ライフサイエンスコーパス: saddle

1 nvolves the active site and, indirectly, the saddle.

2 orphyrin conformations: planar, ruffled, and saddled.

3 , the porphyrin core is found to be severely saddled.

4 Near a saddle a system moves slowly and the state may be percei

5 ng Design using Dimer Likelihood Estimation (SADDLE), a stochastic algorithm for design of multiplex

6 rt toward the deepest potential wells in the saddle and 5.5-kilometer crater regions.

7 onoids highly accumulated in the funiculi of saddle and black but not yellow cultivars, and immature

8 while the T6 tract bypasses the AMMC via the saddle and forms collaterals terminating in the posterio

9 The estimated numerical contribution of saddled and ruffled components is 0.68:0.32, respectivel

10 an otherwise normal pattern of dorsal orange saddles and lateral blotches, our results indicate that

11 s ligands with DFT retain the characteristic saddling and ruffling only if the protein matrix is take

12 d coat color: yellow (colorless), bicolored (saddle), and black.

13 tructures with linking number of zero (ring, saddle, and ribbon shapes), two (infinitene-like shape),

14 constant Gaussian curvature (spherical caps, saddles, and cones) or zero mean curvature (Enneper's su

15 materials morph into complex shapes, such as saddle, axisymmetric cup, and a plate with waves when su

16 hese orthonormal deformations, which include saddling (B2u), ruffling (B1u), doming (A2u), waving (Eg

17 The melting then rapidly accelerates as the saddle between the two domes gets lower, producing nine

18 For both modelled pulses, the saddle between the two ice domes becomes subject to surf

19 d catheter connected to a laser-lithographed saddle coil at the distal tip.

20 ocatheter prototype with lithographed double-saddle coils at the distal tip was deflected with real-t

21 ex 3D volume microcoils (i.e., solenoids and saddle coils).

22 This mechanism of an ice 'saddle collapse' probably explains MWP-1A and the 8,200-

23 grees ), illustrating the flexibility of the saddle conformation and its dependence on the packing.

24 also shows the macrocycle to be in a mainly saddled conformation, but with a significant ruffled com

25 ImH) complex shows the macrocycle to be in a saddled conformation, with the ligands in perpendicular

26 nalized derivatives in crown-crown and crown-saddle conformations, as well as in complexes with water

27 rown conformer of TTPC was observed, a crown-saddle conformer of TAAC was also assigned in aqueous so

28 In saddle cultivars, PTGS is spatially inhibited in the cen

29 The WAVE complex recruits IRSp53 to sites of saddle curvature but does not depend on IRSp53 for its o

30 ed to produce less than 30% of the wild-type saddling deformation.

31 tions and experiments, we study how the bulk saddle deformations of each hole interact to create defe

32 region known to be sensitive to ruffling and saddling deformations, as well as increased vibrational

33 In addition to NGS, SADDLE-designed primer sets can also be used in qPCR set

34 etween the N-terminal domain and DNA for the saddle diminishes the DNA binding affinity of the full-l

35 (96 cm(-1)) that can be correlated with the saddling distortion observed in the X-ray structure.

36 ctra of porphyrin-protein complexes reveal a saddling distortion of the porphyrin.

37 ppears, probably indicating a decreased heme saddling distortion.

38 , two replacement dolomite phases, and three saddle dolomite phases.

39 also applies to low-dimensional systems with saddle-dynamics.

40 layed by low-dimensional magnetic chaos near saddle equilibria in enhancement of the switching rate.

41 )PC](O), and Re[Br(8)TpFPC](O) revealed mild saddling for one Cl(8) structure and the Br(8) structure

42 both zero (e.g., helices) and nonzero (e.g., saddles) Gaussian curvature geometries.

43 tive (negative) mean curvature or hyperbolic saddle geometries with negative (positive) mean curvatur

44 dle; these are located in regions with local saddle geometry to minimize the nematic distortions and

45 the porphyrin core adopts relatively purely saddled geometry.

