ライフサイエンスコーパス: safeguard

1 at youthful skin was designed to envelop and safeguard.

2 , intercellular signaling, and proliferative safeguards.

3 ries exert an important function as promoter safeguards.

4 etween excessive and insufficient procedural safeguards.

5 will provide an invaluable tool for nuclear safeguards.

6 ed and eliminated, and tissue homeostasis is safeguarded.

7 AD as an essential proteostasis mechanism to safeguard a healthy stem cell pool by regulating the ste

8 ntacts with multiple regulatory elements and safeguards a complex regulatory program of its target ge

9 Which genes safeguard accurate progression through meiosis is largel

10 ble role of ZFP36L1 as a posttranscriptional safeguard against aberrant hypoxic signaling and abnorma

11 called "critical propagule," which acts as a safeguard against accidental release.

12 To safeguard against an imbalance between supply and demand

13 Additionally, to safeguard against any confounding effects of altered pla

14 approaches to enhance antitumor immunity and safeguard against autoimmunity.

15 dividing, these mechanisms provide a second safeguard against brain somatic aneuploidy.

16 mediates the spindle assembly checkpoint, a safeguard against chromosome missegregation and aneuploi

17 f care (facilitate informed decision-making, safeguard against coercion, ensure psychological safety,

18 Natural killer (NK) cells safeguard against early tumor formation by destroying tr

19 We propose that LKB1 acts as a safeguard against HPV-stimulated aerobic glycolysis and

20 ae and preserve long-term renal function and safeguard against ill-effects of hypertension.

21 and it may therefore act as a cell-intrinsic safeguard against inappropriate CTL differentiation and

22 Plants use autophagy to safeguard against infectious diseases.

23 rrelevant auxiliary information, providing a safeguard against inflated false-discovery rates due to

24 e adequate sodium current (I(Na)) reserve to safeguard against numerous threats to reliable cardiac i

25 ate that higher levels of lamin B1 in ANSPCs safeguard against premature differentiation and regulate

26 Pleural manometry is widely used to safeguard against pressure-related complications during

27 UF1-induced immunoregulation, which safeguard against proinflammatory diseases, including NE

28 The observed mechanism seems to be a safeguard against the accumulation of dysfunctional CI a

29 es internal bodily homeostasis and acts as a safeguard against the detrimental effects of stress.

30 We discover a "rule of thumb" to safeguard against the long-term catch depletion of parti

31 Such an evidence-informed value scale would safeguard against the proliferation of low-value innovat

32 he complement system is tightly regulated to safeguard against tissue damage that results from unwant

33 re, regulation by NK cell licensing helps to safeguard against TNFSF14 production in response to heal

34 that error-prone TLS by Poltheta provides a safeguard against tumorigenesis and suggest that cancer

35 ) to provide appropriate medical care, 4) to safeguard against unacceptable discrimination, and 5) to

36 nflated soil organic carbon gains, failed to safeguard against warming from trees at high latitudes a

37 cellular protein homeostasis, ribosomes are safeguarded against dysregulation by myriad processes.

38 s discriminated by intended communicants and safeguarded against the ecological pressures of social e

39 OS regulation promotes differentiation while safeguarding against a hybrid stem-epithelial-B-cell phe

40 processes in physiological angiogenesis and safeguarding against aberrant angiogenic responses.

41 nvironments has become an important task for safeguarding against biological threats and broadening t

42 omains of BubR1 in preventing aneuploidy and safeguarding against cancer.

43 the quiescent state of muscle stem cells by safeguarding against cell-cycle entry and lineage progre

44 he importance of protein immune chaperone in safeguarding against immune pathology.

45 ngs highlight a role for specific snoRNAs in safeguarding against oncogenic insult and demonstrate a

46 ammalian cells, reducing TBC1D15 levels, and safeguarding against proteotoxic challenges.

47 36l1/l2 therefore act as posttranscriptional safeguards against chromosomal instability and replicati

48 e DNA repair with chromosome segregation and safeguards against genome destabilization.

49 in e-liquids over foreseeable storage times, safeguards against high concentrations of metals in the

50 fosters direct monetary relationship with no safeguards against mutual exploitation.

