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1 petitive neurotransmitter application (i.e., rundown).
2 ed accurately despite conditions of unstable rundown.
3 ephosphorylation events that lead to current rundown.
4 IP(2) degradation; PLC inhibition attenuates rundown.
5 racteristic time-dependent decline, known as rundown.
6 ltered the speed kinetics of TMEM16A current rundown.
7 m intact cells or permeabilized cells before rundown.
8 ed chromaffin cells that had been allowed to rundown.
9 acking p63 undergo a premature proliferative rundown.
10  slower acute desensitization and functional rundown.
11 ular Ca2+ concentration and underwent little rundown.
12 molecule, poly-L-lysine, accelerated channel rundown.
13 on accompanied by a parallel partial current rundown.
14  cyclosporin A or deltamethrin increases the rundown.
15 t and somewhat larger following more NBCe1-A rundown, 62% smaller in the absence of Na(+), and 90% sm
16  activates the channel directly and restores rundown activity.
17 probability of BKCa and completely inhibited rundown after activation by Bt2cGMP.
18                                  The channel rundown after initial excision suggested that modulation
19        We asked whether functional GABA(A) R rundown also occurs in human HH neurons.
20           GABAARs displayed an ATP-dependent rundown and a low sensitivity to Zn2+.
21  with the Q559K mutant that shows no current rundown and less outward rectification in excised patch,
22                              Here we examine rundown and MgADP activation of wild-type and Kir6.2-F33
23  functionally with SUR2A to modulate channel rundown and MgADP activation.
24 t of mutating the adjacent residue, G334, on rundown and MgADP activation.
25                                 In contrast, rundown and MgADP reactivation of wild-type and Kir6.2-G
26 egment, a region implicated in use-dependent rundown and NMDA channel inactivation.
27  The purines, ATP and adenosine, control the rundown and termination of swimming in the Xenopus embry
28 nhibition appeared to be a result of channel rundown and was not seen in whole-cell recordings.
29        Refuelling kinases with Mg-ATP slowed rundown, and combining ATP with a PLC inhibitor further
30 epletion of the RRP contribute to STP during rundown, and for low stimulation rates, F2 can also cont
31 speed of end plate potential (EPP) amplitude rundown, and greatly slowed the recovery from synaptic d
32 , synthetic PIP(2) rescued the current after rundown, and the application of PIP(2) modulating agents
33 reported that TMEM16A currents exhibit rapid rundown at high intracellular Ca(2+) concentrations, pro
34 e of A6 distal nephron cells showed a sudden rundown beginning at 4 min after forming the inside-out
35 related inhibitory peptide each prevents the rundown; blockade of the phosphatase calcineurin with ei
36 ases or refuelling kinases with Mg-ATP slows rundown but does not fully prevent it.
37  We propose that PIP(2) protects I(CAN) from rundown by interacting directly with underlying ion chan
38 of PIP(2) using beta-glycerophosphate slowed rundown by nearly 3-fold.
39 hed the function of ATP-Mg in restoration of rundown channel activity, demonstrating that PIPs produc
40 P-Mg underlies ATP-induced activation of the rundown channel.
41  Thapsigargin and ryanodine each inhibit the rundown, demonstrating further a requirement for calcium
42                         Manifestation of the rundown depends in part on the loss of intracellular com
43                                          The rundown depends on calcium influx through the receptors
44 but slower in light response and has greater rundown, fails these tests.
45                   The channel exhibits rapid rundown following patch excision with Po decreasing from
46 tly, functional GABA(A) receptor (GABA(A) R) rundown has been described in surgically resected human
47 plication of diC8-PIP(2) and Ca(2+) prevents rundown, highlighting the dual role of Ca(2+) in channel
48  TMEM16A currents undergo Ca(2+)-accelerated rundown in excised inside-out patches due to PIP(2) depl
49 overexpression of NCS-1 resulted in a faster rundown in exocytosis.
50 e, paired synaptic facilitation, or synaptic rundown in longer trains.
51 entration, with elevated Ca(2+) accelerating rundown in part by activating membrane-associated phosph
52 SP activation and different rates of current rundown in ruptured patch recordings.
53                             The resetting of rundown in the motor systems can be reformulated as an a
54 at 40-second intervals) induced GABA current rundown in Xenopus oocytes microinjected with HH membran
55 2+ channels, because a similar degree of ICa"rundown" in control cells did NOT result in fracturing o
56 d by a biphasic increase and then decrease ("rundown") in open probability.
57                                 Such current rundown is common among channels regulated by phosphatid
58                    We found that the rate of rundown is modulated by intracellular Ca(2+) concentrati
59 lular components via dialysis because little rundown is seen if perforated patch-clamp recording is u
60 ged stimulation in inside-out patches; this "rundown" is due to PIP(2) depletion.
61                           Conversion of post-rundown K[ATP] channels to the spontaneously operative c
62 g gelsolin, as a result of decreased current rundown; kainate-induced currents were similar in neuron
63 nvestigated how intracellular Ca(2+) affects rundown kinetics of TMEM16A currents by performing insid
64 PSCs, evoked EPSCs, paired pulse plasticity, rundown kinetics upon intense activity and the readily r
65                                              Rundown may be a marker for impaired GABAergic function
66                                              Rundown occurred even if PMA was applied before changing
67 s revealed that PEA selectively affected the rundown of ACh currents in epsilon-AChRs.
