ライフサイエンスコーパス: satellite DNA

1 tely the same rate as the adjacent non-alpha-satellite DNA.

2 ricentromeric sequence to higher-order alpha-satellite DNA.

3 some, which is comprised of repetitive alpha satellite DNA.

4 to C/EBP regulatory elements in centromeric satellite DNA.

5 ndogenous C/EBP beta from 3T3-F442A cells to satellite DNA.

6 were predominantly recovered near regions of satellite DNA.

7 much more recent concerted evolution of this satellite DNA.

8 ification is not a general property of alpha-satellite DNA.

9 C/EBP consensus-binding sites in centromeric satellite DNA.

10 s colocalize with foci of heavily methylated satellite DNA.

11 arker chromosomes that lack detectable alpha-satellite DNA.

12 pancentromeric nor chromosome-specific alpha-satellite DNA.

13 ypes is accompanied by a loss of centromeric satellite DNA.

14 haracterized by distinct haplotypes of alpha satellite DNA.

15 ranslocations retain ribosomal genes or beta-satellite DNA.

16 lated to hypomethylation of juxtacentromeric satellite DNA.

17 t prominently in centromeric satellite/micro-satellite DNA.

18 n of the abundant and aspen-specific PtaM147 satellite DNA.

19 nopartite genome or through the capture of a satellite DNA.

20 ound to CENP-A(Nuc) reconstituted onto alpha-satellite DNA.

21 duplicated genes, LTR retrotransposons, and satellite DNA.

22 despite the reported turnover of centromeric satellite DNA.

23 rge ( 2 Mb) centromeres are not dominated by satellite DNA.

24 at binds to the 17-bp DNA sequences on alpha-satellite DNA.

25 in Alu repeats and in heterochromatic alpha-satellite DNA.

26 lly coincident with diverse subsets of alpha satellite DNA.

27 reas Rsp is a large pericentromeric block of satellite DNA.

28 ional de-repression of the tandemly repeated satellite DNA.

29 human neocentromere lacking repetitive alpha-satellite DNA.

30 centromeres in platypus are not enriched in satellite DNA.

31 including postmitotic bridges enriched with satellite DNA.

32 cation of late-replicating sequences such as satellite DNAs.

33 organized nucleoli, ribosomal DNA (rDNA) and satellite DNAs.

34 cified by structural features of centromeric satellite DNA [1-3] or by specific DNA sequences, analog

35 Thirty-four satellite DNA (21 for the first time in this work) have

36 s (including segmental duplications [35.4%], satellite DNA [22.3%], or regions enriched in GA/AT-rich

37 e-specific nucleosomes are enriched in alpha-satellite DNA [8].

38 erely impairs its ability to methylate major satellite DNA, a DNMT3A-preferred target, but has no ove

39 ert effect on the ability to methylate minor satellite DNA, a DNMT3B-preferred target.

40 ximately 8.4% (31 kb) of the highly repeated satellite DNA (AATAT and TTCTC) was sequenced, represent

41 In MEL cells, this gamma-satellite DNA activity depends on binding of Ikaros prot

42 We were able to identify two abundant satellite DNAs, alpha (~340 bp) and CapA (~1,500 bp), fr

43 However, the organization of satellite DNA and chromatin at mouse centromeres and per

44 Instead, telomere-restricted satellite DNA and DNA transposon fragments occupy its te

45 We also find rapid turnover of satellite DNA and extensive structural divergence in het

46 cleosome reconstitution studies, human alpha-satellite DNA and Lytechinus variegatus 5S DNA, and find

47 atin states, because both higher-order alpha-satellite DNA and noncentromeric DNA were enriched for m

48 n discontinuous blocks of higher-order alpha-satellite DNA and noncentromeric DNA.

49 ents that includes CENP-A nucleosomes, alpha-satellite DNA and pericentromeric cohesion.

