ライフサイエンスコーパス: safety margin

1 cies to climate warming by reducing 'thermal safety margins'.

2 nterventions are expensive and have a narrow safety margin.

3 n, despite being constrained within a narrow safety margin.

4 to-normal-tissue ratios and achieving a wide safety margin.

5 this variation was linearly related to xylem safety margin.

6 l valves for species with high KS , or a low safety margin.

7 ause they have a much narrower vulnerability safety margin.

8 totherms do not have a physiological thermal-safety margin.

9 epilepsy, at dose levels that confer a good safety margin.

10 myography can predict PNP with a comfortable safety margin.

11 APC platforms for assessing a drug's cardiac safety margin.

12 ward cancer prevention because of their wide safety margin.

13 lenium is an essential element with a narrow safety margin.

14 ety margin by 50% to 100% above the baseline safety margin.

15 s in visuomotor processing by way of altered safety margins.

16 h a broad chemotherapeutic spectrum and wide safety margins.

17 to possess very good antiviral efficacy and safety margins.

18 put settings while still allowing acceptable safety margins.

19 ed by the patient's physician using standard safety margins.

20 leaf cooling to maintain leaf-to-air thermal safety margins.

21 resistance to embolism (P(50) ) and negative safety margins.

22 data to predict dose-resolved DILI risks and safety margins.

23 may be used to predict in vivo efficacy and safety margins.

24 naceae, and among species with low hydraulic safety margins.

25 ead to local recurrences if not excised with safety margins.

26 eatures, such as fast parasite killing, good safety margin, a potentially novel mode of action and a

27 of slip, grip force (GF) control includes a safety margin above the force level ordinarily sufficien

28 om old age disability by providing a greater safety margin above the threshold of disability.

29 ts of thermal and desiccation tolerances and safety margins across a gradient of urbanization, for th

30 e defensive peripersonal space represents a "safety margin" advantageous for survival.

31 This provides a safety margin against arrhythmia in normal ventricular m

32 in animals, while demonstrating considerable safety margins against platelet reduction in a nonhuman

33 owever, we found no differences in hydraulic safety margin among species, suggesting that all trees m

34 However, our study showed a narrower safety margin and a limited increased efficiency at the

35 sult in an inadequate chronic defibrillation safety margin and could limit the safety of smaller puls

36 was positively correlated with the hydraulic safety margin and negatively correlated with the leaf ar

37 ation of M1 in vivo, resulting in acceptable safety margins and an improved pharmacokinetic profile.

38 ical compounds 6 and 7 exceeded conservative safety margins and possessed optimal pharmacological and

39 sure less variable APC datasets and improved safety margins and proarrhythmic risk assessments.

40 etic properties in preclinical species, good safety margins, and its potential for a balanced metabol

41 er vulnerability to xylem embolism, narrower safety margins, and lower mortality rates during extreme

42 bility in terms of years until acute thermal safety margins are breached (less than 500 years) than h

43 vert clinical ALS phenotype may develop when safety margins are exceeded subsequent to years of mitoc

44 asure the beam's range during dose delivery, safety margins around the tumor are applied, compromisin

45 tent anti-tumour activity with an acceptable safety margin as a single agent in several cancers.

46 lism resistance maintained similar hydraulic safety margin as in LSF.

47 autoregulation rather than by a blood flow "safety margin', as in peripheral nerve.

48 s-based model, we determine attenuation with safety margins at many watersheds for total nitrogen (TN

49 which is consistent with the smaller thermal safety margins at sea.

50 fibrillator recipients using a vulnerability safety margin based on a T-wave scan at 15.

51 y tested the hypothesis that a vulnerability safety margin based on the ULV can be used as an implant

52 body temperatures also limits birds' thermal safety margin before reaching lethal levels.

53 The application of cocaine increased the safety margin by 50% to 100% above the baseline safety m

54 With this strategy, they first ramp up safety margins by squeezing before relaxing their grasp.

55 Defibrillation safety margin can be assessed without VF induction using

56 Vulnerability to embolism and hydraulic safety margins can predict mortality risk at given level

57 Toxicology studies confirmed a wide safety margin consistent with the high degree of selecti

58 By contrast, hydraulic safety margins correlated well with probability of morta

59 of Tcrit and Tmax , we also found that these safety margins could shrink in a warmer world, as rising

60 ows for a reduction of added (normal tissue) safety margins designed to account for interfraction pat

61 as >200 bpm was identical (97.3%), despite a safety margin difference of 5.2+/-1.1 J for the 2-step g

62 consequences of an inadequate defibrillation safety margin (DSM) remain largely unknown.

