ライフサイエンスコーパス: scam

1 e substituted cysteine accessibility method (SCAM).

2 e substituted cysteine accessibility method (SCAM).

3 e substituted cysteine accessibility method (SCAM).

4 e substituted cysteine accessibility method (SCAM).

5 ow been analyzed by scanning mutagenesis and SCAM.

6 ved in spine/synapse maturation, Shank and S-SCAM.

7 y other GPCR in which TM6 has been mapped by SCAM.

8 tive impairment, are vulnerable to fraud and scams.

9 d a self-report measure of susceptibility to scams.

10 nts of decision making and susceptibility to scams.

11 decisions and are selectively vulnerable to scams.

12 herapy resulted in a significant decrease in sCAMs.

13 SCaM-1 and M144V produced greater inhibition of NOS's ox

14 r the protein phosphatase calcineurin (CaN); SCaM-1 half-maximally activated mammalian CaN at approxi

15 SCaM-1 is a plant calmodulin (CaM) isoform that is 91% i

16 A V144M back mutation in SCaM-1 significantly restored its ability to activate NO

17 thionine at position 144, is responsible for SCaM-1's inhibition of mammalian NOS.

18 xide synthase (NOS) at 180 nM while another (SCaM-1) served as a competitive antagonist (Ki approxima

19 r competitive antagonism of NOS, M144V, like SCaM-1, exhibited a similar dose-dependent activation of

20 with a similar K(i) (approximately 15 nM) as SCaM-1.

21 ed mammalian CaN at approximately 12 nM, and SCaM-4 competitively antagonized (Ki approximately 70 nM

22 One cloned soybean CaM isoform (SCaM-4) half-maximally activated mammalian nitric oxide

23 mGluR1 internalization by interacting with S-SCAM, a protein that has been implicated in vesicular tr

24 periment that mimicked a real-world imposter scam, a sizable number of older adults engaged without s

25 Furthermore, SCAMs actively proliferate and self-propagate through mu

26 lication of Synaptic Scaffolding Molecule (S-SCAM, also called MAGI-2), which encodes a postsynaptic

27 rt that the synaptic scaffolding molecule (S-SCAM; also called membrane-associated guanylate kinase i

28 vel of decision making and susceptibility to scams; analyses controlled for age, sex, education, and

29 Patients meeting aCAM, eCAM, sCAM and DAWN-CCM criteria had higher rates of 90-day go

30 l substituted cysteine accessibility method (SCAM) and a new fluorescence binding assay.

31 The SCAM approach involved a systematic probe of receptor st

32 g levels of soluble cell adhesion molecules (sCAMs) are more pronounced in DM2-MV than in DM2 and con

33 We identify S-SCAM as a novel component of neuronal nicotinic synapses

34 reas and standard clinical ASPECTS mismatch (sCAM): ASPECTS 6-10.

35 Low scam awareness among older persons is a harbinger of adv

36 ematically examined the associations between scam awareness and adverse cognitive outcomes.

37 ression models examined associations between scam awareness and Alzheimer disease pathology, particul

38 hazards models examined associations between scam awareness and incident Alzheimer dementia and mild

39 Decreased scam awareness may be an early indicator of impending Al

40 The measure of scam awareness used here is too weak for prediction at t

41 Low scam awareness was also associated with increased risk f

42 Finally, low scam awareness was associated with a higher burden of Al

43 Low scam awareness was associated with increased risk for Al

44 Scam awareness was measured via questionnaire, incident

45 those in the conversion group had the lowest scam awareness.

46 PSD-93 and S-SCAM bind to APC and its binding partner beta-catenin, r

47 to decreased postsynaptic accumulation of S-SCAM, but not PSD-93.

48 validate a causal relationship of the rare S-SCAM CNV and provide supporting evidence for the rare CN

49 which may explain the pathogenic nature of S-SCAM copy number variations.

