ライフサイエンスコーパス: sarcosine

1 lytes (proline, sorbitol, sucrose, TMAO, and sarcosine).

2 ch as N-methyltryptophan or N-methylglycine (sarcosine).

3 ell as N-methylated amino acids (e.g. MeAIB, sarcosine).

4 k cat and a 150-fold decrease in k cat/ K m sarcosine.

5 y, are required for the conversion of DMG to sarcosine.

6 oval of S-adenosylmethionine by synthesis of sarcosine.

7 ne and with the glycine transport inhibitor, sarcosine.

8 n) (n =1-3), where X is glycine, alanine, or sarcosine.

9 M-) dependent methylation of glycine to form sarcosine.

10 sm of choline, converting dimethylglycine to sarcosine.

11 rs at less than 1% of the rate observed with sarcosine.

12 r emphasis on the reduction of the enzyme by sarcosine.

13 ependent and blocked by the GlyT-1 inhibitor sarcosine.

14 s induced in various bacteria upon growth on sarcosine.

15 LNCaP tumor cells by excess unlabeled (cold) sarcosine.

16 thionine-dependent methylation of glycine to sarcosine.

17 et) dependent methylation of glycine to form sarcosine.

18 lycine to form S-adenosyl-l-homocysteine and sarcosine.

19 e-carbon donors such as serine, glycine, and sarcosine.

20 ctive surface capable of binding exclusively sarcosine.

21 o bind to SARDH and to modulate the level of sarcosine.

22 ies equivalent to a premolten globule in 1 M sarcosine.

23 he binding of a radiolabeled agonist ((125)I-sarcosine(1) Ang II) and a radiolabeled antagonist ((125

24 ng II) and a radiolabeled antagonist ((125)I-sarcosine(1), isoleucine(8) Ang II) in brain homogenates

25 -(1-7) competed with low affinity for (125)I-sarcosine(1), isoleucine(8) angiotensin II binding to AT

26 incubated with five concentrations of (125)I-sarcosine(1), isoleucine(8) angiotensin II to assess the

27 ns of choline, betaine, dimethylglycine, and sarcosine (12-46%; P </= 0.08) in both pregnant and nonp

28 unosuppressive analog of cyclosporine (CsA), sarcosine-3(4-methylbenzoate)-CsA (SmBz-CsA), we found a

29 gen in the diastereotopic methylene group of sarcosine-3.

30 g a k(cat) value (8700 min(-)(1)) similar to sarcosine (7030 min(-)(1)).

31 inhibition of glycine transport with excess sarcosine (a substrate for system Gly) whilst systems A

32 -1 and Capan-2 cells was similar to glycyl-L-sarcosine absorption by Caco-2 cells and a Chinese hamst

33 abidopsis and showed that pipecolate but not sarcosine accumulated 6-fold when AtSOX expression was s

34 s of amino acids (glycine), biogenic amines (sarcosine), acylcarnitines and phospholipids.

35 The osmolytes, TMAO, betaine, sarcosine, alanine, glycine, and proline to varying degr

36 4'-fluorophenyl)-3-(4'-phenylphenoxy)propyl])sarcosine (ALX 5407), and examined its activity against

37 The GlyT1 transport inhibitors sarcosine, ALX-5407, and Org-24598 were tested and shown

38 nd findings from studies showing efficacy of sarcosine, an endogenous, non-selective glycine-reuptake

39 Sarcosine, an N-methyl derivative of the amino acid glyc

40 Sarcosine, an N-methyl derivative of the amino acid glyc

41 ide to MSOX does not affect the binding of a sarcosine analogue (MTA, methylthioactetate) above the r

42 ppropriate functionalities, for example, the sarcosine analogue 9, were found to retain AMPA (IC50 =

43 rtually mirror images of those observed with sarcosine analogues (N,N'-dimethylglycine, N-benzylglyci

44 hibitors of glycine transport through GlyT1 (sarcosine and (N-[3-(4'-fluorophenyl)-3-(4'-phenylphenox

45 These analogues contained sarcosine and aminocyclopropanoic acid in place of Gly5,

46 neration glycine transport inhibitors (e.g., sarcosine and bitopertin), as well as recent positive st

