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1 twist, Helical twist, Minor groove width and Roll.
2 ignaling are both important for the Rock and Roll.
3 binations of azimuth and tilt, i.e. pitch or roll.
4 cord the molecular adhesion events from cell rolling.
5 rmation, which interacts with ICAM-1 to slow rolling.
6 a mixture of antibodies, and biomimetic cell rolling.
7 comotion modes of peristalsis, crawling, and rolling.
8         We identified a photo-sensitive leaf rolling 1 (psl1) mutant with 'napping' (midday depressio
9              Data were measured monthly on a rolling 12-month mean basis.
10  min on days 1 and 15 of a 28-day cycle in a rolling 6 study design with de-escalation upon dose-limi
11 bicin (12 mg/m(2)) as a single dose, using a rolling-6 accrual strategy.
12 ed by a multistep process that includes cell rolling, activation, adhesion, and transmigration throug
13 verage of the cell surface by knobs and that rolling adhesion becomes more stable and slower for high
14 d could accommodate the alphaLbeta2-mediated rolling adhesion of leukocytes.
15 ensity and receptor multiplicity per knob on rolling adhesion of schizonts.
16                                 We find that rolling adhesion requires a homogeneous coverage of the
17                                              Rolling adhesion, in which cells passively roll along su
18 e at the border between transient and stable rolling adhesion.
19 vel are deemed limited, mainly consisting in rolling, adhesion, and aggregate formation.
20                                     Monocyte rolling, adhesion, and transmigration across the endothe
21 thelial cell interactions, such as leukocyte rolling, adhesion, and ultimately transendothelial migra
22 py showed decrease in leukocyte adhesion and rolling after ethanol consumption.
23                        Circulating platelets roll along exposed collagen at vessel injury sites and r
24   Rolling adhesion, in which cells passively roll along surfaces under shear flow, is a critical proc
25 than out-of-plane stresses that lead to bead rolling along the cell long axis (i.e., alignment of act
26  L-selectin regulates leukocyte adhesion and rolling along the endothelium.
27 crostructure in the bulk of a sample of cold rolled aluminum, further deformed locally by a hardness
28 the material choice is restricted by roll-to-roll and benign solvent processing requirements and desi
29 exit the spleen for the CNS where they first roll and crawl along the luminal surface of leptomeninge
30 ophils and effector T cells use selectins to roll and integrins to arrest in postcapillary venules.
31 ds showed comparable corrosion resistance to rolled and annealed super duplex stainless steel.
32  torsion phenotype results from differential rolling and aberrant patterning of peristaltic waves of
33 fed mice there is reduced systemic leukocyte rolling and adherence, circulating neutrophil numbers, n
34 avital microscopy revealed reduced leukocyte rolling and adhesion in P2X7-deficient mice.
35 ng revealed a dramatic increase in leukocyte rolling and adhesion in veins near the optic nerve (ON)
36 inal fluid, (iv) blinatumomab-induced T-cell rolling and adhesion to vascular endothelial cells in vi
37 h1 cells promoted alphaLbeta2-dependent slow rolling and arrest in vitro and in vivo and migration in
38 tion is a multistep process preceded by cell rolling and arrest on the vessel wall via the formation
39 k of T. gondii infection, exhibited distinct rolling and crawling behavior, and accumulated within th
40 how that mechanisms mediating leukocyte slow rolling and emigration are impaired in Gal-3(-/-) mice,
41 tically, Cosmc-deficient B cells have normal rolling and firm arrest on high endothelium venules (HEV
42                             After multi-pass rolling and intermittent annealing at 550 degrees C for
43 o1e-deficient neutrophils showed alternating rolling and jumping movements.
44 ic and elastic energies explain the membrane rolling and the bilayer separation-Debye length relation
45 ple cells can be wrapped in individual micro-rolls and artificially reconstructed into hollow or fibr
46 gulate the rate by which tumor cells tether, roll, and adhere to vascular walls.
47 gle about a principal axis of rotation: yaw, roll, and pitch.
48 chanical effects such as jumping, splitting, rolling, and breaking upon UV illumination.
