ライフサイエンスコーパス: roadmap

1 emissions reduction by 2050 (European Energy Roadmap).

2 tions to implement this important scientific roadmap.

3 lic and private R&D decisions and technology roadmaps.

4 ould inform current updates of protocols and roadmaps.

5 beyond those envisaged in current technology roadmaps.

6 ve the current requirements for the industry roadmap(4).

7 cs, towards establishing an opto-electronics roadmap, akin to the International Technology Roadmap fo

8 p shape the neutrophil maturation trajectory roadmap and challenge the current definition of GMPs.

9 tudy design selection framework to provide a roadmap and description of methods that may be utilized

10 thy blood epigenomes from the BLUEPRINT, NIH ROADMAP and ENCODE consortia by their cell type.

11 igenomic resources by ENCODE, the Epigenomic Roadmap and others has led to strategies that seek to in

12 ls, we believe that this model can provide a roadmap and potentially an in silico testbed for future

13 e potential to generate a therapeutic target roadmap and rejuvenate the current drug-discovery pathwa

14 ns that could promote future neurotechnology roadmaps and industrial-academic-government collaborativ

15 terrogation of Encyclopedia of DNA Elements, Roadmap, and other data sets.

16 Three key components of the roadmap are: support and improve the Affordable Care Act

17 Hence, comprehensive developmental roadmaps are crucial to channel stem-cell differentiatio

18 us reports are needed to continue developing roadmaps at a global level.

19 The work presented here is a roadmap both for the development of improved vaccine str

20 The proposed roadmap can be used to efficiently develop a cGMP-compli

21 specific epigenomics annotations from ENCODE/Roadmap consortium covering 127 cell/tissue types and 8

22 tics analysis of eQTL and histone marks from Roadmap data has evidenced a possible role of the identi

23 e a custom genome browser from the Epigenome Roadmap dataset.

24 its within Encyclopedia of DNA Elements- and Roadmap-derived regulatory regions.

25 This Roadmap discusses important considerations necessary to

26 latory regions in various cells using Encode Roadmap DNase-hypersensitive site data.

27 We then present a roadmap emerging as one possible future for quantitative

28 Collectively, this roadmap enables navigation of mesodermal development to

29 and the National Institutes of Health (NIH) Roadmap Epigenetics Program have now annotated more than

30 s in matched cell types and tissues from the Roadmap Epigenomics and ENCODE consortia.

31 ing ChromDiff to the 127 epigenomes from the Roadmap Epigenomics and ENCODE projects, we provide nove

32 epressive) for 98 additional cell types from Roadmap Epigenomics and ENCODE projects.

33 iling data for 77 cell and tissue types from Roadmap Epigenomics and ENCODE, and from H3K27Ac ChIP-se

34 g amount of regulatory data from the ENCODE, Roadmap Epigenomics and other consortia provides a wealt

35 with data from large consortia including the Roadmap Epigenomics and the ENCODE projects.

36 om IDEAS is uniformly more accurate than the Roadmap Epigenomics annotation and the improvement is su

37 ase I hypersensitive regions from ENCODE and Roadmap Epigenomics cell lines.

38 To address this need, the NIH Roadmap Epigenomics Consortium generated the largest col

39 The Roadmap Epigenomics Consortium has published whole-genom

40 an Reference Epigenome Map, generated by the Roadmap Epigenomics Consortium, contains thousands of ge

41 lysis of 127 human cell types studied by the Roadmap Epigenomics Consortium.

42 existing methods, including that used by the Roadmap Epigenomics Consortium.

43 Integrating meQTL and Roadmap Epigenomics data could assist fine-mapping effor

44 ata sets (CpG Shore data, THREE data and NIH Roadmap Epigenomics data), studied previously in other w

45 an interact with EpiCompare by investigating Roadmap Epigenomics data, or uploading their own data fo

46 NIH projects such as ENCODE and Roadmap Epigenomics have revealed surprising complexity

47 rimental datasets, we compared the IDEAS and Roadmap Epigenomics maps.