47 studies show that MS-325 can displace dansyl sarcosine and dansyl-L-asparagine from HSA with inhibiti

48 sed by 85%, although formate production from sarcosine and dimethylglycine (choline metabolites) was

49 The structural similarity between sarcosine and glycine led us to hypothesize that sarcosi

50 Results indicated sarcosine and its combination with taurine protected Met

51 Exposure to sarcosine and its derivative resulted in an increased co

52 stive sensory materials for the detection of sarcosine and its ethyl ester hydrochloride in water wit

53 Target metabolite analyses of sarcosine and its natural precursors, glycine and cholin

54 reductive half-reaction of ETF catalyzed by sarcosine and medium chain acyl-CoA dehydrogenases which

55 Steady-state kinetic studies with sarcosine and N-methyl-L-alanine in the absence or prese

56 s and increased extracellular nutrients like sarcosine and ornithine.

57 ion of N-methylazomethine ylide derived from sarcosine and paraformaldehyde.

58 hese materials for the specific detection of sarcosine and related metabolites in biological fluids.

59 n of glycine by S-adenosylmethionine to form sarcosine and S-adenosylhomocysteine.

60 Propionyl-CoA is reacted with sarcosine and the formed N-propionylsarcosine is assayed

61 Turnover with sarcosine and the limiting rate of the reductive half-re

62 Two initiation channels, one producing sarcosine and the other producing N-methylaminomethylpho

63 effects of urea and the protecting osmolytes sarcosine and TMAO are reported on the thermally unfolde

64 e of protecting osmolytes glycerol, proline, sarcosine and trimethylamine-N-oxide (TMAO).

65 et) to methylate glycine to N-methylglycine (sarcosine) and produces S-adenosylhomocysteine (AdoHcy),

66 ontaining the proposed piezolytes glutamate, sarcosine, and betaine were used, as well as solutions c

67 f one-carbon donors such as serine, glycine, sarcosine, and dimethylglycine.

68 tes the local accumulation of urea, glycine, sarcosine, and glycine betaine and removes the minimum i

69 However, glycine, sarcosine, and glycine betaine are not necessarily local

70 The local accumulation of glycine, sarcosine, and glycine betaine at single strands relativ

71 he cosolutes ethylene glycol, urea, glycine, sarcosine, and glycine betaine at the single-stranded DN

72 concentrations of betaine, dimethylglycine, sarcosine, and methionine (13-55%; P < 0.001).

73 bonds for their maintenance in sodium lauryl sarcosine- and sodium dodecyl sulfate-insoluble complexe

74 tylproline amide) and 4 x 10(5) M(-1) s(-1) (sarcosine anhydride).

75 hylenediaminemonoacetate, iminodiacetate and sarcosine are secondary amines with at least one N-acety

76 Other secondary amino acids (e.g., sarcosine) are oxidized at a slower rate.

77 ns of prostate cancer progression, we reveal sarcosine as a potentially important metabolic intermedi

78 Since charge transfer interaction with sarcosine as donor is possible only with the anionic for

79 n Escherichia coli, AtSOX enhanced growth on sarcosine as sole nitrogen source, showing that it has S

80 MSOX probably binds the zwitterionic form of sarcosine, as judged by the spectrally similar complexes

81 The reductive half-reaction with sarcosine at 4 degrees C exhibits saturation kinetics (k

82 The discoveries that sarcosine-based tertiary amides in the context of molecu

83 ilize exogenous sarcosine opportunistically, sarcosine being a common soil metabolite.

84 ng osmolytes, trimethylamine-N-oxide (TMAO), sarcosine, betaine, proline, glycerol, sorbitol, sucrose

85 ture of MSOX and residue conformation in the sarcosine binding cavity are unaffected by replacement o

86 contact with the si face of the flavin ring; sarcosine binds just above the re face.

87 nd wide linear range (1-70 muM) amperometric sarcosine biosensor with excellent anti-interference pro

88 Methylation of glycine led to elevated sarcosine but further methylation to dimethylglycine and

89 Absorption of the model dipeptide glycyl-L-sarcosine by AsPc-1 and Capan-2 cells was similar to gly

90 atidylethanolamine methyltransferase, and of sarcosine by glycine N-methyltransferase.

