ライフサイエンスコーパス: sand fly

1 sruption of transmission by the phlebotomine sand fly.

2 the presence of Leishmania in the gut of the sand fly.

3 cted long term when challenged with infected sand flies.

4 were used to coinfect Lutzomyia longipalpis sand flies.

5 following a natural challenge with infected sand flies.

6 st bite in volunteers exposed to colony-bred sand flies.

7 isceral leishmaniasis (VL) is transmitted by sand flies.

8 t of L. major transmission by L. longipalpis sand flies.

9 an hosts by the bites of bloodsucking vector sand flies.

10 long-term reservoir of infection for vector sand flies.

11 g-term reservoir of infection back to vector sand flies.

12 Leishmania protozoa transmitted by infected sand flies.

13 ania mexicana-infected Lutzomyia longipalpis sand flies.

14 Diptera, such as Drosophila, mosquitoes and sand flies.

15 eficient mice challenged by bite of infected sand flies.

16 Leishmania major metacyclic promastigotes by sand flies.

17 s, but in the context of Leishmania-infected sand flies.

18 nse in mosquitoes, ticks, triatome bugs, and sand flies.

19 ial for late-stage Leishmania development in sand flies.

20 nfection transmitted by the bite of infected sand flies.

21 d macular PKDL, and VL, can be infectious to sand flies.

22 All patients infected sand flies.

23 rasite patches that govern infectiousness to sand flies.

24 y blood-feeding female Lutzomyia longipalpis sand flies.

25 vaccinated dogs that are also infectious to sand flies.

26 d are transmitted by bites from phlebotomine sand flies.

27 ckettsia were reported for the first time in sand flies.

28 Fabaceae family was detected in 94.7% of the sand flies.

29 ism of Leishmania transmissibility to vector sand flies.

30 nated papers was determined with wild-caught sand flies.

31 ansmitted to the vertebrate host by infected sand flies.

32 opy (NIRS) to age-grade Phlebotomus papatasi sand flies, a primary vector of Leishmania major, a caus

33 distribution reduces the expected number of sand flies acquiring parasites, it increases the infecti

34 s papatasi, and to maintain infection in the sand fly after excretion of the digested bloodmeal.

35 to endogenous self-Dsg1 and exogenous LJM11 sand fly Ag.

36 echanisms to the different environments of a sand fly alimentary tract and the acidic mammalian host

37 d development and transmission competence in sand flies, allowing one to be selected for GMP producti

38 colonizes the midgut of Phlebotomus duboscqi sand flies and impacts the development of L. major paras

39 phoglycans (lpg2-) were unable to survive in sand flies and macrophages, but retained the ability to

40 Sand flies and mosquitoes belong to separate lineages of

41 ternate between flagellated promastigotes in sand flies and nonflagellated amastigotes in mammals, ca

42 life cycle involving transmission by biting sand flies and replication within mammalian macrophage p

43 in macrophages and mice, colonisation of the sand fly and motility.

44 n of molecules present in the midgut of this sand fly and the transcripts potentially modulated by bl

45 rast to bloodsucking Nematocera (mosquitoes, sand flies, and black flies), appear to concentrate a go

46 including mosquitoes, ticks, triatome bugs, sand flies, and tsetse flies.

47 is study, we show that salivary Ags from the sand fly, and specifically the LJM11 salivary protein, a

48 ndemic area for visceral leishmaniasis (VL), sand flies are abundant for a short period of <=3 months

49 Phlebotomine sand flies are hematophagous insects that harbor bacteri

50 y, Leishmania-infected, D. tsuruhatensis-fed sand flies are less able to transmit L. major parasites

51 Sand flies are the exclusive vectors of the protozoan pa

52 Lutzomyia longipalpis sand flies are the major natural vector of Leishmania in

53 Phlebotomine sand flies are the vectors of medically important Leishm

54 rent age-grading techniques for phlebotomine sand flies are time-intensive and destructive as they re

55 e, we demonstrate that gut microbes from the sand fly are egested into host skin alongside Leishmania

56 the Leishmania parasites and the gut of the sand fly are poorly understood.