63 To ensure an acceptable DFT safety margin, early defibrillator systems frequently re

64 t, encompassed 97.5% of data points within a safety margin, ensuring reliability, versatility, and br

65 mune tolerance while potentially providing a safety margin favoring combination with other immune-act

66 ssessment of biosafety extended for a 30-day safety margin, followed by a subsequent 10-day residual

67 of myostatin inhibitors provides an adequate safety margin for clinical studies.

68 age-dependent current amplifier, raising the safety margin for conduction; they also may contribute t

69 lity is a good estimate of the minimal acute safety margin for implantable cardioverter-defibrillator

70 t of vulnerability and to evaluate a minimal safety margin for implantable cardioverter-defibrillator

71 of the synaptic response, thus reducing the safety margin for neuromuscular transmission.

72 en for used catheters there is a substantial safety margin for power injection with the particular tr

73 ects on kidney nephrons and relatively small safety margin for some surface waters may warrant a long

74 espect to overall endplate depolarisation or safety margin for synaptic transmission.

75 s, we show that CO should have a wide enough safety margin for therapeutic applications.

76 ould be emphasized that having a wide enough safety margin for therapeutic use does not mean that it

77 Additionally, we identified substantial safety margins for clinically relevant doses of rHuPH20.

78 water potentials (Psi(MD) ), and calculated safety margins for damage (Psi(MD) - thresholds) and tes

79 ning of the optimal trajectory and to define safety margins for drilling forces during robotic-assist

80 ly reported and used as a basis to calculate safety margins for drug candidates.

81 e recommend the development of case-specific safety margins for intensification preventing double los

82 Safety margins for persistent declines in F(v) /F(m) , b

83 the lung, potentially improving efficacy and safety margins for the treatment of respiratory conditio

84 mple, [Formula: see text](50)) and hydraulic safety margins (for example, HSM(50)) are important pred

85 he minimum water potential, implying a lower safety margin from lethal hydraulic failure under drough

86 Grip force, relative safety margin (grip force exceeding the minimum to avoid

87 A safety margin >1.5x the DFT for electrically induced VF

88 ydraulic failure (expressed as the hydraulic safety margin (HSM)) and growth, where inherent fast-gro

89 to function near the edge of their hydraulic safety margin (HSM), making these ecosystems vulnerable

90 terizing dehydration tolerance and hydraulic safety margins (HSMs) in plants.

91 The 2 plaques provided a safety margin in 43% versus 40% eyes, provided no safety

92 ctors including levels of endogenous CO, its safety margin in comparison to commonly encountered biom

93 ing that the human motor system sizes the GF safety margin in proportion to an internal estimate of L

94 The GSM displayed a >40-fold safety margin in rats based on a comparison of the syste

95 icology studies in rats indicate a > 30-fold safety margin in relation to the predicted human efficac

96 % inhibition of IDO1 displayed an acceptable safety margin in rodent toxicology and dog cardiovascula

97 F-06463922 demonstrated high selectivity and safety margins in a variety of preclinical studies.

98 ED99 <30 mg kg(-1) and displays good in vivo safety margins in guinea pigs and rats.

99 dependent AB reduction and showed sufficient safety margins in preclinical models.

100 clearance in preclinical species, acceptable safety margins in rats, and a predicted human dose of 12

101 degrees ) regions have the narrowest thermal safety margins in upper canopy leaves; these regions are

102 degrees ) regions have the narrowest thermal safety margins in upper canopy leaves; these regions are

103 Skin slipperiness explained relative safety margin increases until age 60 years.

104 The safety margin (intramuscular LD50/ED50 ratio) for Cyto-0

105 The current view is that this safety margin is based on the expected LF dynamics, amou

106 s no indication of neurotoxicity and a large safety margin (LD(50) > 2000 mg/kg).

107 city showed no neurotoxic effects and a high safety margin (LD(50) > 2000 mg/kg).

108 No patient developed an inadequate safety margin (< 9 J) during follow-up.

109 r vision, consistent with altered visuomotor safety margins, maximum grip force is nevertheless reduc

110 ulnerability safety margin or defibrillation safety margin may allow for inductionless or limited sho

111 illation at 25 J for automated vulnerability safety margin noninduced patients.

112 A 95 percentile safety margin of 30-40% for TN and 6-10% for TP, applied

113 95% CI: 85, 100) of 43 target tumors, with a safety margin of 5-10 mm, and was confirmed at immediate

114 An absolute safety margin of 7 J was associated with a 96% probabili

115 ul defibrillation is achieved at an absolute safety margin of 7 J, and a 98% success rate is achieved

116 With a rigorous implantation algorithm, a safety margin of about 5 J is adequate for safe implanta

117 Traditionally, a safety margin of at least 10 J between the maximum outpu

118 These data suggest that the safety margin of BoNT/A can be improved by modulating th

119 for reducing hERG potency and increasing the safety margin of compounds in development.

