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1 actors, glutamatergic signaling, and protein scaffolding.
2 iences (PacBio) assembly with Hi-C-supported scaffolding.
3 ion of laminin trimers and basement membrane scaffolding.
4 lished findings and a refined model of IQGAP scaffolding.
5 in compared to control mice that received no scaffolding.
6 desensitization is directed by PKA via AKAP scaffolding.
7 omosome conformation capture data for genome scaffolding.
8 romosome conformation capture for long range scaffolding.
9 roteins move within the laminin and collagen scaffoldings.
10 hanisms, including sporadic mutations in its scaffolding A and regulatory B subunits or more frequent
11 ighly regulated biogenesis process, with the scaffolding A subunit existing as two highly related iso
12 ind that ARPP-16 interacts directly with the scaffolding A subunit of the serine/threonine protein ph
14 , PME-1, and SET (to reactivate PP2A) or the scaffolding A-subunit of PP2A (PPP2R1A) (to inhibit PP2A
16 tase 2A (PP2A) is a heterotrimer composed of scaffolding (A), catalytic (C), and regulatory (B) subun
18 gest that TGF-beta stimulates a noncanonical scaffolding action of PI3Kgamma, which recruits TRPV4-PI
19 the number of lumens formed, whereas SGEF's scaffolding activity is critical for regulation of actom
20 epsilonRI stimulation, indicating that MALT1 scaffolding activity is insufficient to drive the cytoki
23 st step of VLP assembly and, in concert with scaffolding along the NA, can seed the formation of two-
24 ction of presynaptic vesicles, ion channels, scaffolding and adapter proteins, and membrane receptors
25 related liverwort, M. polymorpha, to improve scaffolding and annotation, aid in the identification of
26 esults indicate that the respective roles of scaffolding and coat proteins may have been redistribute
27 We propose that AC9 dually regulates ERK7 by scaffolding and concentrating it at its site of action w
28 read sequencing technology by assisting with scaffolding and detecting large and complex structural v
30 which CAV1 phosphorylation facilitates CAV1 scaffolding and GRK2-CAV1 interaction, thus clustering e
34 etracycline-inducible expression of pairs of scaffolding and regulatory subunits with complementary c
35 g the kinase arm, PI3Kgamma inhibits PP2A by scaffolding and sequestering, playing a key parallel syn
38 The assembly of the AIS requires membrane, scaffolding, and cytoskeletal proteins, including Ankyri
39 tropes, which affect the molecular motor and scaffolding; and mitotropes, which influence energetics.
42 s, including structural variation detection, scaffolding assembled contigs and mis-assembly detection
47 we conclude that extracellular transsynaptic scaffolding by ELFN2 in the brain is a cardinal organiza
48 hat combines the chromosome-wide phasing and scaffolding capabilities of single-cell strand sequencin
49 on their apical surface to increase membrane scaffolding capacity and enhance function potential.
52 uclear translocation of Raptor, a regulatory scaffolding component in mTORC1, and localization of Rap
55 is study provides evidence that lamin A/C, a scaffolding component of the nuclear envelope, is critic
56 h-quality sequencing, phasing, SV detection, scaffolding, cost-effective diploid de novo genome assem
62 blocked CAV1 phosphorylation induced by CAV1 scaffolding domain, indicating that CAV1 interaction wit
63 SCRT machinery initiates virus abscission by scaffolding early-acting ESCRT-I within the head of the
64 t of PP2A to dephosphorylate p-Akt, and this scaffolding effect of Aldob is independent of its enzyma
68 r results therefore identify GORAB as a COPI scaffolding factor, and support the view that defective
69 ected by the giant protein titin, which is a scaffolding filament, signaling platform, and provider o
70 onomic details of diversity are an essential scaffolding for biology education, yet outdated methods
71 behaviors, interneuron networks serve as the scaffolding for one-shot learning by replaying, reversin
72 chments to humans [1,3], which could provide scaffolding for the development of human-like socio-cogn
73 a plesiomorphic median fin fold can serve as scaffolding for the evolution and development of novel,
74 n of the clot is the first step in providing scaffolding for the formation of new epithelial and cuti
75 teaching and learning resource that provides scaffolding for undergraduate students acculturating to
