ライフサイエンスコーパス: scaffold

1 ase modulators (GSMs) based on an oxadiazine scaffold.

2 nthesis of a 3-amino-1,2,4-oxadiazine (AOXD) scaffold.

3 LUMO stabilization about the diketophophanyl scaffold.

4 leads to the formation of an azatetraquinane scaffold.

5 he design of new drugs based on the nicotine scaffold.

6 umber of hydroxyl groups on the triterpenoid scaffold.

7 unstable superreduced form of the bimetallic scaffold.

8 e heme axial ligation within this simplified scaffold.

9 tial secondary and tertiary structure of the scaffold.

10 ontrolling the stress distribution along the scaffold.

11 ps to a previously unannotated region of the scaffold.

12 to exploit the versatility of the diterpene scaffold.

13 agonists of GHSR based on the 1,2,4-triazole scaffold.

14 e and activity of virtually any nucleic acid scaffold.

15 s through the UNC-40-dependent intracellular scaffold.

16 occurring substitutions in a simplified AgRP scaffold.

17 antigen outside the confines of the antibody scaffold.

18 n to the analogous indolo[3,2,1-jk]carbazole scaffold.

19 ring entirely novel functions on the peptide scaffolds.

20 to LLL of sirolimus-eluting absorbable metal scaffolds.

21 ity (N50: 9.88 Mb) with 23 chromosomes on 24 scaffolds.

22 processes that occur within these molecular scaffolds.

23 ge bone defects with 3D-printed personalized scaffolds.

24 (~4.3-4.9 nm), uniform (+/-0.3 nm) cage-like scaffolds.

25 ification and incorporation into kinase drug scaffolds.

26 g as an attractive fabrication technique for scaffolds.

27 integrate small-peptide units into designed scaffolds.

28 ts kinase functions, mammalian Cyclin B also scaffolds a localised signalling pathway to help preserv

29 tase 2A (PP2A) is a heterotrimer composed of scaffolding (A), catalytic (C), and regulatory (B) subun

30 s defects in the filamentous actin (F-actin)-scaffolded acroplaxome during spermatid elongation and a

31 oup dnCSP is therefore a promising drug lead scaffold against S. pneumoniae infections that could be

32 structural properties provide a specialized scaffold against which nascent polypeptides can begin to

33 d chemical changes on a conserved structural scaffold allow for the emergence of complexity in a fund

34 The biodegradable scaffolds, along with MDSCs, are implanted into corpus c

35 Thylakoid membranes scaffold an assortment of large protein complexes that w

36 uted seven-membered nitrogenous heterocyclic scaffolds, an efficient method, employing 2-aminoaryl N-

37 1 and IRAK and appears to function both as a scaffold and a protease.

38 -1710) to date based on a covalent inhibitor scaffold and apply this probe to identify and quantify t

39 nts revealed that IFITM3 functions as a PIP3 scaffold and central amplifier of PI3K signalling.

40 9 to elastin-like polypeptides (ELPs) as the scaffold and characterize the biological and cell attach

41 ronic acid (An-BA) probe to a biomimetic DNA scaffold and consequently, to use the unique photophysic

42 as a proliferative monolayer over the shaped scaffold and cultured as stem/proliferative cells to exp

43 otoisomerization in the heptamethine cyanine scaffold and demonstrate the dramatic effect of restrain

44 l for proper nanoscale patterning of the BRP scaffold and needed for SV recruitment of SVs under stro

45 he differentiation of cells is guided by the scaffold and signals, a bottom-up method involves direct

46 g key components of the nuclear pore complex scaffold and the transmembrane nucleoporin POM121.

47 We propose that AC9 dually regulates ERK7 by scaffolding and concentrating it at its site of action w

48 e described a detailed SAR in TLR2 agonistic scaffolds and also covered the design and chemistry for

49 opment of new compounds with unique chemical scaffolds and enhanced influenza antiviral capabilities.

50 elated odorants spanning a range of chemical scaffolds and functional groups.

51 le with late-stage functionalization of drug scaffolds and natural products.

52 e residues/side chains) into diverse protein scaffolds and sites.

53 and vasculature and to fabricate customized scaffolds and surgical guides by 3D printing.

54 e engineering of the set of template/blocker scaffolds and their coupling to a nicking/polymerization

55 rimer, P(1), to the gated replication of the scaffolds and to the displacement of four components tha

56 ctose 3'-sulfate ligated to an inert polymer scaffold, and binding was inhibited by competing dextran

57 The maintenance of this scaffold, and consequently axon pathfinding, is dependen

58 synthesized using the lysine-urea-glutamate scaffold, and PSMA inhibition constants were determined.