49                          Neutrophil binding, rolling, and migrating along and between ECs is associat
50                   Although the central jelly roll architecture is conserved among the three determine
51                                    The micro-rolls are formed of twin-layered films consisting of two
52                               More acrobatic rolls are typically used to target small, less dense kri
53                        Methods We define the rolling-arms design with the goal of minimizing the comp
54 the potential gains of a platform design-the rolling-arms design-that adds and removes arms on a roll
55                               Conclusion The rolling-arms platform design is applicable to a broad va
56                                    Results A rolling-arms platform design with two to five experiment
57 very if these therapies had been tested in a rolling-arms trial.
58 to control flight direction (pitch, yaw, and roll axes).
59 stable but also most maneuverable around the roll axis, yet our knowledge of roll control in biologic
60 le their testing and/or tracing rates and/or rolling back reopening by 25%, while eight states requir
61 ension movements with the goal to position a rolling ball on table into a target.
62  adults randomly selected from the electoral roll (baseline survey population).
63 -arms design-that adds and removes arms on a rolling basis.
64 n also be used as a guiding cue for the ball-rolling beetles.
65 tingly, we observed a striking discontinuous rolling behavior termed "intermittent rolling," during w
66 Drosophila larvae, we found that nociceptive rolling behavior was triggered at lower temperatures and
67 ditional change (V403A) within the mu1 jelly roll beta barrel domain.
68 xin binding interface that extends the jelly-roll beta-sandwich of LNS2 of neurexin-1 into neurexophi
69              Cells expressing E-selectinE88D rolled but detached faster.
70                    Emx2 facilitates Rock and Roll by delaying apical protrusion of its nascent HCs bu
71  of published microbiome 16S and RNA-seq and roll call data.
72 is sufficient to represent the similarity of roll-call votes by U.S. senators in recent years.
73 rity of their political orientation based on roll-call voting patterns.
74 ss icosahedral viruses with the double jelly-roll capsid proteins.
75 croscopy sampling showed a generally uniform rolled capsular edge, but interspersed with areas of irr
76 resolution is achieved through a novel jelly roll cell design, which allowed these studies to be perf
77 atial distribution of adhesive properties on rolling cell surfaces.
78  extract the rotational motion of individual rolling cells.
79 ion nicking reactions mediated hyperbranched rolling circle amplification (HRCA).
80                         Quantitative (q)PCR, rolling circle amplification (RCA) and droplet digital (
81  we present a dNTP assay based on isothermal rolling circle amplification (RCA) and rapid time-gated
82 Applications of conventional linear ligation-rolling circle amplification (RCA) are restricted by the
83 nation of a (1) padlock probe (PLP)-mediated rolling circle amplification (RCA) bioassay and an (2) a
84                 Padlock probe ligation-based rolling circle amplification (RCA) can distinguish singl
85                                              Rolling circle amplification (RCA) combined with padlock
86         In order to reduce sequencing error, Rolling Circle Amplification (RCA) has been used to impr
87                                              Rolling circle amplification (RCA) is frequently applied
88                                   Isothermal rolling circle amplification (RCA) is used to detect nuc
89                  Ebola cDNA was amplified by rolling circle amplification (RCA) on magnetic particles
90         Here, we developed and evaluated the rolling circle amplification (RCA) products that are bas
91 sign of the demonstrated assay consists of a rolling circle amplification (RCA) technique, responsibl
92 mediated isothermal amplification (LAMP) and Rolling Circle Amplification (RCA) techniques for c-MYC
93             NESA mediated techniques such as rolling circle amplification (RCA), strand displacement
94      Here, we demonstrate the combination of rolling circle amplification (RCA)-based nucleic acid am
95 ibodies enhanced signals can be obtained via rolling circle amplification (RCA).
96 than one round of padlock probe ligation and rolling circle amplification (RCA).
97 tal timing of an STR expansion gene, we used rolling circle amplification and CRISPR/Cas9-mediated ge
98 workflow using synthetic DNA minicircles and rolling circle amplification enables comparable biocatal
99 ration sequencing (NGS) of DNAs amplified by rolling circle amplification from 6 tomato (Solanum lyco
100 ing (ISS) method based on padlock probes and rolling circle amplification has been used to spatially
101 nd ligation of gene-specific padlock probes, rolling circle amplification of the probes yielding barc
102 of 97.9% using our nanopore sequencing-based Rolling Circle Amplification to Concatemeric Consensus (
103  a new metagenomics-based approach involving rolling circle amplification with random PCR amplificati
104 ation, recombinase polymerase amplification, rolling circle amplification, nucleic acid sequence-base
105 ay multi-arrayed fiberoptics conjugated with rolling circle amplification.