46 vature-positive for spheres and negative for saddles-has proven a versatile tool to guide the self-as

47 As saddle height increased, peak stresses decreased.

48 Edge weights endcode the corresponding saddle heights and thus measure the difficulties of thes

49 While PPM-saddle horn distance increased in both groups (1.5+/-1.3

50 espectively; P<0.05 versus preischemia), APM-saddle horn distance increased in Control (1.0+/-1.2 mm;

51 ng; P.001), only slightly decreased the PPM-"saddle horn" distance (0.3+/-0.3 mm reduction; P.03), an

52 smaller versus pre-cinching; P.001), and PM-"saddle horn" distances (0.9+/-0.7 and 1.0+/-0.8 mm reduc

53 apillary muscle from the midseptal annulus ("saddle horn") was greater in CIMR(+) animals: 6.5+/-3.2

54 r (PPM) PM tips and the mid-septal annulus ("saddle horn") were calculated from 3-D marker coordinate

55 d posterior PM tips and mid-septal annulus ("saddle horn") were calculated from the 3-dimensional (3D

56 llary muscle tip distances to midseptal MA ("saddle horn"), and distance of each leaflet marker to th

57 ositioned both PM tips closer to the annular saddle horn.

58 A saddle in megathrust slip separates the northwestern edg

59 It partially shields the DNA binding saddle in octameric TBP, shifting upon dissociation to m

60 the first aspect of the classical "inverted saddle" interstitial direct current waveform of SD.

61 data suggest that the predominant process is saddle inversion accompanied by simultaneous rotation of

62 Saddle inversion becomes slow on the 2D NMR time scale a

63 consistent with the expected J-coupling and saddle inversion dynamics, respectively.

64 A saddle is predicted in the folding progress surface (pro

65 The position of the saddle is sensitive to the intrinsic delta C degrees of

66 individual hemes and show that ruffling, not saddling, is the dominant factor influencing the frequen

67 ts were within 95-98% of human estimates; at Saddle Island, the model estimated 894 seals compared to

68 TBP does not bind DNA using its TATA-binding saddle, it does photocross-link to a 22-bp sequence that

69 ition the ring clearly resembles that of the saddle (K form) of N(4)P(4)Cl(8).

70 Several mutations in the saddle led to a surprising increase in transcription, th

71 ine-rich domain of BCMA and BAFF-R both have saddle-like architectures, which sit on the horseback-li

72 (GPRG(POG)(7)C-carbamidomethyl)(3), mapped a saddle-like binding cleft on CBD.

73 lar) anchoring conditions to induce complex, saddle-like deformations.

74 lometers across, but there is a 10-kilometer saddle-like depression with attributes of a large degrad

75 counterparts, algal blades, have a typical, saddle-like midsurface and rippled edges.

76 omplexity of the lipid bilayer, organized on saddle-like minimal surfaces.

77 estrindane-based polyaromatic compounds with saddle-like structures is reported.

78 The resulting saddle-like structures of NG1 and NG2 are electron-rich

79 R out-of-plane vibrational mode gamma(15), a saddling-like mode that is strong in the wild-type enzym

80 thalpy of unfolding approaches zero near the saddle making the unfolding largely invisible to DSC und

81 Dimeric molecule 20 contains two saddle moieties with very similar conformations, theta =

82 point and the checkpoint is represented by a saddle node loop bifurcation.

83 rges are well-defined mathematical events: a saddle-node and homoclinic bifurcation, respectively.

84 ition from subthreshold activity to spiking, saddle-node and Hopf bifurcation.

85 it occurs through a type of bifurcation - a saddle-node bifurcation - that possesses an intrinsic ir

86 ether occur when the system passes through a saddle-node bifurcation as the probe position is varied.

87 Functionally, the directional saddle-node bifurcation ensures a CPT proceeds towards a

88 tipping point which is a 'ghost' of a nearby saddle-node bifurcation from dynamical systems theory, a

89 slowing down, 2) the scaling laws suggest a saddle-node bifurcation governing slowing down, and 3) t

90 e is a dynamical threshold, resulting from a saddle-node bifurcation mainly determined by IK1 and INC

91 ps involve an efficient search for potential saddle-node bifurcation points using an optimization tec

92 Because of the saddle-node bifurcation, the system can automatically de

93 analyses of static soliton formation through saddle-node bifurcation.

94 etween these regimes occurs as a result of a saddle-node bifurcation.

95 cally, new loops are shown to form through a saddle-node bifurcation.

96 can be understood in terms of an underlying saddle-node bifurcation.