120 The safety margin of neuromuscular transmission is compromis

121 th caution, in disorders that compromise the safety margin of neuromuscular transmission.

122 likely contribute importantly to the reduced safety margin of neuromuscular transmission.

123 r at the excision site if not excised with a safety margin of surrounding uninvolved skin.

124 d to the interplay between the wider thermal safety margin of terrestrial versus marine species and t

125 of 91.4%, 97.9%, 99.1%, 99.6%, and 99.8% for safety margins of 0, 1, 2, 3, and 4 steps above the DFT+

126 ommon occurrence, the narrow therapeutic and safety margins of antiepileptic medications, and the rec

127 had TN attenuation factors per km, including safety margins, of 0.19-1.6%, medium rivers of 0.14-1.2%

128 ould take a lane position that increased the safety margin on their blind side was tested with a driv

129 h HH take a lane position that increases the safety margin on their blind side; however, absolute lan

130 g. leaf water potential, native embolism and safety margin) on >150 trees from 12 genera (36 species)

131 Screening with vulnerability safety margin or defibrillation safety margin may allow

132 herapy defibrillator underwent vulnerability safety margin or defibrillation safety margin screening

133 positioning (hazard ratio [HR], 2.81 for no safety margin; P = 0.041).

134 F control that includes a variability-driven safety margin predicts highly asymmetric GF adaptation b

135 ediction of population decline, this thermal safety margin provides an index of the physiological str

136 apid and could be predicted by the hydraulic safety margin, providing strong support for leaf vulnera

137 exposure of EDI048, providing a substantial safety margin required for a paediatric indication.

138 a prospective, randomized assessment of the safety margin requirements for modern implantable cardio

139 ulnerability safety margin or defibrillation safety margin screening at 14 J in a randomized order.

140 20 patients who underwent 14-J vulnerability safety margin screening, 322 (76.7%) passed.

141 6 patients who underwent 14-J defibrillation safety margin screening, 343 (82.5%) passed, and 338 (98

142 ty margins were small at low latitudes, with safety margins smallest for species occupying both humid

143 e to embolisms (low P(50) values) and higher safety margins ( SMP50 ) were more resistant to immediat

144 sm-resistant leaf xylem and greater stomatal safety margins (SSM) than smaller, spring-flowering spec

145 Vascular resection and retroperitoneal safety margin status did not affect disease relapse.

146 y valves by relating Kleaf and the hydraulic safety margin (stem water potential minus the water pote

147 This combination of excellent efficacy and safety margin strongly validates PAR4 antagonism as a pr

148 ensive peripersonal space (DPPS) is a vital "safety margin" surrounding the body.

149 spective study of an automated vulnerability safety margin system was conducted, which measured T-wav

150 r, prospective trial comparing vulnerability safety margin testing versus defibrillation safety margi

151 safety margin testing versus defibrillation safety margin testing with a single VF induction/defibri

152 ntified all patients who failed conventional safety margin testing, while inducing only 19% of patien

153 Carbonyl iron has a greater safety margin than the iron salts.

154 The thermal safety margin (the difference between thermal limit and

155 tality was best predicted by a low hydraulic safety margin-the difference between typical minimum xyl

156 ution of the hERG assay; laboratory-specific safety margin threshold may be required to account for s

157 ompounds will possess a superior therapeutic safety margin to currently available bidentate HPOs.

158 y margin in 43% versus 40% eyes, provided no safety margin to guard foveola in 17% versus 33%, and di

159 ominal settings typically allow a sufficient safety margin to prevent later loss of capture with pote

160 xcellent safety profile and had a sufficient safety margin to qualify it for use in human testing.

161 A wide safety margin to the efficacious exposure in toxicologic

162 d circumpapillary choroidal melanomas (and a safety margin) to be included in the radiation targeted

163 s sufficient to maintain stable leaf thermal safety margins (TSMs) across different growth temperatur

164 Remarkably, the vaccine safety margin was at least 1,000-fold higher for A12-P1

165 skin surrounding primary tumors targeted by safety margins, we used array comparative genomic hybrid

166 Stem P50 and hydraulic safety margin were the most strongly related physiologic

167 r defibrillation has been used because lower safety margins were associated with unacceptably high ra

168 On land, the smallest thermal safety margins were found for species at mid-latitudes w

169 the marine species with the smallest thermal safety margins were found near the equator.

170 Similar to previous studies, thermal safety margins were small at low latitudes, with safety

171 ed, however, if the motor system reduces the safety margin when LF variability is low and increases i

172 60 years and older increased their relative safety margins when the friction of the gripped surfaces

173 its (xylem resistance to embolism, hydraulic safety margin, wood density) at the range margins and ra

174 had the lowest warming tolerance and thermal safety margin (WT and TSM; respectively the thermal buff