ライフサイエンスコーパス: scar

1 orage) and late gadolinium enhancement (LGE, scar).

2 act in anisotropically resistive structures (SCARS).

3 action dose delivered to the area of culprit scar.

4 d injury contributing new cells to the glial scar.

5 otic cardiomyocytes, and a larger myocardial scar.

6 ion due to the formation of a glial-fibrotic scar.

7 recurrent strabismus secondary to stretched scar.

8 y specimens that are painful and permanently scar.

9 ntribute collagen to the forming post-injury scar.

10 o penetrate the inhibitory spinal cord glial scar.

11 as are localized to regions of prior defined scar.

12 slower CV compared with areas without dense scar.

13 repeat containing 1), and localize into the scar.

14 rgery is needed in patients with a stretched scar.

15 herapy in children with foveal toxoplasmosis scars.

16 in the treatment of hypertrophic and keloid scars.

17 CI, 37.4-100) with resulting permanent flat scars.

18 ith external features resembling modern fire scars.

19 glycans (CSPGs)-a primary component of glial scars.

20 ions including their use in the treatment of scars.

21 were at risk of progression of trachomatous scarring.

22 e are associated with post-burn pruritus and scarring.

23 ue repair due to accelerated closure without scarring.

24 analyses to evaluate inflammation and renal scarring.

25 ibrogenic cell in the liver, and drive liver scarring.

26 ract can lead to irreversible fallopian tube scarring.

27 ns (pannus and/or HPs) plus any conjunctival scarring.

28 y epidermal appendage neogenesis and lack of scarring.

29 al signs and moderate or severe conjunctival scarring.

30 st patients respond well to steroids without scarring.

31 recent rigid contact lens wear, and corneal scarring.

32 improved and finally turned to conjunctival scarring.

33 d in 1 tumor (9%, 95% CI, 0.2-50.6), and all scars (100%, 95% CI, 49.9-100) showed pigmentary changes

34 dification was performed in 15 patients with scar (79%).

35 in high-risk, vascularized herpetic corneal scars achieves clinical outcomes that remain stable for

36 The formation of ductular scaring affects liver function; however, scar-generating

37 of heart scars, regulates the size of heart scars after ischemic injury.

38 ctable imaging time for quantification of LA scar and fibrosis in patients with AF.

39 Moreover, noninvasive imaging of myocardial scar and hibernation can inform the risk of sudden cardi

40 Similar to the hypertrophic scar and keloids, the efficacy of glucorticoids (GC) for

41 lminates in transformed barriers composed of scar and metaplastic epithelium.

42 dary strabismus by excision of the stretched scar and muscle fixation to the sclera using non-absorba

43 Corneal scarring and blindness are consequences of the immune re

44 infections caused by HSV-1 can cause corneal scarring and blindness.

45 diated inflammatory responses promoted renal scarring and compromised renal function, as indicated by

46 of the quadrant depended upon the amount of scarring and conjunctival mobility.

47 sex, and the presence of preoperative apical scarring and environmental allergies in a multivariable

48 y response in some individuals that leads to scarring and in-turning of the eyelids in later life.

49 ing concern because it poses a risk of renal scarring and irreversible loss of kidney function.

50 mulation reveals a novel mechanism of genome scarring and is critical to exploring therapies to count

51 derived from skin biopsy studies that cause scarring and may be impractical in large-scale clinical

52 or ductular regeneration, demonstrating that scarring and regeneration can be uncoupled in adult bili

53 mate human biology, as well as comparison of scarring and regenerative phenotypes to uncover master r

54 bullous keratopathy, postinfectious corneal scarring and thinning and keratoconus were the most comm

55 owing a recurrent episodes, it progresses to scarring and visual impairment.