51 myocardial excitability and conduction that safeguards against temperature-sensitive conduction fail

52 To address this question in a manner that safeguards against the confounding effects of altered ma

53 1-Pno1 network establishes a checkpoint that safeguards against the release of immature ribosomes int

54 e-tune the Wnt pathway and provides multiple safeguards against tumorigenesis.

55 g by CRISPR/Cas9 revealed that OCT4 and SOX2 safeguard an accessible chromatin neighborhood to assist

56 and volunteer engagement, while striving to safeguard and encourage opportunities for serendipitous

57 l stress activates a mitonuclear response to safeguard and repair mitochondrial function and to adapt

58 ons will occur under research protocols with safeguards and criteria mandated by the National Institu

59 erials will facilitate maintenance of proper safeguards and ensure safe and efficient processing of m

60 While engineered safeguards and personal protective equipment can reduce

61 he importance of ensuring that the necessary safeguards and policies are in place.

62 RA-based signaling system with robustness by safeguarding appropriate RA concentration despite natura

63 hing consequences on marine food webs unless safeguards are in place to avoid depleting forage fish t

64 Safeguards are needed to protect participants' privacy a

65 l extracytoplasmic glycopeptide polymer that safeguards bacteria against osmotic lysis and determines

66 cellular pathogens to block apoptosis and to safeguard bacterial replicative niches.

67 bee functional genomics and potentially for safeguarding bee health.

68 t therefore focus equally on strategies that safeguard biodiversity and ecosystems.

69 anting targeted conservation partnerships to safeguard biodiversity in an era of global change.

70 Protected areas are intended to safeguard biodiversity in perpetuity, yet evidence sugge

71 on species distributions hamper prospects of safeguarding biodiversity and ecosystem services, and ad

72 nment of particular levels of diversity when safeguarding biodiversity and ecosystems that provide es

73 tual property disputes and in monitoring and safeguarding biosecurity.

74 -seq analyses, we conclude that TET proteins safeguard bivalent promoters from de novo methylation to

75 ionary pressure on the organism to eject the safeguard by spontaneous mutagenesis or horizontal gene

76 s, whereas genes with CpG-poor promoters are safeguarded by methylation.

77 lity of chromosome segregation in mitosis is safeguarded by the precise regulation of kinetochore mic

78 ntigen concentrations binary IL-2 expression safeguards by its spatial distribution selective STAT5 a

79 calcium, and gap junctional conductances to safeguard cardiac conduction.

80 es and features of genomic organization that safeguard cell identity in the context of reprogramming

81 ts of cell polarity factors during ER stress safeguard cell survival and the timely cell-cycle re-ent

82 ions suggests that kinetic barriers exist to safeguard cell-type identity.

83 es, consistent with the role of occlusion in safeguarding cell identities.

84 Unfolded protein responses (UPRs) safeguard cellular function during proteotoxic stress an

85 ty according to brain perfusion levels, thus safeguarding cellular homeostasis by preventing mismatch

86 ation of misfolded proteins, which typically safeguards cellular differentiation and protects cells f

87 How the five proteins work together to safeguard chromosome ends and promote telomere length ho

88 nfiguration(1,2), which has been proposed to safeguard chromosome ends from being recognized as DNA d

89 -generation anthrax vaccines is important to safeguard citizens and the military.

90 id not include the full range of options and safeguards considered here.

91 ng both transcriptional and recombinational "safeguard" control of essential gene function.

92 the safety of these products, but additional safeguards could be implemented, and unlike drugs, there

93 To safeguard current and future generations from the increa

94 indicate robust compensatory mechanisms that safeguard cytoskeleton dynamics at the synapse.

95 Efforts are underway to streamline and safeguard data use.

96 enzymes that play a special protective role, safeguarding DNA from DNDGIC, display a classical half-o

97 y of whole blood donation exist primarily to safeguard donor health.

98 escence (OIS) is considered to function as a safeguard during development of pancreatic ductal adenoc

99 obal environmental standards is essential to safeguard ecological systems and human societies.

100 the registration of systemic insecticides to safeguard ecosystem integrity.

101 uring their registration process in order to safeguard ecosystem integrity.