59 roduces highly contiguous, chromosome-length scaffolds, and we identify hundreds of TE insertions tha

60 While both protein families are membrane scaffolds appreciated for their role in exosome formatio

61 the identification of a novel quinazolinone scaffold are described, along with optimization efforts

62 omic molecules integrated inside a rigid MOF scaffold are discussed.

63 d biologically compatible 3D printed PCL-rGO scaffolds are a promising platform for regenerative engi

64 revealed that excitons within the cage-like scaffolds are robust, even under extreme heat stress, an

65 cture-activity analysis revealed the decalin scaffold as the best moiety for the selectivity-enabling

66 renewed interest in bicyclic nitroimidazole scaffolds as a source of therapeutics against infectious

67 Collagen scaffolding assembly methods are provided, along with th

68 tructure-activity relationship study for CAY scaffold-based BLT2 agonists is presented.

69 focuses on the properties and indications of scaffold-based extracellular matrix (ECM) technologies a

70 nfluence the characteristics and behavior of scaffolding biomaterials.

71 7-AC9 complex reveals that AC9 is not only a scaffold but also inhibits ERK7 through an unusual set o

72 of the lesion with a bioresorbable vascular scaffold (BVS) plus guideline-directed medical therapy (

73 he dynamic domain is anchored to the helical scaffold by a secondary hydrophobic core, pinning down t

74 Second, active zone proteins may scaffold Ca(V)2s to presynaptic release sites, and synap

75 introduced nitrogen atoms into the inhibitor scaffold can act as hydrogen bond acceptor sites to the

76 hat combines the chromosome-wide phasing and scaffolding capabilities of single-cell strand sequencin

77 Such scaffolding causes communities to participate directly i

78 otency and selectivity, alternative chemical scaffolds, change of mechanism of action (covalents, PRO

79 Miniproteins are a diverse group of protein scaffolds characterized by small (1-10 kDa) size, stabil

80 ms or, if pure LLPS is unfeasible, as binary scaffold-client mixtures.

81 ned morphology of carbon, termed Carbon Nano-Scaffold (CNS) with wide a range of high surface area gr

82 receives its Fe-S cluster from the SUFBC(2)D scaffold complex and serves in the maturation of specifi

83 uclear translocation of Raptor, a regulatory scaffolding component in mTORC1, and localization of Rap

84 is study provides evidence that lamin A/C, a scaffolding component of the nuclear envelope, is critic

85 this work, we prepared 3D printed composite scaffolds comprising polycaprolactone (PCL) and various

86 candidate structures, one-dimensional carbon scaffolds comprising six- and four-membered rings that p

87 A set of four DNA template/blocker scaffolds coupled to the polymerase/dNTP replication mac

88 Also, sequence-engineered template/blocker scaffolds, coupled to the polymerase/dNTP machinery, lea

89 The different positions of the central scaffold, designed using a merging strategy of both targ

90 re introduced with thinner struts, different scaffold designs (to improve deliverability while mainta

91 We incorporated cassettes of two F30-scaffolded dimers of the Broccoli aptamer into a SINV cD

92 e, being used for visualization, clustering, scaffold-diversity analysis and active-series identifica

93 This work shows that V1V2 scaffold DNA priming immunization provides a method to f

94 Deletion of Cav-1 scaffold domain binding (CSD) motif in EphB1 prevented E

95 imer revealed a structural similarity to the scaffold domain of TBK1, suggesting an evolutionary simi

96 etazoan-specific additions to the core STING scaffold enabled a switch from direct effector function

97 trate the unrevealed potential of a confined scaffold environment for tailoring a material's photophy

98 We designed and fabricated a new scaffold exhibiting (1) high tensile strength and biomec

99 based on standardized recombinase-driven DNA scaffolds expressing different genes according to the or

100 rt for a role of the TBC1D1 PTB domains as a scaffold for a range of Rab regulators, and also the VPS

101 ify a potential for optimizing the SS-RJW100 scaffold for antagonist design.

102 n which SNAP23 plays a crucial function as a scaffold for ATG16L1 necessary for the suppression of BA

103 Various materials can be utilized as a scaffold for bioactive peptides; however, it may be adva

104 le and afforded a central spirocyclobutanone scaffold for carbocyclic nucleosides.

105 They guide our future actions, form a scaffold for constructing the self, and continue to shap

106 a mechanistically selective and irreversible scaffold for cysteine conjugation.

