ライフサイエンスコーパス: role

1 -surface humidity plays an equally important role.

2 semblages differentiate and perform distinct roles.

3 However, the role and fate of the oxide ligands in such intriguing ad

4 e double mutant, provides insight into their roles and a quantitative measure of their functional red

5 nucleosome performs a fundamental regulatory role, apart from the histone "tails," which modulate gen

6 -down mice of either sex further support its role as a D-serine reuptake system.

7 ibition does not, however, involve canonical roles as part of the RISC; rather, AGO1 controls cell an

8 non-human animals has challenged the primary role assigned to culture, in determining this spatial nu

9 In addition to homeostatic roles, astrocytes respond to neurotransmitters with calc

10 mediated by the CB7 portal and an inhibitory role attributed to the lower interaction of the thiocarb

11 Consistent with a repressive regulatory role, DDX3 localized to cytoplasmic puncta with SG marke

12 r, whether SNr deactivation has an essential role driving or regulating active avoidance responses is

13 idance receptor 2 (ROBO2) plays an important role during early kidney development.

14 at the time of implantation, plays a crucial role during early pregnancy.

15 ion in cells expressing mSTING, suggesting a role for 2C in recruiting STING to RV-A replication orga

16 ococcus conjugative elements, highlighting a role for Acrs in the dissemination of plasmids.

17 optotic degeneration of photoreceptors and a role for apoptosis in secondary degeneration of cones, h

18 This study supports an important role for B cells in indirect T cell priming and further

19 Recent work has uncovered a role for B cells in the induction and activation of Treg

20 Our data highlight an integral role for CaMKII in neuronal TRPV4-associated Ca(2+) resp

21 However, a role for CBFA2T3 in myeloid differentiation of AML has n

22 l evidence from patients with MS points to a role for CD8+ T cells in disease pathogenesis.

23 The results reveal a local role for CEPR1 in the maternal reproductive tissue in de

24 e (NAD)-capped RNAs in mammalian cells and a role for DXO and the Nudix hydrolase Nudt12 in decapping

25 ction, consistent with a prolonged postnatal role for EphA4 in adolescent muscle growth.

26 mmunity and clinical diagnosis may suggest a role for epigenetics in T1D pathogenesis; however, funct

27 Mechanistically, we show a pivotal role for ESRRB in regulating the activity of ESC-specifi

28 We propose a role for Gdf5 in tissue remodelling and repair after inj

29 ects in an IgE-dependent manner suggesting a role for glycolipid in the effector phase of IgE-mediate

30 In vivo recordings revealed a strong role for hAPP/Abeta, but not tau, in the emergence of EC

31 ing age-dependent variation and suggesting a role for IgG glycosylation in immunocompetence.

32 These findings indicate a pivotal role for LDH in modulating cytokine-mediated T cell diff

33 combination, these findings establish a key role for microbiome-dependent circadian GLP-1 secretion

34 lution live-cell microscopy, we identified a role for mitochondria-lysosome contacts in regulating mi

35 cyte development and repair and reveal a new role for Nedd4 in glial biology.

36 These studies define a new role for Notch3 in manipulating the tumor microenvironme

37 ighs the evidence that supports a pathogenic role for PAD enzymes in RA as both promoters and targets

38 uo, Kasahara et al. (2020) reveal a critical role for pDCs in antifungal immunity.

39 Here, we report a critical role for proline catabolism in non-small cell lung cance

40 ly affected by RPLP1/2 knockdown, implying a role for RPLP1/2 in multi-pass transmembrane protein bio

41 ruptions in chromatin structure and reveal a role for Suv39h2 in depositing sufficient H3K9me3 to pro

42 Recent research has highlighted a role for the hippocampus and a Posterior Medial cortical

43 Altogether, these data identify a role for TLR2 in DENV infection and provide insights int

44 This study implies a protective role for VD sufficiency throughout pregnancy, particular

45 We uncovered a role for Xinbeta in signaling via the Hippo-YAP pathway

46 Both basic and clinical evidence reveal dual roles for GJs, in tumor suppression, generally referred

47 been a growing appreciation for non-mitotic roles for KIF11.