102 which the resulting carbon-nitrogen feedback safeguards ecosystem carbon sequestration remains unclea

103 containment strategy containing overlapping 'safeguards'-engineered riboregulators that tightly contr

104 ; among those are nuclear forensics, nuclear safeguards, environmental survey, and geosciences.

105 against aberrant processing, 53BP1 and RIF1 safeguard epigenetic integrity at loci that are disrupte

106 Thus, DMD is required to safeguard ER-targeted mRNA translation, intracellular ca

107 species and regions of particular value for safeguarding evolutionary diversity.

108 without the need for genetic engineering to safeguard feed and food supply for the generations to co

109 preservation can be considered an option for safeguarding fertility.

110 sidered, with regular obstetric follow-up to safeguard foetal growth.

111 t effective way to control plant diseases to safeguard food and feed production.

112 al intensification of mainstream farming can safeguard food production, with accompanying environment

113 ovide novel solutions that can contribute to safeguarding food for the rapidly growing human populati

114 laws in some states that provide additional safeguards for genetic data, should reassure patients th

115 , remote protected areas are thought to best safeguard forest elephants by supporting large populatio

116 Conserving tree populations safeguards forests since they represent key elements of

117 of the Ca(2+)-CaMKK2-AMPK signaling axis in safeguarding fork structure to maintain genome stability

118 is how to provide appropriate healthcare and safeguard functionality of a healthcare system that also

119 ths during the remainder of this century and safeguard future generations from the ravages of tobacco

120 To safeguard genome integrity in response to DNA double-str

121 ational pathway that represses metabolism to safeguard genome integrity.

122 on can be separated from a novel function in safeguarding genome integrity.

123 In its DNA repair role, TDP2 safeguards genome integrity by hydrolyzing 5'-tyrosyl DN

124 ing heterochromatin during early development safeguards genome integrity in Drosophila.

125 onent of this fork protection pathway, which safeguards genome stability after replication stress.

126 In addition, SMC1B safeguards genome stability following irradiation wherea

127 Without Knl1 or p53-dependent safeguards, genome-damaged cells are not cleared, allevi

128 ps, implying a role for this modification in safeguarding genomic stability.

129 labor among all family members: p63 and p53 safeguard germ line fidelity, whereas TAp73 ensures fert

130 orming future prospective studies as well as safeguarding guidelines.

131 Although safeguards have been designed to control cell growth by

132 es disease or loss of cell fitness, cellular safeguards have evolved to protect the genome, especiall

133 The fight against fraud to safeguard high-quality productions requires an effective

134 uding AXIN2(+) pericentral hepatocytes, that safeguard homeostasis and repair has been controversial.

135 acrine and circulating regulatory factors-to safeguard homeostasis.

136 This is of special relevance to safeguard human health considering Palythoa species are

137 d sensing of pharmaceutical compounds toward safeguarding human health and ecosystems on a global sca

138 this has been a very successful strategy for safeguarding human health and protecting aquatic ecosyst

139 conservation plans should include efforts to safeguard hundreds of direct-developing amphibian specie

140 of the commons," shared environments will be safeguarded if international cooperation succeeds and de

141 s Gal1 serves as a homeostatic rheostat that safeguards immune tolerance and prevents age-dependent d

142 FOXP3-expressing regulatory T (Treg) cells safeguard immunological tolerance.

143 The staged approach to safeguard implementation revealed mechanisms of escape a

144 th MeV eradication vaccine programs and as a safeguard in oncolytic viral therapy.

145 r sustainability in California may be poorly safeguarded in some places and that the base-of-fresh-wa

146 r inhibit ASMase restore both these critical safeguards in the RPE and avert complement-induced mitoc

147 ft upward, shallow wells may warrant special safeguards, including a mandatory registry of locations,

148 livers an array of bioactive components that safeguard infant growth and development and maintain hea

149 3 SUMO ligase Pli1 acts at arrested forks to safeguard integrity of nascent strands and generates pol

150 , we propose that steady-state CHK1 activity safeguards its stability to maintain intrinsic checkpoin

151 verprescribed or prescribed without adequate safeguards, leading to an alarming rise in medication-re

152 Thus, commensal enteric fungi safeguard local and systemic immunity by providing tonic

153 fectiveness of protection elevation alone in safeguarding long-term viability of tiger habitats.