107 Nestin thus creates a selective scaffold for DCX with activated cdk5/p35.

108 ng that the three-finger fold is a promising scaffold for developing G protein-coupled receptor modul

109 inor groove of DNA and is actively used as a scaffold for developing potential anticancer and antibio

110 and synthesis of a novel promising bicyclic scaffold for FKBP51 ligands.

111 dentified for the first time as a privileged scaffold for further cost-effective development of valua

112 dition, we show that maltotriose is an ideal scaffold for infection imaging agents encompassing bette

113 MT) cytoskeleton serves as both a supportive scaffold for organelles and an arborized system of track

114 teins that make up the dystrophin complex, a scaffold for signaling proteins and transporters at the

115 The long non-coding RNA NEAT1 serves as a scaffold for the assembly of paraspeckles, membraneless

116 le moiety provides a suitable pharmacophoric scaffold for the design of chemically stable, highly pot

117 The NIPPED-A protein, a scaffold for the SAGA and Tip60 histone modifying comple

118 ", a photoswitchable nonelectrophilic ligand scaffold for the transient receptor potential ankyrin 1

119 phasize the versatility of the Sec14-fold as scaffold for translating the binding of chemically disti

120 ion sequencing enabled near chromosome-level scaffolds for all 11 genomes.

121 the outer surface of the phagophore serve as scaffolds for binding of other core autophagy proteins a

122 e cavitands commonly serve as supramolecular scaffolds for construction of coordination-driven self-a

123 ng of HCN4 channel function, and as possible scaffolds for coordination of signaling pathways.

124 ins (EMPs) play a key role as the structural scaffolds for regulating mineral morphology during ename

125 velopment of inflammation modulating polymer scaffolds for soft tissue repair with minimal postsurgic

126 ed in several foldamer families can serve as scaffolds for the predictable spatial arrangement of fun

127 ional interconnection between these membrane scaffolds for the production of exosomes.

128 The scaffold-free cellu-robots comprise only highly packed c

129 in that assembles to form a dynamic cellular scaffold, frequently perturbed during oncogenic transfor

130 Previously, we developed fibrous scaffolds from complex carbohydrate polymers [i.e. chiti

131 abling the construction of complex molecular scaffolds from simple precursors, has been a long-standi

132 ccess to complex three-dimensional molecular scaffolds from simple reactants.

133 different timescales makes investigations of scaffold functions challenging.

134 Here we define how a multimodular scaffold, GIV (a.k.a. Girdin), titrates such inflammator

135 increase in high-throughput screening data, scaffold graphs have proven useful for the navigation an

136 ore components of a destruction complex that scaffolds GSK3beta and CK1 to earmark beta-catenin for p

137 Scaffold-guided formation of neuronal-like networks, esp

138 in (loratadine) and Clarinex (desloratadine) scaffolds have been enantio- and chemoselectively N-oxid

139 Electrospun scaffolds have great potential for improving wound heali

140 The results show that all BLs prefer scaffolds having electron pair donors: KPC-2 is preferen

141 We applied scaffold hopping and bioisosteric replacement concepts t

142 Scaffold hopping from benzoxazine to chroman and indane

143 Using a scaffold-hybrid strategy, we develop a novel potent and

144 y, these results indicate that atelocollagen scaffolds improve hMSC chondrogenic differentiation and

145 The redox noninnocence of the TAML scaffold in cobalt-TAML (tetra-amido macrocyclic ligand)

146 ribe an unexpected role for the radial fiber scaffold in directing corticospinal and other axons at t

147 l cyclooctadienes are a frequently occurring scaffold in natural products and specialty chemicals, an

148 uired the addition of vocalization onto this scaffold in order to turn such jaw oscillations into voc

149 C2 carbon atoms, respectively, at the indole scaffold in the presence of catalytic iodine and air at

150 stituents attached to the benzenesulfonamide scaffold in three ways, namely, substitutions at the 3,5

151 ered transcriptional regulators and membrane scaffolds in interactomes of importance to human disease

152 Azine-containing biaryls are ubiquitous scaffolds in many areas of chemistry, and efficient meth

153 In conclusion, the value of spirocyclic scaffolds in medicinal chemistry is discussed.

154 l interaction of ligands loaded on polymeric scaffolds, in both a continuum and discrete setting, and

155 Optimal substitution on the PP scaffold included 2-pyridyl ethers directed into the hyd

156 rials, and short syntheses of the privileged scaffold indeno[1,2-c]isoquinolinone were achieved by an

157 upracellular cytoskeletal network provides a scaffold integrating local oscillatory actomyosin contra

158 The number of possible scaffold interaction partners and the ability for these

159 The data for 8 indicated that the pyridine scaffold is a good bioisostere for phenyl, allowing the

160 on of dihydro-furan/indole-fused phthalimide scaffolds is discussed.