106 hich are assembled in yeast and amplified by rolling circle amplification.
107 s of a DNA assay based on padlock probes and rolling circle amplification.
108 g elements (DNA hairpins) were introduced by rolling circle amplification.
109 multaneously synthesize and package DNA with rolling circle and rolling circle-like DNA replication p
110 TVd circles are replicated via an asymmetric rolling circle mechanism to form linear multimeric RNAs.
111 ansposons, CRISPR loci, ribosomal RNA genes, rolling circle origins of replication, and areas where p
112  DNA strands and Mg2 PPi crystals during the rolling circle process, ultimately leading to the direct
113 roducing tandem CpG and shRNA via concurrent rolling circle replication and rolling circle transcript
114 brid micro/nanostructures, fabricated by the rolling circle technique.
115               First, a long RNA generated by rolling circle transcription acts as both the "smart zip
116 ia concurrent rolling circle replication and rolling circle transcription, (2) self-assembling CpG an
117 size and package DNA with rolling circle and rolling circle-like DNA replication proteins.
118 endent occasions, from the Reps of bacterial rolling circle-replicating plasmids.
119 t-specific oligonucleotide sequence within a rolling-circle amplification (RCA).
120 cular HBV genome structure, using isothermal rolling-circle amplification to enrich HBV DNA, generati
121 re first circularized and then amplified via rolling-circle amplification to produce long stretches o
122 ion of the essential A protein that mediates rolling-circle DNA replication.
123                                          The rolling-circle replication is the most common mechanism
124 ify transcript errors, we applied an adapted rolling-circle sequencing approach to Escherichia coli,
125 tiation, RNA shape-shifting, and interrupted rolling-circle synthesis), and describe emergence from D
126                     This was a retrospective rolling cohort study.
127 and plated metallic lithium in a multilayer (rolled) commercial pouch cell battery were obtained.
128 s including stress corrosion crack (SCC) and rolling contact fatigue (RCF).
129 k the hydrocarbon lubricant in high pressure rolling contacts has so far been ignored.
130 able regions in the materials, correspond to rolling contacts that are about to slide, whose density
131 e around the roll axis, yet our knowledge of roll control in biological fliers remains limited.
132                                         Both rolling (cooperative) and sliding particle rotations are
133 004 and 2008, six rounds of cluster-sampled, rolling, cross-sectional parasitological and questionnai
134 ive in Triconodontidae in contrast to active roll described for extant therians.
135  protein (MCP) with a predicted double jelly-roll domain.
136 tion revealed an NTD consisting of two jelly-roll domains interacting across each subunit interface.
137 whereas schizonts (late-stage iRBCs) tend to roll due to their almost spherical shape.
138 easurable orientation behavior has made ball-rolling dung beetles an attractive model organism for th
139 rce competition for food, South African ball-rolling dung beetles carve a piece of dung off a dung-pi
140                           South African ball-rolling dung beetles exhibit a unique orientation behavi
141 by recording the direction and size of their rolls during lunge feeding events, we show how these ani
142 inuous rolling behavior termed "intermittent rolling," during which Myo1e-deficient neutrophils showe
143 es (WFEs), coaxial fiber devices (CFEs), and rolled electrodes (REs).
144 quent diffusion through the lattice of steel rolling element bearings.
145                          E-selectin-mediated rolling facilitates pancreatic cancer cell adhesion to h
146                        Selectin-induced cell rolling facilitates surface recruitment of cancer cells,
147 amed tissues involves elements of neutrophil rolling, firm adhesion, and crawling onto the EC surface
148    One such phenomenon, the formation of log-rolling flocs, which is ubiquitously observed in suspens
149        Using this fluorescent multiplex cell rolling (FMCR) assay, each sample is labeled with a diff
150 sglycosidases that adopt a common beta-jelly-roll fold and are active on a range of terrestrial and m
151 e found that the S. pombe Cnp3(CENP-C) jelly roll fold harbors an inner binding pocket that is used t
152  2 capsid proteins with variant single jelly-roll folds form pentamers and hexamers which assemble in
153 springs facilitate the forefoot's ability to roll forward at the end of stance, toe springs may also
154 itive manner and to calculate differences in rolling frequency, velocity, and tethering capability of
155        This redox shift controls the uranium roll-front mobilization and results in high cU(aq) withi
156 onditions is a result of a nitrate-triggered roll-front mobilization of geogenic uranium in the studi
157 dominant U((IV)) species in an undisturbed U roll-front ore deposit in Wyoming, USA.