76 K19 governed IFN-gamma responses through its scaffolding function (i.e., it was kinase independent).
77 a, we discuss the insights obtained from the scaffolding function and how this non-canonical role cou
80 dence from recent studies implicate that the scaffolding function of enzymes could be as important in
83 in vitro experiments inform the basis of the scaffolding function of PSD-95 and provide a detailed mo
84 osphorylation, we have demonstrated that the scaffolding function of receptor interacting protein kin
86 nic action of DNAJ-PKAc involves an acquired scaffolding function that permits recruitment of Hsp70 a
88 e that both caspase-8 enzymatic activity and scaffolding functions contribute to inflammatory cytokin
90 hese findings, we propose that Brc1 provides scaffolding functions linking gammaH2A, Rhp18, and Smc5/
91 of kindlins is well established, but how the scaffolding functions of kindlins are regulated at the m
93 , tyrosine kinase engagement, and additional scaffolding functions with the phosphorylation-dependent
95 oss of inhibitory cells and their protective scaffolding, gain of glial glutamate antiporter xCT expr
97 2alpha competes with LAP2beta for GLI1 while scaffolding HDAC1 to deacetylate the secondary binding s
98 al examples, and a case study of the role of scaffolding in an independent project ('capstone') of a
99 uanylate kinase class of proteins that forms scaffolding interactions with partner proteins, includin
101 otic genomes; however, at present additional scaffolding is needed to achieve chromosome-level assemb
103 ing new technology for sequence assembly and scaffolding, large structural variant detection, and dia
104 layer recruits and is organized by an outer scaffolding layer to drive local assembly of a stable st
105 colocalized with nuclear paraspeckles, whose scaffolding lncRNA NEAT1 is dramatically upregulated in
106 ury (SCI), we demonstrated that the tailored scaffolding maintained hMSC stemness, engraftment, and l
107 ombining the programming ability of DNA as a scaffolding material with a one-step lithographic proces
108 The cultivation of human living cells into scaffolding matrices has progressively gained popularity
110 dings identify a mitochondrial surface-based scaffolding mechanism separating the entry and actions o
111 merging evidence that catalysis-independent "scaffolding" mechanisms contribute to tankyrase function
122 ated that viral ORF57 inhibits primarily the scaffolding of GW182 at the initial stage of PB formatio
124 atal experiences may shape the somatosensory scaffolding of later perceptual, cognitive, and social d
128 re unknown, but it is known to function as a scaffolding or adaptor protein at cell-cell junctions an
129 ther, our data revealed a complex functional scaffolding or signaling role for GPR158 controlling Go
131 ased the binding affinity for MUPP1, a known scaffolding partner of connexin36, and increased the bin
133 uitination, which markedly modifies PSD-95's scaffolding potentials, enables its synaptic targeting,
134 We find that nanopore sequencing with Hi-C scaffolding produces highly contiguous, chromosome-lengt
135 and show that CpmB competes with the 80alpha scaffolding protein (SP) for a binding site on the capsi
136 ring development where it interacts with the scaffolding protein 4.1B and the dynein regulator lissen
139 pacity, MALT1 has two functions, acting as a scaffolding protein and as a substrate-specific protease
140 mponent, has been broadly characterized as a scaffolding protein and is required for the recruitment
141 l Cell, Budnar and colleagues report how the scaffolding protein anillin uses cycles of transient bin
142 bstitutions ranged from inefficient internal scaffolding protein B binding to faulty procapsid elonga
144 74 morphogenesis, 240 copies of the external scaffolding protein D organize 12 pentameric assembly in
146 -CDF) of CaV1.3 channels that depends on the scaffolding protein densin and CaMKII and that outlasts
147 Assess occurrence of the dendritic spine scaffolding protein Drebrin as a pathophysiologically re
149 egradation and, in yeast, recruit Atg11, the scaffolding protein for selective autophagy initiation.