161 actions between redox-active, pai-conjugated scaffolds is of interest when developing new conducting

162 trategy to efficiently assemble multiprotein scaffolds-known as megamolecules-without the need for pr

163 X-ray crystal structures of MEK bound to the scaffold KSR (kinase suppressor of RAS) with various MEK

164 The MEDI3726 protein scaffold lacks interchain disulfide bonds and has an ave

165 layer recruits and is organized by an outer scaffolding layer to drive local assembly of a stable st

166 gies available to generate novel NP-inspired scaffolds, limiting both the number and types of compoun

167 colocalized with nuclear paraspeckles, whose scaffolding lncRNA NEAT1 is dramatically upregulated in

168 the bioabsorbable sirolimus-eluting metallic scaffold (Magmaris) remain unknown.

169 MEDI3726 revealed catabolism of the protein scaffold manifested by the more rapid clearance of the A

170 ated by dinucleating, pacman dipyrrin ligand scaffolds ((Mes)dmx, (tBu)dmx: dimethylxanthine-bridged,

171 is performed stepwise and involves molecular scaffolds, metallochaperones, radical chemistry, and nov

172 However, the role of the scaffolding molecule, neurogranin (Ng), in governing the

173 The scaffolding molecule, Ng, when present in significant co

174 lator dissociates Galphai*betagamma trimers, scaffolds monomeric Galphai with RTKs, and facilitates t

175 for the generation and analysis of molecular scaffold networks and trees, with the capability of proc

176 difications on the trisubstituted piperidine scaffold of 11i yielded compounds with high CXCR7 antago

177 t is required to produce the distinct carbon scaffold of colchicine.

178 o the Delta(2,2('))-bi(2H-1,4-benzothiazine) scaffold of red hair pigments is disclosed herein.

179 ith optimization of the thioxotriazinoindole scaffold of the novel AR inhibitor cemtirestat by replac

180 The combination of the scaffold of the polar antioxidant lead 7-methoxy-2,2-dim

181 re dimeric major histocompatibility molecule scaffolds of defined composition.

182 The combination of the scaffolds of the cholinesterase inhibitor huprine Y and

183 used bicyclic gamma-lactones, two privileged scaffolds often found in natural products.

184 - and fibrin-based hemostatic hydrogels as a scaffold on pulp regeneration in a minipig model.

185 in the maize seedling and provide a valuable scaffold on which to better dissect the genetic control

186 c peptidomimetic inhibitors was employed for scaffold optimization, mapping of subsite interactions,

187 re unknown, but it is known to function as a scaffolding or adaptor protein at cell-cell junctions an

188 the design of helical hydrocarbons as rigid scaffolds or as hydrophobic components in soft materials

189 ogous cell-seeded constructs, with nonseeded scaffolds or by suturing.

190 ent RAS activation (such as by targeting the scaffolding phosphatase SHP2).

191 imentally determined and found that the AOXD scaffold possesses promising properties for drug develop

192 The softer ligand scaffold possibly provides increased stability towards t

193 We find that nanopore sequencing with Hi-C scaffolding produces highly contiguous, chromosome-lengt

194 These implanted scaffolds promote tissue ingrowth, which upon cancer ini

195 in the down-regulation of Discs Large MAGUK Scaffold Protein 3 (DLG3), resulting in Golgi complex fr

196 ts of EARLY FLOWERING 3 (ELF3)(4,7), a large scaffold protein and key component of temperature sensin

197 summarize current knowledge about the Atg11 scaffold protein and review recent findings in the conte

198 osphorylation in a complex that includes the scaffold protein Axin and associated kinases.