56 Due to the substantial improvement in skin scarring and well-established clinical safety profile, l

57 n a slowly progressive uveitis, with retinal scars and atrophy observed in the chronic stage by fundo

58 gonal order with specific elongated defects, scars and pleats, where the 5-valence and 7-valence vert

59 BCG-Denmark and BCG-Japan induced more BCG scars and PPD reactions than BCG-Russia.

60 spersion mapping, to assess heterogeneity of scar, and evaluated its prognostic role in patients with

61 Peripheral neovascularization, stromal scarring, and features of limbal stem cell deficiency (L

62 Telangiectasia, dyspigmentation, scar appearance, edema, and pain were detected at low ra

63 Scars are a serious health concern for burn victims and

64 Moreover, we show that the mono(ADP-ribose) scars are lost from the chromatin of ARH3-defective cell

65 Voltage indexed scar area at baseline but not changes in scar over time

66 Dense scar areas have, on average, 1.97- to 2.66-fold slower C

67 thesis are evident in characteristic genomic scars as insertions of 3 to 30 bp of sequence that is id

68 Using these "molecular scars" as a guide to discover gene functions, we discove

69 ty of life (EuroQol 5-level EQ-5D), surgical scar assessment (Patient and Observer Scar Assessment Sc

70 rgical scar assessment (Patient and Observer Scar Assessment Scale), and chronic pain (Douleur Neurop

71 equirement and generates distinctive genomic scars associated with pathogenic genome instability.

72 ell identity and survival to instead drive a scar-associated macrophage phenotype.

73 Larger scars at baseline but not changes over time were associa

74 can act as an eraser of ADP-ribose chromatin scars at sites of PARP activity during DNA single-strand

75 gnificantly improved hypertrophic and keloid scars based on both subjective and objective analyses an

76 The 3D CNN identified patients with a large scar burden (>15%) with 98% accuracy (202 of 207) (95% c

77 GE cardiovascular magnetic resonance-defined scar burden is independently associated with inducible V

78 d myocardial scar in three of 17 cases (18%, scar burden of 7% +/- 4).

79 ot only poised to prevent progressive tissue scarring, but also have the potential to reverse establi

80 injury and promote the formation of ductular scars by upregulating pro-fibrogenic cytokines and posit

81 nifested as molecular "scars." Some of these scars can influence brain functions throughout the entir

82 severity of dryness, corneal ulceration and scarring, cataract, and glaucoma are factors associated

83 Myocardial scar cell types and intercellular contacts were analyzed

84 significant corneal injuries and subsequent scarring collectively represent a major global human hea

85 of decay with distance from the electrode in scars compared with uninjured regions, suggesting reduce

86 me season in which the individual showed new scars, confirming that the squid-white shark interaction

87 are required to exclude the other causes of scarring conjunctivitis until more sensitive and specifi

88 After surgical correction of the stretched scar, consecutive deviations in the form of consecutive

89 fibroblasts (OFs) were treated with the pro-scarring cytokine, transforming growth factor beta (TGFb

90 CTBs track along scars deep into the myometrium and beyond.

91 scharge, irreversible tissue destruction and scar development.

92 iopathic pulmonary fibrosis is a progressive scarring disease characterized by extracellular matrix a

93 Eleven showed progression of conjunctival scarring during a median follow-up of 42 months (range,

94 might be a therapeutic tool to prevent renal scarring during acute pyelonephritis.

95 val scarring on presentation or worsening of scarring during follow-up, even in the setting of negati

96 flammatory cells significantly contribute to scar electrophysiology through coupling mediated at leas

97 distorted tracheids was associated with the scarring event.

98 Scar expansion occurred in 1 tumor (9%, 95% CI, 0.2-50.6

99 ed1 profibrotic fibroblasts, responsible for scar extracellular matrix deposition, were significantly

100 Scar firmness showed a significant improvement of 1.2% (

101 all mammals studied to date exhibits spinal scarring following SCI.