154 These multilayered safeguards maintain robust growth in permissive conditio

155 ns to Mars and other places, and the need to safeguard martian scientific sites and potential resourc

156 MeaB also safeguards MCM, which uses radical chemistry, against in

157 ss of cell fate decision, and they provide a safeguard mechanism against stem cell proliferation indu

158 of chromosomes to microtubules, an important safeguard mechanism ensuring faithful chromosome segrega

159 These findings reveal an unforeseen safeguard mechanism that prevents extreme fusion of mito

160 esults demonstrate that quiescence acts as a safeguard mechanism to ensure survival of the HSC pool d

161 le assembly checkpoint (SAC) is an essential safeguarding mechanism devised to ensure equal chromosom

162 Safeguard mechanisms can ameliorate the potential risks

163 inducing genomic instability and suppressing safeguard mechanisms for the development of the cerebral

164 that lack of mitochondrial division leads to safeguard mechanisms, induced by transient mitochondrial

165 omes to spindle microtubules and integrating safeguard mechanisms.

166 fficient process, suggesting the presence of safeguarding mechanisms that counteract cell fate conver

167 Loss of HDAC3 in macrophages safeguards mice from lethal exposure to lipopolysacchari

168 ress oxidative stress, enforce survival, and safeguard mitochondrial function in nascent CTLs.

169 Here, we review the pathways that safeguard mitochondrial genomes and examine the insights

170 oadly accepted that protected intact habitat safeguards more biodiversity and generates greater ecosy

171 regulators of WNT and MAPK-ERK signaling to safeguard naive pluripotency.

172 t a central role for intracellular Ca(2+) in safeguarding naive pluripotency.

173 esign transnational conservation policies to safeguard native vertebrates, and ensure that the "empty

174 ale and illustrates their strategic value in safeguarding native biodiversity.

175 se additional herbivore functional groups in safeguarding natural controls of algal growth in times o

176 biodiversity and carbon storage suggest that safeguarding natural habitats for biodiversity protectio

177 and accurately informing development of site-safeguard networks.

178 elin defects in vitro, suggesting that ADAR1 safeguards neural crest derivatives from aberrant MDA5-m

179 witch may constitute a general principle for safeguarding neuronal identity throughout life.

180 nous strategy of functional gene rescue that safeguards neuronal RNA signatures in an ELAV loss-of-fu

181 ghlights the importance of CD4(+) T cells in safeguarding neurons against axonal blebbing and poliomy

182 ion of NMD substrates involves proteins that safeguard normal mRNAs.

183 h marks the nucleosome core on active genes, safeguards normal differentiation of CD8(+) T cells.

184 des unique insights into the mechanisms that safeguard notochord and spine development.

185 we uncover a potential mechanism of how PTEN safeguards NSCs, and establish a cellular platform to id

186 at the disposal of international agencies to safeguard nuclear facilities and to verify the States' c

187 onizes actomyosin contractility, as proteins safeguarding nuclear integrity.

188 in ECs, suggesting that a Hey-lamin network safeguards nuclear organization and differentiated cell

189 estes, behind a protective barrier to ensure safeguarding of germline DNA from environmental insults.

190 gation of such pollution is paramount to the safeguarding of human health, animal and aquatic life, a

191 Identification and safeguarding of patients at risk of violence should be p

192 As such, our results establish SSB1/2 as safeguards of B cell development and unveil their differ

193 RecQ family helicases function as safeguards of the genome.

194 thods applied in, for example, international safeguards or nuclear forensics.

195 ay be used to identify mitigation options to safeguard orchard production against the risk of pollina

196 The immune system safeguards organ integrity by employing a balancing act

197 e and chemotherapeutics are being created to safeguard our future.

198 t) responsibilities to patients to carefully safeguard patient privacy, and to the public to ensure t

199 s should be committed to best practices that safeguard patient safety and the rights of physician-pat

200 regulator Cdx2, suggesting that Sox21 helps safeguard pluripotency.

201 Therefore, the JNK-JUN pathway safeguards pluripotency from precocious DE differentiati

202 major target of miR-92a that constitutively safeguards podocyte cell cycle quiescence.