199 Because it does not interact with the scaffold protein cullin 1 (CUL1), we hypothesized that F

200 The scaffold protein HIGH CHLOROPHYLL FLUORESCENCE244 (HCF24

201 We propose that motifs of the scaffold protein IKKgamma/NEMO partly facilitate such fu

202 The SHANK3 gene encodes a postsynaptic scaffold protein in excitatory synapses, and its disrupt

203 IQGAP1 is a scaffold protein involved in a range of cellular activit

204 The scaffold protein IQGAP1 regulates intracellular signalin

205 sulfurase enzyme IscS provides sulfur to the scaffold protein IscU, which templates the Fe-S cluster

206 A, the farnesylated precursor of the nuclear scaffold protein lamin A.

207 cal reconstitution shows that Bre1 binds the scaffold protein Lge1, which possesses an intrinsically

208 st that the conformational fluctuations in a scaffold protein play a positive role in recruiting down

209 SD) protein that binds to PDZ domains of the scaffold protein PSD-95.

210 An additional interaction detected with the scaffold protein SUFD enabled us to build a model in whi

211 emical approaches, we identified the initial scaffold protein, mitochondrial ISCU (ISCU2) and the sec

212 of SRC family kinase (SFK) signaling by the scaffold protein, PAG1, influences cell fate decisions f

213 derstanding the biological functions of this scaffold protein.

214 de novo synthesis of a [2Fe-2S] cluster on a scaffold protein; Hsp70 chaperone-mediated trafficking o

215 Interactions of NEMO, a scaffolding protein central to NF-kappaB signaling, exem

216 Assess occurrence of the dendritic spine scaffolding protein Drebrin as a pathophysiologically re

217 naling by direct binding to the postsynaptic scaffolding protein gephyrin.

218 P2/T507K possesses a higher affinity for the scaffolding protein Grb2-associated binding protein 1 (G

219 ession from clinical samples, and found that scaffolding protein RACK1 deficiency plays a significant

220 We previously showed that the scaffolding protein SAV1 promotes Hippo signaling by cou

221 S-SCAM is a unique synaptic scaffolding protein that localizes to both excitatory an

222 PIKfyve complex comprises five copies of the scaffolding protein Vac14 and one copy each of the lipid

223 Elp1 is best known as a scaffolding protein within the nuclear hetero-hexameric

224 However, the role of scaffold proteins in these processes is poorly understoo

225 posite binding sites are built into existing scaffold proteins matching the intended binding site geo

226 tracellular compartments by association with scaffold proteins, including by multivalent A-kinase anc

227 the receptor or recruitment of beta-arrestin scaffolding proteins could preserve the analgesic proper

228 repeat proteins, as well as their associated scaffolding proteins, including SHANKs and others, on so

229 xes and contain cytoskeletal, regulatory and scaffolding proteins, which regulate channel conductance

230 ed long-read sequencing and state-of-the-art scaffolding protocols(1) to generate, to our knowledge,

231 ts of the inactive Rag dimer, the pentameric scaffold Ragulator, and the FLCN:FNIP2 (FLCN-interacting

232 In addition to neointimal hyperplasia, late scaffold recoil contributed significantly to LLL of siro

233 Late absolute scaffold recoil was less among patients with LLL <0.5 mm

234 ynthesis and late-stage functionalization of scaffolds relevant to medicinal chemistry.

235 Chemistry efforts on the scaffold revealed a dynamic structure activity relations

236 Analysis of the decellularised scaffolds revealed an acellular matrix with histological

237 and flexible macrocyclic peptides, and that scaffold rigidity can be used to tune optimal lipophilic

238 but it is unclear whether in addition to the scaffolding role betaarrs can allosterically activate th

239 Their scaffolding role depends on specific interactions betwee

240 erates a robust SAC signal, and it reveals a scaffolding role for the key mitotic kinase, Cyclin B1:C

241 Here we use biodegradable polymer scaffolds seeded with autologous cells to restore uterin

242 Here, we investigate thiol-ene micropillar scaffold sheets ("synthetic paper") as the solid substra

243 Moreover, the scaffolds showed excellent osteoconductivity in vitro an

244 olytic polyubiquitin chains regulate protein scaffolding, signaling complex formation, and kinase act

245 uilt from-thus held together by-a continuous scaffold strand, which in turn limits the modularity and

246 d, in a one-pot two-step procedure, valuable scaffolds such as ketene aminals, pyrazolones, and tetra

247 iferative cells to expand them and cover the scaffold surface with the crypt-shaped structures.

248 vior boosts Q beyond that of any multivalent scaffold system.

