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1 the tortoise-hare pattern is an indicator of ruggedness.
2 terms of assay sensitivity, selectivity, and ruggedness.
3 tal elevation model for a measure of terrain ruggedness.
4 e state, or could slow folding by increasing ruggedness.
5 verage values of Delta occur at intermediate ruggedness.
6 ed by precipitation, winter cold and terrain ruggedness.
7  towards the native state is larger than its ruggedness.
8  additional contributions from curvature and ruggedness.
9 ttest genotype, while increasing the overall ruggedness.
10 ms of selectivity, sensitivity, accuracy and ruggedness.
11 etection capability, trueness, precision and ruggedness according to the Youden's approach.
12 y of fitness optima, which dominates at high ruggedness and acts to decrease Delta.
13 increase the fitness, which dominates at low ruggedness and acts to increase Delta; and (2) a higher
14 e landscape is difficult owing to both local ruggedness and amino acid-specific epistatic hotspots an
15 t likely to emerge at intermediate levels of ruggedness and environmental relatedness.
16 ories by multiple chemists authenticates the ruggedness and good reproducibility of the analytical pr
17 nges for theory and experiments owing to the ruggedness and high dimensionality of these potentials,
18 mplified design could improve robustness and ruggedness and may allow device construction via nontrad
19 ciated with higher elevations with increased ruggedness and overall shrub cover.
20 ition, can epistasis-the source of landscape ruggedness and path constraints-play a different role, i
21 cificity and sensitivity along with improved ruggedness and portability, paves the way to a new gener
22 basin) has the largest average depth-related ruggedness and slope, at all resolutions.
23 apeutic monoclonal antibodies, demonstrating ruggedness and suitability for high-throughput process a
24 ite residents as well as an index of terrain ruggedness and the number of lynchings in the previous d
25 eve fast binding by overcoming the landscape ruggedness and thereby efficiently mediate protein allos
26 the sensor to overcome technical problems of ruggedness and would therefore be ideal for industrial p
27  components in the GC system, thus improving ruggedness and, consequently, reducing need for frequent
28 ty, measured as surface rugosity and terrain ruggedness, and a detectable loss of habitat volume one
29  are attractive because of their small size, ruggedness, and amenability to automated handling.
30            A combination of bathymetry data, ruggedness, and backscatter from a trans-Atlantic corrid
31 , the number of energy basins, the landscape ruggedness, and the slope decrease accordingly; ii), the
32                    Analysis speed and system ruggedness are key requirements for bioanalysis of thous
33 y mutant library, we show that heterogeneous ruggedness arises from sparse epistatic hotspots, whose
34 n of the new function depends upon the local ruggedness around the starting location in the genotype
35 d de novo variants reduced fitness landscape ruggedness as compared to standing variation, increasing
36 ecreased mutational robustness and increased ruggedness, as measured by fitness effects of mutations
37 centrations, but the tradeoff induces a high ruggedness at intermediate antibiotic concentrations.
38 etween two cutoffs for 5% and 10% artificial ruggedness becomes negligible for potentials decreasing
39             Furthermore, we confirmed method ruggedness by assembling a second ACTIS instrument and c
40 oach has improved both assay sensitivity and ruggedness, compared to the whole plasma protein digesti
41  landscape in such a way that path-orienting ruggedness confers global smoothness.
42 approach identified a combination of surface ruggedness, curvature, planform curvature, and surface c
43                               The artificial ruggedness decreases to tolerable thresholds for cutoffs
44 folding experiments of proteins and RNA, the ruggedness energy scale epsilon, can be directly measure
45                              This artificial ruggedness exists for short cutoffs and gradually disapp
46 arity, sensitivity, accuracy, precision, and ruggedness, for both of these methods were comparable wi
47 tensional strain rates, paleotopography, and ruggedness), global temperature, and diversity dynamics.