48 21 human cell types and tissues from the NIH Roadmap Epigenomics Project as well as 8 histone marks (

49 As large consortia including ENCODE and Roadmap Epigenomics Project continue to generate high-th

50 with epigenomes of cell-types defined by the Roadmap Epigenomics project revealed that enhancers are

51 aedia of DNA Elements consortium and the NIH Roadmap Epigenomics Project to predict haploinsufficienc

52 g information from the ENCODE Consortium and Roadmap Epigenomics Project to prioritize variants for p

53 and histone modification from ENCODE and the Roadmap Epigenomics Project, as well as through in vivo

54 seq datasets from different tissues from the Roadmap Epigenomics Project, ME-Class significantly outp

55 Large-scale epigenome mapping by the NIH Roadmap Epigenomics Project, the ENCODE Consortium and t

56 lysing 111 reference epigenomes from the NIH Roadmap Epigenomics project, we determine tissue-specifi

57 For 127 tissues and cell types in the ENCODE/Roadmap Epigenomics Project, we provide catalogs of puta

58 to the 127-epigenome dataset released by the Roadmap Epigenomics project, with enrichment for enhance

59 anatomy and development using data from the Roadmap Epigenomics Project.

60 ns and studies on the real data from the NIH Roadmap Epigenomics project.

61 27 reference epigenomes from ENCODE 2012 and Roadmap Epigenomics, incorporating regulator binding dat

62 a hubs, including data from the 4DN, ENCODE, Roadmap Epigenomics, TaRGET, IHEC and TCGA consortia; (i

63 This roadmap focuses on five key opportunities for community

64 Overall, these observations provide a roadmap for a 'human knockout project', a systematic eff

65 e, and identify gaps, to provide a potential roadmap for accelerating translation of microbiome scien

66 The key areas identified provide a roadmap for action regarding the continued use of polymy

67 es are identified, which together lays out a roadmap for actuators with drastically improved performa

68 nges to studying this population and offer a roadmap for an ethical approach to conducting research o

69 Our study provides a roadmap for applying findings in animal models to indivi

70 The proposed action plan could provide a roadmap for Arab mental health researchers and research

71 Richerson et al. provide a much needed roadmap for assessing cultural group selection (CGS) the

72 hanges in functionality, thereby providing a roadmap for bacteriophage engineering.

73 These data provide a roadmap for brown adipocyte development and indicate tha

74 O(2) at the atomic level and envisioning the roadmap for C(2) products generation.

75 in the virion, which could further provide a roadmap for capsid assembly.

76 pproaches described here provide a potential roadmap for centers that must rapidly adapt to the treme

77 pathogenic variants in CREs, to establish a roadmap for characterizing regulatory variation in the h

78 terizing evanescent fields, and we provide a roadmap for comparing TIRF data across images, experimen

79 in which activation occurs, could provide a roadmap for creating neuroprosthetics that feel as if th

80 This study outlines a roadmap for DAC cost reductions through the exploitation

81 ential housekeeping mechanism and provides a roadmap for defining the function of HSF1 as a driver of

82 Overall, our work provides a roadmap for designing fluorophores, photoswitching agent

83 We provide a roadmap for designing, evaluating, and modeling interven

84 In this paper we propose a roadmap for developing an open source cardiovascular cir

85 suppressor by inhibiting MALT1 and provide a roadmap for developing new strategies to inhibit MALT1-d

86 We present a roadmap for development and translation of monoclonal an

87 The present paper provides a roadmap for development of neuro-oscillatory responses a

88 Specifically, the International Roadmap for Devices and Systems recommends(4) the develo

89 monstrated a bioinformatics-driven discovery roadmap for drug repurposing and development in overcomi

90 These results provide a roadmap for efficient site selection to increase the eff

91 f definitive endoderm to generate a coherent roadmap for endoderm differentiation.

92 Therefore, this piece may offer a roadmap for enhancing development of both degraders and

93 The structure provides a roadmap for experimental probing and manipulation of vir

94 on of thermodynamic processes and provides a roadmap for exploiting these processes in future reactio

95 To provide a roadmap for exploration of the multiple roles of UL21, w

96 ated model of AVN morphology, and describe a roadmap for exploring AVN cellular heterogeneity.