249 by a more sterically accessible dipyrrinato scaffold (tBu)L ((tBu)L = 5-mesityl-(1,9-di-tert-butyl)d

250 Here we show a new, air-stable bimetallic scaffold that acts as a single-chromophore photocatalyst

251 e condensation reaction-based small molecule scaffold that can undergo rapid condensation reaction up

252 of substituents is tolerated with this novel scaffold that increased cellular metabolic rates in vitr

253 herefore, Cyclin B1 is the long-sought-after scaffold that links MAD1 to the corona, and this specifi

254 rect access to novel non-racemic spirolactam scaffolds that are likely to be of interest to early-sta

255 atalysis of novel functionalized tetracyclic scaffolds that incorporate a fused azabicyclo[3.2.0]hept

256 s, cell and tissue matrices, and immunoassay scaffolds that utilize hydrogel materials is informed by

257 de specificities, all based on a single scFv scaffold, that allows the same CAR to be tested for toxi

258 subunit and, through its C-terminal region, scaffolds the beta subunit of VGCC and the p11/Anxa2 com

259 Ahnak, through its N-terminal region, scaffolds the L-type pore-forming alpha1 subunit and, th

260 r kinetochore, known as the corona, where it scaffolds the spindle assembly checkpoint (SAC) machiner

261 sion of Nog1 demonstrate that this extension scaffolds the tunnel domain of uL4 in the NPET to help m

262 ement in the construction of complex organic scaffolds, the formation of C-C bonds remains a challeng

263 thesis of two very different natural product scaffolds: the (dihydro)pyrazine-N-oxides and the diazen

264 CV entry, and CD81's function as a molecular scaffold; these insights are relevant to CD81's varied r

265 nt entry into the 3-azabicyclo[3.2.0]heptane scaffold through the C-C coupling or oxidative deborylat

266 The unique ability of the ligand scaffold to adapt to the geometric preference of the bri

267 e of payload release from this newly derived scaffold to be directly proportional to the concentratio

268 Herein, we use an alpha-helical scaffold to control the iron coordination geometry when

269 pha-peptides, making them an ideal molecular scaffold to design alpha-helical mimetics.

270 in promotes regeneration by functioning as a scaffold to link axonal organelles, motors and membranes

271 We designed a macrocyclic scaffold to mimic the spatial conformation of the minima

272 0-MALT1 complex, wherein MALT1 acts as (a) a scaffold to recruit components of the canonical NF-kappa

273 ntertwined, with motor behavior serving as a scaffold to shape the sensory input.

274 pulp tissue and evaluate the ability of such scaffold to support stem cell repopulation.

275 sex difference in the adaptation of the PSD scaffold to synGAP haploinsufficiency.

276 t developing next-generation cellularized 3D scaffolds to mimic anatomical size, tissue architecture,

277 tes that EF skills can be cultivated through scaffolded training and are a promising target for thera

278 throughout one of the most popular antibody scaffolds, trastuzumab, used for antibody engineering an

279 hydropyran-fused indoles and other oxacyclic scaffolds under very low catalyst loadings.

280 cytoplasmic tripartite module containing the scaffolds USH1C and ANKS4B and the actin-based motor MYO

281 ts for the first time a rapid creation of 3D scaffolds using magnetic levitation of calcium phosphate

282 esign and production and testing of numerous scaffolded V2 region immunogens.

283 The stereospecific binding modeled for this scaffold was confirmed by resolving the two most potent

284 tudy, the well-established pyrrolopyrimidine scaffold was modified with structural motifs identified

285 The in vitro response of the scaffolds was assessed using human adipose-derived stem

286 The scaffolds were 3.56 +/- 0.43 mm (x-axis) and 4.02 +/- 0.

287 rmations to demonstrate the utility of these scaffolds were also investigated.

288 After decellularisation, the scaffolds were characterised histologically, immunohisto

289 Two different protein scaffolds were engineered to bind to hRBP4 when loaded w

290 g LIVE/DEAD stain kit and the recellularised scaffolds were further assessed histologically and immun

291 NO-OCT derivative, as compared to the parent scaffold, were noted, with the second-order rate constan

292 high spatial symmetry as a site-programmable scaffold, which can be prescribed with desired valence m

293 Aedes aegypti Nbr adopts a HEAT-like repeat scaffold with basic patches constituting an RNA-binding

294 linked azole substituents on a benzisoxazole scaffold with improved Gram-positive antibacterial activ

295 ar proteins, but the construction of protein scaffolds with cavities that could accommodate large sig

296 ting small molecule binding sites or protein scaffolds with existing shape complementarity for a targ

297 ete setting, and compare it with multivalent scaffolds with fixed number of binding sites.

298 by offering rapid access to these privileged scaffolds with high chemo-, regio- and enantioselectivit

299 sing 3D-printed customized calcium phosphate scaffolds with or without surgical vascularization.

300 ANKS4B is known to be an essential scaffold within the IMAC, although its functional proper