48                            Despite this high ruggedness, however, all the fitness maxima in the lands
49 vation energy to include width and landscape ruggedness identified in the simulated energy landscapes
50 plexes agree with the analysis of artificial ruggedness in a dataset of 62 protein-protein complexes,
51 lyte for improved specificity and analytical ruggedness in quantitative LC-MS-MS.
52 ic ELISA involving end-point detection lacks ruggedness inasmuch as the generation or etching of NP i
53 e predictions in simulated populations where ruggedness is manipulable, we explore average fitness in
54                       Although the landscape ruggedness is sensitive to the mutations and fluorophore
55                               Increasing the ruggedness leads to two competing effects: (1) more poss
56 ility (<21% over the maximum residue limit), ruggedness (&lt;5.6%) and stability.
57 ptics with drastically improved compactness, ruggedness, manufacturability and functionality compared
58 le structural complexity, captured by vector ruggedness measure (VRM), showed resolution-specific res
59                         We identify specific ruggedness measures that are both predictive of search p
60           We provide a tool based on terrain ruggedness modelling of individual catchments to predict
61                   Despite these hallmarks of ruggedness, most high peaks are evolutionarily accessibl
62                          Our work shows that ruggedness need not be an obstacle to Darwinian evolutio
63 between Ca2+ and binding residue reduces the ruggedness of ligand exchange landscape by acting as a l
64 hat demonstrate the potential usefulness and ruggedness of LTP-MS for the detection of explosives of
65 ness of the sequence space combined with the ruggedness of many fitness functions.
66   The interaction cutoff contribution to the ruggedness of protein-protein energy landscape is studie
67                  However due to the size and ruggedness of RNA energy landscape, energy-guided search
68           These data demonstrate that severe ruggedness of RNA folding landscapes extends into confor
69 ow that search efficacy is determined by the ruggedness of the appropriately-defined ecological lands
70                             By analyzing the ruggedness of the associated potential energy landscape,
71 ter (ATATGCATAT) of the sequence reduces the ruggedness of the dynamics landscape by eliminating a nu
72           We show that the LCO heightens the ruggedness of the energy landscape and raises activation
73 loop-receptor interaction in determining the ruggedness of the energy landscape for folding of the Te
74  in the loop contribute significantly to the ruggedness of the energy landscape.
75 on-native secondary structure determines the ruggedness of the energy landscape.
76 dispersion in fitness that characterizes the ruggedness of the evolutionary landscape.
77  multiple sequence changes, can modulate the ruggedness of the folding energy landscape.
78 zymes and provided a preliminary view of the ruggedness of the landscape, relating function to struct
79  vs the above parameters, we demonstrate the ruggedness of the method in predicting VD through the Oi
80 s controlled by solvent friction alone, with ruggedness of their energy landscapes having no conseque
81 ional states of each mutant and evaluate the ruggedness of their free energy landscapes.
82                           To demonstrate the ruggedness of this approach, optimized cocktails were fi
83                                          The ruggedness of this interface was evident by the continuo
84                           The robustness and ruggedness of Topino were confirmed by comparing the res
85 re response time, cyclability (frequency and ruggedness), sizing, payload capacity, amenability to me
86                                       In the ruggedness test, sample amount, pre-extraction time, des
87                                      Through ruggedness tests, the application field of radiochemical
88 lifetimes and increases their robustness and ruggedness, thus making them more amenable for field app
89 chniques allow their unprecedented oxidative ruggedness to be monitored and verified.
90 elief and fine-scale complexity using vector ruggedness (VRM), estimated nitrogen (N) and phosphorus
91                                        Assay ruggedness was demonstrated by consistent internal stand
92 quate instrumental performance, some lack of ruggedness was encountered during routine application.
93                                    The assay ruggedness was improved by optimizing the trypsin digest
94 h %CV of 8.2-9.9 and 7.1-9.8%, respectively; ruggedness with %CV of 9.3-17.5%; spike recovery of 80-1
95 ee-energy surface that exhibits native-state ruggedness with apparently similar barrier heights to fo