158                                       Larger rolls (>180 degrees ), conversely, occurred more often a
159  Although the mechanics of selectin-mediated rolling have been extensively studied, little is known r
160 meters such as body length, body angle, head roll, head yaw, head pitch, and path and speed of hand m
161 a 260-bp deletion in its gene displayed leaf rolling in response to high light intensity and/or low h
162 fucosylated glycan ligands mediate leukocyte rolling in the vasculature under shear forces.
163  undergone thrombectomy during an open-label roll-in period.
164                  A total of 341 patients, 78 roll-in, and 263 in the primary analysis cohort, were en
165 eered cells exhibited enhanced tethering and rolling interactions on E-selectin-bearing endothelium u
166 be accounted for by inhibition of neutrophil-rolling interactions with the inflamed vasculature and o
167 materials in the current 2D library could be rolled into their 1D counterparts and a plethora of func
168 /W > 10) convert to sheets (L/W -> 1) before rolling into cochleates.
169 t, redefined as two processes named Rock and Roll, is required for positional acquisition of HCs.
170 ng off a dung-pile, shape it into a ball and roll it away along a straight line path.
171                                      Smaller rolls (</=180 degrees ) predominantly occurred at depth
172 composed of 8,280 copies of the double jelly-roll major capsid protein (MCP) p72, arranged in trimers
173 nstrated high-throughput, economical roll-to-roll manufacturing of the metamaterial, which is vital f
174  is a promising candidate for future roll-to-roll mass manufacturing and practical application of hig
175 ion and the rate of change of body pitch and roll, may enable researchers to refine movement-based me
176                                Our "rock-and-roll" model provides an explanation for previous finding
177        With the desire to synthesize surface-rolling molecular machines that can be translated and ro
178 shows that a molecule in a stack of two beta roll molecules unfolds in a step-wise fashion mainly fro
179 istry, and in silico analysis, we identify a rolling motion at a yet unexplored interface between the
180 -a-chip, micro/nano-fluidic devices, roll-to-roll nano-imprint fabrication, self-cleaning surfaces, a
181        Unlike modern carnivores, significant roll of around 10 degrees of the active hemimandible occ
182                      E-selectin mediates the rolling of circulating leukocytes during inflammatory pr
183 terol resulted in the uniform, CD44-mediated rolling of monocytes on the E-selectin-coated surfaces.
184  beta3 strand to form the oxyanion hole, and rolling of the beta3-beta4 loop toward the active site.
185 lation-based cohort study from the electoral rolls of the cities of Dijon, Bordeaux, and Montpellier,
186  and hardening behavior, respectively, sharp roll off from the passband to the stopband is achievable
187 other, to realize a bandpass filter of sharp roll off from the passband to the stopband.
188 ) was achieved, with transmission efficiency rolling off for the lower mobility ions (e.g., K(0) ~ 1.
189 iency (EQE) of 17%, considerably reduced EQE roll-off (EQE > 10% to current densities as high as 2000
190 ic light-emitting diodes; namely, efficiency roll-off and degradation.
191 which allows for relatively small efficiency roll-off and shows an external electroluminescence quant
192  is demonstrated that the anisotropy of drop roll-off angle is influenced by the geometry, compliance
193  angles (greater than 150 degrees) and small roll-off angles (less than 10 degrees).
194  hydrophobicity of the scales; and a maximum roll-off anisotropy of 6.2 degrees is achieved.
195 and brightness of 54 000 cd/m(2) with modest roll-off at high currents.
196 nt organic light-emitting diodes with better roll-off behavior based on these novel hosts are fabrica
197 sensitivity of 98 dB and a single-sided 6-dB roll-off depth of 2.5 mm.
198                                         Such roll-off likely limits the effectiveness of prestin in c
199 y (EQE) of 30.8% with a very flat efficiency roll-off of 7% at 1000 cd m(-2) .
200                                The magnitude roll-off of prestin activity across frequency surpasses
201 ious demands for OLEDs with high EQE and low roll-off.