91 encode a sarcosine oxidase, are required for sarcosine catabolism.

92 alpha-products was also realized with Co(II)/sarcosine catalyst.

93 The Co(II)/sarcosine catalytic system is shown to perform efficient

94 the reactions proceed via an initial enzyme.sarcosine charge transfer complex and a novel spectral i

95 Sarcosine, citicoline, and N-acetylcysteine are promisin

96 ults may be due to the fact that alanine and sarcosine coelute on an HPLC reversed-phase column and t

97 at the V/K(O)()2 value is independent of the sarcosine concentration at all accessible concentrations

98 ormation exhibits a hyperbolic dependence on sarcosine concentration with a finite Y-intercept, consi

99 n displays a simple hyperbolic dependence on sarcosine concentration.

100 A sarcosine-containing con-T truncation analog, con-T[1-9/

101 nation of the relative rates of synthesis of sarcosine, creatine, and phosphatidylcholine by rapid me

102 ine or knockdown of the enzyme that leads to sarcosine degradation, sarcosine dehydrogenase, induced

103 d agreement with that observed for rat liver sarcosine dehydrogenase ( approximately 100,000 Da).

104 The predicted mass of the mature human liver sarcosine dehydrogenase (99,505 Da) is in good agreement

105 Sarcosine is then transformed to glycine by sarcosine dehydrogenase (E.C. number 1.5.99.1).

106 ll as hydroxymethylglutaryl-CoA synthase and sarcosine dehydrogenase (SarDH), are S-nitrosylated by N

107 atography and mass spectrometry, we identify sarcosine dehydrogenase (SARDH), the enzyme that convert

108 The sarcosine dehydrogenase and 5,10-methylenetetrahydrofola

109 e demonstrated production of formaldehyde by sarcosine dehydrogenase and dimethylglycine dehydrogenas

110 ogenase exhibits 89% identity with rat liver sarcosine dehydrogenase and strong homology ( approximat

111 Human sarcosine dehydrogenase exhibits 89% identity with rat l

112 mpete with the dimethylglycine dehydrogenase/sarcosine dehydrogenase family for access to electron tr

113 rain libraries, were assembled from the same sarcosine dehydrogenase gene by the use of alternate pol

114 first report of the genomic structure of the sarcosine dehydrogenase gene in any species.

115 The human sarcosine dehydrogenase gene is at least 75.3 kb long an

116 Sarcosine dehydrogenase is a liver mitochondrial matrix

117 A full-length cDNA for human sarcosine dehydrogenase was isolated from an adult liver

118 and porcine dimethylglycine dehydrogenase or sarcosine dehydrogenase were incubated together in the a

119 aminase, fructose-bisphosphatase aldolase B, sarcosine dehydrogenase, and cysteine sulfinic acid deca

120 he enzymes dimethylglycine dehydrogenase and sarcosine dehydrogenase, in which protein-bound tetrahyd

121 enzyme that leads to sarcosine degradation, sarcosine dehydrogenase, induced an invasive phenotype i

122 h rat liver dimethylglycine dehydrogenase, a sarcosine dehydrogenase-related protein from Rhodobacter

123 We developed a sarcosine derivative, (R)-(N-[3-(4'-fluorophenyl)-3-(4'-

124 ure shows a good drift rate of 3.84 mV/h and sarcosine detection with improvement of approximately 10

125 However, sarcosine differed from glycine because less NMDAR desen

126 ine sarcosine N-methyltransferase (GSMT) and sarcosine dimethylglycine N-methyltransferase.

127 rms a charge transfer Michaelis complex with sarcosine (E-FAD(ox).sarcosine) that exhibits an intense

128 Protein stabilization by sarcosine eliminated the effect of urea and GdmCl on VDA

129 hed in a single step with EDTA and N-lauroyl sarcosine (ES; pH 8.5 to 9.3) incubation at 50 degrees C

130 Condensation of the aldehyde 6 and sarcosine ethyl ester hydrochloride salt gives an interm

131 ve demethylation of dimethylglycine to yield sarcosine, formaldehyde, and hydrogen peroxide.