50 bundance, and variation of highly repetitive satellite DNA and presents approaches to understand thei

51 ading resolution to this paradox posits that satellite DNA and satellite-associated chromosomal prote

52 CENP-A nucleosome containing a native alpha-satellite DNA and solved its structure by the cryo-elect

53 omeres (ENC) are composed of large arrays of satellite DNA and surrounded by segmental duplications.

54 al and genomic analyses further suggest that satellite DNA and the heterochromatic chromosome arms ar

55 e immediately flanking the centromeric alpha-satellite DNA and the other targeted to the zinc finger

56 these chromosomes confirm the lack of alpha-satellite DNA and the presence of CENtromere proteins (C

57 oss of transcription of the underlying alpha-satellite DNA and to no longer efficiently recruit HJURP

58 es well and contains mouse centromeric minor satellite DNA and variable amounts of major satellite DN

59 ption, revealing the universal importance of satellite DNAs and chromocenters.

60 s suggest a common origin of the Tetragnatha satellite DNAs and evolutionary constraint in the length

61 applications, identifying repeat units from satellite DNAs and reconstructing circular RNAs from rol

62 h for their characteristic repeat sequences (satellite DNA) and for being epigenetically defined.

63 fruit fly Drosophila melanogaster shows that satellite DNA, and corresponding small non-coding RNA, h

64 e.g. GAATG, classical satellites e.g. alpha satellite DNA, and locus specific VNTR arrays.

65 with neocentromeres lacking detectable alpha-satellite DNA, and the lack of CENP-A association with a

66 embled genomic regions enriched with complex satellite DNA, and we further demonstrate the utility of

67 r histocompatibility complex (MHC) variants, satellite DNAs, and segmental duplications.

68 Satellite DNA are long tandemly repeating sequences in a

69 Satellite DNAs are known for an unusual and nonuniform e

70 Repetitive sequences such as satellite DNAs are potentially informative cytogenetic m

71 ear microchromosomes contain exogenous alpha satellite DNA, are mitotically and cytogenetically stabl

72 omosome(3), we reconstructed the centromeric satellite DNA array (approximately 3.1 Mb) and closed th

73 e cell fate by using ZFP819, which targets a satellite DNA array, ZP3AR.

74 ast centromeres, interspersed in centromeric satellite DNA arrays [4,5].

75 We show that human gamma-satellite DNA arrays allow a transcriptionally permissiv

76 intenance and/or organization of centromeric satellite DNA arrays rather than a more direct involveme

77 Human centromeres are defined by alpha satellite DNA arrays that are distinct and chromosome sp

78 are defined by megabases of homogenous alpha-satellite DNA arrays that are packaged into specialized

79 In addition, satellite DNA as a nuclear marker suggests that hybridiz

80 Recent studies have implicated alpha-satellite DNA as an integral part of the centromere, imp

81 C/EBP alpha (p42 and p30 forms) can bind to satellite DNA as homo- or heterocomplexes in vitro.

82 O-2 or the SUMO E2 ligase Ubc9 reduces alpha-satellite DNA association with nucleoli.

83 The abundance and sequence of satellite DNA at and around centromeres is evolving rapi

84 At least for such marker chromosomes, alpha-satellite DNA at levels detectable by FISH appears unnec

85 d within the megabase-long, repetitive alpha-satellite DNAs at each centromere.

86 nd Prod shift from low affinity sites within satellite DNA back to euchromatic sites as a self-assemb

87 ne cells, during nurse cell growth the major satellite DNAs become highly under-represented by a mech

88 n little recombination and homogenization of satellite DNA between these two sets of centromeres.

89 In both cases the loss of alpha-satellite DNA binding coincided with an elevation in the

90 between chromocenter modules, consisting of satellite DNA binding proteins and their cognate satelli

91 role of RNAPII in the transcription of alpha-satellite DNA, binding of centromere protein C, and the

92 Thus, we reveal that a satellite DNA-binding protein functions during embryogen

93 We have constructed a fluorescent alpha-satellite DNA-binding protein to explore the motile and

94 Here, we use 2 satellite DNA-binding proteins, D1 and Prod, as baits to

95 e associations between two sequence-specific satellite DNA-binding proteins, D1 and Prod, bound to th

96 During mitosis in Drosophila, satellite DNA binds proteins that, during interphase, bi

97 focus corresponds to an unusual decondensed satellite DNA block, and both active genes and the XNP f

98 roteins, D1 and Prod, bound to their cognate satellite DNAs, bring the full complement of chromosomes

99 ally within an island are well resolved with satellite DNA but much less so with mtDNA.