97 e human pancreatic islet cistrome provides a roadmap for exploring the effects of these variants and

98 protein and protein complexes and provides a roadmap for extending the performance metrics for studie

99 this new subfamily classification provides a roadmap for functional glycogenomics that will guide fut

100 ISC differentiation and provide a chromatin roadmap for further dissecting cis regulation of cell fa

101 Finally, a research roadmap for further improvement in AAEM fuel cell perfor

102 energy conversion and storage, outlining the roadmap for future applications.

103 t species in a given community and provide a roadmap for future avenues of research on dominant speci

104 Our findings provide a roadmap for future breeding efforts to enhance carrot fl

105 value of radiotheranostics and to outline a roadmap for future development.

106 These results provide a roadmap for future engineering efforts to further expand

107 Here, we provide a roadmap for future experiments to explore the nature of

108 to gas-phase transfer of IDPs and provide a roadmap for future investigations into flexible systems

109 Our results provide a roadmap for future plant metabolic engineering efforts a

110 electronic applications, thereby providing a roadmap for future research and development.

111 the art and knowledge gaps and to develop a roadmap for future research initiatives.

112 We provide a roadmap for future research into the post-translational

113 tal and evolutionary lineages, and present a roadmap for future research.

114 roaches might be challenged to develop a new roadmap for future research.

115 reatments for pediatric anxiety, providing a roadmap for future research.

116 We also outline a roadmap for future research.

117 t of structural brain measures) and define a roadmap for future studies investigating the genetic cov

118 architectures described here can serve as a roadmap for future studies of effector function and evol

119 the population-scale, our results serve as a roadmap for future studies on host-microbe interactions

120 Our results provide a roadmap for future studies on the characterization of mo

121 e to any MOF architecture and can serve as a roadmap for future synthesis of MOFs with predefined pro

122 pathological anxiety and thereby provides a roadmap for future therapeutic development.

123 d testing vaccine candidates have provided a roadmap for future vaccine development.

124 is important viral protein and also offers a roadmap for future work to map functional and antigenic

125 ing sepsis diagnostic criteria and provide a roadmap for future work.

126 Overall, this work provides a detailed roadmap for high-resolution profiling and analysis of DI

127 In this respect, CERN is a roadmap for how a region can prepare to respond to publi

128 (2019) provide a computational roadmap for how the pulvinar might influence various cog

129 tate of cardioprotection today and provide a roadmap for how we might progress towards successful cli

130 Our results provide a roadmap for human knockout studies and should guide the

131 ation provided in this essay will serve as a roadmap for hypothesis-driven, experimentally validated

132 These findings provide a roadmap for identifying additional conserved features of

133 cells, and delineate a generally applicable roadmap for identifying functional Notch sites in cellul

134 tics of dilated cardiomyopathy and provide a roadmap for implementing genomic information into future

135 rway defense and a general molecular/genetic roadmap for internal organ sensation by the vagus nerve.

136 quantitative and categorical data provides a roadmap for interrogating the wide-ranging toxicity data

137 for regulation of ADAM activity and offer a roadmap for its modulation.

138 oach and collate recent reports to provide a roadmap for its optimal use.

139 ed in trafficking the beta1-AR and provide a roadmap for its trafficking via type I PDZs versus non-P

140 l, the project provides a valuable synthetic roadmap for medicinal chemists to access a range of fluo

141 In the present article, we present a roadmap for metabolomic analyses in epidemiologic studie

142 c materials processing and offer a potential roadmap for new developments of such materials.

143 We provide a roadmap for new science needed to improve the representa

144 This Perspective provides a roadmap for next-generation studies in electrochemistry

145 nges and opportunities, this work provides a roadmap for next-generation SWCNT-based computing.

146 to approach these questions and to develop a roadmap for personalized prognosis and treatment managem

147 The resulting findings provide a useful roadmap for planning focused empirical studies of SARS-C

148 raft-versus-host disease (GVHD), providing a roadmap for precision medicine.

