ライフサイエンスコーパス: rotarod

1 ractivity, stereotypies, motor impairment in rotarod).

2 accelerating rotating rod (the accelerating rotarod).

3 motor skill, as assessed by the accelerated rotarod.

4 , which exhibited an enhanced ability on the rotarod.

5 phases of skill learning on an accelerating rotarod.

6 r firing rate while mice were running on the rotarod.

7 impaired motor learning on the accelerating rotarod.

8 ivity, hypothermia, and ataxia assessed on a rotarod.

9 in spontaneous locomotor activity and on the rotarod.

10 sed by open field testing, balance beam, and rotarod.

11 eneration and motor deficits, as assessed by rotarod.

12 y declining performances on the accelerating Rotarod.

13 nce upon repeated testing on an accelerating rotarod.

14 display motor impairment or sedation using a rotarod.

15 mice also showed better motor skills on the rotarod 3 days after injury, and improved performance in

16 box, a decrease in the latency to fall on a rotarod, a reduction in synaptic strength and pair-pulse

17 Wild-type 129/SvEv mice had the poorest rotarod ability of all groups tested, suggesting that li

18 y the screen test, static dowel, fixed-speed rotarod, accelerating rotarod, grip strength, or loss of

19 ssive dopaminergic degeneration and improved rotarod activity.

20 walking on grids, and fall off platforms and rotarods, although they do not have a jerky gait.

21 its are present, as measured by accelerating rotarod analysis, together with a progressive decrease i

22 pts hind paw movement during locomotion on a rotarod and a runway.

23 ramatic deficits in motor performance on the rotarod and ataxia.

24 pendent impairment in motor tasks, including rotarod and balance beam performance.

25 in astrocytes improves motor performance in rotarod and balance beam tests and improves cognitive fu

26 Rotarod and balance beam tests have revealed abnormal ne

27 Rotarod and balance beam tests revealed impaired neuromu

28 es with reduced proprioceptive input, unlike rotarod and balance beam tests.

29 The rotarod and Barnes maze acquisition and probe tests were

30 and improved motor deficits, as assessed by rotarod and clasping behavioural tests.

31 eased motor coordination on the accelerating rotarod and deficits in working memory as measured in th

32 d in standard conditions in the accelerating rotarod and ErasmusLadder test.

33 ovements in treated mice on the accelerating rotarod and fear conditioning.

34 jection showed improved motor performance in rotarod and foot grip tests in treated Sh3tc2-/- mice co

35 Rotarod and gait analysis indicated motor system decline

36 ved motor outcome as assessed using both the rotarod and grid test.

37 Functional deficits were tested on the rotarod and grip-strength meter at 24, 48 and 72 h after

38 ment in ability to remain on an accelerating rotarod and increased grip strength observed in the pMCA

39 vement in functional outcomes as assessed by Rotarod and Morris Water Maze and a reduction in positiv

40 more, R6/2_50 mice outperform WT mice on the rotarod and show equal or better performance in the two

41 le AS mice enhances their performance in the rotarod and T-maze tests.

42 M on L-DOPA efficacy was evaluated using the rotarod and the cylinder test after the establishment of

43 t in motor function on forced tasks, such as rotarod and treadmill tests, caused by substantia nigra

44 LPS and DSP-4 decreased rotarod and wirehang activity, reduced dopaminergic neur

45 combination therapy increased latency during rotarod and wirehang testing at 12 wk, in comparison wit

46 evere motor control impairment (falling from rotarods and 1-inch wide beams).

47 bited improved behavioral outcomes in motor (rotarod) and cognitive (Morris water maze) assays compar

48 little effect on sensorimotor coordination (rotarod) and spatial cognitive functions (Y-maze).

49 Neuroinflammation, motor coordination (rotarod), and depressive behaviors (social withdrawal, i

50 ocomotion in an open field, performance on a rotarod, and grid walking were significantly impaired in

51 We found motor deficits on the rotarod, and learning deficits in the Morris water maze

52 re deficient in contact righting, wire hang, rotarod, and pole climbing tasks.

53 in the null mutants on open field activity, rotarod, and wire hang, replicating and extending previo

54 We used the accelerating rotarod as a motor learning task.

55 Using rotarod as a test for motor learning, we found that expr

56 or recovery after injury, as measured by the rotarod assay and an inclined beam-walking task, was com

57 e on the accelerating versus the fixed-speed rotarod assay can be completely dissociated under some t

58 otor behavior of the mice was tested using a rotarod assay.