100 nto C/EBPalpha that reduces binding to alpha-satellite DNA but permits normal binding to sites in som

101 Human centromeres form primarily on a-satellite DNA but sporadically arise de novo at naive ec

102 is responsible for the production of a small satellite DNA called msDNA.

103 e transcriptases (RT) to synthesize peculiar satellite DNAs called multicopy single-stranded DNA (msD

104 Ectopic expression of satellite DNA can phenocopy BRCA1 loss in centrosome amp

105 ts demonstrate for the first time that alpha-satellite DNA can seed de novo centromeres in human cell

106 specialized chromatin that consists of alpha satellite DNA complexed with epigenetically modified his

107 Satellite DNA comprises ~11% of the mouse genome and is

108 sequencing to analyze cmDNA and showed that satellite DNAs consisting of both of simple (CCATT)(N) r

109 B1 and B2, both strands of near-centromeric satellite DNAs consisting of tandem repeats, and multipl

110 riants, including large differences in alpha-satellite DNA content, which may influence the fidelity

111 The study also reveals gain-loss of satellite DNA copies during species diversification.

112 Satellite DNA de-repression was also observed in mouse a

113 ticle (NCP) reconstituted with a human alpha-satellite DNA derivative revealed both DNA ends to be hi

114 e accompanied by rapid turnover of the major satellite DNA detected in (peri)centromeric regions.

115 , while distinct families of heterochromatic satellite DNA differ in their bias for replicating in la

116 orphometric analysis revealed that the alpha-satellite DNA domain bound by CENPB-GFP becomes elongate

117 fferent heterochromatic properties appear on satellite DNA during successive embryonic division cycle

118 long-range physical map of centromeric alpha-satellite DNA (DXZ1) by pulsed-field gel analysis, as we

119 Here, we have used two kinds of alpha satellite DNA, DXZ1 (from the X chromosome) and D17Z1 (f

120 sample and it mapped to a highly repetitive satellite DNA element on chromosome 1.

121 Adding to their interest, satellite DNA elements evolve at high rates; among Droso

122 Tandemly repeating satellite DNA elements in heterochromatin occupy a subst

123 e annotation of new genomes and the study of satellite DNA evolution even if such repeats are not ful

124 in the light of current life-cycle models of satellite-DNA evolution.

125 Because satellite DNAs evolve in a concerted manner, we use thes

126 of satellite repeats and identified 12 novel satellite DNA families.

127 SarkOne is a genus-specific satellite-DNA family, isolated from the genomes of the s

128 In this paper we use satellite DNAs for phylogenetic analysis of a rapidly ev

129 linking of linearized PACs containing alpha satellite DNA from chromosomes X and 17 with sizes of 12

130 ey possess regions of sequence similarity to satellite DNA from several bivalve species.

131 the major centromeric repetitive DNA, alpha-satellite DNA, has been extensively sequenced and shown

132 mitotically stable chromosomes lacking alpha-satellite DNA have been reported.

133 While several types of alpha satellite DNA have been used to assemble de novo centrom

134 CENP-A nucleosomes contain centromeric alpha satellite DNA, have equimolar amounts of H2A, H2B, CENP-

135 Cancer-linked satellite DNA hypomethylation was independent of RNA lev

136 d DNMT3B deficiency causing juxtacentromeric satellite DNA hypomethylation.

137 underreplication we estimated the amount of satellite DNA in each of these species.