48 More recent ideas emphasize roles for positive emotionality and impulsivity as well.

49 Taken together, our data indicate functional roles for RhoA and Rho-kinase in mediating depression-li

50 species with core structural and functional roles for their use in restoration.

51 ted functions in vitro demonstrated critical roles for USP22 in prostate cancer.

52 ological differences could play an important role governing their distribution patterns.

53 However, its role has not been investigated in gastric epithelial cel

54 f NAD in plant metabolism and its regulatory role have been investigated extensively at the biochemic

55 esults suggest that gaze dynamics play a key role in action selection during challenging visuomotor b

56 Cytotoxic T cells play a key role in adaptive immunity by killing infected or cancero

57 d other drug use, and they have a continuing role in addressing the opioid crisis and Ending the HIV

58 drainage within the surface texture, and its role in affecting impalement under ambient conditions th

59 pro-inflammatory cytokine, plays a critical role in alveolar macrophage homeostasis, lung inflammati

60 tubule-associated protein that plays a major role in Alzheimer's disease (AD) and other tauopathies.

61 Synaptic dysfunction plays a central role in Alzheimer's disease (AD), since it drives the co

62 d chromatin remodeling factor has a distinct role in anti-microbial defense.

63 Nanomaterials can play an essential role in bacterial sensing owing to their unique optical,

64 The HLA system plays a pivotal role in both clinical applications and immunology resear

65 description of the ER, its function, and its role in cancer progression and treatment.

66 oth the molecular function of STEAP1 and its role in cancer progression remain elusive.

67 t proteins and have been suggested to play a role in carcinogenesis.

68 Inflammation plays an important role in cardiovascular disease (CVD) development.

69 iant histidine residues that play a critical role in catalytic activity.

70 F1 is a phosphoprotein that plays a critical role in cell growth control as the central regulator of

71 ests that genetic factors play a significant role in completed suicide.

72 ipation and thermoregulation with a possible role in contributing to Earth surface temperature regula

73 However, their role in controlling VEGF A and FGF 2 signaling in the CL

74 ary mechanosensory neurons play an important role in converting mechanical forces into the sense of t

75 wth factor-beta1 (TGF-beta1) plays a premier role in fibrosis.

76 m the ERGIC, as demonstrated by an essential role in forming the replication vacuole of Legionella pn

77 untranslated region (UTR) play an important role in Gag:RNA interactions leading to genome packaging

78 Snow plays a fundamental role in global water resources, climate, and biogeochemi

79 h we found to play an unexpected stimulatory role in GPCR-mediated eNOS signaling.

80 ulated is crucial to revealing these lipids' role in health and disease.

81 sults indicate that the apicoplast has a key role in heme biology in T. gondii and is important for b

82 n early plants, H3K27me3 played an essential role in heterochromatin function, suggesting an ancestra

83 regulation of the AHR/CYP1A1 axis may play a role in inflammatory skin disease.

84 transient neurons of the subplate play a key role in integrating spontaneous and sensory-driven activ

85 and phototransduction genes known to play a role in light detection in most animals.

86 getica gangetica), which plays a significant role in maintaining the structure, functions and integri

87 cellular function(s) and whether it plays a role in maintenance of genome stability remain to be det

88 , the data reveals that TET2 plays a pivotal role in mammary gland development and luminal lineage co

89 the adult brain, little is known about their role in mature neurons.

90 rimary motor cortex (M1) plays a significant role in mediating its therapeutic effects.

91 hat the region D1 in p27 plays a significant role in mediating the association kinetics, undergoing c

92 ome (APC/C) is reported to play an important role in metaphase-to-anaphase transition.

93 ike RNA and other polynucleotides play a key role in modulating protein phase separation.

94 water body availability, play a significant role in modulating the probability of a bird being infec

95 retched cells) during their brief phagocytic role in nurse-cell engulfment.

96 NA methylation plays an important regulatory role in oligodendrocyte development and CNS myelination.

97 ryological processes, and it has a conserved role in patterning the dorsal-ventral body axis.

98 lated under FR light supports MAAs playing a role in photon dissipation and thermoregulation with a p

99 Their role in plant immunity against hemibiotrophic fungal inf

100 ws that genetic factors are likely to play a role in PNES or its comorbidities in a subset of individ

101 ing polymerizations currently play a central role in polymer chemistry.