132 ss spectrometry (LC-MS) method that resolves sarcosine from alanine isomers, allowing its accurate qu

133 h-throughput LC-MS method is able to resolve sarcosine from alpha- and beta-alanine and is useful for

134 cavitand-functionalized MCs to discriminate sarcosine from glycine in water.

135 ethyl transferase, the enzyme that generates sarcosine from glycine, attenuated prostate cancer invas

136 receptor and it was proven able to recognize sarcosine from its nonmethylated precursor, glycine, in

137 The currents evoked by 20 mM glycyl-sarcosine (Gly-Sar) at pH 5.0 were dependent upon membra

138 , and F297C-hPepT1) showed negligible glycyl-sarcosine (gly-sar) uptake activity and may play an impo

139 rbitol), five amino acids (glycine, alanine, sarcosine, glycine betaine, and proline), and urea.

140 s revealed significant stepwise increases of sarcosine, glycine, and choline tissue levels from benig

141 udes the genes encoding GB, dimethylglycine, sarcosine, glycine, and serine catabolic enzymes and the

142 tions of the 2 pathways for the formation of sarcosine (ie, N-methylglycine).

143 s also air-stable but is readily oxidized by sarcosine imine, a reaction accompanied by release of we

144 Sarcosine improved negative symptoms (SMD = -0.65, 95%CI

145 l observation of increased concentrations of sarcosine in ALF patients.

146 c defect characterized by elevated levels of sarcosine in blood and urine.

147 d beta-alanine and is useful for quantifying sarcosine in serum and urine samples.

148 e ectodomain results in a decreased level of sarcosine in the cells.

149 ealed low levels of pipecolate but almost no sarcosine in wild type Arabidopsis and showed that pipec

150 , glycine and a substrate agonist for GlyT1, sarcosine, induced voltage-dependent inward currents tha

151 homology with monomeric sarcosine oxidase, a sarcosine-inducible enzyme found in many bacteria.

152 as a peroxisomal enzyme in mammals and as a sarcosine-inducible enzyme in soil bacteria.

153 a low level throughout the plant and is not sarcosine-inducible.

154 Sarcosine is a known substrate of proton-coupled amino a

155 Conclusion:(11)C-sarcosine is a novel radiotracer for PATs and shows init

156 osine and glycine led us to hypothesize that sarcosine is also an agonist like glycine.

157 Sarcosine is an amino acid involved in one-carbon metabo

158 We found that sarcosine is an NMDAR co-agonist at the glycine binding

159 esence of tetrahydrofolate, the oxidation of sarcosine is coupled to the formation of 5,10-methylenet

160 The carboxyl group of sarcosine is essential for binding since none is observe

161 The methyl group of sarcosine is not essential but does contribute to bindin

162 The amino group of sarcosine is not essential, but binding affinity depends

163 s C (k(cat) = 24.5 min(-1)), suggesting that sarcosine is oxidized at a kinetically significant rate

164 Sarcosine is then transformed to glycine by sarcosine de

165 ate, a competitive inhibitor with respect to sarcosine, is bound at the FAD site.

166 Sarcosine levels were also increased in invasive prostat

167 Thus, sarcosine may enhance NMDAR function by more than one me

168 at the uncatalyzed Na(2)CO(3) and Na(2)CO(3)-sarcosine MECS had lower CO(2) absorption rates relative

169 SOX catalyzes the oxidative demethylation of sarcosine; methylthioacetate (MTA) is a substrate analog

170 ults indicate that the pK(a) of enzyme-bound sarcosine must be considerably lower than the free amino

171 methylation of glycine, catalyzed by glycine sarcosine N-methyltransferase (GSMT) and sarcosine dimet

172 and catalyzes the oxidative demethylation of sarcosine ( N-methylglycine).