149 These findings provide a roadmap for predicting and testing the curvature sensiti

150 By sharing our joint experiences, we offer a roadmap for proceeding and aim to mobilize the global re

151 ical tool for BRD7/9 knockdown and provide a roadmap for PROTAC development against seemingly incompa

152 The pipeline provides a roadmap for rapid antibody-discovery programmes against

153 hallenges and delineates the principles on a roadmap for rational application of precision medicine t

154 skeletal muscle diseases, but also provide a roadmap for recapitulating skeletal myogenesis in vitro

155 Based on this experience, we also provide a roadmap for replicating these projects in other low-reso

156 We present a roadmap for research to address whether wildflower garde

157 ng targets for deoptimization and suggests a roadmap for SARS-CoV-2 vaccine development, which can be

158 The International Technology Roadmap for Semiconductors challenges the device researc

159 oadmap, akin to the International Technology Roadmap for Semiconductors.

160 Our study provides a roadmap for setting national health priorities.

161 We provide a roadmap for sex and gender analysis across scientific di

162 UK, France, Australia, and US and provide a roadmap for sharing strategies, standards, and data inte

163 ailed analysis of design parameters offers a roadmap for significant future improvement in both radia

164 hlight current challenges but also provide a roadmap for software selection to answer specific resear

165 Our results provide a roadmap for structure-guided vaccine development to maxi

166 This information provides a roadmap for studying descending axonal projections that

167 atlas of collagen-producing cells provides a roadmap for studying the roles of these unique populatio

168 ks, proposing at the same time an innovative roadmap for the automated computing of hierarchical ecol

169 survivors have not answered and to develop a roadmap for the design and implementation of studies wit

170 monizing Outcomes Measures for Eczema (HOME) roadmap for the development and implementation of COSs,

171 This work provides a roadmap for the development of future therapeutics and d

172 d selective GBA2 inhibitors, also provides a roadmap for the development of high-throughput assays fo

173 g antibodies to HIV-1, providing a potential roadmap for the development of HIV-1 vaccine strategies

174 t this review article offers the impetus and roadmap for the development of next-generation catalysts

175 anding of DILI, and proposes our vision of a roadmap for the development of predictive preclinical mo

176 Our framework constitutes a roadmap for the empirical studies required to understand

177 anding of inherited variation and provides a roadmap for the epigenomic dissection of causal regulato

178 The study proposes a possible roadmap for the ethical assessment of sham surgery clini

179 Our work provides a roadmap for the experimental realizations of highly effi

180 discuss successful strategies and outline a roadmap for the exploitation of nanomaterials for enabli

181 We outline milestones on the roadmap for the future development of disease maps, incl

182 This work provides a roadmap for the identification of phosphatase substrates

183 digital SERS protocol, suggested here, is a roadmap for the implementation of SM-SERS as a routine t

184 Correction for 'An updated roadmap for the integration of metal-organic frameworks

185 ions for future studies; and (iii) provide a roadmap for the integration of SVs in ecoevolutionary st

186 cuss how technical advances facilitate a new roadmap for the isolation and analysis of macrophages at

187 Collectively, these three articles provide a roadmap for the most important emerging trends in GPCR p

188 ding disease prevention and health promotion roadmap for the nation since its inception in 1979.

189 ity and dynamism of the cerebellum provide a roadmap for the next decade of cerebellar research, chal

190 On the basis of these concepts, we propose a roadmap for the next steps in interfacial design for HaP

191 ummarized, potentially providing a technical roadmap for the next wave of innovations and breakthroug

192 e mutations during development, as well as a roadmap for the optimization of in vitro differentiation

193 We provide an RNA-seq roadmap for the stress-sensitive vDG.

194 The network will provide a roadmap for the structural and functional elucidation of

195 Our results provide a high-resolution roadmap for the transcription-factor-mediated reprogramm

196 implications of these findings and suggest a roadmap for the use of genetics in the detection of earl

197 In addition, we define a translational roadmap for the widespread clinical implementation of op

198 dressing key knowledge gaps and recommends a roadmap for this effort.

199 results offer both a quantitative synthesis roadmap for this important class of functional oxides, a

200 was used to construct a continuous molecular roadmap for three independent reprogramming systems.

201 ied aspects of gas sensing and with the 2025 roadmap for ubiquitous gas monitoring.