102 nsition zones between healthy myocardium and scar form a spatially complex substrate that may give ri

103 ws the complexity of retinal fibrosis, where scar formation is regulated both by TGFbetaR and non-TGF

104 adult mouse GFPtpz-collagen donors, enhances scar formation via cell autonomous production of collage

105 erefore, understanding whether we can reduce scar formation while maintaining a pro-regenerative micr

106 cord injury in mammals is thought to trigger scar formation with little regeneration of axons(1-4).

107 late the inflammatory process and may affect scar formation.

108 nimizing the myocardial damage, healing, and scar formation.

109 of SVZ-derived reactive astrocytes to lesion scar formation.

110 duction of Wnt-ligands reduces the amount of scar formed around the bile duct, without reducing the d

111 Myofibroblasts are scar-forming cells that are ultimately responsible for t

112 , functional heterogeneity and regulation of scar-forming cells that occur during human kidney fibros

113 fibroblasts as the main cellular sources of scar-forming myofibroblasts during human kidney fibrosis

114 (2020) report how typically scar-forming wound fibroblasts enter a transcriptionally

115 diameter and cell wall thickness in the pre-scarring fossilized wood show a response similar to that

116 eatures of wood anatomy associated with fire scars found on fossil tree trunks is likely to increase

117 The frog, Xenopus, can achieve both scar-free healing and tissue regeneration during its lar

118 strategies that could be used to facilitate scar-free healing in the adult mammalian nervous system.

119 to the spinal cord in neonatal mice leads to scar-free healing that permits the growth of long projec

120 activated and have at least two key roles in scar-free healing.

121 ith regeneration of all skin components in a scar-free manner.

122 wound healing by being faster and typically scar-free, has been unexplored.

123 ive or recurrent strabismus due to stretched scar from 2012 to 2017.

124 Congenital anomalies or scarring from previous surgeries, which prevents full ca

125 lar scaring affects liver function; however, scar-generating portal fibroblasts also provide importan

126 ificant differences in lesion size, fibrotic scar, gliosis or neuroinflammation between groups.

127 Patients with a stretched scar had significantly less correction per millimeter (2

128 ver, doxycycline's potential effects on skin scarring have not been explored in vivo.

129 LGE-dispersion mapping is a marker of scar heterogeneity and provides a better risk stratifica

130 q to probe unsorted cells from regenerating, scarring, homeostatic, and developing skin, we identifie

131 of the Wiskott-Aldrich syndrome protein and SCAR homolog (WASH) complex that activates actin nucleat

132 rmed involving 21 patients with hypertrophic scars (HS) (n = 9) and keloids (n = 12) resulting from v

133 ide by virtue of enumerating the dehydration scars imprinted on the O-glycosylated sites.

134 edema cleared in 12/30 eyes and cleared with scar in 18/30 eyes.

135 Endocardial voltage maps showed myocardial scar in 19 patients (90%).

136 Cardiac MRI LGE showed myocardial scar in three of 17 cases (18%, scar burden of 7% +/- 4)

137 ression of CD80 by HSV-1 exacerbated corneal scarring in BALB/c mice.

138 scues the phenotype of increased post-injury scarring in collagen-V-deficient mice.

139 te col4a1 in zebrafish significantly reduces scarring in cryoinjured hosts.

140 lational target relevant to inflammation and scarring in kidney disease.

141 ranslate these findings in order to minimize scarring in patients.

142 rchitecture of the lung and drive pathologic scarring in pulmonary fibrosis.

143 OCT confirmed macular scars in 5 patients, with varying degrees of foveal arch

144 study the electrophysiological properties of scars in fetal liver chimeric mice generated using conne

145 ysical examination revealed well-healed VATS scars in the chest wall.

146 generation because it does not fibrose (i.e. scar) in response to tissue injury as most other mammals

147 P-activated protein kinase activation in the scar, increased vessel density in the penumbra, higher t

148 management of stretched scar -induced secondary strabismus by excision of the st

149 nsecutive and 6 recurrent cases of stretched scar -induced strabismus were identified and all cases w

150 factors, such as bacterial infection, tissue scarring, inflammation, and vasculature damage, as well

151 face area of bipolar voltage consistent with scar is uncommon during the intermediate term.