138 Here, replication of alpha-satellite DNA in endogenous human centromeric regions an

139 eviously been profiled and the role of alpha-satellite DNA in initiation of DNA replication has not y

140 Given our discovery of gamma-satellite DNA in pericentromeric regions of most human c

141 An insertion of heterochromatic satellite DNA in the euchromatic brown (bw) gene of Dros

142 We also mapped both satellite DNAs in S. boliviensis, S. sciureus, S. vanzol

143 made up of highly repetitive DNA sequences (satellite DNA) interspersed with middle repetitive DNA s

144 osed that the interchromosomal clustering of satellite DNAs into nuclear structures known as chromoce

145 demonstrate for the first time that complex satellite DNA is a structural component of the kinetocho

146 g to the concerted-evolution pattern of this satellite DNA is a time-dependent process by which new m

147 timate that the mutation rate of centromeric satellite DNA is accelerated by more than 2.2-fold compa

148 Satellite DNA is an enigmatic component of genomic DNA w

149 This satellite DNA is composed of repeats with a consensus le

150 Further, because complex satellite DNA is evolutionarily unconserved, these resul

151 The overwhelming majority (97%) of alpha-satellite DNA is found to be assembled with histone H3.1

152 Classical satellite DNA is normally heavily methylated at cytosine

153 which is composed exclusively of centromeric satellite DNA, is hypomethylated compared with the peric

154 structures in simple and complex centromeric satellite DNAs leads us to suggest that these centromeri

155 yielded infections with significantly higher satellite DNA levels.

156 mon ancestor forming what has been called a 'satellite DNA library'.

157 s allowed multiplex imaging of four types of satellite DNA loci with a single array, revealing their

158 ere, we review how TEs and (peri)centromeric satellite DNA may contribute to aging and neurodegenerat

159 We propose that satellite DNAs may control developmental fate transition

160 omprise megabase-size arrays of 171 bp alpha-satellite DNA monomers.

161 limited by the repetitive centromeric alpha-satellite DNA needed to form a centromere.

162 on of alpha-satellite DNAs, the main type of satellite DNAs on human centromeres.

163 ctopic exchange among euchromatic islands of satellite DNAs on the X chromosome and separately spawne

164 s as well as proteins previously unlinked to satellite DNA or chromocenters, thereby laying the found

165 d were preferentially located in centromeric satellite DNA or in Kruppel-associated box domain-contai

166 found only in PCs and located in centromeric satellite DNA or zinc-finger genes, both associated with

167 g recurrent shifts between retroelements and satellite DNAs over short evolutionary timescales.

168 Two rDNAs and a satellite DNA (PaB6) from regular chromosomes were mappe

169 llite DNA binding proteins and their cognate satellite DNA, package the Drosophila genome within a si

170 consists of higher-order repeat (HOR) alpha-satellite DNA packaged into two chromatin domains: the k

171 P) II transcription on non-coding repetitive satellite DNAs plays an important role in chromosome seg

172 The satellite DNA present in heterochromatin contains multip

173 lutionary studies indicate that, while alpha satellite DNA present throughout the pericentromeric reg

174 ion, cycE01672, that increases the amount of satellite DNA propagated in nurse cells.

175 BRCA1 binds to satellite DNA regions and ubiquitylates H2A in vivo.

176 th difficult-to-replicate heterochromatin at satellite DNA regions enriched in histone H3 lysine 9 tr

177 osophila contain multi-megabase stretches of satellite DNA repeats and a handful of protein-coding ge

178 derstanding of cellular functions enabled by satellite DNA repeats and their associated proteins.

179 Noncoding satellite DNA repeats are abundant at the pericentromeri

180 he ubiquity and abundance of pericentromeric satellite DNA repeats in eukaryotes has remained poorly

181 egabase chromosomal regions containing alpha-satellite DNA repeats, which contain binding sites for t

182 ich is a mouse subspecies lacking methylated satellite DNA repeats.

183 ved piRNA Cluster Locus (MCpiRCL) made up of satellite DNA repeats.

184 intain integrity of the long arrays of alpha-satellite DNA repeats.