59 motor deficits (quantified in beam-walk and rotarod assays) and reduced PC loss observed in untreate

60 uts, dKO mice were impaired in sensorimotor (rotarod, balance beam assays) and spatial memory tasks (

61 significantly underperformed wt controls in rotarod, balance beam, string test, pole test and cotton

62 neurological impairment that was evident in rotarod, balance, and climbing tests by 13 months of age

63 izer reduced learning and performance of the rotarod behavior.

64 tor learning; acquisition and retention of a Rotarod behavioral task is significantly better in K(b)D

65 h post-MPTP in BMT-treated mice assayed by a rotarod behavioral test.

66 voluntary wheel running and the accelerating rotarod, but show only minor abnormalities in gait and b

67 ll (improved balance) using the accelerating rotarod compared with nonexercised mice.

68 In conclusion, time-to-fall off a rotarod correlated well with several measures, including

69 rform a complex motor task, the accelerating Rotarod, correlated with localization of mGluR1alpha to

70 N586-82Q mice show a clear progressive rotarod deficit by 4 months of age, and are hyperactive

71 A rotarod deficit was not present in Q175 mice until 18 mo

72 ersensitivity, hyperexploratory behavior and rotarod deficits, all pointing to changes in dopamine (D

73 t young PGC-1alpha (-/-) mice exhibit severe rotarod deficits, decreased rearing behavior, and increa

74 re and produced deficits in performance on a rotarod device for the entire duration of the study.

75 everity-related deficits in performance on a rotarod device were also found at both slow and fast acc

76 after traumatic brain injury by the use of a rotarod device.

77 a-syn pathology by longitudinally conducting rotarod, diffusion magnetic resonance imaging (MRI), res

78 ing a long-term training in the accelerating rotarod display marked hippocampal transcriptional chang

79 ercise capacity, assessed by rats performing rotarod exercise and treadmill running, was improved in

80 a faster recovery of motor incoordination in rotarod experiments and a shorter sedative effect in los

81 ell depletion improved motor recovery on the rotarod (F((1,28)) = 4.264; p = 0.048) compared to isoty

82 s C) for 2 h, and forced motor activity on a rotarod for 30 min, failed to alter extracellular 5-hydr

83 hy, novel object recognition, grip strength, rotarod, glucose tolerance test (GTT) and insulin tolera

84 tic dowel, fixed-speed rotarod, accelerating rotarod, grip strength, or loss of righting reflex tests

85 seizures (6 Hz mouse model) without typical rotarod impairment of A(1)AR agonists.

86 ale mice, better balance on the accelerating rotarod in females, and improved motor coordination duri

87 Motor function was evaluated by using rotarod, inclined-plane, and forelimb/hindlimb flexion t

88 non-noxious input, generated by walking on a rotarod, induces Fos in the PKCgamma interneurons.

89 Rotarod, inverted screen, and open field motor function

90 The rotarod is one of the most commonly used tests to measur

91 me-to-fall off an accelerating rotating rod (rotarod) is widely utilized to evaluate rodent motor per

92 CN-105 treatment, as quantified by increased Rotarod latencies on Days 1-5 post-ICH, and long-term im

93 dose adeno-associated virus vector increased Rotarod latency by 75% at 4 wk, in comparison with vecto

94 The rotarod latency was >200 s at 16 RPM in all rats pre-MCA

95 overt behavioral effects and did not change rotarod latency.

96 ted gene Arc in individual M2 neurons during rotarod learning by in vivo two-photon imaging of a knoc

97 Here, neuroligin-3 mutations increased rotarod learning by specifically impeding synaptic inhib

98 Rotarod learning is known to drive refinement of cortico

99 Using a mouse rotarod-learning task, we showed that lesion or inactiva

100 sensorimotor behavioral deficits measured by rotarod, limb placing, and elevated body swing tests.

101 including analgesia, hypothermia, catalepsy, rotarod locomotor impairment, or conditioned place avers

102 flex, visible platform Morris water maze and Rotarod measurements were conducted to test vision and v

103 e hang, grip strength), sensorimotor skills (rotarod), mechanical sensitivity (von Frey hair), and th

104 inna reflex, Digiscan open field locomotion, rotarod motor coordination, hanging wire, footprint path

105 Using rotarod motor learning as a proxy for acquired repetitiv

106 nd rats performed poorly on balance beam and rotarod motor tests 24 h later.