152 Preoperative apical scarring led to worsening haze (P = .0001), more astigma

153 ing a Cas9-based single-step marker-less and scar-less genomic integration method.

154 on of CD80 has a detrimental role in corneal scarring, likely by increasing CD8(+) T cell recruitment

155 techniques, we found the presence of evident scars made by large squids on the body of the white shar

156 In doxycycline-treated scar matrices, collagen I content was significantly redu

157 The appearance and location of these scars may cause physicians to overlook associated amblyo

158 ar matrix (ECM)-derived coatings to regulate scar-mediated healing.

159 ces of cranial implants, which include glial scarring, meningeal lymphangiogenesis, and increased gly

160 droitinase ABC (chABC), tested here in glial scar models, and ability of cervically-patterned scNSCs

161 After ablation and scar modification, the arrhythmia was noninducible in 19

162 minimally invasive treatment alternative for scar modulation and volume reduction.

163 FBS amplified the catalytic effect of 100 nM sCAR nearly 3-fold.

164 es these diseases result in chronic ductular scarring, necessitating liver transplantation.

165 t associated with the presence of myocardial scar (odds ratio per 1 SD higher, 1.12 [95% CI, 0.86-1.4

166 trended towards a protective effect against scarring (odds ratio 0.71, P = 0.10).

167 size, the GG homozygotes demonstrated worse scarring (odds ratio 1.88, P = 0.005) compared to AG het

168 e scar, was 0.48 +/- 0.04 mm (n = 11) in the scar of the bmpCTL group and decreased 37.5% in the bmpK

169 retion, ependymal denudation, and damage and scarring of intraventricular and parenchymal (glia-lymph

170 ent reactivation events can lead to blinding scarring of the cornea.

171 stitial lung disease characterized by patchy scarring of the distal lung with limited therapeutic opt

172 lateral canthus in each eye and 2 others had scarring of the eyelid margins and blepharitis.

173 ied by epithelial remodeling and progressive scarring of the gas-exchange region.

174 lmonary Fibrosis (IPF), there is unrelenting scarring of the lung mediated by pathological mesenchyma

175 ) is a complex lung disease characterized by scarring of the lung that is believed to result from an

176 atients who have Foster stage 3 conjunctival scarring on presentation or worsening of scarring during

177 oor HRQOL on multivariable analysis; pain on scars on chest (odds ratio (OR) 1.27; 95% CI 0.97-1.65),

178 ed patient cells accumulate mono(ADP-ribose) scars on core histones that are a molecular memory of re

179 ry or foraging behavior, including predation scars on trilobites [7], directionality of invertebrate

180 g accumulation of large clathrin-containing "scars" on the cell surface.

181 ) of BCG, ascertained based on presence of a scar or vaccination history, against latent tuberculosis

182 to be unique among mammals by showing little scarring or fibrosis after skin or muscle injury, but th

183 xed scar area at baseline but not changes in scar over time is associated with progressive increase i

184 h the finding of an intraoperative stretched scar (P < .001).

185 The presence of corneal scarring (P < .00001; OR: 3.00), corneal ulceration (P <

186 cuity risk was 11.1-fold higher with macular scarring (p = 0.001) and 14-fold higher with optic atrop

187 ficits were associated with larger stretched scars (P < .001).

188 ildren for clinical evidence of trachomatous scarring, pannus and Herbert's pits (HPs) or limbal foll

189 decreased in 12 (30%), related to subfoveal scar, persistent subretinal fluid, reactive exudation, r

190 Scars, pleats and other complex defects found in ascidia

191 e, absence of bacillus Calmette-Guerin (BCG) scar, presence of donor-specific antibody, and KTR group

192 s CTHRC1 as a novel regulator of the healing scar process and a target for future translational studi

193 s consistent with adverse remodeling but not scar progression.