102 y indicates that MAP1A may play a beneficial role in preserving the survival of PV(+) neurons, and th

103 sures have been suggested to play a dominant role in prevention.

104 also become increasingly recognized for its role in promoting metastasis of breast cancer, prostate

105 expressed in reward-related brain areas, its role in regulating motivation and preference for nutrien

106 longs to SLC30 family and plays an essential role in regulating Zn(2+) accumulation in the insulin se

107 sted that microRNAs might play a significant role in regulation of PRF expression.

108 to other brain regions, serving an essential role in sensory perception and motor execution.

109 ive sweeps are thought to play a significant role in shaping patterns of variability across genomes;

110 cetylcholine in the striatum plays a pivotal role in such adaptation, and its release has been causal

111 ogical, imaging techniques play an important role in supporting the diagnosis, grading the severity o

112 Irrigation plays an essential role in sustaining crop production in water-limited regi

113 need to be investigated, as they play a key role in synaptogenesis and corticogenesis during prenata

114 of Notch signaling, could have a suppressive role in T-ALL.

115 port that CD2 costimulation plays a critical role in target cell killing by freshly isolated human CD

116 the cochlea and highlights MYO7A's essential role in tensioning the hair cell MET complex.

117 ed receptor (GPCR) kinases (GRKs) play a key role in terminating signals initiated by agonist-bound G

118 esults suggest that the vmPFC plays a causal role in the acquisition of new learning and not just in

119 The Akt/mTOR pathway played a critical role in the AML-EV-induced phenotypical and functional t

120 tion of disulfide-reduced mSOD1 might play a role in the amyotrophic lateral sclerosis-linked aggrega

121 the differentiation of transposons and their role in the asymmetric evolution of these two closely re

122 e-labeled particles, suggesting a phagocytic role in the clearance of AMFs.

123 Here, we tested their role in the clinically relevant polysaccharide conjugate

124 ACT) because of its protumor effects and its role in the cytokine release syndrome.

125 in particular diet, are known to play a key role in the development of Coronary Heart Disease.

126 of cells, but it is unclear whether it has a role in the development of multicellular systems.

127 ations are increasingly recognized to play a role in the etiology and pathophysiology of schizophreni

128 development is essential to understand their role in the evolutionary origin of developmental novelti

129 Reduced sulfur (S) has a contrasting role in the fate of arsenic (As) in peatlands.

130 However, their role in the formation of a permissive metastatic niche i

131 chaea), 2 microbial groups that play a major role in the global carbon cycle.

132 thway of which it is a part, determining its role in the initial evolution of the Aquilegia nectar sp

133 dominant species and other taxa could play a role in the interplay of microbial community and environ

134 t the bacterial sRNA SsrA plays an essential role in the light-organ symbiosis between Vibrio fischer

135 old may be helpful to confirm this potential role in the management pathway.

136 hile magnetic fluctuations play an important role in the materials' unusual electronic states, the na

137 strate that exonuclease 1 (EXO1) plays a key role in the resolution of, and replication through, telo

138 r ribonucleoprotein (snRNP) has an essential role in the selection of the precursor mRNA branch-site

139 ed to flash droughts and can play a critical role in the spread of human ignited wildfires.

140 gia nectar spur, and examining its potential role in the subsequent evolution of diverse spur morphol

141 ting enhancement in proteome flux may play a role in the survival of N2a cells upon prion infection.

142 Consistent with its role in the synthesis of heparan sulfate, we show that t

143 ods are reviewed, as these play an important role in the wide range of applications towards which pol

144 anger pendrin is unclear, as are potassium's role in this response and the receptor's effect on inter

145 clinical immunologists should have a leading role in this unprecedent challenge.

146 in subglacial environments, which play a key role in trace elemental cycles, with potentially importa

147 ntercellular communications in CCA and their role in tumor progression.

148 ond their potential clinical application and role in tumorigenesis, recent studies have shown that MA

149 of difference 1, is known to play a crucial role in virulence and pathogenesis of M. tuberculosis In

150 s (NiV) matrix protein (NiV M) plays a major role in virus assembly.

