ライフサイエンスコーパス: sIgA

1 sIgA Abs also visibly reduced toxin binding to the lumin

2 sIgA binding and retro-translocation by M cells was char

3 sIgA less than 2637 mug/g had a negative predictive valu

4 sIgA may be a useful tool for clinicians in timing OFC.

5 sIgA treatment resulted in rapid immune exclusion of pil

6 sIgA was quantified in infant stool (mean age 3.7 months

7 sIgA were higher in allergic than in tolerant patients:

8 Hcbetatre-Ad2F-immunized mice produced a sIgA response equivalent to mice coimmunized with CT.

9 ds to both human secretory immunoglobulin A (sIgA) and complement factor H (FH).

10 In addition, secretory immunoglobulin A (sIgA) antibodies were detected in the saliva and mucosal

11 PspK bound human secretory immunoglobulin A (sIgA) but not the complement regulator factor H and did

12 between natural secretory immunoglobulin A (sIgA) capsular antibodies in breast milk and the occurre

13 termine if stool secretory immunoglobulin A (sIgA) concentrations in children with AGE increase more

14 lactoferrin, and secretory immunoglobulin A (sIgA) in human milk of a subsample of 250 mothers.

15 ated circulating secretory immunoglobulin A (sIgA) in KD patients, as well as elevated sIgA and IgA d

16 Secretory immunoglobulin A (sIgA) plays an important role in gut barrier protection

17 al peptides, and secretory immunoglobulin A (sIgA) protect the intestinal mucosa against infection.

18 Secretory immunoglobulin A (sIgA) represents the immune system's first line of defen

19 actoferrin (LF), secretory immunoglobulin A (sIgA), basal lipase (BL), cytokine TGF-2, vitamin C and

20 actoferrin (LF), secretory immunoglobulin A (sIgA), basal lipase (BL), cytokine TGF-2, vitamin C and

21 e of whole human secretory immunoglobulin A (sIgA), M6 protein-specific sIgA, and M6 protein-specific

22 olves intestinal secretory immunoglobulin A (sIgA).

23 ial extracts were assayed for bound amylase, sIgA, lactoferrin, and lysozyme.

24 remes for unstimulated whole saliva amylase, sIgA, lactoferrin, and lysozyme in an initial screening

25 erum of Group A (p = .047 and p = .0039) and sIgA(2) to Phl p in Group B (p = .032 and p = .0098) at

26 t component, containing amylase activity and sIgA, bound to hydroxyapatite to promote adhesion of S.

27 Calprotectin, EDN, and sIgA were comparable in tolerant patients and controls.

28 for the first time that although both FH and sIgA binding has been localized to the alpha-helical dom

29 Thus, we conclude that FH and sIgA can bind concurrently to the alpha-helical region o

30 cally, preincubation of D39 with both FH and sIgA led to a 21-fold increase in adherence.

31 In this study, we investigated FH- and sIgA-mediated pneumococcal adherence to human cell lines

32 ble to induce the production of EHEC IgG and sIgA in sera and feces.

33 ociated with enteropathy and (with LOCID and sIgA) liver disease.

34 ithelial cells were treated with SPD-MAA and sIgA and TGF-B was measured.

35 ied whole sIgA, M protein-specific sIgA, and sIgA preabsorbed with M protein were able to decrease si

36 bulin) immunoglobulin (sIg [sIgE, sIgG4, and sIgA]) levels relative to the long-term outcomes of milk

37 ols correlated with a decrease in antifungal sIgA antibody titre with affinity to two hyphae-associat

38 Our findings indicate that antifungal sIgA produced in the gut can play a role in regulating i

39 These PspC variants bind FH yet fail to bind sIgA.

40 Both sIgA and IgG antibodies compete for the attachment of so

41 Analysis of the human gut mycobiota bound by sIgA revealed a preference for hyphae, a fungal morphoty

42 he binding of FH to PspC is not inhibited by sIgA.

43 Milk casein sIgA differed in the long term among high-milk consumers

44 4/IgE levels increased, and long-term casein sIgA was highest compared with the low-dose and avoidanc

45 At 100-fold molar excess concentration, sIgA (but not IgG) Abs inhibited ricin attachment to the

46 Inflammatory markers (FC, CRP, sIgA, HBD-2, Fel-1) were not correlated with symptom sev

47 Decreased sIgA and increased TGF-B were observed in bronchoalveola

48 n mucosal epithelium, resulting in decreased sIgA transcytosis to the mucosa.

49 ll TGF-B, down-regulates pIgR, and decreases sIgA transcytosis.

50 ssion of epithelial cell pIgR and decreasing sIgA.

51 Women with cholera did not develop sIgA anti-CtxB responses in serum.

52 ound that a portion of the microbiota-driven sIgA response is induced by and directed towards intesti

53 d Th2 cytokines and production of fecal EHEC sIgA, with pVAX-56.2 reducing EHEC cecum colonization.