57 attractive to a greater proportion of female sand flies as the infection progresses.

58 fter feeding on the Leishmania that uses the sand fly as a vector.

59 athogen, and the Leishmania that utilize the sand fly as a vehicle for transmission between mammalian

60 the way to function characterization of the sand fly associated microbiome.

61 ave identified the first representative of a sand fly-associated flavivirus, Ecuador Paraiso Escondid

62 icantly more attractive to 50% of the female sand flies at the end of infection compared to before in

63 icantly more attractive to 75% of the female sand flies at the end of infection.

64 ania species are zoonotic agents; therefore, sand fly-based control strategies are essential to preve

65 vade and exploit the innate host response to sand fly bite in order to establish and promote disease.

66 hallenge with L. major by needle or infected sand fly bite in resistant C57BL/6 mice.

67 stained neutrophilic infiltrate at localized sand fly bite sites.

68 are introduced into mammalian skin through a sand fly bite, but different species cause distinct clin

69 Following challenge by infected sand fly bite, polyprotein-vaccinated animals had compar

70 o protection following challenge by infected sand fly bite.

71 ds were transmitted to the mammalian host by sand fly bite.

72 Individuals exposed to sand fly bites develop humoral and cellular immune respo

73 te the durability and T(H)1 nature of DTH to sand fly bites in humans living in a cutaneous leishmani

74 The relevance of DTH to sand fly bites in humans living in a leishmaniasis-endem

75 Pre-exposure to uninfected sand fly bites or immunization with defined sand fly sal

76 control, but their impact on interruption of sand fly bites remains untested in Sri Lanka.

77 ns have proven to be effective in preventing sand fly bites, and subsequently infection.

78 vary gland homogenates (SGHs) or by infected sand fly bites.

79 ir vertebrate hosts by infected phlebotomine sand fly bites.

80 leishmaniasis have established infection via sand fly bites.

81 be transmitted from humans to humans through sand fly bites.

82 probably caused by insufficient exposure to sand fly bites.

83 This represents the first sand fly-borne flavivirus identified in the New World.

84 replication of vesicular stomatitis virus in sand fly cells and resulted in strains that initially re

85 nduces robust host protection against vector sand fly challenge and because it is marker free, can be

86 s, isolated from mosquitoes and phlebotomine sand flies collected in Brazil, Peru, the United States,

87 oth diseases are transmitted by phlebotomine sand flies competent for infection with Leishmania speci

88 rior exposure of mice to bites of uninfected sand flies conferred powerful protection against Leishma

89 ion for developing intervention strategy for sand fly control.

90 . scapularis nymphs, other tick species, and sand flies could also be fed using the membrane describe

91 cted dogs and household spraying to kill the sand fly) could be effective, but have proven hard to ma

92 ural similarities indicate that mosquito and sand fly D7 proteins have evolved from similar progenito

93 To mimic natural transmission, we used sand fly-derived metacyclic forms of L. major and preexp

94 ration of immune homeostasis in phlebotomine sand flies during the growth of bacterial and Leishmania

95 profile of certain midgut transcripts in the sand fly during blood meal digestion and that this modul

96 Identifying genes important for sand fly ecological adaptability and sand fly-Leishmania

97 greatly facilitate the understanding of the sand fly ecology, which would provide critical informati

98 Notably, sand flies efficiently acquired parasites after feeding

99 protein from Lutzomyia intermedia, predicted sand fly exposure and was associated with increased risk

100 omprehensive study has been conducted on the sand fly fauna and their morphological characterization

101 The bites of uninfected sand flies favor the transmissibility of L. donovani by

102 Sand flies feeding at sites in mouse ears that had a DTH

103 rasites, it increases the infection load for sand flies feeding on a patch, increasing their potentia

104 Importantly, 45.6%, 50.0%, and 33.3% of sand flies feeding on ear, mouth, and testicular lesions

105 cales provide the best fit with experimental sand fly feeding data, pointing to the importance of the

106 luding descriptive morphological criteria of sand flies, first description of Phlebotomus species, a

107 r organisms, <4% were identical to described sand fly genes, and 42% had no match to any database seq

108 colonization, related with the induction of sand fly gut dysbiosis.