185 heir natural location, we suggest that gamma-satellite DNA represents a unique region of the function

186 to a 17 bp CENP-B box motif common to alpha-satellite DNA, resulted in enrichment of alpha-satellite

187 an in-depth study of the complete set of the satellite DNA (satDNA) families (i.e. the satellitomes)

188 Highly repetitive satellite DNA (satDNA) repeats are found in most eukaryo

189 eres and subtelomeres, which are enriched in satellite DNA (satDNA).

190 Consequently, the few satellite DNAs (satDNAs) mapping on the B chromosome wer

191 Large blocks of tandemly repeated DNAs-satellite DNAs (satDNAs)-play important roles in heteroc

192 of about 158 bp and 312 bp are organized as satellite DNAs (Sau3A satellites I and II), whereas the

193 The Rsp locus comprises repeated copies of a satellite DNA sequence and Rsp copy number correlates wi

194 nformations and the rapid expansion of novel satellite DNA sequence families, which form large and co

195 resenting the largest data set of Drosophila satellite DNA sequence to date.

196 obes, specific for human chromosome 17 alpha satellite DNA sequence variants, that distinguish cytoge

197 Highly repetitive satellite DNA sequences are main components of heterochr

198 /- cells exhibit prominent decondensation of satellite DNA sequences at metaphase and increased siste

199 ryological data by more fully characterizing satellite DNA sequences in the Saimiri genus.

200 We conclude that satellite DNA sequences may potentially be very useful f

201 The present study characterizes the satellite DNA sequences of three endemic Hawaiian spider

202 with primary localization to certain AT-rich satellite DNA sequences within heterochromatin.

203 Satellite DNA spans megabases of eukaryotic sequence and

204 nd two nuclear markers and that deduced from satellite DNA (stDNA) sequences suggests that the differ

205 tionary new centromere devoid of centromeric satellite DNA, suggesting that centromeric function may

206 al defense, including RNA editing and retron satellite DNA synthesis.

207 ution of repetitive DNA sequences, including satellite DNA, tandem duplications, and transposable ele

208 of 404 kb encompassing long tracts of alpha satellite DNA, telomeric sequences, and the human hypoxa

209 c elements such as transposable elements and satellite DNAs that can bias their transmission through

210 t TopII, promotes the transcription of alpha-satellite DNAs, the main type of satellite DNAs on human

211 atogenesis, the maintenance and evolution of satellite DNAs, the possible roles of small interfering

212 ation and sites of array transition into non-satellite DNA, typically defined by transposable element

213 common bean (Phaseolus vulgaris) centromeric satellite DNA using genomic data, fluorescence in situ h

214 The reduction in C/EBPalpha binding to alpha-satellite DNA was induced by the co-expression of the tr

215 This YAC, which also included non-alpha satellite DNA, was modified to contain human telomeric D

216 the normal functioning centromere and alpha-satellite DNA, we have studied eight accessory marker ch

217 lthough 99% of this variation corresponds to satellite DNA, we identify 230 regions of euchromatic DN

218 satellite DNA and variable amounts of major satellite DNA which probably comprise the functional cen

219 unusually low abundance of highly repetitive satellite DNA, which allowed us to determine its sequenc

220 ducing C/EBPalpha binding to the major alpha-satellite DNA, which elevated the concentration of C/EBP

221 meres are composed of tandem arrays of alpha-satellite DNA, which spans up to several megabases.

222 s of near-identical tandem repeats, known as satellite DNAs, which offer a limited number of variant

223 have combined long synthetic arrays of alpha satellite DNA with telomeric DNA and genomic DNA to gene

224 ppressive effect of co-injecting mouse alpha satellite DNA with the transgene.

225 CENP-A localizes to a subset of the alpha-satellite DNA, with clusters separated by ~562 nm and a

226 defined by uninterrupted higher-order alpha-satellite DNA, with human artificial chromosomes that co

227 ting the rapid divergence of the centromeric satellite DNA within the Glycine genus.

228 uced by mtDNA and allozymes, except that the satellite DNA yields much longer branches, with higher l