54 A (sIgA) in KD patients, as well as elevated sIgA and IgA deposition in vascular tissues in a mouse m

55 Endogenous sIgA was found associated with the apical membrane of co

56 patients showed abnormal levels of CRP, FC, sIgA, HBD-2, and Fel-1 compared to standard thresholds.

57 stress symptom trajectories and infant fecal sIgA concentrations.

58 Very low fecal sIgA concentrations were more common in infants of mothe

59 elivered offspring who exhibited lower fecal sIgA concentrations especially in later infancy.

60 sIgA was bound at UC; strain differences for sIgA were inconsistent across sites.

61 To determine mechanisms for sIgA deficiency, we examined intrinsic and extrinsic asp

62 Furthermore, sIgA had an additive effect on adherence to HUVEC; speci

63 a live HCMV vaccine, 8 had IgG to gB, 4 had sIgA, and 2 had mucosal IgA in samples collected 10-20 m

64 seropositive adults, 10 had IgG to gB, 5 had sIgA, and 0 had mucosal IgA.

65 ents of a gB vaccine, 8 had IgG to gB, 7 had sIgA, and 7 had mucosal IgA in samples collected just be

66 ntrast, nonspecific high rates of anti-hsp60 sIgA antibodies suggest chronic or repeat stimulation fr

67 model system of intestinal epithelia, human sIgA and IgG contribute to the uptake of V. cholerae by

68 vo, pneumococci were preincubated with human sIgA before intranasal challenge in a mouse model of col

69 Previous work has identified sIgA and sIgT as mediators of gut homeostasis.

70 Secretory IgA (sIgA) Abs are polymeric Igs comprised of two or more IgA

71 with Hcbetatre produced weak secretory IgA (sIgA) and plasma IgG Ab response.

72 secretions were analyzed for secretory IgA (sIgA) antibody against the B subunit of cholera toxin (C

73 its, bind and retro-transport secretory IgA (sIgA) from the tear film.

74 ht salivary antigen and (iii) secretory IgA (sIgA) light chain and alpha-amylase.

75 Secretory IgA (sIgA) plays a critical role in providing protection agai

76 t differences for tear IgA or secretory IgA (sIgA) reactivity to hsp60 or for tear sIgA and IgG react

77 immunization routes elicited secretory IgA (sIgA) responses at multiple mucosal sites.

78 n of FlaA-specific intestinal secretory IgA (sIgA) responses required immunization with higher doses

79 the immunoglobulins (Ig)G and secretory IgA (sIgA) that function together in host defense.

80 ilic derived neurotoxin), and secretory IgA (sIgA) underwent comparative paired analysis.

81 , including factor H (FH) and secretory IgA (sIgA) via the secretory component.

82 and zinc bound to human milk secretory IgA (sIgA) was investigated.

83 B) neutralize, levels of IgG, secretory IgA (sIgA), and mucosal IgA1 antibodies to HCMV were measured

84 kers fecal calprotectin (FC), secretory IgA (sIgA), beta-defensin 2 (HBD-2), fecal elastase (Fel-1),

85 ency of B-lymphocyte-produced secretory IgA (sIgA), the primary effector molecule of mucosal immunity

86 the levels of SFB coated with secretory IgA (sIgA), which resulted from the significantly different l

87 rotein, by naturally acquired secretory IgA (sIgA).

88 decreased levels of anti-MAA secretory IgA (sIgA).

89 The role of specific IgA (sIgA) in oral immunotherapy (OIT) and natural tolerance

90 ceptor for secretory immunoglobulin A (IgA) (sIgA) facing the lumen of the epithelial surfaces.

91 nst albumin, amylase, carbonic anhydrase II, sIgA, IgG, IgM, lactoferrin, lysozyme, proline-rich prot

92 Biomarkers of innate salivary immunity (sIgA and alpha-amylase), antimicrobial proteins (AMPs, i

93 and placebo groups in the median changes in sIgA concentrations when comparing day 0 to day 5 median

94 receptor) knockout mice showed no changes in sIgA.

95 ccines currently under development to induce sIgA responses warrant investigation as potential mediat

96 a significant correlation of vaccine-induced sIgA titers in rectal secretions with delayed acquisitio

97 tory was associated with reduced mean infant sIgA concentrations (beta=-0.07, P < .01) and a two fold

98 iated with microbial induction of intestinal sIgA.

99 ble to produce and secrete covalently joined sIgA.

100 Significantly less sIgA was bound at UC; strain differences for sIgA were i

101 The implications of lowered sIgA concentrations in infant stool are altered microbe-

102 human HAEC observations of decreased luminal sIgA and mouse models of other inflammatory bowel diseas

103 The presence of antibodies (mainly sIgA) in the lumen of the small intestine led us to expl

104 When comparing measured sIgA concentrations between days 0 and 5, we found no tr

105 g the dysbiotic microbiome and pIgR-mediated sIgA transport as potential therapeutic approaches in pr

106 RPs), statherins, and histatins but not MG1, sIgA, secretory component, or cystatins.

107 trations in infant stool are altered microbe-sIgA interactions, greater risk for C difficile coloniza

108 Breast milk sIgA capsular antibodies were associated with lower risk

109 Normally, sIgA is the product of two different cell types with hea

110 Characterization of sIgA affinity and polyreactivity showed that hyphae-asso

111 Significant levels of sIgA against goat IgG were present in tears of pre-immun

112 vide a mechanism for the decreased levels of sIgA observed in smokers who misuse alcohol.