109 Sand fly gut populations of both L. mexicana and L. infa

110 The Leishmania protozoa reside in the sand fly gut, but the nature of the immune response to t

111 The sand flies have adapted to various ecological niches in

112 following transmission to the skin by vector sand flies have been difficult to examine directly.

113 To investigate the sand fly immune response and its interaction with the Le

114 have demonstrated that the activation of the sand fly immune system, via depletion of a single gene,

115 pertaining to the effect of gut microbiota, sand fly immunity, and changes in metacyclogenesis upon

116 The abundance of sand flies in IRS and non-IRS villages was significantly

117 keys for the morphological identification of sand flies in the Middle East and Mediterranean regions.

118 s and enterobacteria, both are shared in the sand flies in the two regions.

119 ngs suggest that the ecological diversity of sand fly in Sichuan and Henan may contribute to shaping

120 papatasi saliva, the only other human-biting sand fly in the ISC.

121 a vector-borne disease transmitted by female sand flies infected with Leishmania parasites.

122 the genome of the parasites before and after sand fly infection revealed a strong population bottlene

123 evealed haplotype and allelic changes during sand fly infection that seem under natural selection giv

124 ive DNA damage in the parasite genomes after sand fly infection, suggesting that Leishmania suffers f

125 odel of Leishmania genomic adaptation during sand fly infection, with oxidative DNA damage and DNA re

126 evolutionary adaptation during experimental sand fly infection.

127 During sand fly infections by the protozoan parasite Leishmania

128 sistant hybrids in vitro and in vivo (during sand fly infections) to assess the importance of conserv

129 Sand flies inject saliva while feeding in the vertebrate

130 During Leishmania transmission sand flies inoculate parasites and saliva into the skin

131 ment site inside the alimentary tract of the sand fly insect vector.

132 Leishmania-sand fly interactions are reviewed in the context of the

133 This review looks at Leishmania-sand fly interactions as the parasites develop from amas

134 phoglycan-containing molecules in Leishmania-sand fly interactions were tested by using mutants speci

135 sed sugars of its LPG to manipulate parasite-sand fly interactions.

136 Leishmania development in sand flies involves critical attachment steps to the mid

137 For Leishmania, transmission by sand flies is critical to early survival involving an ir

138 nfected mice to transmit parasites to vector sand flies, it was observed that following low-dose chal

139 udied plant feeding of Lutzomyia longipalpis sand flies, known vectors of Leishmania infantum/chagasi

140 fter transmission through the bite of female sand flies, Leishmania spp. can cause a broad spectrum o

141 ant for sand fly ecological adaptability and sand fly-Leishmania genetic co-variation could be helpfu

142 Female phlebotomine sand flies Lutzomyia longipalpis naturally harbor popula

143 ries constructed from midgut tissue from the sand fly Lutzomyia longipalpis and analyzed the transcri

144 that salivary gland lysate of the New World sand fly Lutzomyia longipalpis markedly enhanced L. majo

145 istributed hematophagous insect vectors, the sand fly Lutzomyia longipalpis s.l., the mosquitoes Anop

146 n with Leishmania major is enhanced when the sand fly Lutzomyia longipalpis salivary peptide maxadila

147 isolated from salivary gland lysates of the sand fly Lutzomyia longipalpis, a vector of leishmaniasi

148 LJM11, an abundant salivary protein from the sand fly Lutzomyia longipalpis, belongs to the insect "y

149 nformation of the transcripts present in the sand fly Lutzomyia longipalpis.