194 enes that were significantly associated with scarring progression included those encoding proinflamma

195 A and PDGF were significantly upregulated in scarring progressors relative to in nonprogressors.

196 shown to contribute to myofibroblasts during scarring, promote metaplastic differentiation of airway

197 network (CNN)-based method for automated LGE scar quantification in patients with HCM.

198 mances were evaluated with respect to manual scar quantification performed in a core laboratory setti

199 based on U-Net architecture was used for LGE scar quantification.

200 with longer-lived pseudopods and patches of Scar recruitment.

201 echanism of anti-inflammation-based fibrotic scar reduction.

202 In 3 patients, there was localized scar regression of the LAPW ablation, albeit without con

203 hat collagen V, a minor constituent of heart scars, regulates the size of heart scars after ischemic

204 ndergoing 21 catheter ablation procedures of scar-related VT, site of origin localization accuracy wa

205 underlying acute pyelonephritis-driven renal scarring remain unknown.

206 Skin scarring represents a major source of morbidity for surg

207 ote the reprogramming of myofibroblasts into scar-resolving cells.

208 ic injury, corneal wound healing can cause a scarring response that stiffens the tissue and impairs o

209 Hypertrophic and keloid scars result from abnormal wound healing and can have a

210 We demonstrate that the ADP-ribose chromatin scars result in reduced endogenous levels of important c

211 nt with this, myofibroblasts in human tendon scar samples displayed enhanced prosurvival signaling co

212 Scarring was measured using the Vancouver Scar Scale (VSS).

213 aluations were performed using the Vancouver Scar Scale, Doppler ultrasound, Cutometer, Mexameter and

214 ghts that are consistent with a compensatory/scarring scenario for brain pathological changes.

215 d patients) with low DNA damage (low genomic scar score with chromosome 9 gain) and a superior outcom

216 Conjunctival scarring score at presentation in both biopsy-positive a

217 SCAR (sequence characterized amplified region) markers w

218 No treatment scar showed gliosis, foveal involvement, or retinal trac

219 d with a reduction in cardiac cell death and scar size as well as enhanced angiogenesis.

220 .2 logMAR lines, P = .006) and 1.1 mm larger scar size at 3 months after controlling for baseline mea

221 3 days, 3 weeks, and 3 months, infiltrate or scar size at 3 weeks and 3 months, 3-day smear and cultu

222 ations demonstrate that collagen V regulates scar size in an integrin-dependent manner.

223 heart function, longer survival, and smaller scar size than control mice 28 days post-MI.

224 h A1 and A3 showed a significant decrease in scar size versus A2; however, A1 showed a further 24% re

225 Visual acuity and scar size were analyzed with multiple linear regression

226 to a paradoxical increase in post-infarction scar size with worsening of heart function.

227 left ventricle cardiac function, reduced MI scar size, and enhanced post-MI neovascularization in MI

228 nction, inhibited cell apoptosis, reduced MI scar size, and promoted post-MI neovascularization, wher

229 ncluded 3-week and 3-month visual acuity and scar size, corneal perforation, and/or the need for ther

230 ically significant predictor of perforation, scar size, or final visual acuity.

231 There was no difference in infiltrate or scar size, percentage of epithelialized or adverse event

232 yet little is known about factors regulating scar size.

233 hat drive fibroblast activation and increase scar size.

234 factors and may be manifested as molecular "scars." Some of these scars can influence brain function

235 ata were analyzed in relation to progressive scarring status between baseline and the final time poin

236 fivefold over the following 4 years and bite scars suggest significantly more intraspecific fighting

237 eve demonstration shows the potential of the SCARS technology for the development of unobtrusive, wea

238 ve and either disappear or leave a calcified scar that is associated with seizures.