173 Sarcosine (N-methylglycine) and beta-alanine were also a

174 hat catalyzes the oxidative demethylation of sarcosine (N-methylglycine) and contains covalently boun

175 OX) catalyzes the oxidative demethylation of sarcosine (N-methylglycine) and contains covalently boun

176 that catalyze the oxidative demethylation of sarcosine (N-methylglycine) and N-methyl-L-tryptophan, r

177 ysteinyl)FAD] and catalyzes the oxidation of sarcosine (N-methylglycine) and other secondary amino ac

178 tly bound FAD and catalyzes the oxidation of sarcosine (N-methylglycine) and other secondary amino ac

179 hat catalyzes the oxidative demethylation of sarcosine (N-methylglycine) to yield glycine, formaldehy

180 elta, 11 kDa) and catalyzes the oxidation of sarcosine (N-methylglycine) to yield hydrogen peroxide,

181 talyzes the oxidation of the methyl group in sarcosine (N-methylglycine).

182 Met-dependent methylation of glycine to form sarcosine (N-methylglycine).

183 lycine generating S-adenosylhomocysteine and sarcosine (N-methylglycine).

184 des contain an N-terminal acetyl-A-(Sar)(3) (sarcosine; N-methylglycine) tag and a C-terminal lysine

185 (4'-fluorophenyl)-3-(4'-phenylphenoxy)propyl]sarcosine (NFPS)) reduced glycine currents by approximat

186 (4'-fluorophenyl)-3-(4'-phenylphenoxy)propyl]sarcosine [NFPS]) provides a tool for evaluation of the

187 plants and that plants can utilize exogenous sarcosine opportunistically, sarcosine being a common so

188 Addition of exogenous sarcosine or knockdown of the enzyme that leads to sarco

189 n reduced form upon anaerobic reduction with sarcosine or L-proline.

190 aerobic reaction with N-methyl-L-tryptophan, sarcosine, or the carbinolamine formed with L-tryptophan

191 taining peptide from another corynebacterial sarcosine oxidase (C. sp. U-96).

192 glucose oxidase (GOX) (His516) and monomeric sarcosine oxidase (MSOX) (Lys265).

193 Monomeric sarcosine oxidase (MSOX) and N-methyltryptophan oxidase

194 Monomeric sarcosine oxidase (MSOX) and N-methyltryptophan oxidase

195 Monomeric sarcosine oxidase (MSOX) binds the L-proline zwitterion

196 Monomeric sarcosine oxidase (MSOX) catalyzes the oxidation of N-me

197 Monomeric sarcosine oxidase (MSOX) catalyzes the oxidative demethy

198 Monomeric sarcosine oxidase (MSOX) contains covalently bound FAD a

199 Monomeric sarcosine oxidase (MSOX) contains covalently bound FAD a

200 appears to be a new member of the monomeric sarcosine oxidase (MSOX) family of amine oxidizing enzym

201 Monomeric sarcosine oxidase (MSOX) is a flavoenzyme that catalyzes

202 Monomeric sarcosine oxidase (MSOX) is a flavoprotein that contains

203 Monomeric sarcosine oxidase (MSOX) is a prototypical member of a r

204 Monomeric sarcosine oxidase (MSOX) is an inducible bacterial flavo

205 The covalently bound FAD in native monomeric sarcosine oxidase (MSOX) is attached to the protein by a

206 FAD in monomeric sarcosine oxidase (MSOX) is covalently linked to the pro

207 duction and sarcosine oxidation in monomeric sarcosine oxidase (MSOX) occur at separate sites above t

208 ificantly affect the expression of monomeric sarcosine oxidase (MSOX), covalent flavinylation, the ph

209 ajority of flavoenzymes, including monomeric sarcosine oxidase (MSOX), perform non-light-driven physi

210 with reference to the structure of monomeric sarcosine oxidase (MSOX).

211 ymes creatininase (CA), creatinase (CI), and sarcosine oxidase (SOx) and for separating the neutral h

212 Sarcosine oxidase (SOX) is known as a peroxisomal enzyme

213 , large subunit of putative heterotetrameric sarcosine oxidase (SoxA) and glutamine synthetase type I