113 d from the significantly different levels of sIgA obtained from the mothers' milk during the suckling

114 This lowering of sIgA yielded a large effect size in older infants (4-8 m

115 -immunized mice showed a more rapid onset of sIgA and plasma IgG Ab responses that were supported by

116 The presence of sIgA enhanced adherence to SK-MES-1 6-fold and to pharyn

117 e to efficiently produce large quantities of sIgA of defined specificity in mammalian cells.

118 pression could be reversed by stimulation of sIgA+ B cells with fibroblasts expressing CD40L; such a

119 The increased susceptibility of sIgA+ B cells, but not of sIgM+/sIgD+ B cells, to Ig cro

120 ti-IgA-dextran pretreatment had no effect on sIgA+ B cell survival.

121 Cigarette smoke and alcohol co-exposure on sIgA and TGF-B in human bronchoalveolar lavage fluid and

122 tration of amino acids, fat, lactoferrin, or sIgA between the study arms.

123 low serum immunoglobulin (sIg), particularly sIgA, whereas noninfectious complications and disease se

124 Ig receptor cross-linking renders postswitch sIgA+ B cells unresponsive to subsequent stimulation via

125 e IgM+ (sIgM+/sIgD+) B cells and postswitch (sIgA+) B cells.

126 suckling period and, later, of self-produced sIgA in the small intestine.

127 We demonstrate that purified sIgA+ B cells pretreated with anti-IgA-dextran at low co

128 its importance in gut bacterial regulation, sIgA targets the uniquely fungal phenomenon of hyphal fo

129 minant Ig type in gastrointestinal sections, sIgA Abs are centrally important in adaptive immunity to

130 Serum sIgA remained unchanged after OIT.

131 Serum sIgA to ovalbumin and ovomucoid were determined at inclu

132 Induction of serum sIgA(1) to Phl p was seen in Groups A and B, albeit the

133 No specific trend on serum sIgA was observed in five PEA-EA who developed natural t

134 TEA and PEA had similar serum sIgA.

135 We aimed to study serum sIgA in induced and natural tolerance to egg.

136 Thus, serum sIgA seems not to be associated with induced or natural

137 )), L-selectin(int/-), and sIgM(+), sIgG(-), sIgA(+/-) lymphocytes.

138 ected with V. cholerae developed significant sIgA anti-CtxB responses in endocervical samples (P< or

139 Pilus-1 binding by specific sIgA led to bacterial agglutination, but adherence requi

140 immunoglobulin A (sIgA), M6 protein-specific sIgA, and M6 protein-specific serum IgG in the inhibitio

141 Purified whole sIgA, M protein-specific sIgA, and sIgA preabsorbed with M protein were able to d

142 es in individuals who acquired RrgB-specific sIgA from prior episodes of colonization with piliated s

143 Although stool sIgA decreased between day 5 and day 28 within both grou

144 The primary endpoint was the change in stool sIgA concentrations on day 5 compared with baseline.

145 Median stool sIgA concentrations did not differ between the probiotic

146 However, despite extensive studies, sIgA structures have remained elusive.

147 y IgA (sIgA) reactivity to hsp60 or for tear sIgA and IgG reactivity to MOMP.

148 tors were bound by these antibodies and that sIgA influenced C. albicans morphotypes in the murine gu

149 A can act as an endogenous adjuvant and that sIgA is important for the antigen-sampling function of M

150 We conclude that sIgA Abs in mucosal secretions may serve as receptor ana

151 In this study, we demonstrate that sIgA Abs may also function in innate defense against ric

152 Here, we demonstrate that sIgA antibodies isolated from pooled healthy human colos

153 nisms of action and of additional roles that sIgA and its components play in human milk.

154 ort previous findings of others showing that sIgA can act as an endogenous adjuvant and that sIgA is

155 The sIgA components were first separated by two-dimensional

156 The sIgA made using this approach has great potential as an

157 The local origin of the sIgA antibodies was further shown by measuring antibodie

158 e led us to explore the participation of the sIgA receptor and antibodies in the interaction of Caco-

159 of the characteristics and properties of the sIgA should elucidate the mechanism leading to this prot

160 eptor ganglioside GM(1) colocalizes with the sIgA receptor in cells of the epithelial monolayer.

161 Conjunctival M cells bind and translocate sIgA from the tear film.

162 Capsular serotype Ia, Ib, III, and V sIgA antibody concentrations were measured using the flu

163 Purified whole sIgA, M protein-specific sIgA, and sIgA preabsorbed with

164 of developing serotypes Ia and III LOD with sIgA concentrations >=0.14 ug/mL and >=2.52 ug/mL, respe

165 Consistent with our previous work, sIgA, pIgR, and IL-4 decreased with PN, whereas the addi