97 furcation, and the competition model has two saddle-node bifurcations (in which case the system exhib

98 By tuning this offset, we induce saddle-node bifurcations from sub-optimal to optimal sol

99 Two saddle-node bifurcations occur for increasing N (mono --

100 on affects cell fate trajectory by modifying saddle-node bifurcations(2).

101 lts from the interplay between pitchfork and saddle-node bifurcations, with predictions validated thr

102 nfiguration changes due to the occurrence of saddle-node bifurcations.

103 ical dynamics were well described by a noisy saddle-node on invariant circle bifurcation with action

104 t disorders at the time of enrollment (e.g., saddle-nose deformity).

105 odes involve the same region of the arms and saddle of HU.

106 The structure shows the prototypical beta-saddle of LAGLIDADG homing endonucleases that is contrib

107 These data suggest that the DNA-binding saddle of monomeric unliganded yeast TBP is only partial

108 cated on the top surface and the DNA-binding saddle of the C-terminal domain differs between TBP and

109 ecially Trp256) are directly involved in the saddling of the porphyrin substrate.

110 is, on the surface opposite the DNA-facing "saddle" of TBP) and onto the side of the first TBP repea

111 Some residues within the DNA-binding "saddle" of the C-terminal domain are protected upon form

112 e four residues surrounding the "DNA binding saddle" of the C-terminal domain.

113 ifest as plaquelike, polypoid, semiannular ("saddle") or annular lesions.

114 Amplicon sequencing of several independent saddle pattern mutants from different genetic background

115 regions of two Clark isolines having similar saddle phenotypes mediated by CHS siRNAs but different g

116 coordinate and the average structure of the saddle point along that coordinate.

117 of the potential energy surface, namely the saddle point and the conical intersection.

118 Recently, a saddle point approximation (SPA) based single-variant te

119 two-dimensional (2D) materials consists of a saddle point connecting electron-like and hole-like band

120 In the absence of a saddle point connecting the skyrmion solution to the fer

121 The saddle point connecting these isomers lies 0.6 kcal/mol

122 The saddle point corresponds to a crossing of two interactin

123 onding with the second H atom, bypassing the saddle point entirely.

124 The recognition that the saddle point governing the HAT mechanism is on the shoul

125 Arising from the extreme/saddle point in electronic bands, Van Hove singularity (

126 of activation from the initial state to the saddle point in PEL and the following step of relaxation

127 ached not in the dispersion minimum but at a saddle point in reciprocal space.

128 leads to the collapse of fully connected 1D saddle point lines around the square centers, due to a s

129 r, it has become increasingly clear that the saddle point of the free-energy surface in most reaction

130 However, the C(s) symmetric second-order saddle point on the B3LYP energy surface is only 0.3 kca

131 tio calculations identified a 'roaming-type' saddle point on the ground state.

132 transition state is a surface, not a single saddle point on the potential energy surface.

133 Trajectories initiated from a protonation saddle point on the potential of mean force surface are

134 different branch of the seam separated by a saddle point on the seam.

135 e the learned Hessians at every step for the saddle point optimizations.

136 Here we show how the saddle point region that connects the two minima is enco

137 amics and the conventional analysis based on saddle point structure.

138 conical intersection structures and relevant saddle point structures are presented for the reactions

139 We found no first-order saddle point structures for "center-to-center" proton tr

140 on average to transverse the region near the saddle point where bonding changes occur.

141 Lateral inhibition is described by a saddle point with many unstable directions.

142 ) structure is a local maximum (second-order saddle point).

143 screte eigenstates (e.g. Dyson's disordered, saddle point, and metabolically active toy cell states).

144 ransition-state region, rather than a single saddle point, contributes to reaction kinetics.

145 protected bound state in the continuum, at a saddle point, thanks to coupling of this electromagnetic

146 e distance at the conventional isomerization saddle point, which is a strong indicator of 'roaming'.

147 th the smallest spacing are localized at the saddle point.

148 illation frequency decreasing to zero at the saddle point.

149 o equilibrium C2h configurations via the D2h saddle point.

150 y barriers, such as the width of the barrier saddle-point or the presence of parallel paths through m

151 in a problem statement similar to that of a saddle-point problem.

