreciable frequency only in

280 Since HOXB13 p.G84E is a prostate cancer risk allele, we evaluated the association between HOXB13

281 re (GRS) constructed as the sum of inherited risk alleles, weighted by allelic effects established in

282 Risk alleles were also associated with either increased

283 APOL1 risk alleles were associated under an additive model wit

284 The CAVS risk alleles were associated with higher mRNA expression

285 APOL1 risk alleles were associated with overall SBP (pcom = 7.

286 For 18 loci, schizophrenia risk alleles were associated with poorer cognitive perfo

287 de polymorphisms determining APOL1 G1 and G2 risk alleles were genotyped in BioMe and imputed in BioV

288 Psychiatric risk alleles were indexed by polygenic risk scores (PRS)

289 Risk alleles were weighted by the log of odds ratios rep

290 The ORs per 10 risk alleles, were for TG 0.91 (95%CI: 0.72-1.16, p = 0.

291 ese disorders could represent causal disease risk alleles whose effect may be modifiable by vitamin D

292 We estimated the relationship of the PAI-1 risk allele with FEV1/FVC by multivariate linear regress

293 Bipolar disorders share genetic risk alleles with other mental and medical disorders.

294 om rare, highly penetrant variants to common risk alleles with small effect sizes.

295 ed with T2D (odds ratio 1.07 [1.06-1.09] per risk allele), with a stronger effect observed in nonobes

296 Identification of an endometrial cancer risk allele within a member of the PI3K/AKT signaling pa

297 Our functional annotation of the risk alleles within 15q24.3 coupled with previously esta

298 ted MN was initially found to associate with risk alleles within HLA-DQA1, but subsequent studies hav

299 enic transmission of common, low-effect-size risk alleles within multiplex-vitiligo-affected families

300 letion variant, GCTGT-->A (in which A is the risk allele), yielded a shorter transcript that escaped