50 The SCAM data were consistent with a C-terminus at 4.58, but

51 Combining the SCAM data with rhodopsin-based molecular models of the r

52 The tumor rapidly drives SCAM differentiation, with intratumoral injections suffi

53 roportion of qualifying patients followed by sCAM, eCAM, aCAM and DAWN-CCM (93.5%, 92.6%, 90.6%, 90%

54 in vivo functional characterization, in vivo SCAM, electrophysiological studies, and disulfide-trappi

55 However, consequences of aberrant S-SCAM expression on GABAergic synapses is little studied.

56 er the many regulatory bodies, current honey scams have been challenging to identify with conventiona

57 study, using a method coined as the "in vivo SCAM", identified several residues in the channel pore t

58 These results reveal the role of S-SCAM in controlling Axin-dependent synaptic localization

59 nraveling the complex network of interacting sCAMs in glutamatergic synapses will be an important str

60 The levels of sCAMs in malaria are thus not an accurate reflection of

61 ere, we review the literature on the role of sCAMs in social affiliative behaviors.

62 e substituted cysteine accessibility method (SCAM) in transmembrane domains 6 (TM6) and 7 (TM7) and e

63 implicated synaptic cell adhesion molecules (sCAMs) in several such disorders that involve marked red

64 t addresses the impact of a diverse group of sCAMs, including neurexins, neuroligins, protocadherins,

65 Further, S-SCAM increased surface AMPAR levels in the absence of PS

66 S-SCAM is a unique synaptic scaffolding protein that local

67 Together, these results suggest that S-SCAM is an essential AMPAR scaffolding molecule for the

68 he earliest identifiable podocytes, MAGI-2/S-SCAM is first detected in junctional complexes in podocy

69 Here we report the effect of S-SCAM knockdown and overexpression on GABAergic synapses.

70 e induction of long term-depression, while S-SCAM knockdown did not.

71 S-SCAM knockdown in cultured hippocampal neurons caused a

72 Conversely, decreasing S-SCAM levels by RNA interference-mediated knockdown cause

73 g the duplication conditions, elevation of S-SCAM levels in excitatory neurons of the forebrain was s

74 Increasing S-SCAM levels in rat hippocampal neurons led to specific i

75 tion in skin biopsies did not correlate with sCAM levels or disease severity.

76 duplication and deletion mutations of the S-SCAM/MAGI-2 gene are associated with schizophrenia and i

77 S-SCAM/MAGI-2 gene duplication is associated with schizoph

78 g N-cadherin, alpha-N-catenin, p120ctn and S-SCAM/Magi2.

79 x proteins from glomerular lysates, MAGI-2/S-SCAM (membrane-associated guanylate kinase inverted 2/sy

80 Overexpression studies using S-SCAM mutants with various domain deletions indicated tha

81 This review finds that the disruption of sCAMs often manifests in changes in social affiliative b

82 of GSK3beta during long-term depression in S-SCAM overexpressing neurons.

83 and increased synaptic GSK3beta levels in S-SCAM overexpressing neurons.

84 Surprisingly, S-SCAM overexpression also attenuated GABAergic synapses,

85 Finally, S-SCAM overexpression hampered NMDA-induced internalizatio

86 S-SCAM overexpression in the forebrain induces SCZ-like ph

87 supporting that GABAergic synapse loss by S-SCAM overexpression is due to the activity-induced dispe

88 calcineurin inhibitor FK506 abolished the S-SCAM overexpression-induced loss of GABA(A) receptors, s

89 ated that Axin-binding is required for the S-SCAM overexpression-induced synaptic GSK3beta reduction.

90 ision making and increased susceptibility to scams (p's<0.001).

91 tween cognitive decline, decision making and scams persisted in analyses restricted to persons withou

92 These results suggest that abnormal S-SCAM protein levels disrupt excitation/inhibition balanc

93 We show that S-SCAM, PSD-93, neuroligin and neurexin are enriched at al

94 fer any user protection, so police raids and scams regularly cause large losses to marketplace partic

95 Importantly, S-SCAM regulated synaptic AMPAR levels in a manner, depend

96 e vulnerability of older adults to fraud and scams relies almost exclusively on self-reported data, w

97 SCAMs represent a unique tumor-specific TREM2(+) populat

98 e CB2 binding pocket, further confirming our SCAM results.