152 Gs exhibit and phrase it as a convex-concave saddle-point problem.

153 The emergence of saddle-point Van Hove singularities (VHSs) in the densit

154 plane N-inversion correspond to second-order saddle points (SOSP) on the potential energy surface.

155 eme and prove that it can effectively escape saddle points and ensure convergence to a second-order s

156 in two dimensions, resulting from high-order saddle points and exhibiting power-law divergent density

157 -from the ground state, through intermediate saddle points and finally to the configurations of separ

158 y surface (such as multiple minima, valleys, saddle points and ridges) that correspond to characteris

159 tive energetic accessibility of the reaction saddle points and the D0/D1 conical intersection seams.

160 c alveolar flow--characterized by stagnation saddle points associated with alveolar vortices--governs

161 ectronic dispersion whose miniband edges and saddle points can be reached by electrostatic gating.

162 frequencies corresponding to the first-order saddle points corresponding to endo-TS1 and exo-TS1 allo

163 These structures, formally saddle points for concerted displacements on the potenti

164 First-order saddle points for the proton transfer from H3S+ to both

165 es, eigenstates well above the isomerization saddle points have been characterized.

166 n seam of the two lowest states and reaction saddle points located on the shoulders of this seam.

167 s in periodic systems due to the presence of saddle points of energy dispersion in momentum space.

168 in the atomic displacements and stresses at saddle points of the potential energy landscape, we show

169 ost of the time in stasis in the vicinity of saddle points on the fitness landscape.

170 Identifying transition states-saddle points on the potential energy surface connecting

171 All sandwich dimers (4a-e) are found to be saddle points on the potential energy surfaces.

172 model reveal topological surface states with saddle points that are located in the vicinity of a Dira

173 are predicted to be second- or higher-order saddle points that lie more than 40 kcal/mol higher than

174 s into two degenerate I = 1 Dirac cones, and saddle points with a linear Dirac spectrum emerge.

175 unction has multiple intermediate states and saddle points, and is hence a "rough" free energy landsc

176 gions of singularities, such as vortexes and saddle points, due to poor expressiveness.

177 the structural resemblances of both types of saddle points, significant differences are found in term

178 nvex optimization is avoiding convergence to saddle points, which significantly degrade optimization

179 tric and energetic proximity to the reaction saddle points.

180 surface is a complex terrain of valleys and saddle points.

181 mediate states correspond to local minima or saddle points.

182 appears to reflect a dual origin: a strongly saddled porphyrin skeleton, which alleviates electrostat

183 Two radiologists selected those with saddle pulmonary embolism and evaluated the clot burden

184 gh ominous in appearance, most patients with saddle pulmonary embolism are hemodynamically stable and

185 Most patients with saddle pulmonary embolism found on computed tomography a

186 Two of 37 saddle pulmonary embolism patients (5.4%) died in the ho

187 Saddle pulmonary embolism represents a large clot and a

188 Saddle pulmonary embolism was found in 37 of 680 patient

189 For patients with saddle pulmonary embolism, the median age was 60 yrs and

190 Her course was complicated by another saddle pulmonary embolus, heparin-induced thrombocytopen

191 ocus, which restrict pigment to the hilum or saddle region of the seed coat, respectively.

192 ecifically in the central region of immature saddle seed coat and inhibited the dicing activity of DC

193 tion, increased height (P<0.001), and deeper saddle shape (ratio of height to intercommissural diamet

194 s increased, a long flat lamina deforms to a saddle shape and/or develops undulations that may lead t

195 a complex structure with a three-dimensional saddle shape annulus.

196 Late-systolic MVD annular saddle shape deepened but annular area excessively enlar

197 Flattening of the annular saddle shape is associated with progressive leaflet bill

198 The fact that the saddle shape is conserved across mammalian species provi

199 The saddle shape of the mitral annulus confers a mechanical

200 The saddle shape of the mitral annulus imparts a more subtle

201 l significant nonplanar distortions (i.e., a saddle shape) and remarkably large Stokes-shifted emissi

202 (P<0.0001) indicating flattening of annular saddle shape, redundant leaflet surfaces (P<0.0001), gre

203 The p180C adopts an elongated asymmetric saddle shape, with a three-helix bundle in the middle an

204 D, but height was similar resulting in lower saddle shape.

205 Our 1D simulations reproduce the "inverted saddle" shape of the extracellular voltage signal for th

206 he annulus remained dynamic without systolic saddle-shape accentuation (P=0.30).