202 he mouse visual cortex, this work provides a roadmap for understanding the diversity of cell types an

203 Our study provides a roadmap for understanding the genetic basis of miRNA exp

204 m targets of LP circuits, our data provide a roadmap for understanding the mechanisms of higher-order

205 opportunity to present a neurodevelopmental roadmap for understanding, preventing, and treating psyc

206 rrent concepts in BAV genetics and propose a roadmap for unraveling unanswered questions about BAV th

207 vide a combined experimental and theoretical roadmap for using time-resolved extreme UV spectroscopy

208 eting delegates agreed on taking a step-wise roadmap for which the first output would be a consensus

209 lable to provide the necessary developmental roadmaps for in vitro differentiation.

210 tumors that provide a molecular "recipe" or "roadmap" for pathways that control human beta cell regen

211 progress in scaling up and also in achieving Roadmap goals.

212 ge data sets that serve as a gene expression roadmap highlighting gene expression changes during huma

213 This roadmap highlights key elements to consider in choosing

214 ls afford the neuroscientist a theory-driven roadmap in the quest for the neural mechanisms of reinfo

215 onal guidance of a SPECT/CT-based 3D imaging roadmap, in this process we studied to which extend fluo

216 04 as a component of the Molecular Libraries Roadmap Initiatives of the US National Institutes of Hea

217 This sketch also serves as a roadmap into the vast and exciting new landscape of ques

218 We believe that the HOME roadmap is a useful methodological framework to develop

219 The proposed roadmap is based on the following 4 steps/levels: safety

220 This research roadmap is intended to identify and prioritize these nee

221 Such a roadmap is particularly relevant for early-childhood-ons

222 evelopment of 2D colloids, and plots a clear roadmap - "lamellar solid - LCs - macroscopic fibers - f

223 The main aim is to provide a roadmap of atherosclerotic CVD risk management and preve

224 Further refinement of a roadmap of breast cancer progression will facilitate the

225 ificity that together delineate a phenotypic roadmap of disease progression culminating in serially t

226 Collectively, these data provide a roadmap of mTEC development and demonstrate the power of

227 2016, the Blue Ribbon Panel (BRP) set out a roadmap of recommendations designed to exploit new advan

228 ince no 2D material has been featured in the roadmap of standard photovoltaic technologies, a proper

229 These profiles provide a roadmap of stress-induced changes in a genetically homog

230 We conclude with a roadmap of the conceptual, methodological, practical, an

231 Our single cell atlas provides a molecular roadmap of the lymph node blood vasculature and defines

232 The results of our study define a roadmap of the properties of emitted as well as detected

233 , and behavioral datasets provide a valuable roadmap of the putative health risks for future human sp

234 Here we provide a roadmap of these advances and identify hitherto unrecogn

235 s can be employed for formulating the future roadmap of various photovoltaic technologies.

236 In this white paper, we outline a roadmap of what needs to be done to make this translatio

237 well as other cell types and constructed a "roadmap" of human skeletal muscle ontogeny across develo

238 ene expression to trace the transcriptional "roadmap" of individual CD4+ T cells throughout immunothe

239 ng' approaches to trace the transcriptional 'roadmap' of individual CD8(+) T lymphocytes throughout t

240 and current challenges are highlighted as a roadmap proposal for research in this emerging field.

241 Conclusion: The preoperative imaging roadmap provided by SPECT/CT enhanced the detection of p

242 isualization of these data and will act as a roadmap relating molecules to cells, circuits, and compu

243 nitiative of Indonesia along with the future roadmap required to meet sustainable development goals b

244 METHODS AND ROADMAP (Risk Assessment and Comparative Effectiveness o

245 The prospective observational ROADMAP study (Risk Assessment and Comparative Effective

246 This research roadmap summarizes key gaps in our current understanding

247 er group) or (99m)Tc-nanocolloid to create a roadmap that depicted all sentinel nodes (SNs).