151 P2/T507K possesses a higher affinity for the scaffolding protein Grb2-associated binding protein 1 (G
154 l-drinking elevates BNST levels of the mGlu5-scaffolding protein Homer2 and activated extracellular s
155 rtant new insights into the role of FAK as a scaffolding protein in molecular complexes that regulate
156 omplementation group A (XPA) is an essential scaffolding protein in the multiprotein nucleotide excis
159 the CAV3 gene encoding caveolin-3 (Cav3), a scaffolding protein integral to caveolae in cardiomyocyt
160 dates, MPP7 (MAGUK p55 subfamily member 7, a scaffolding protein involved in cell-cell contacts) and
161 previously shown that Huntingtin (HTT), the scaffolding protein involved in Huntington's disease, re
162 protein (CD2AP), a slit diaphragm-associated scaffolding protein involved in survival and regulation
164 containing CaMKII and Shank3, a postsynaptic scaffolding protein known to interact with L-type calciu
166 also called AKAP450/CG-NAP/AKAP9) is a large scaffolding protein located at both the centrosome and G
167 sis of human metastatic genes identified the scaffolding protein metastasis suppressor 1 (MTSS1) as a
168 Mutations in NBEAL2, the gene encoding the scaffolding protein Nbeal2, are causal of gray platelet
169 Disrupted in Schizophrenia 1 (DISC1) is a scaffolding protein of significant importance for neurod
175 ating cell nuclear antigen (PCNA), a nuclear scaffolding protein pivotal in DNA synthesis, controls n
176 = 0.68) when overexpressing the postsynaptic scaffolding protein PSD-95, which increased receptor clu
177 where it associates with and stabilizes the scaffolding protein PSD95, promoting dendritic spine mat
178 ession from clinical samples, and found that scaffolding protein RACK1 deficiency plays a significant
184 IFICANCE STATEMENT Mutations in the synaptic scaffolding protein SHANK3 are commonly associated with
185 ises the NAD-dependent deacetylase Sir2, the scaffolding protein Sir4, and the nucleosome-binding pro
191 chizophrenia 1 (DISC1) is a multi-functional scaffolding protein that has been associated with neurop
193 cells by knocking down ANLN, a cytoskeletal scaffolding protein that regulates cytokinesis and might
195 t occurs through initial mobilization of the scaffolding protein Tks5 and F-actin accumulation, follo
196 t RA T cells abundantly express the podosome scaffolding protein TKS5, which enables them to form tis
199 PIKfyve complex comprises five copies of the scaffolding protein Vac14 and one copy each of the lipid
200 parate study, we reported that the autophagy scaffolding protein WDFY3 is required for cerebral corti
201 bule actin cross linking factor 1 (MACF1), a scaffolding protein with binding sites for microtubules
203 protein (also known as KAP1 and TIF1beta), a scaffolding protein without intrinsic repressive or DNA-
204 ng of DNA from the histone octamer; that the scaffolding protein XRCC1 enhances the ligation; that th
205 9 (AC9) is found tightly associated with the scaffolding protein Yotiao and the IKs ion channel in he
206 +) exchange regulatory cofactor (NHERF)-1, a scaffolding protein, anchors multiple membrane proteins
207 nding of CCCTC-binding factor, a chromosomal scaffolding protein, and increases histone and DNA methy
209 multiple ankyrin repeat domains 3 (SHANK3B) scaffolding protein, defective expression of which has b
210 uitously expressed cytoplasmic lipid droplet scaffolding protein, is hypothesized to contribute to NA
211 cond WW domain (WW2) of the kidney and brain scaffolding protein, KIBRA, has an isoleucine (Ile-81) r
212 than tightly clustered by the intracellular scaffolding protein, rapsyn, as at the intact neuromuscu
213 3 "writer," and with TRIM28, an abundant HP1 scaffolding protein, to form complexes with increased mu
214 nhibitor, pointed to a mechanism involving a scaffolding protein, Wag31, involved in polar elongation
215 n into dodecameric rings, possibly forming a scaffolding protein-portal protein nucleation complex th
222 , the portal forms a nucleation complex with scaffolding proteins (SPs) to initiate procapsid (PC) as
224 total mGlu1 protein or its coupling to Homer scaffolding proteins after methamphetamine withdrawal, n
225 n domains in the kinase or via anchoring and scaffolding proteins and can drastically increase the ki
226 ely form via interactions among postsynaptic scaffolding proteins and receptors and align with putati
227 ion, we observed marked loss of postsynaptic scaffolding proteins and reduced complexity of the sub-s
228 as associated with reduced recruitment of TZ scaffolding proteins and reduced Smoothened levels at ci
231 the receptor or recruitment of beta-arrestin scaffolding proteins could preserve the analgesic proper
232 In the central nervous system (CNS), Homer scaffolding proteins form signaling complexes with two C
233 a suggest that aphthoviruses actively target scaffolding proteins G3BP1 and G3BP2 and antagonize SG f
236 eodomain finger-containing (BRPF) family are scaffolding proteins important for the recruitment of hi
237 iated guanylate kinase (Dlg/MAGUK) family of scaffolding proteins in beta-catenin signaling, we studi
238 multiple pre- and post-synaptic membrane or scaffolding proteins including glutamatergic ion channel
239 ac1 and nuclear ERK activity depended on the scaffolding proteins IQ motif-containing GTPase-activati
241 d guanylate kinases (MAGUKs) are a family of scaffolding proteins that are expressed in excitatory gl
242 ) exchanger regulatory factor (NHERF) family scaffolding proteins that are required for many aspects
243 T The presynaptic active zone is composed of scaffolding proteins that functionally interact to local
244 hatases and kinases complex, are multidomain scaffolding proteins that play important biologic roles.