214 The crystal structure of heterotetrameric sarcosine oxidase (TSOX) from Pseudomonas maltophilia ha

215 Heterotetrameric sarcosine oxidase (TSOX) is a complex bifunctional flavo

216 The reaction of heterotetrameric sarcosine oxidase (TSOX) of Arthrobactor sp. 1-IN has be

217 In situ reconstitution of sarcosine oxidase activity is achieved by assaying apoCy

218 The closest structural relatives of ThiO are sarcosine oxidase and d-amino acid oxidase.

219 Biosensors based on lactate oxidase, sarcosine oxidase and mixture of fumarase and sarcosine

220 ed for the covalently bound FAD in monomeric sarcosine oxidase and N-methyltryptophan oxidase, enzyme

221 Heterotetrameric (alphabetagammadelta) sarcosine oxidase from Corynebacterium sp. P-1 (cTSOX) c

222 Sarcosine oxidase from Corynebacterium sp. P-1 is a hete

223 Sarcosine oxidase from Corynebacterium sp. P-1 is a hete

224 ate oxidase, sarcosine oxidase, and fumarase/sarcosine oxidase in the three sensing channels.

225 amadoriase I has 22% homology with monomeric sarcosine oxidase in which FAD is also linked to a homol

226 Monomeric sarcosine oxidase is a flavoenzyme that catalyzes the ox

227 ha-(N3-histidyl)FMN found in corynebacterial sarcosine oxidase represents a novel type of covalent fl

228 arcosine oxidase and mixture of fumarase and sarcosine oxidase were used for monitoring of organic ac

229 ultienzyme system (creatininase, creatinase, sarcosine oxidase) is immobilized on top of the permsele

230 asis of its sequence homology with monomeric sarcosine oxidase, a sarcosine-inducible enzyme found in

231 mperometric biosensors with lactate oxidase, sarcosine oxidase, and fumarase/sarcosine oxidase in the

232 hat the soxBDAG genes, predicted to encode a sarcosine oxidase, are required for sarcosine catabolism

233 gy that is most similar to that of monomeric sarcosine oxidase.

234 ygen-unreactive FAD site in heterotetrameric sarcosine oxidase.

235 subunit of TSOX is very similar to monomeric sarcosine oxidase.

236 und FAD and NAD+, similar to corynebacterial sarcosine oxidase.

237 In contrast, two monomeric sarcosine oxidases (from Bacillus sp. and an unidentifie

238 Studies with sarcosine oxidases from Arthrobacter sp. and Pseudomonas

239 causes only a modest decrease in the rate of sarcosine oxidation (9.0- or 3.8-fold, respectively), as

240 Significantly, the active sites for sarcosine oxidation and oxygen reduction are located on

241 Oxygen reduction and sarcosine oxidation in monomeric sarcosine oxidase (MSOX

242 The 15(kcat/Km) kinetic isotope effect for sarcosine oxidation is pH-dependent with a limiting valu

243 ransfer between the noncovalent FAD (site of sarcosine oxidation) and the covalent FMN (site of enzym

244 No redox intermediate is detectable during sarcosine oxidation, as judged by the isosbestic spectra

245 role for His45 in covalent flavinylation or sarcosine oxidation.

246 t that Arg49 also plays an important role in sarcosine oxidation.

247 t is one of several plausible mechanisms for sarcosine oxidation.

248 (P = 0.041), a higher urinary enrichment of sarcosine (P = 0.041), and a greater plasma enrichment r

249 duct coordinately regulate components of the sarcosine pathway.

250 AMPA oxidation pathway over the glycine and sarcosine pathways, particularly under acidic pH.

251 background ratios (TBRs) obtained from (11)C-sarcosine PET were significantly elevated compared with

252 -3 and LNCaP tumor cells and performed (11)C-sarcosine PET with CT in the first human subject with lo

253 (11)C-sarcosine produced high-contrast images in 1 case of loc

254 Sarcosine prostate cancer biomarker with the low concent

255 cular approach for the specific detection of sarcosine, recently linked to the occurrence of aggressi

256 GlyT1 inhibitors ALX 5407 and sarcosine reduced total glycine uptake to 80% whereas th

257 Decarboxylation of the amino acid sarcosine resulted in the accumulation of significant co

258 only approximately 10% of CF recovery while sarcosine (SAR) showed insignificant effects.