248 This study provides a translational roadmap that is important for understanding human psycho

249 nd we provide a comprehensive transcriptomic roadmap that sheds new light on the molecular mechanisms

250 protein interactions, providing provisional roadmaps that can be explored using experimental approac

251 Thus, GWAS are useful "roadmaps" that require functional analysis to establish

252 relationship of metal nanowire networks as a roadmap, this Progress Report describes different synthe

253 As recently encouraged by EMA in its roadmap to 2025, we should create more unity through a c

254 dly, these findings illuminate an actionable roadmap to a more general and automated approach for sma

255 These results provide a therapeutic roadmap to achieve hepatic regeneration without provokin

256 ess and challenges, and identify a potential roadmap to address the gap.

257 ogether these approaches outline a potential roadmap to an era of quantum phenomena on demand.

258 eling and measurement efforts, and propose a roadmap to community cyberinfrastructure development tha

259 e (DHS) information from the NIH Epigenomics Roadmap to construct an improved reference DNA methylati

260 Our results provide a roadmap to develop a single antibody-based treatment eff

261 Our study provides a practical roadmap to develop effective human HCC vaccines that may

262 iety of University of Surgeons prepared this roadmap to encourage and guide the next generation of su

263 nd analysis of wheat's progenitor provides a roadmap to enhance genomics-assisted breeding and improv

264 ally, the approach developed here provides a roadmap to examine hydrogen on other materials.

265 These studies provide a roadmap to exploit genomic analyses by directing investi

266 features of an ideal platform and provide a roadmap to facilitate the efficient writing of large gen

267 We have developed a strategic five-phase roadmap to foster the clinical validation of biomarkers

268 The roadmap to future implementation must take into account

269 These results provide a roadmap to future studies of human retinal development a

270 tential and provides a readily interpretable roadmap to guide functional studies of RNA viruses and o

271 the cofactor binding site, which provided a roadmap to guide further optimization of this lead compo

272 for each particle we develop a foundational roadmap to guide future investigations.

273 o NAb activity and could serve as a valuable roadmap to guide the choice and interpretation of serolo

274 t pitfalls, learn new lessons, and provide a roadmap to guide the development of next-generation babe

275 The workshop aimed to provide a roadmap to help strategically guide research efforts dur

276 and mouse genomes and suggests an affordable roadmap to high-quality references for thousands of spec

277 tions, pan-cancer network analyses provide a roadmap to investigate new diagnostic and therapeutic op

278 We provide researchers with a roadmap to plan aquatic landscape genomics projects by a

279 Here, we provide a roadmap to plant immunity, with a focus on cell-surface

280 WHO has defined a Roadmap to reach 2020 targets, which was endorsed by mem

281 A roadmap to reducing child stunting at scale includes sev

282 Conclusion: We designed a roadmap to standardize the development, formulation, and

283 search are proposed in an updated high-level roadmap to stimulate the next steps towards MOF-based mi

284 ation of the extent of disease and provide a roadmap to surgery as well as detect recurrence and meta

285 The resulting roadmap to symmetry breaking paves the way for determini

286 egrative approaches presented here provide a roadmap to uncover the therapeutic potential of transcri

287 signatory countries that will require clear roadmaps to set priorities over the next 15 years.

288 agents have been developed and can serve as "roadmaps" to support prioritization of compounds for cli

289 Phase diagrams provide 'roadmaps' to the possible states of matter.

290 This document also serves as a roadmap toward confirming cardio-oncology as a subspecia

291 al methodology/strategy establishment, and a roadmap toward practical applications.

292 wborn Action Plan provides an evidence-based roadmap towards care for every woman, and a healthy star

293 and downregulating miR-21 and establishes a roadmap towards clinical translation of modulating miRs

294 These results reveal a roadmap towards future ultradense nanophotonic integrate

295 t health-care system in the USA and offers a roadmap towards the achievement of universal health care

296 In this Roadmap, we discuss representative examples of biochemic

297 se according to a stage-specific cardiogenic roadmap, we established a new paradigm of familial DCM p

298 To characterize this epigenomic roadmap, we have performed MethylC-seq, ChIP-seq (H3K4/K

299 In this Roadmap, we identify the challenges of data sharing acro

300 ost recent manufacturing data and technology roadmaps, we compare present and projected environmental