203 We conclude by discussing implications for safeguarding pollination services in the face of global

204 d management responses can be implemented to safeguard pollinators and sustain pollination services.

205 Despite its importance in safeguarding proper chromosome segregation, how hMps1 is

206 adation of the resulting partial proteins to safeguard proteome integrity.

207 , needing control and certainty of outcomes, safeguarding psychological wellbeing), justifying donor

208 , and long-term multidimensional policies to safeguard public health are indicated.

209 f a nuclear facility or nuclear material for safeguarding purposes.

210 to enforce legislation and to implement and safeguard reliable measurements.

211 dictions call for conservation strategies to safeguard relict tree populations and anticipate how man

212 combination (HR) cooperate during S-phase to safeguard replication forks integrity.

213 These molecular safeguards should enable the development of safe CRISPR

214 tion is an effective but underused method to safeguard spermatozoa.

215 known about the proteostasis mechanism that safeguards stem cells.

216 ling and growth test suggest high fitness of safeguarded strains, an important characteristic for wid

217 e drives as well as split drives as flexible safeguarding strategies for gene drive experiments by sh

218 Our safeguarding strategy is modular and employs conserved m

219 A fourth and fifth safeguard subject has been identified: recognizing the r

220 They result in three safeguard subjects: the Asset of Natural Resources, thei

221 The stem cells that safeguard synovial joints in adulthood are undefined.

222 genetics postulate that XNA could be used to safeguard synthetic biology organisms by storing genetic

223 Our studies identify an elaborate safeguarding system that prevents individual Sm proteins

224 imp1 repression is functionally critical for safeguarding T(FH) cell differentiation.

225 g a strategy to optimize CTL responses while safeguarding TCR diversity.

226 volving IL-33, decidual B cells and PIBF1 in safeguarding term pregnancy and suggest new therapeutic

227 The mitotic checkpoint is a cellular safeguard that prevents chromosome missegregation in euk

228 thin cells, the protein homeostasis network, safeguards that proteins are correctly folded and functi

229 ondrial stress response, named mitochondrial safeguard, that adjusts the balance of fusion and divisi

230 Two mechanisms safeguard the bipolar attachment of chromosomes in mitos

231 TC-PTP is therefore shown to be required to safeguard the dynamic transcriptome necessary for effici

232 States to expand voting-by-mail programs to safeguard the electoral process.

233 obal climate policy has a larger capacity to safeguard the future of emperor penguins than their intr

234 Immediate action is required to safeguard the future of the world's most important and v

235 ur data therefore suggest that Daxx and Atrx safeguard the genome by silencing repetitive elements wh

236 on heterochromatin is tightly suppressed to safeguard the genome, and in ccRCC cells, JARID1C inacti

237 Interventions are needed to safeguard the health of women after fistula repair.

238 their functions into ERA testing schemes to safeguard the integrity of aquatic ecosystems.

239 All organisms must safeguard the integrity of their DNA to avoid deleteriou

240 Addition of NaCl did not safeguard the katB mutant from H2O2, suggesting that Kat

241 of hemostasis that functions with the LVV to safeguard the lymphatic vascular network throughout life

242 n of efficient photoprotection mechanisms to safeguard the photosynthetic machinery.

243 road range of environmental conditions could safeguard the processes that lead to such adaptations(1-

244 ve ChIP-seq) shows that EZH1 could partially safeguard the role of EZH2 in the formation of H3K27me2.

245 ostats of tissue homeostasis, functioning to safeguard the SC epigenome from a breach in lineage conf

246 in Neotropical reforestation projects could safeguard the sequestration of 6.7 Gt CO(2) over the nex

247 o further elucidate regulatory pathways that safeguard the somatic state, we performed two comprehens

248 regulatory elements within adjacent loci and safeguard the specificity of action of promoters and enh

249 Comprehensive support should be provided to safeguard the wellbeing of health-care providers.

250 destruction of vessel-encasing tumors while safeguarding the encased vessel.

251 rdian of genome" duties at least in part via safeguarding the epigenome of ESCs.

252 could be such a target for its dual role in safeguarding the genome and the epigenome, by performing

253 ors and pathways underlies the importance of safeguarding the genome through multiple means.