207 MD versus FED display poorer contraction and saddle-shape accentuation in early systole and abnormal

208 MVD annulus remains dynamic without systolic saddle-shape accentuation.

209 ction (P=0.99), height increase (P=0.11), or saddle-shape deepening (P=0.35).

210 ion with early-systolic area contraction and saddle-shape deepening contributing to mitral competency

211 loss of early-systolic area contraction and saddle-shape deepening despite similar magnitude of vent

212 ural diameter ratio, which appraises annular saddle-shape depth) were measured throughout the cardiac

213 P, ZnTTFP, and CuTTFP revealed that a severe saddle-shape distortion was observed with the dithiole r

214 a self-complementary dimer comprised of two "saddle shaped" complexes.

215 ions the CLEC-2N structure face down in the "saddle"-shaped binding site which lies between the aggre

216 n=12), rigid, complete St Jude Medical rigid saddle-shaped (n=12), Carpentier-Edwards Physio (n=12),

217 ramework structure consists of unprecedented saddle-shaped [Be(12)(OH)(12)](12+) rings connected thro

218 nular phantoms encompassing flat to markedly saddle-shaped annular heights.

219 ble band (COS; n=12), St Jude complete rigid saddle-shaped annuloplasty ring (RSA; n=10), Carpentier-

220 , strains increased significantly with rigid saddle-shaped annuloplasty ring, Carpentier-Edwards Phys

221 ncremental unwinding of an initially twisted saddle-shaped apoA-I double belt structure.

222 aphylococcus aureus strains and some showing saddle-shaped binding to the active site of protein-tyro

223 s to account for cell division planes in the saddle-shaped boundary region.

224 nes have mobile joints and are arranged in a saddle-shaped configuration, as in the mobile linkage of

225 double belt structures with the same general saddle-shaped conformation of both our previous molecula

226 The Si-TPP complex presents a saddle-shaped conformation that is stable under STM mani

227 ne)-9, 10-dihydroanthracene moieties adopt a saddle-shaped conformation.

228 duced in the luminal domain which binds to a saddle-shaped crevice on a distal tip of BoNT/B.

229 the individual lipid leaflets have the same saddle-shaped curvature as the hypothetical stalk-interm

230 annulene-based discotic LC compound 6 with a saddle-shaped cyclooctatetrathiophene core has been synt

231 of FliN from Thermotoga maritima revealed a saddle-shaped dimer formed mainly from beta strands.

232 bridization change in the former case versus saddle-shaped distortion originating from conflicting in

233 tween the domains and are perpendicular to a saddle-shaped DNA binding surface, formed by two four-st

234 A series of saddle-shaped donor-acceptor n-systems, termed TTFAQ-AQs

235 nation of open structures and doubly curved, saddle-shaped edges.

236 and release, which we explain in terms of a saddle-shaped exoskeletal spring mechanism.

237 n separately converted, in six steps, to the saddle-shaped fenestrindane derivatives in optically pur

238 " of some amphibians and amniotes, lacking a saddle-shaped flare on one wall of the ampulla.

239 eometry of the parent compounds into a novel saddle-shaped fold in which all four backbone NH groups

240 ne are both flexible pai-molecules and adopt saddle-shaped geometry of C(2) and D(2 d) symmetry, resp

241 gated waveguide array that supports a unique saddle-shaped high-Q dispersion band-parabolic along the

242 ), it has been proposed that D-shaped versus saddle-shaped mitral annulus (MA) segmentation is more b

243 1 and 7 carbons of a fifth PDI to produce a saddle-shaped molecule (PDI(5)).

244 Functionalized derivatives of the saddle-shaped molecule tetrabenzo[8]circulene were succe

245 eling analysis which (1) identified a common saddle-shaped nucleophilic region on the surfaces of bot

246 been proposed to generate compression in the saddle-shaped organ-meristem boundary domain.

247 Conversion from a discoidal to a saddle-shaped particle involves loss of helicity and for

248 helicity provide additional support for the saddle-shaped particle model.

249 down and equilibration further supports the saddle-shaped particle model.

250 hthacene has also been determined; this is a saddle-shaped polycyclic aromatic hydrocarbon.