107 avior, but not in the control open field nor rotarod motor tests; cyclic AMP responses to stimulation

108 , with change in maximum fall latency on the rotarod (n = 17, R = .89, p = .000001), and with blood c

109 Time on the rotarod or calorie consumption, and food and water intak

110 In R6/2 mice, however, JQ1 had no effect on rotarod or grip strength but exacerbated weight loss and

111 n or pain perception were observed using the rotarod or hot-plate tests, and there was no change in G

112 trained on either the standard accelerating rotarod or the motirod for four trials per day on four c

113 ampus than those trained on the accelerating rotarod or those that received no training.

114 wt mice on composite neuroscore (P < 0.001), rotarod (P < 0.05), and beam balance (P < 0.02) tests.

115 st three days post-trauma as demonstrated by rotarod (p<0.05) and beam balance test (p<0.05), respect

116 ity to learn motor skills in an accelerating rotarod paradigm.

117 Accelerating rotarod performance also distinguished phenotypes in Lys

118 ce, to identify the genetic loci controlling rotarod performance and its relationship with body weigh

119 F/AdNoggin-treated R6/2 mice sustained their rotarod performance and open-field activity and survived

120 loss, mortality and behavioral impairment in rotarod performance and spontaneous motor activity were

121 ive dose (MED) for significant impairment in rotarod performance and the MED for significant neuropro

122 S-AMPA injection led to impaired rotarod performance and widespread axonal degeneration a

123 showed more severe exercise-induced fatigue, Rotarod performance deficits, and gait anomalies than md

124 al gait and ataxia characterized by impaired rotarod performance improved by treatment with a GABA(B)

125 lum, substantially impaired beam-walking and rotarod performance in mice.

126 ed environmental enrichment slows decline in RotaRod performance in R6/2 mice, despite rapid disease

127 ed statistically significant improvements in rotarod performance in treated animals compared to AAV2.

128 For example, while rotarod performance is normal until 10 weeks, it is impa

129 male N171-82Q mice show a greater deficit in rotarod performance than female N171-82Q mice.

130 Despite persistent behavioral deficits in rotarod performance up to the time of brain extraction (

131 Body weight and rotarod performance varied widely across CC strains and

132 Rotarod performance was comparable in the 3 strains.

133 Water maze, open field, and rotarod performance was tested 2 and 8 weeks after ICH.

134 Rotarod performance was tested at days 1-5 and maze perf

135 Impaired novel object recognition and rotarod performance were consistent across cohorts of nu

136 mice demonstrate only modest alterations in rotarod performance with aging and lack reproducible alt

137 tein aggregate reduction, reduced decline in rotarod performance, and alleviation of clasping in R6/2

138 hich is aggravated by flunitrazepam, reduced rotarod performance, and reduced locomotor activity in t

139 pected finding was reflected by worsening of rotarod performance, increase of anxiety-related explora

140 oved motor function as indicated by improved rotarod performance, longer stride length, lower stride

141 vation period and there was no difference in rotarod performance, object recognition, social interact

142 mal gait, inability to run or swim, impaired rotarod performance, reduced neuromuscular strength, dys

143 lation, decreased striatal atrophy, improved rotarod performance, reduction of weight loss, normaliza

144 However, 45 loci affected rotarod performance, seven of which were also associated

145 al thalamus and improved motor impairment on rotarod performance.

146 able but exhibit hindlimb clutching and poor rotarod performance.

147 enetic background to open-field activity and rotarod performance.

148 ayed motor development and markedly impaired rotarod performance.

149 ing pattern, grip strength, balance beam and rotarod performance.

150 vehicle, though these groups had comparable rotarod performances and survival times.

151 SCs, and lower spontaneous firing rates, but rotarod performances were indistinguishable.

152 lterations in body weight changes, lifespan, RotaRod performances, grip strength, overall activity an

153 med equally as well as wild-type mice in the rotarod, pole, and cagetop tests of motor coordination.

154 nding and technically-difficult version of a rotarod procedure.

155 y hyperlocomotive, had better balance on the rotarod, showed altered gait properties, and displayed a

156 showed performance deficits at all phases of rotarod skill learning.

157 imming speed and time spent on quadrant) and rotarod (stayed a longer period of time) tests.

158 significantly reduced retention times on the Rotarod, suggesting a role for Bergmann glia-expressed P

159 also prevented sensorimotor impairment on a rotarod task 30 days later, long after L-NAME cleared th

160 ated significantly better performance on the rotarod task after 20 days of 'rehabilitation'.

161 pendent locomotor behaviors: training on the rotarod task and locomotor sensitization to amphetamine.