254 ions cause brain developmental disorders, in safeguarding the genome through S phase during early ste

255 cription beyond its well-established role in safeguarding the genomic integrity.

256 to repress transposon transcription, thereby safeguarding the germline genome.

257 g self from non-self plays a crucial role in safeguarding the germlines of metazoa from mobile DNA el

258 med at maximizing the organ donor pool while safeguarding the interests of potential living donors.

259 characteristic; it initially contributes in safeguarding the malignant cell survival, whereas long-l

260 By safeguarding the molecules from the intensity of the max

261 Disabilities (CRPD) is a major milestone in safeguarding the rights of persons with disabilities.

262 e transcription factor Nanog and its role in safeguarding the stem cell pluripotency, which can be un

263 in this care might play an important role in safeguarding the trust of adolescents.

264 that CD8(+) T cell-intrinsic IL-27 signaling safeguards the ability of TCF1(hi) cells to maintain pro

265 t on a new and critical task of Ste24, which safeguards the essential process of translocation.

266 a unique type of chromatin regulation which safeguards the expression of an essential multifunctiona

267 globally acting coactivator that selectively safeguards the functionality of cell-type-specifying tra

268 ility, uncovering a signaling circuitry that safeguards the genome against R loops.

269 Thus, epigenetic compensation safeguards the genome against transposon activation, ind

270 regulated, pluripotency-specific lncRNA that safeguards the hESC state by disrupting SIRT6 activity.

271 the Asi1/Asi2/Asi3 ubiquitin ligase complex safeguards the INM proteome through the clearance of mis

272 erstood as a bona fide tumor suppressor that safeguards the integrity of the genome via regulating nu

273 Proper regulation of RAG1/2 expression safeguards the ordered assembly of Ag receptors and the

274 state, indicates a mechanism that naturally safeguards the virus against genome loss.

275 would enable gluten-sensitive individuals to safeguard their food safety.

276 eeded to boost the resilience of ecosystems, safeguard their wildlife, and protect their capacity to

277 nd establishes the fate of these structures, safeguarding their asymmetric inheritance during Sacchar

278 Discovering native breeds and safeguarding their genetic diversity through specific co

279 e lymphocytes with a cellular "fitness" that safeguards their persistence later in life during episod

280 in 70, stabilizes bluetongue virus proteins, safeguarding them from proteasomal degradation.

281 uncover a critical role of Ovol proteins in safeguarding this intricate process.

282 Safeguarding this rich biotic reservoir is essential for

283 ases Parp1 and Parp7 play a critical role in safeguarding this state by occupying key pluripotency ge

284 With appropriate safeguards, this novel and emerging field of research of

285 matin ensures that positional information is safeguarded through cell division such that individual L

286 1-ETO coexpressing FLT3-ITD, SIRT1 acts as a safeguard to counteract oncogene-induced stress, and leu

287 ne drive propagation could serve as a potent safeguard to either slow or completely reverse drive sys

288 ll-intrinsic restriction of ATP represents a safeguard to eliminate autoreactive or pre-malignant B c

289 Hif2a acts as a safeguard to initiate sinusoidal reconstruction only upo

290 es by using RNA surveillance mechanisms as a safeguard to protect their transcriptome profiles.

291 encompassed the perceived necessity of legal safeguards to determine legitimacy of relationships, ens

292 context specific, highlighting the need for safeguards to ensure that expansion of land for mitigati

293 at proper regulation of miR-27 is pivotal to safeguarding Treg-mediated immunological tolerance.

294 ify potential reservoirs of infection and to safeguard uninfected regions through enhanced biosecurit

295 d from bone marrow megakaryocytes (MKs) that safeguard vascular integrity but may also cause patholog

296 s, a detailed understanding of how platelets safeguard vascular integrity in tumors is urgently deman

297 s and regional food production while helping safeguard vital ecosystem services and globally signific

298 ir causes, frequency, severity, and existing safeguards were identified.

299 evelop hPSC lines bearing two drug-inducible safeguards, which have distinct functionalities and addr

300 le periods is a necessary and vital step for safeguarding women and their fetuses against disease cau