151 The marrow adipocyte also has an endocrine role in whole body homeostasis through its varied secret

152 nds are versatile donors that play important roles in a wide array of subdisciplines of inorganic che

153 Thus, AHLs have potentially important roles in agriculture and aquaculture.

154 (IL)-13 is a type 2 cytokine with important roles in allergic diseases, asthma, and tissue fibrosis.

155 cell adhesion proteins, which play essential roles in animal evolution, tissue development, and homeo

156 f extracellular proteins that play important roles in bacterial viability and in interactions of path

157 Although APE2 plays essential roles in base excision repair and ATR-Chk1 DNA damage re

158 these insights are relevant to CD81's varied roles in both health and disease.

159 oprenoid-derived carotenoids serve essential roles in chloroplast development and photosynthesis.

160 data suggest that they exert neuroprotective roles in CNS homeostasis through continued refinement of

161 ta3 subunits play distinct but complementary roles in driving formation of structural and functional

162 understanding of animal movements and their roles in ecological processes and for building realistic

163 As) regulate gene expression, play important roles in epigenetic pathways, and are hypothesized to co

164 growth factor (FGF) signaling plays pivotal roles in generating and maintaining NPCs during kidney d

165 d diverse phenotypes indicating differential roles in insulin sensitization, suggesting mechanisms br

166 ey can play either beneficial or detrimental roles in lesion pathogenesis, depending on the nature of

167 s also a tumor suppressor and has beneficial roles in multiple organs.

168 show that RGS10 and RGS18 have complementary roles in platelets.

169 , multi-protein/RNA complexes with essential roles in processing ribosomal and tRNAs.

170 Teachers and mentors commented that their roles in programme delivery were unclear.

171 ic modifications on chromatin play important roles in regulating gene expression.

172 hat redox modifications could play prominent roles in regulating mitotic processes.

173 eceptor-like protein kinases (RLKs) play key roles in regulating plant growth, development and stress

174 nomic regions harboring genes with prominent roles in T cell development in both strains.

175 lts suggest that Notch ligands play specific roles in the adult pancreas and highlight a novel functi

176 cellular matrix) interactions play essential roles in the morphogenesis of PAAs and their derivatives

177 Interlayer coupling plays essential roles in the quantum transport, polaritonic, and electro

178 prototype of PC4-like proteins, which plays roles in transcription and maintenance of genome stabili

179 ex (Csm3/Tof1 and Mrc1), which has important roles including aiding normal replication rates and stab

180 due to the atherothrombosis, where a pivotal role is played by platelet activation, it would be argua

181 with physical domain (physical functioning, role limitations caused by physical health problems) rem

182 Due to PTMs' extremely important roles, many major PTMs have been studied, while the func

183 Role misidentification is more prevalent among female re

184 Collectively, these findings unveil the role of a novel lncRNA in vascular inflammation by cis-r

185 First, we validated the crucial role of active STAT5 as a survival factor for functional

186 ynamics of episodic memory and highlight the role of alpha rhythms in revealing when and where differ

187 However, the central role of alpha-klotho in metabolism remains largely unexp

188 n endothelial cell line, we investigated the role of AMP-activated protein kinase (AMPK), a master re

189 Specifically, we identified the role of an early-season national show in the propagation

190 debate outlined opposing views regarding the role of animal products in human diets.

191 uitinated OAT1 degrades and unveiled a novel role of anticancer drugs bortezomib and carfilzomib in t

192 netic stimulation (TMS) and fMRI to test the role of awake consolidation processes by targeting hippo

193 In particular, the central role of B cells in the disease has been demonstrated by

194 The role of betaCA3 in the high CO(2) -mediated response in

195 Our data also highlight the role of biofilms in creating spatially distinct geochemi

196 However, little is known about the role of calcineurin in promyelinating SCs after birth.

197 Our findings suggest a pivotal role of caspase 3 signaling in mediating spine injury an

198 The role of CCC1 ion transporter activity in the regulation

199 However, the role of cDC1s in expansion of tumor-specific CD8(+) T ce

200 As such, the relevance of OXPHOS status and role of CI mutations in chRCC remain unknown.

201 stribution data also suggest an accelerating role of climate change in the range expansion of M. sole