202 Moreover, developmental biology continues to roll on, budding off more disciplines, while retaining i
203                     We show that tumor cells rolling on E-selectin were approximately 40-fold more li
204 als that promoted alphaLbeta2-dependent slow rolling on ICAM-1 in vitro and in vivo.
205                We found that mouse Th1 cells rolling on P- or E-selectin triggered signals that promo
206 ed, little is known regarding how tumor cell rolling on selectins facilitates adhesion to a distinct
207 hat were pre-exposed to colchicine failed to roll or accumulate on activated endothelial monolayers,
208                                    Pitch and roll orientation tuning is anchored to gravity and indep
209 e COVID crisis as a means to recommit to the roll out of markets in global health, this involving the
210                       Interventions could be rolled out as disease burden demands and budgets allow.
211 ion of HIV replication has been successfully rolled out at large scale to HIV-positive patients in lo
212                 While this strategy is being rolled out globally, rigorous evaluation of outcomes at
213 sure prophylaxis (PrEP) is being adopted and rolled out in diverse regions, communities, and groups.
214 ke advantage of new cheap technologies being rolled out to collect isolates and submit them to the Wo
215 utrition-specific and -sensitive initiatives rolled out within the country.
216        As typhoid conjugate vaccine (TCV) is rolled out, surveillance should continue to monitor chan
217 lactic intervention; therefore, we recommend rolling out SDR in all settings where contact tracing an
218  that current strategies can ultimately slow roll-out and contribute to stigma surrounding PrEP use.
219 and resolve remaining safety concerns, wider roll-out could be recommended from 2021 onwards.
220 roaches and long-acting formulations as PrEP roll-out expands.
221       In low- and middle-income regions, ART roll-out has improved outcomes, but has resulted in incr
222 shown to be effective, in some settings PrEP roll-out has lagged, in part due to flawed messaging.
223 e residual burden of HIV mortality after the roll-out of a public sector ART programme in KwaZulu-Nat
224                                          The roll-out of antiretroviral therapy (ART) has changed con
225                                    Since the roll-out of ART in 2004, adult life expectancy increased
226 spectives will be key considerations for the roll-out of effective products.
227 l monitoring and assessment to accompany the roll-out of MDA programmes to ensure that the considerab
228 r-enforced environmental laws, the widescale roll-out of payments for ecosystem service schemes, and
229 ed Malawi as one of three sites to pilot the roll-out of RTS,S/AS01 in phase 4 trials.
230 us (HIV) drug resistance from antiretroviral roll-out programs remain a threat to long-term control o
231  highlight the potential pitfalls of current roll-out strategies focused on selective and siloed serv
232 -matching warrants consideration during PrEP roll-out.
233  his 1st year of life and was slow to crawl, roll over, and stand up.
234 vention on pre-specified dates until all had rolled over to the CQI intervention.
235 received the high dose, 11 sat unassisted, 9 rolled over, 11 fed orally and could speak, and 2 walked
236                                   Neutrophil rolling over E-selectin at precise shear stress transmit
237 s, while a smooth fault plane will develop a roll-over anticline with a bend on only one limb.
238 of adhesion molecules relevant for leukocyte rolling (P-selectin) and platelet capture (von Willebran
239 used to virtually decrypt highly degraded or rolled papyri.
240 e) oriented vortex that imposed a continuous roll perturbation, measured wing kinematics and neuromot
241                       Rice mutants with leaf-rolling phenotypes were screened in a field.
242 by the flippers to perform maneuvers such as rolls, pitch changes and turns [1].
243 nment allowing easy integration on a roll-to-roll platform for economical manufacturing of bioresorba
244 , and may be scaled to large area by roll-to-roll printing for lightweight solar power systems.
245 ocessable printing techniques (e.g., roll-to-roll printing).
246 anding of the processes helps to improve the rolling process in order to exploit the alloying element
247                  This study shows how a self-rolling process initiated by polymerization of a micropa
248  at different stages of the thermomechanical-rolling process.
249 ng the strain engineering and a self-folding rolling process.
