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1 gh both its kinase activity and nonenzymatic scaffolding function.
2 TING ligand-binding domain self-assembly and scaffolding function.
3 is after assembly and appears to perform the scaffolding function.
4 r WDR62 dimerization and is critical for its scaffolding function.
5 ed by phosphorylation regulation of the Axin scaffolding function.
6 PKC signaling and activity through a direct scaffolding function.
7 al flexibility likely to be critical for its scaffolding function.
8 f the tyrosine phosphorylation cascade via a scaffolding function.
9 that inactive caspase-8 also has a pro-death scaffolding function.
10 sent in high-order oligomers and may serve a scaffolding function.
11 S encodes a phosphorylation-dependent cyclin scaffolding function.
12 enable distinct ARRDC3 binding partners and scaffolding functions.
13 g to different partners that impact distinct scaffolding functions.
14 inase catalytic functions from the protein's scaffolding functions.
15 t for >80% of the mass of the APC/C, provide scaffolding functions.
16 le protein interaction motifs to achieve its scaffolding functions.
17 abetics, implicating PAK1 in islet signaling/scaffolding functions.
18 ers, where they can serve both enzymatic and scaffolding functions.
19 cells has considered actin largely for its 'scaffolding' function.
20 a, we discuss the insights obtained from the scaffolding function and how this non-canonical role cou
21 se that the processing of MyD88 disrupts its scaffolding function and uncouples the activation of TLR
22 oteins in the context of their enzymatic and scaffolding functions and in terms of their interactions
24 PhiEC6098 virion suggests that key external scaffolding functions are likely performed by coat prote
25 ts demethylase activity, LSD1 has a critical scaffolding function at genomic sites occupied by the SN
26 isoforms are emerging with localizations and scaffolding functions at sites away from the NE, suggest
27 evidence shows that in addition to canonical scaffolding functions, Barrs can allosterically activate
28 nner face of the plasma membrane and serve a scaffolding function between membrane proteins and the a
29 ion of the downstream components of this FAK scaffolding function by Y315F endophilin A2 mutant or MT
30 hibition of SRC impairing both catalytic and scaffolding functions confers increased anticancer prope
31 e that both caspase-8 enzymatic activity and scaffolding functions contribute to inflammatory cytokin
32 vivo analyses of domains important for MAGUK scaffolding functions demonstrate that while the Vari HO
37 We propose that beta-arrestins via their scaffolding function facilitate Amer1 interaction with P
39 These observations identify a physiologic scaffolding function for IQGAP2 and establish the presen
41 -Src, consistent with the receptor serving a scaffolding function for recruitment and activation of S
42 e concept that DARC provides a high affinity scaffolding function for surface retention of chemokines
45 e data suggest that in addition to canonical scaffolding functions, GPCR-Barr complexes directly allo
46 K19 governed IFN-gamma responses through its scaffolding function (i.e., it was kinase independent).
48 , these results identify a novel role of FAK scaffolding function in breast cancer, which could serve
49 duced disruption of cav-1alpha chaperone and scaffolding function in PAECs likely accounts for divers
52 ting the balance of RIP1 kinase activity and scaffolding function in vivo during development and TNF-
53 ike focal adhesion kinase (FAK) also possess scaffolding functions in intracellular signaling, but su
54 results indicate that both CIT catalytic and scaffolding functions in NPC cytokinesis are critical fo
56 ode uses a kinase domain independent edge, a scaffolding function, in the signaling pathway leading t
59 hat the kinase activity of RIP1, but not its scaffolding function, is dispensable for viability and h
60 d this interaction appears critical for KSR1 scaffolding function, it has been argued that the kinase
61 hese findings, we propose that Brc1 provides scaffolding functions linking gammaH2A, Rhp18, and Smc5/
62 ved framework (FR) subdomains, which serve a scaffolding function maintaining the conformation of loo
63 AK4 signaling is driven by its catalytic and scaffolding functions, necessitating complete removal of
64 et for inflammation and cancer, requires the scaffolding function of beta-arrestins for chemotaxis.
65 Our findings support a kinase-independent scaffolding function of CK2alpha that promotes resistanc
66 ase A anchoring protein, we suggest that the scaffolding function of E3KARP binding to both ezrin and
67 dence from recent studies implicate that the scaffolding function of enzymes could be as important in
71 activation loop mutant uncover an essential scaffolding function of Jak2 within the IFNGR receptor c
75 in vitro experiments inform the basis of the scaffolding function of PSD-95 and provide a detailed mo
77 osphorylation, we have demonstrated that the scaffolding function of receptor interacting protein kin
78 first molecular explanation of the essential scaffolding function of Rev1 and highlights the Rev1 CTD
80 lesion synthesis in vertebrates requires the scaffolding function of the C-terminal domain (CTD) of R
81 optotic cells and that cleavage destroys the scaffolding function of the full-length KSR1 protein and
82 P hydrolysis of kappaB-Ras1 that relies on a scaffolding function of the GTPase rather than on cataly
83 at betaAR-LTP still required a nonionotropic scaffolding function of the N-methyl-D-aspartate-type gl
87 of kindlins is well established, but how the scaffolding functions of kindlins are regulated at the m
88 degrader probe to study the noncatalytic and scaffolding functions of LRRK2 in vitro and in vivo and
92 Tight homodimerization may be central to the scaffolding functions of PRX and AHNAK2 in molecular com
93 es as a chemical probe for investigating the scaffolding functions of RIPK1 and as a potential therap
97 t least two proteins that contribute to this scaffolding function; one is the maturational protease p
98 pletion suggest that OGT's glycosylation and scaffolding functions play distinct roles in the replica
99 graders, nonbromodomain ligands that disrupt scaffolding functions, post-translational modification (
100 eam signaling but may require a nonenzymatic scaffolding function provided by type II receptors to fo
104 inding and NC-RNA interactions serve similar scaffolding functions so that one can functionally compe
105 f cancer cells, where it has a novel nuclear scaffolding function that controls gene expression.
106 k kinase activity, but also its noncatalytic scaffolding function that is linked to drug resistance.
107 RAC1/PAK1 and promoted a kinase-independent scaffolding function that led to recruitment and phospho
108 nic action of DNAJ-PKAc involves an acquired scaffolding function that permits recruitment of Hsp70 a
109 sion components exhibit dual biochemical and scaffolding functions that are critically modulated by f
110 ation, thereby inhibiting both enzymatic and scaffolding functions that prevent phosphorylation and c
112 l to the plasma membrane is required for its scaffolding function, the precise mechanism(s) regulatin
113 t proteins with no functional consequence or scaffolding function to achieve the desired phenotype.
114 suppressor homologs 1/2 (LATS1/2), uses its scaffolding function to link MST1/2 with MARK3, and inhi
115 a structural role, it is believed to play a scaffolding function to organize and inactivate signalin
116 We suggest that the larger fragment serves a scaffolding function to stabilize the basement membrane
117 the unusually long Mdv1 coiled coil serves a scaffolding function to stabilize the Mdv1-Fis1 complex.
120 ify motifs in ZO-1 critical for its putative scaffolding functions, we focused on the SH3-GUK module
122 , tyrosine kinase engagement, and additional scaffolding functions with the phosphorylation-dependent