245 s mammalian homologues, LLGL1 and LLGL2, are scaffolding proteins that regulate the establishment of
247 1 bound, phosphorylated, and inactivated KSR scaffolding proteins ultimately inhibited Ras/ERK signal
248 al cellulosome assembly, including conserved scaffolding proteins unique to the Neocallimastigomycota
249 se disorders are those encoding postsynaptic scaffolding proteins with roles in synaptic transmission
250 ganization of neurotransmitter receptors and scaffolding proteins within the postsynaptic density.
252 repeat proteins, as well as their associated scaffolding proteins, including SHANKs and others, on so
253 s the interaction between membrane proteins, scaffolding proteins, signalling proteins and enzymes to
254 itic instability and alterations in synaptic scaffolding proteins, studies of glutamate receptor leve
255 ignal through Gi/o-coupled G-proteins and/or scaffolding proteins, such as beta-arrestin, we find tha
256 mes are spatially controlled by cytoskeletal scaffolding proteins, which both recruit and organize th
258 xes and contain cytoskeletal, regulatory and scaffolding proteins, which regulate channel conductance
262 ed long-read sequencing and state-of-the-art scaffolding protocols(1) to generate, to our knowledge,
263 alysis addresses the question of whether the scaffolding provided for a capstone assignment affects i
265 but it is unclear whether in addition to the scaffolding role betaarrs can allosterically activate th
267 erates a robust SAC signal, and it reveals a scaffolding role for the key mitotic kinase, Cyclin B1:C
268 sity between LATS1 and LATS2, and uncovers a scaffolding role of LATS1 in mediating a cross-talk betw
270 Here, we report that, in addition to this scaffolding role, TRIB1 promotes nuclear localization of
272 olytic polyubiquitin chains regulate protein scaffolding, signaling complex formation, and kinase act
275 The canonical PP2A holoenzyme comprises a scaffolding subunit (PP2A Aalpha/beta), which serves as
276 ort the biological importance of PSMD12 as a scaffolding subunit in proteasome function during develo
277 NF-kappaB essential modulator (NEMO) is the scaffolding subunit of the inhibitor of kappaB kinase (I
279 lexes that are recruited to chromatin by the scaffolding subunit transformation/transcription domain-
280 n PPP2R1A, the gene encoding the PP2A Aalpha scaffolding subunit, have been identified across multipl
282 use long-read sequencing methods and modern scaffolding techniques (PacBio, 10X, and Hi-C) to produc
285 apid development in long-read sequencing and scaffolding technologies is accelerating the production
286 aced within the historical context of genome scaffolding technologies that have been in existence sin
288 g assembly, and made improvements by further scaffolding the assembly and removing low-quality sequen
292 nsic role that developmental vision plays in scaffolding the neural implementation of touch perceptio
293 ving provided by parents, and parents aid in scaffolding the process of maturation during childhood.
295 ytic (through UBR5 stabilization) as well as scaffolding (through FACT binding) activities of OTUD5 a
296 on laser lithography is employed for LC cell scaffolding to accurately verify theoretical predictions
297 Here, we use nanopore sequencing and Hi-C scaffolding to produce de novo genome assemblies for two
300 of chromosome number and minimizes errors by scaffolding with the assistance of an assembly graph.