150 lly isolated from the salivary glands of the sand fly Lutzomyia longipalpis.

151 th the distribution of its known vector, the sand fly Lutzomyia verrucarum.

152 e of leishmaniasis, a disease transmitted by sand fly (Lutzomyia longipalpis) bites.

153 confined to promastigotes developing in the sand fly midgut.

154 w that the concentration of ROS increased in sand fly midguts after they fed on the insect pathogen S

155 gotes and procyclic LPG were able to bind to sand fly midguts in vitro whereas metacyclic parasites a

156 at Leishmania are transmitted exclusively by sand flies, none of the experimental models of leishmani

157 are transmitted exclusively by phlebotomine sand flies of the genera Phlebotomus and Lutzomyia.

158 Lutzomyia longipalpis is a phlebotomine sand fly of medico-veterinary importance and the primary

159 ect the biosynthetic pathways leading to the sand fly pheromone sobralene and taxadiene have been mad

160 Sand fly Phlebotomus chinensis is a primary vector of tr

161 In this article, we investigate whether the sand fly Phlebotomus papatasi, known to produce a strong

162 asite transmitted in nature by the Old World sand fly Phlebotomus papatasi.

163 Infected sand fly pools were collected from diverse microhabitats

164 sity of Leishmania and Bartonella species in sand fly populations from Andean and Amazonian regions.

165 ance of Leishmania and Bartonella species in sand fly populations from these endemic regions.

166 shown for the first time in the wild-caught sand fly populations of Turkey.

167 e that prior exposure to bites of uninfected sand flies potentiates their ability to transmit infecti

168 ed a 12-fold increase in hybrid formation in sand flies provided a second blood meal containing IgMn

169 ids and parental lines were only observed in sand flies provided with IgMn.

170 e where it was discovered, was isolated from sand flies (Psathyromyia abonnenci, formerly Lutzomyia a

171 Sand flies reared in slightly cooler insectary condition

172 he blood or skin as a source of infection to sand flies remains unclear, and the possible effect of m

173 ditionally, loss of parasite adhesion in the sand fly results in reduced physiological changes to the

174 demonstrates a differential response of the sand fly ROS system to gut microbiota, an insect pathoge

175 fly or by silencing a gene that expresses a sand fly ROS-scavenging enzyme.

176 experiments demonstrate that pre-exposure to sand fly saliva confers protection against leishmaniasis

177 Together, these results imply that the sand fly saliva facilitates Leishmania evasion of the ho

178 mmune activation, oxidative stress, and anti-sand fly saliva IgG concentrations in dog sera with diff

179 A panel of biomarkers and anti-sand fly saliva IgG were measured in canine sera.

180 e describe the duration and nature of DTH to sand fly saliva in humans from an endemic area of Mali.

181 Immunity to sand fly saliva in rodents induces a T(H)1 delayed-type

182 od mononuclear cells (PBMCs) stimulated with sand fly saliva in vitro.

183 Sand fly saliva is known to enhance Leishmania infection

184 l needle challenge with Leishmania major and sand fly saliva when vaccinated intravenously.

185 SDS-PAGE coupled to LC-MS analysis of sand fly saliva, before and after enzymatic deglycosylat

186 We also explore how sand fly saliva, egested parasite molecules and vector g

187 mine the diversity of N-glycan structures in sand fly saliva, enzymatically released sugars were fluo

188 the vertebrate host is also inoculated with sand fly saliva, which exerts powerful immunomodulatory

189 species, meaning that the applicability of a sand fly saliva-based vaccine will be limited to a defin

190 PBMCs from 98% of individuals responded to sand fly saliva.

191 Antibodies to sand fly salivary antigens are biomarkers for vector-hos

192 functional genomics approach to identify the sand fly salivary components that are responsible for th

193 moglein 1 (Dsg1) cross-reacts with the LJM11 sand fly salivary gland Ag.