259 LMWC) such as arginine (Arg), taurine (Tau), sarcosine (Sar), and trimethylamine oxide (TMAO) present

260 Through combined alanine, proline, and sarcosine scans coupled with a competitive fluorescence

261 nic acid, ornithine, phenylalanine, proline, sarcosine, serine, threonine, tryptophan, tyrosine, and

262 mples from 42 subjects were used to evaluate sarcosine serum/urine correlation.

263 (11)C-sarcosine showed a favorable radiation dosimetry with an

264 eine (SMD = -0.87, 95%CI = -1.27; -0.47) and sarcosine (SMD = -0.5,95%CI = -0.87-0.13) outperformed p

265 steine (SMD = -0.89,95%CI = -1.35,-0.43) and sarcosine (SMD = -0.61,95%CI = -1.02,-0.21) outperformed

266 Sarcosine (SMD = -1.26,95%CI = -1.91; -0.60), citicoline

267 the presence and absence of 6 M urea or 1 M sarcosine solution is sufficient to allow large changes

268 panel of 4(P) variants containing alanine or sarcosine substitutions along the putative alpha- or PPI

269 protecting osmolytes trimethylamine N-oxide, sarcosine, sucrose, and proline and the nonprotecting os

270 diated autaptic currents decayed faster with sarcosine suggesting that NMDAR deactivation also differ

271 blocked by the GlyT1 inhibitors ALX 5407 and sarcosine, suggesting that the high-affinity glycine upt

272 use less NMDAR desensitization occurred with sarcosine than with glycine as the co-agonist.

273 g larger when NMDAR activation occurred with sarcosine than with glycine.

274 following NMDAR activation were larger with sarcosine than with glycine.

275 steady-state kinetic patterns obtained with sarcosine that are consistent with a rapid equilibrium o

276 Michaelis complex with sarcosine (E-FAD(ox).sarcosine) that exhibits an intense long-wavelength abso

277 -carbon of serine and the N-methyl carbon of sarcosine to formate without the addition of any other c

278 plantlets slowly metabolized supplied [(14)C]sarcosine to glycine and serine.

279 ydrogenase (SARDH), the enzyme that converts sarcosine to glycine, as a TMEFF2-interacting protein.

280 combinant protein catalyzed the oxidation of sarcosine to glycine, formaldehyde, and H(2) O(2) in vit

281 course observed for conversion of E-FAD(ox).sarcosine to reduced enzyme at 25 or 5 degrees C.

282 in part by the ability of N-methyl glycine (sarcosine) to competitively inhibit glycine transport.

283 We characterized (11)C-sarcosine transport in PC-3 and LNCaP tumor cells and pe

284 rboxylic acid, competitively inhibited (11)C-sarcosine tumor cell uptake, confirming PAT-mediated tra

285 In vitro assays indicated blockage of (11)C-sarcosine uptake into PC-3 and LNCaP tumor cells by exce

286 rization of the kinetics of FAD reduction by sarcosine using stopped-flow methods.

287 in-based voltage-sensitive fluorescent dyes (sarcosine-VoltageFluors) that can be covalently attached

288 and PC-3 tumors (TBR: 1.89 +/- 0.2 for (11)C-sarcosine vs. 1.34 +/- 0.16 for (11)C-choline [n = 7; P

289 line in DU-145 (TBR: 1.92 +/- 0.11 for (11)C-sarcosine vs. 1.41 +/- 0.13 for (11)C-choline [n = 10; P

290 Sarcosine was discovered to be an excellent ligand for c

291 Vmax for apical uptake of [14C]glycyl-[14C]sarcosine was increased 1.64 (+/- 0.34)-fold after incub

292 While sarcosine was recently identified as a potential urine b

293 Methods:(11)C-radiolabeled sarcosine was tested as a new PET imaging probe in compa

294 c properties of MTOX with the slow substrate sarcosine were determined.

295 V), and employ a tertiary amide derived from sarcosine, which aids in membrane localization and simul

296 ynergistic effect has also been observed for sarcosine, which can form hemiaminals but not imines.

297 an and other N-methyl amino acids, including sarcosine, which is a poor substrate.

298 ers are at micromoles per liter, such as for sarcosine, which was recently discovered as a biomarker

299 Results suggest that Sarcosine with/without taurine can be used as a food add