250   Copper foils might be suitable for roll-to-roll processes, but are unlikely to be compatible with a
251 is method and its compatibility with roll-to-roll processing make it promising for many applications,
252            Furthermore, E-selectin-dependent rolling promotes adhesion to HA by both physically slowi
253            Here we assess PCV carriage using rolling, prospective nasopharyngeal carriage surveys bet
254 scale production techniques, such as roll-to-roll (R2R) processing, may fulfill requirements of low-c
255  with a flexible commercial process, roll-to-roll (R2R), for thermoelectric applications.
256 a melanogaster larvae generate a curling and rolling response.
257  per se, is the main determinant of aversive rolling responses to noxious mechanical stimuli.
258 nipulative actions (drag, drop, grasp, push, roll, rotate, squeeze) in four visual formats.
259   Markedly, achieving three dimensional (3D) rolling rotation of single cells within a larger group o
260 tructure of Aly36B belongs to the beta-jelly roll scaffold, adopting a typical beta-sandwich fold.
261 vealing the self-healing ability of the beta roll stack.
262            Remarkably, receptors locked in a rolled state display "super-activity" and resistance to
263 ay an important role in stabilizing the beta roll structure of the molecule on top by strengthening t
264 to a universal stability diagram for the log-rolling structures and allows for application of shear-i
265       Participants (n = 145) completed a die-rolling task where they could misreport their outcomes t
266 cro-patterned all-polymer films called micro-rolls that we use for encapsulating, manipulating, and o
267                   Blood droplets (35 microL) roll through the tubes at 15 degrees sliding angles with
268     VM patients were abnormally sensitive to roll tilt, which co-modulates semicircular canal and oto
269                            Transition of PMN rolling to firm adhesion critically depends on Coro1A by
270 g large-scale production techniques, such as roll-to-roll (R2R) processing, may fulfill requirements
271 chniques with a flexible commercial process, roll-to-roll (R2R), for thermoelectric applications.
272 arly if the material choice is restricted by roll-to-roll and benign solvent processing requirements
273  we demonstrated high-throughput, economical roll-to-roll manufacturing of the metamaterial, which is
274 IC blend is a promising candidate for future roll-to-roll mass manufacturing and practical applicatio
275 n lab-on-a-chip, micro/nano-fluidic devices, roll-to-roll nano-imprint fabrication, self-cleaning sur
276 t environment allowing easy integration on a roll-to-roll platform for economical manufacturing of bi
277 displays, and may be scaled to large area by roll-to-roll printing for lightweight solar power system
278 ution-processable printing techniques (e.g., roll-to-roll printing).
279           Copper foils might be suitable for roll-to-roll processes, but are unlikely to be compatibl
280 st of this method and its compatibility with roll-to-roll processing make it promising for many appli
281                                          The roll-to-roll ultraviolet nanoimprint lithography (R2R UV
282                          E-selectin-mediated rolling transmits signals into neutrophils that trigger
283 with Lewy body disease; resting tremor, pill-rolling tremor and hallucinations were more frequent in
284                                  The roll-to-roll ultraviolet nanoimprint lithography (R2R UV-NIL) te
285 ived catch-bonds that support slow leukocyte rolling under shear stress.
286  waves are associated with asymmetric embryo rolling, unveiling a new chirality marker in Drosophila
287  bespoke "dog-leg" track design, that can be rolled up for ease of assembly.
288 be (CNT) can be described as carbon sheet(s) rolled up into a cylinder that is nanometers wide and na
289 g of the "zipping program," resulting in the rolling up of oligophenylene chains.
290 , a high velocity jet forms, inducing vortex roll-up around it.
291                                              Rolled-up diamond tubular microcavities exhibit pronounc
292  883 households were selected from municipal rolls using two-stage random sampling stratified by prov
293 ce resulted in a dose-dependent reduction in rolling velocity associated with increased numbers of ad
294 cifically, Myo1e deficiency caused increased rolling velocity, decreased firm adhesion, aberrant craw
295 activated endothelium encompass (1) platelet rolling via interaction of platelet glycoprotein Ib-IX-V
296 fting double mutant of the 26 nt potato leaf roll virus RNA pseudoknot.
297                                              Roll was likely passive in Triconodontidae in contrast t
298 illet and fish homogenate and dynamically by rolling with cut fillet cubes.
299  yield and the biocompatibility of the micro-rolls with any length in the release process without cyt
300 ll, of factory-made cigarettes [FMC], and of roll-your-own tobacco [RYO]), in the total sample and st

 
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