162 l memory performance were assessed using the rotarod task and Morris water maze.

163 n significant impairments in training on the rotarod task of coordinated movement.

164 1 neuronal ensembles during the accelerating rotarod task that limit motor learning.

165 rent strains had variable performance on the rotarod task, which correlated with the expression of >2

166 STT) and long-term (LTT) trained mice in the rotarod task.

167 stinguishably from wild-type siblings on the rotarod task.

168 ral alterations in the open field and in the rotarod task.

169 learning and memory deficits in swimming and rotarod tasks.

170 showed normal ethanol-induced ataxia on the rotarod test after administration of a 2.5 gm/kg dose.

171 formed as well as wild-type littermates on a rotarod test and had increased numbers of large-diameter

172 0 exhibited negligible acute toxicity in the rotarod test and statistically significant analgesic eff

173 than wild-type controls in the accelerating rotarod test for motor coordination.

174 We show here that exactly how the rotarod test is performed can markedly alter the apparen

175 rated by comparing it with the commonly used rotarod test of motor coordination and by using eye move

176 ith well chosen parameters, the accelerating rotarod test showed very high inter- and intralaboratory

177 Body weight and motor performance on the rotarod test were significantly improved in creatine-sup

178 rm memory (LTM) contextual fear testing, and rotarod test when compared to wild type (WT) littermates

179 ased latency to fall during the accelerating rotarod test) and possess an increased sensitivity to ni

180 eliorates motor symptoms (assessed using the rotarod test) and prevents loss of body weight induced b

181 generally normal on locomotor activity, the rotarod test, acoustic startle response, prepulse inhibi

182 st, impaired coordination and balance in the rotarod test, and increased spasticity as shown by a cla

183 latively mild or no motor impairments in the rotarod test, in spite of a dramatic (~60%, as estimated

184 nd wild-type (WT) mice were evaluated in the rotarod test, to be sacrificed at about 12-13 or 19 week

185 Using a rotarod test, we demonstrated that early BMT greatly del

186 e motor function of rats was assessed by the rotarod test.

187 h an improvement in neuro-behavior using the rotarod test.

188 y assessment of motor coordination using the rotarod test.

189 not produce motor impairment as measured by rotarod test.

190 ot change the performance in an accelerating rotarod test.

191 says of walking gait and in the accelerating rotarod test.

192 ar to that of non-lesioned control mice in a rotarod test.

193 ounds were administered i.p. 30 min prior to rotarod testing or onset of ischemia.

194 c mice began to display motor dysfunction in rotarod testing.

195 weight loss or neurotoxicity as measured by rotarod testing.

196 with motor deficits assessed by accelerating rotarod testing.

197 In the formalin and rotarod tests ACEA-1328 and MK-801 produced both antinoc

198 Swimming and rotarod tests demonstrate that the two Dfnb31 mutants ha

199 nglion neurons, and using the tail-flick and rotarod tests in mice.

200 Results from open field and rotarod tests show A53T mice develop age-dependent chang

201 functions were determined in open-field and rotarod tests, followed by Western blotting, quantitativ

202 Using Morris Water Maze and rotarod tests, quantitative RT-PCR, immunoblotting, bioc

203 otor learning in vestibulo-ocular reflex and rotarod tests, we find that deletion of HCN1 channels fr

204 eficits in both beam-walking and accelerated rotarod tests, while they did not exhibit abnormal nucle

205 ry of motor functions in both open-field and rotarod tests.

206 eficits as measured by the vertical pole and rotarod tests.

207 mice had impaired motor coordination on the rotarod that was corrected in the congenic C57BL/6 backg

208 ed a favorable adverse effect profile in the rotarod, the minimal motor impairment, and the Irwin tes

209 ovement smoothness inversely correlated with rotarod time-to-fall for the three trials.

210 ined to run for 40 min/day, 5 days/week on a Rotarod treadmill at 11.5 cm/s, while control animals (n

211 unction, and applied physical function (e.g. rotarod, treadmill, grip test, and wheel running), we ob

212 s allowed for the separation, after only one rotarod trial, of different-weight, untreated mouse grou

213 ing changes in the performance of repetitive rotarod trials while blinded to genotype.

214 ABAA receptors, the observed behavior in the rotarod, water maze and peripheral nerve injury tests wa

215 ) and functional outcomes (grip strength and Rotarod) were assessed prior to sacrifice.

216 rs sensorimotor learning on the accelerating rotarod without affecting goal-directed instrumental lea