99 < 0.001), such that each 1-unit increase in scam score (indicating lower awareness) was associated w

100 /-SE] in beta-amyloid per 1-unit increase in scam score, 0.22 +/- 0.10 unit; P = 0.029).

101 Seven SCAM-sensitive residues (S3107.33, F3147.37, and I3167.3

102 shoplifting were making money illegally and scamming someone for money.

103 to the accessibility patterns determined by SCAM studies of TMH6 in the opioid and dopamine D2 recep

104 the Xenopus oocyte expression system and the SCAM (substituted cysteine accessibility method), we fou

105 TREM2(+) skin cancer-associated macrophages (SCAMs) support the proliferation of a distinct tumor epi

106 scopic infarcts were associated with greater scam susceptibility (estimate [SE], 0.18 [0.07]; P = .00

107 markers of cerebrovascular pathologies with scam susceptibility and related decision-making outcomes

108 ly cerebral infarcts, is linked with greater scam susceptibility in older adults, independent of comm

109 Scam susceptibility is associated with adverse financial

110 ons who died, 408 had annual assessments for scam susceptibility, cardiovascular risk burden, and cog

111 athy, nor microinfarcts were associated with scam susceptibility.

112 es and thalamus were associated with greater scam susceptibility.

113 the role of cerebrovascular pathologies with scam susceptibility.

114 S-SCAM (synaptic cell adhesion molecule) and PSD-93 (posts

115 inase inverted-2), a protein also known as S-SCAM (synaptic scaffolding molecule).

116 MAGI-2 [also known as S-SCAM (synaptic scaffolding molecule)] is a multi-PDZ dom

117 Financial fraud and scams targeting older adults are on the rise and pose se

118 Here we report that S-SCAM Tg mice have male-specific deficits in synaptic GSK

119 Interestingly, S-SCAM Tg mice show male-specific impairments in synaptic

120 ptic Axin2 levels were increased in female S-SCAM Tg mice.

121 ion with S-SCAM, were also reduced in male S-SCAM Tg mice.

122 We previously used SCAM to identify water-accessible residues that line the

123 e of PSD-95, while PSD-95 was dependent on S-SCAM to increase surface AMPAR levels.

124 e substituted cysteine accessibility method (SCAM) to investigate the membrane-spanning domain struct

125 e substituted-cysteine accessibility method (SCAM) to map the residues in the sixth membrane-spanning

126 e substituted cysteine accessibility method (SCAM) to map the residues of the transmembrane helices (

127 d substituted cysteine accessibility method (SCAM) to provide new evidence for a centrally located ga

128 e substituted-cysteine-accessibility method (SCAM) to the M2 segment and the M1-M2 loop of the acetyl

129 Furthermore, the S-SCAM transgenic mice provide a valuable new animal model

130 Notably, the S-SCAM transgenic mice showed a unique sex difference in s

131 S-SCAM transgenic mice showed an increased number of later

132 e substituted cysteine accessibility method (SCAM) was applied to the first membrane-spanning segment

133 e substituted-cysteine accessibility method (SCAM) was applied to transmembrane span seven of the hum

134 e substituted-cysteine-accessibility method (SCAM), we are mapping the residues that contribute to th

135 e substituted cysteine accessibility method (SCAM), we defined the VirB2 IM topology and then identif

136 e substituted cysteine accessibility method (SCAM), we evaluated the role of possible pore-lining res

137 sidues to thiol blockers (a technique called SCAM), we have identified the pore-lining residues of a

138 e substituted cysteine accessibility method (SCAM), we previously mapped the residues in the third, f

139 helium and increased levels of soluble CAMs (sCAMs), were seen in both severe and uncomplicated malar

140 o which GSK3beta binds in competition with S-SCAM, were also reduced in male S-SCAM Tg mice.

141 jects and of decreased monocyte activity and sCAMs with AT therapy in diabetic subjects with and with

142 ituted cysteine (Cys) accessibility methods (SCAM) with sodium (2-sulfonatoethyl)methanethiosulfonate