68 cell recordings to measure the use-dependent rundown of ACh-evoked currents.
69               5) Cytochalasin D, added after rundown of alpha,beta,gamma-rENaC activity following ATP
70  functional assays, inhibitors of PP2A block rundown of basal CFTR currents and increase channel acti
71 ion by proton currents and are unaffected by rundown of Ca2+ current.
72 ysis proved impractical because of the rapid rundown of calcium channel currents.
73 his channel found in vivo is closed to avoid rundown of cation gradients across the plasma membrane a
74 in cell-attached patches, and each prevented rundown of channel activity when the membrane patch was
75 hat helps regulate PIP5 kinases, accelerated rundown of cytoplasmic Ca(2+) oscillations, and these co
76 anisms have been shown to be involved in the rundown of different ion channels.
77                            Finally, level of rundown of DRN activity co-segregates with extent of beh
78 rotransmission occurred and a faster rate of rundown of EPPs were apparent.
79  greatly attenuated or reversed the observed rundown of expressed channels.
80                                   Functional rundown of GABA currents was significantly attenuated by
81 lly resected human HH demonstrate functional rundown of GABA(A) R-mediated transmembrane currents in
82 nAChR blockade in hippocampal slices reduced rundown of GABAA receptor-mediated whole-cell responses,
83 n the ability of a nucleotide to prevent the rundown of IM and its ability to inhibit calcineurin pho
84 mics, testing the 'unifying hypothesis' that rundown of inhibitory SK responses at resting membrane p
85  Disappearance of the functional activity or rundown of ion channels upon patch excision in many cell
86          All three approaches indicated that rundown of Kir6.2-F333I/SUR2A channels is due to a reduc
87 chanisms have been reported to contribute to rundown of L-type channels, the mechanism of rundown of
88 n-derived neurotrophic factor alleviates the rundown of neurotransmission during high activity.
89 rundown of L-type channels, the mechanism of rundown of other types of VGCC is poorly understood.
90 pression of synaptic strength, observed as a rundown of postsynaptic potential amplitudes, can also d
91 rm minimizes problems associated with modest rundown of response amplitude during the experiment.
92  nor ATP with heat-inactivated PKC rescued a rundown of SOC.
93 inhibited UDP-induced channel activity after rundown of spontaneous channel openings.
94 , and its antagonist adenosine, regulate the rundown of swimming and we therefore proposed that ecton
95                                          The rundown of swimming was reset in a manner similar to tha
96 nactivation, recovery from inactivation, and rundown of the Ca(2+) current.
97                                        After rundown of the Ca(2+) signals following leukotriene rece
98                                          The rundown of the channel is prevented by lipid phosphatase
99 d wortmannin's inhibitory effect, but slowed rundown of the ImAHP and IsAHP .
100                 In this Review, we provide a rundown of the rapidly expanding toolbox for CRISPR-base
101 rectifying K+ channels show an ATP-dependent rundown of their activity.
102 mate decarboxylase led to rapid and complete rundown of transmission, whereas increasing GABA synthes
103 0-second intervals) induced a time-dependent rundown of whole-cell currents in small HH neurons, wher
104                    After an initial in-depth rundown on the pharmacodynamics of the substances involv
105 vated the human TRPV6 channels after current rundown only in the presence of Mg(2+).
106  addition, decreased open probability due to rundown or sulfonylureas caused an increase in ATP sensi
107                              We examined the rundown process of the plant hyperpolarization-activated
108 aptic currents would be long-lasting but may rundown quickly under high-frequency activation.
109                                              Rundown rate increases with intracellular Ca(2+) concent
110                                    The fast 'rundown rate' of the M-current recorded in rat superior
111                                         This rundown reflects persistent intrinsic modulation of VGCC
112 he inhibitory action of glyburide lost after rundown, suggesting that the response of the channel to
113    NBCe1-A currents exhibited time-dependent rundown that was inhibited by removing Mg(2+) in the pre
114 rty of plant shaker-type K+ channels is the 'rundown' that causes channel closure upon membrane excis
115 vation results in channel desensitization or rundown, the mechanism of which is unclear.
116 c alkaline phosphatase (ALP) accelerated the rundown time course.
117 which inhibits ALP activity, slowed the KAT1 rundown time course.
118 e of excised patches sped up TMEM16A current rundown to nearly twice as fast.
119 s, whereas large HH neurons showed much less rundown using the same protocol.
120                                              Rundown was evoked by substituting NMG+ for Na+, showing
121 nging to high [K+] solution, indicating that rundown was independent of PKC activity.
122                                   Functional rundown was not observed in HH neurons with repetitive e
123                                  This sudden rundown was prevented by addition of anionic phospholipi
124                               Following this rundown, we show that the application of a synthetic PI(
125 ha7-containing receptors undergo substantial rundown when the receptors are repeatedly challenged wit
126 ments with phalloidin partially prevents the rundown, whereas collapse of actin filaments with latrun
127 wing evoked fluorescence changes had intense rundown, whereas less than 5% of SnFR-gamma2 ROIs did.
128 conformation; this probably reflects channel rundown, which is the gradual loss of channel activity t

 
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