194 ts the first detailed structural analysis of sand fly salivary glycans.

195 as a vaccine expression system for LJM11, a sand fly salivary protein identified as a good vaccine c

196 the structure and mechanism of action of the sand fly salivary protein lufaxin, which inhibits the fo

197 humoral and cellular immune response to the sand fly salivary protein rLinB-13 and disease severity

198 umulative evidence that immunity to specific sand fly salivary proteins confers a significant level o

199 f immunogenic portions of PdSP15 and LJL143, sand fly salivary proteins demonstrated as potential vac

200 Because of this, sand fly salivary proteins differ structurally from thos

201 Sand fly salivary proteins have been extensively studied

202 sand fly bites or immunization with defined sand fly salivary proteins was shown to negatively impac

203 lop humoral and cellular immune responses to sand fly salivary proteins.

204 analysis to compare with Old- and New-World sand fly salivary proteins.

205 rmal immunization of mice with 500 ng of the sand fly salivary recombinant protein LJM11 (rLJM11) fro

206 nia parasites, underlining the impact of the sand fly salivary yellow proteins on disease outcome.

207 body response to saliva after the end of the sand fly season.

208 n Tbilisi and other endemic areas with brief sand fly seasons.

209 ases that degrade the stomodeal valve of the sand fly; secretion of a neuropeptide that arrests midgu

210 Exposure to L. intermedia sand flies skews the human immune response, facilitating

211 eillance in Peru for the characterization of sand fly species and the discovery of a great diversity

212 Knowledge regarding sand fly species diversity and distribution in leishmani

213 The patterns of courtship songs in New World sand fly species evolve quickly under sexual selection;

214 In Peru, 149 sand fly species have been identified.

215 at included proteins commonly found in other sand fly species such as the yellow, SP15 and apyrase pr

216 laviviruses are rarely (if ever) vectored by sand fly species, at least in the Old World.

217 pendent on the phylogenetic proximity of the sand fly species, meaning that the applicability of a sa

218 m D7 proteins AGE83092 and ABI15936 from the sand fly species, Phlebotomus papatasi and P. duboscqi,

219 ibute to reproductive isolation in New World sand fly species, suggesting that auditory communication

220 Salivary proteins of sand flies, specifically maxadilan and LJM11, have been

221 tudied haptomonad form, which adheres to the sand fly stomodeal valve via a highly modified flagellum

222 ishmania hybrids generated experimentally in sand flies supports a meiotic mechanism of genetic excha

223 The proportion of sand flies testing positive for DNA from a given plant f

224 of Leishmania within the alimentary canal of sand flies the parasites have to survive the hostile env

225 hroids, and susceptibility profile of Indian sand flies, the continued use of DDT in this IRS program

226 and precise morphological identification of sand flies, the proven vectors of the disease, is crucia

227 et of sequence data reported from a specific sand fly tissue and provides further information of the

228 Leishmania parasites need phlebotomine sand flies to complete their life cycle and to propagate

229 rotected against cutaneous disease following sand fly transmission of Leishmania major in susceptible

230 Employing i.d. inoculation to model sand fly transmission of parasites has significant conse

231 eishmania major (L.m.) parasites early after sand fly transmission or needle inoculation, but phagocy

232 against the potency of a Leishmania-infected sand fly transmission.

233 providing a key resource for CHIM studies of sand fly transmitted cutaneous leishmaniasis.

234 ocytic choriomeningitis virus (LCMV), or the sand fly-transmitted arbovirus Toscana virus (TOSV).

235 a controlled human infection model (CHIM) of sand fly-transmitted cutaneous leishmaniasis (CL) caused

236 Cutaneous leishmaniasis is a sand fly-transmitted disease characterized by skin ulcer

237 s the pathology and immunity associated with sand fly-transmitted infection.