202 ades following forest establishment, but the role of climate in driving these trends has not been exp

203 her with case count data, to investigate the role of climate, urbanization and variation in intervent

204 This essay describes the role of community pharmacists in implementing the system

205 We investigated the role of CRBN in the angiogenic process and in propagatin

206 However, the genome-wide role of CSB/Rad26 in TC-NER, particularly in the context

207 Thus, we sought to determine the role of dicarbonyl electrophiles in inflammation-associa

208 In particular, we investigate the role of droplet diffusion, fluctuations, and heterochrom

209 orption spectroscopy, elucidate the critical role of electron transfer (ET) from CdS NRs to MmOGOR.

210 fect of ACC2 deletion demonstrating a causal role of elevated aspartate level in cardiomyocyte hypert

211 Here we report the role of endogenous neuropeptide cholecystokinin (CCK), r

212 The role of ex vivo normothermic perfusion (EVNP) in both or

213 Herein we present a balanced review of the role of exocytosis proteins in T2D, with thoughts on nov

214 These results demonstrate a potential role of extrapyramidal plasticity during functional reco

215 Fam20C knockdown not only confirmed the role of Fam20C itself in OPN phosphorylation, but also r

216 Understanding of the role of focal inflammation, a treatable feature, on neur

217 features of ecological systems, such as the role of generalists during assembly, realistic maximum t

218 longstanding Federal mandate to minimize the role of geography in access to transplant in the United

219 However, the precise role of GR in the pathophysiology of AD remains unclear.

220 neurons (MSNs) in the NAc and determined the role of GSK3beta in spike timing-dependent long-term pot

221 of trans-histone cross-talk and the dynamic role of H2B ubiquitination in stimulating histone methyl

222 The role of hapten-carrier adducts in re-challenge reactions

223 lation of breathing, reveal an unanticipated role of HIF2alpha, and link acute and chronic adaptive r

224 he last developments regarding the potential role of hsTYR in human pathologies, the advances in reco

225 We investigated the role of in vivo RNA secondary structure in miRNA cleavag

226 environmental field sampling to estimate the role of land cover change and soil erosion on river tran

227 The role of lipid peroxidation, a potent form of oxidative s

228 Here, we addressed the role of lipids during morphogenesis of the rhabdomere, t

229 To enhance our understanding of the role of lipids in regulation of lifespan and healthspan

230 studies have presented mixed results on the role of margin status in risk of recurrence after surgic

231 vidence has emerged to support the etiologic role of MCPyV in Merkel cell carcinoma (MCC), an extreme

232 Although the central role of NAD in plant metabolism and its regulatory role

233 e live and fixed cell imaging to uncover the role of Nek8445 in regulating Giardia cell division.

234 Finally, the potential role of nematode effector proteins in triggering such ep

235 ear to play an early and regionally specific role of nerve fiber layer phagocytosis in areas of activ

236 poorly to antibiotic therapy, supporting the role of NETs in a late stage of TB pathogenesis.

237 Only recently has the role of neuroimmune cross-talk surfaced as a key contrib

238 tivation, and food intake, understanding the role of opioid signaling within the OFC is fundamental f

239 Here, we investigated the role of PAG1 in a preclinical mouse model of house dust

240 To examine the role of peripheral ORs in triggering brain hypoxia, we u

241 Rationale: The role of PI (protease inhibitor) type Z heterozygotes and

242 Future work will define the role of pMRI in predicting kidney graft and patient's su

243 The role of post-transcriptional RNA modification is of grow

244 ic regression models were used to assess the role of pre-pregnancy obesity as a mediator in the assoc

245 We established a possible role of PrimPol in tenofovir-induced toxicity in vitro a

246 We also consider the role of rainfall on the species' wintering grounds in No

247 ity and related metabolic disorders, but the role of sleep in long-term weight loss maintenance (WLM)

248 lying hyaluronan and HAS2 regulation and the role of soluble proteoglycan in affecting autophagy and

249 s for prostate cancer to support the crucial role of Sox2 is missing.