251 Minor-groove recognition by the saddle-shaped protein induces the same conformational ch

252 siological three-dimensional shapes, but not saddle-shaped rigid rings or flexible bands, increase AM

253 Relaxation back into saddle-shaped structures after cool down and equilibrati

254 Saddle-shaped structures are present in each protein tha

255 Their dimeric, saddle-shaped structures support the proposal that 14-3-

256 y, and the macrocycles adopt highly deformed saddle-shaped structures.

257 two active centers that bind pterins, and a saddle-shaped surface that resembles nucleic acid bindin

258 Further coalescence of saddle-shaped surfaces leads to diverse topologically di

259 e rods transforms disk-shaped membranes into saddle-shaped surfaces with complex edge structures.

260 lication and fusion events have produced the saddle-shaped TBP molecule, with its two direct-repeat s

261 l dimerization domain of SIP sits across the saddle-shaped upper surface of Siah1, with two extended

262 nt stimulation, we discovered characteristic saddle-shaped VF* maps that were in excellent agreement

263 A "saddle-shaped" mitral annulus with an optimal ratio betw

264 TA, which appeared to be different from the "saddle-shaped" mitral annulus, suggesting an annuloplast

265 ide a complete description of folding smooth saddle shapes from concentrically pleated squares.

266 lipid bilayers is sensitive to kappa(m), the saddle splay (Gaussian curvature) elastic modulus of the

267 edge, this is the first determination of the saddle splay (Gaussian) modulus in a lipid system consis

268 o only marginally stable against spontaneous saddle splay deformation, which is incompatible with lon

269 eory is extended to account for nonvanishing saddle splay modulus within lipid monolayers and perturb

270 e explain after considering the influence of saddle splay on the elastic free energy.

271 for measuring M, the ratio of the Gaussian (saddle splay) elastic modulus to the bending elastic mod

272 ic membranes: defensins selectively generate saddle-splay ("negative Gaussian") membrane curvature in

273 membranes by generating topologically active saddle-splay ("negative Gaussian") membrane curvature th

274 ase higher than that of the L(d) phase and a saddle-splay (Gauss) modulus difference with the Gauss m

275 tually have an intrinsic propensity to adopt saddle-splay arrangements, characterised by the elastic

276 tor deformations, can be rationalized by the saddle-splay contribution to the free energy.

277 The enhancement of saddle-splay curvature generation and relaxation of lipi

278 we show that the requirement for generating saddle-splay curvature implies that a decrease in argini

279 adened the range of lipid compositions where saddle-splay curvature was induced.

280 where more subtle, patterned surfaces enable saddle-splay effects to be both observed and exploited.

281 s of the spontaneous twist, we determine the saddle-splay elastic constant for chromonic liquid cryst

282 For toroidal droplets, we find that the saddle-splay energy screens the twisting energy, resulti

283 ene polymers increased the amount of induced saddle-splay membrane curvature and broadened the range

284 A mechanism of action based on saddle-splay membrane curvature generation is broadly en

285 Importantly, saddle-splay membrane curvature generation places constr

286 weak, but directional, fields switch between saddle-splay-motivated, spontaneously-polar surface stat

287 f the system, in the vicinity of an unstable saddle steady state that separates the basins of attract

288 bution of a ruffled component in the overall saddled structure compared to all other complexes in thi

289 res, fire balloons, flowers, concave lenses, saddle surfaces, waterdrops, and rodents, illustrate the

290 ationary points-successive minima, joined by saddles-that rise monotonically in energy from basin bot

291 upon dissociation to monomers to expose the saddle to DNA.

292 ometries of the porphyrin cores (from purely saddled to saddled with 30% ruffling).

293 mplex models and big data we anticipate that saddle-transitions will be encountered frequently in the

294 mandibular, full-thickness, alveolar ridge, saddle-type defects following surgical implantation of r

295 In fact, the saddle-type mechanism also applies to low-dimensional sy

296 ntly encounter an additional non-bifurcative saddle-type mechanism leading to critical transitions.

297 We develop an early warning sign for the saddle-type transition.

298 The two enantiomeric pairs of saddles were characterized by (1)H and (13)C NMR spectro

299 the porphyrin cores (from purely saddled to saddled with 30% ruffling).

300 Young faculty members in surgery are saddled with many clinical time constraints that often a