238 d controlled protective immune response to a sand fly-transmitted Leishmania somewhat mimicking "leis

239 developmental forms, as it cycles between a sand fly vector and a mammalian host; understanding thei

240 (LPG) implicated in parasite survival in the sand fly vector and the initial stages of establishment

241 ), and a decidedly peripatetic and adaptable sand fly vector are the primary forces.

242 ajor strains during their development in the sand fly vector has been experimentally shown.

243 omes infected with Leishmania major when the sand fly vector injects parasites into skin along with s

244 The saliva of the sand fly vector of leishmaniasis significantly enhanced

245 urring bites from Lutzomyia longipalpis, the sand fly vector of leishmaniasis, immunize individuals w

246 that the infectiousness of patients for the sand fly vector of visceral leishmaniasis is linked to p

247 quence tag library has been generated from a sand fly vector of visceral leishmaniasis, Lutzomyia lon

248 the differentiation of parasites within the sand fly vector to the highly infective metacyclic proma

249 site is transmitted to a mammalian host by a sand fly vector where it develops as an intracellular pa

250 Mating occurred only in the sand fly vector, and hybrids were transmitted to the mam

251 Within their sand fly vector, Leishmania parasites undergo multiple d

252 Its main sand fly vector, Lutzomyia longipalpis s.l.

253 hich were efficiently picked up by a natural sand fly vector, Phlebotomus sergenti.

254 During its life cycle within the sand fly vector, the parasite differentiates from a divi

255 To survive in its sand fly vector, the trypanosomatid protozoan parasite L

256 fter they are deposited into the dermis by a sand fly vector.

257 ishmania spp. is transmitted to mammals by a sand fly vector.

258 l for parasite survival in the midgut of its sand fly vector.

259 cretory gel, in the anterior midgut of their sand fly vector.

260 y large skin lesions and is transmitted by a sand fly vector.

261 otozoan parasites transmitted by the bite of sand fly vectors producing a wide spectrum of diseases i

262 sis is a spectrum of diseases transmitted by sand fly vectors that deposit Leishmania spp. parasites

263 ccurs between Leishmania parasites and their sand fly vectors.

264 vertebrate hosts and the alimentary tract of sand fly vectors.

265 vertebrate macrophages and be transmitted by sand fly vectors.

266 ania parasites, and 4 contained phlebotomine sand fly vectors.

267 is an intracellular protozoan transmitted by sand fly vectors; it causes cutaneous, mucocutaneous, or

268 their ability to transmit L. major to vector sand flies was completely abrogated.

269 From sand flies, we isolated most of the known Phlebovirus st

270 tion of parasites by the bite of an infected sand fly, we identified differences in the preexisting a

271 Sand flies were collected bi-weekly in Rahar Diyara and

272 Sand flies were collected from different towns (Karaburu

273 Sand flies were collected over 32 months with light trap

274 After sterile washing steps, sand flies were dissected and guts were separated.

275 ndoor residual spraying, Leishmania-infected sand flies were found in both villages, with 1.4% (4/285

276 Sand flies were highly resistant to DDT but susceptible

277 The NIR spectra from individual sand flies were used to develop a partial least squares

278 The parasite is transmitted by the bite of sand flies, which inoculate the promastigote forms into

279 s following challenge with L. major-infected sand flies, while non-immunized animals develop large an

280 Microbiome profiling of wild-caught sand flies will be of great help in the investigating of

281 Finally, the treatment of sand flies with an exogenous ROS scavenger (uric acid) a

282 biota by pretreatment of Leishmania-infected sand flies with antibiotics or neutralizing the effect o

283 The coevolution of sand flies with Leishmania species of mammals and lizard

284 In sand flies with mature Leishmania infections the anterio

285 a from colonising the stomodeal valve in the sand fly, without affecting cell growth.

286 Here, we show that members of sand fly yellow salivary proteins induce in vitro chemot

287 ur after exposure to the bite of an infected sand fly, yet only one is under evaluation in humans.