250 actor PIF4 fails to accumulate, indicating a role of SPAs in regulating the phyB-PIF4 module at high

251 However, the role of such proteins in regulating cellular processes i

252 Cathodes are discussed next, focusing on the role of sulfur structure, carbon host chemistry and poro

253 mporal pattern of AP firing, emphasizing the role of temporal code in conveying key information about

254 Our study sheds light onto the role of the chromatin remodeling machinery in intestinal

255 s that drive those systems actually play the role of the corresponding Lagrange multipliers.

256 f research and future perspectives about the role of the different subsets of gammadelta T-cells dete

257 or (CB1R) signaling based on the fundamental role of the endocannabinoid system in synaptic plasticit

258 Confirming the role of the GCX, neuraminidase induced the degradation o

259 theory (DFT) simulations unveil the crucial role of the initial reversible C-C single bond formation

260 The role of the intestinal microbiome in alcoholic hepatitis

261 In this study, we investigated the role of the Kunjin virus helicase on infection in cell c

262 mechanism, drawing on new insights into the role of the medial temporal lobe in auditory cognition.

263 In this study, we examine the role of the NCKAP1 subunit of the pentameric cytoskeleta

264 Mechanistic studies point to the crucial role of the photocatalyst-base interaction.

265 th knob180 repeats suggests that the current role of the TRKIN/TR-1 system is to facilitate the meiot

266 ochromatin function, suggesting an ancestral role of this mark in transposon silencing.

267 However, the knowledge about the role of this protein family in other physiological proce

268 ve been verified in avian cells, whereas the role of TNPO3 has not been studied.

269 mixing processes, which suggests a potential role of vertical transport in structuring mesopelagic NC

270 Here we investigate the casual role of vmPFC in the acquisition of pavlovian threat con

271 Motivated by the widely accepted role of volatility in the emergence of persistence, we c

272 ranslational research, evidence supports the role of WBP2 as a biomarker for early detection, prognos

273 They have been described in wines and the role of yeast in their formation is clear.

274 Our work uncovers an essential role of YTHDF3 in controlling the interaction between ca

275 The roles of asymptomatic hyperuricemia or uric acid (UA) cr

276 we applied genetic approaches to dissect the roles of caspase-8 in cell death and inflammation.

277 trafficking and function and suggested novel roles of EGR1 and SGK1 in the disease state.

278 Here, we study the roles of GABA and insulin signaling in starvation-depend

279 t OPC in mice and humans, but the individual roles of its ligands, IL-17A, IL-17F, and IL-17AF, are l

280 With the increasing understanding of the roles of macrophage immunometabolism in atherosclerosis,

281 we aimed to differentially characterize the roles of PT and aMF in motor compensation by relating di

282 The precise roles of the five remaining genes (Flcn, Map1lc3b, Me2,

283 nrichment analysis highlighted the potential roles of the immune system and polycomb repressive compl

284 The functional roles of the lipid asymmetry of biomembranes are attract

285 Functional roles of the prioritized candidate SNPs were examined wi

286 We have re-examined the roles of the two receptor populations using mice with pi

287 transcript levels to further understand the roles of these decay pathways in KSHV gene expression.

288 way for future investigation of the specific roles of these proteins in SA signalling and their poten

289 provide a paradigm for exploring additional roles of TJ proteins.

290 Our results enlighten the role played by CSA and CSB as part of a ubiquitin/protea

291 In order to better elucidate the complex role played by CYP2J2 in cardiac cells, we performed tar

292 e FPN and CON via distinct but complementary roles reflected in network dynamics.

293 ganisms, particularly because of the central role that light regimes play in determining the timing o

294 However, the endogenous role that PC2 plays in the regulation of general cellula

295 havior encoded in our record reveals the key role that polar ice volume plays in the predictability o

296 rs when compared with other mammals, yet the role that virus-derived endogenous elements may have pla

297 to MNV infection can lead to insights on the roles that specific cell types play during norovirus pat

298 We hypothesized that IDO could play a key role to locally regulate cardiac homeostasis after MI.

299 re, ISMs can play an important complementary role to phylogenetic tree-based analysis, such as is don

300 KIF5B plays a dominant role, whereas KIF13B helps Rab6 vesicles to reach freshl