239 Adhesions are fibrotic scars that form between abdominal organs following surge

240 Ventricular scar, the key substrate for VT, can be noninvasively def

241 of injury was found to significantly reduce scar thickness by 24.8% (P < 0.0001) without compromisin

242 d a significant 27.7% and 28.2% reduction in scar thickness of HS and Keloids, respectively.

243 Scar thickness was reduced by an average of 0.308 +/- 0.

244 In Gal-3 knockout mice, scar thinning ratio, expansion, and cardiac remodeling a

245 isease in which persistent injury results in scar tissue formation.

246 aracterized by the accumulation of excessive scar tissue found throughout the neural retina.

247 osition and the mechanical properties of the scar tissue have been implicated to inhibit neuronal reg

248 , and diminishes the subsequent formation of scar tissue on the surface of the retina.

249 esponse in the infarct area typically yields scar tissue rather than newly formed cardiomyocytes.

250 Scar tissue size following myocardial infarction is an i

251 art regeneration", replacing injured cardiac scar tissue with concomitant electrical integration.

252 Surgical correction involved excision of the scar tissue with muscle re-attachment to the sclera usin

253 ficiency alters the mechanical properties of scar tissue, and altered reciprocal feedback between mat

254 est and the characteristic appearance of the scar tissue.

255 hing intercellular electrical connections in scar tissue.

256 cal examination and biomechanical testing of scar tissue.

257 activation in myofibroblasts in human tendon scar tissue.

258 t eCRT attenuates TGF-beta-mediated fibrosis/scarring to achieve tissue regeneration.

259 ntly no treatment to halt the progression of scarring trachoma due to an incomplete understanding of

260 tubes can lead to damaging inflammation and scarring, ultimately resulting in infertility.

261 ascularized (>=2 quadrants) herpetic corneal scars underwent 2-piece microkeratome-assisted MK.

262 r for episiotomy, and for multiparous women, scarred uterus and multiple pregnancies were risk factor

263 gly correlated with manual quantification of scar volume (r = 0.82-0.99, P < .001) and %LGE (r = 0.90

264 compared with 3D CNN, 2D CNN underestimated scar volume (r = 0.85, P < .001) and %LGE (r = 0.83, P <

265 ardiac MRI late gadolinium enhancement (LGE) scar volume is an important marker for outcome predictio

266 monstrated excellent correlation with manual scar volume quantification (r = 0.88, P < .001) and rati

267 tification (r = 0.88, P < .001) and ratio of scar volume to total left ventricle myocardial volume (%

268 st and accurate quantification of myocardial scar volume, outperforms a two-dimensional convolutional

269 the unambiguous external features of a fire scar was collected for analysis of its fossilized wood.

270 The diagnosis of stretched scar was made in any case of late (>= 1 month) consecuti

271 Scarring was measured using the Vancouver Scar Scale (VS

272 ches 37% of the amplitude at the edge of the scar, was 0.48 +/- 0.04 mm (n = 11) in the scar of the b

273 Blocking Scar/WAVE activation stops phosphorylation in both Dicty

274 The SCAR/WAVE complex is the major driver of lamellipodia fo

275 The Scar/WAVE complex is the principal catalyst of pseudopod

276 CKAP1 subunit of the pentameric cytoskeletal SCAR/WAVE complex, a major downstream target of RAC1, in

277 te how API, a SCAR2 protein component of the SCAR/WAVE complex, controls the root cell wall architect

278 ods and patches of phosphorylation-deficient Scar/WAVE last substantially longer in mutants, altering

279 Phosphorylation-deficient or phosphomimetic Scar/WAVE mutants are both normally functional and rescu

280 Scar/WAVE phosphorylation does not require ERK2 in Dicty

281 SCAR/WAVE proteins and Arp2/3 complex assemble branched

282 ation acts as a pseudopod timer by promoting Scar/WAVE turnover.

283 ant than extracellular signals at regulating Scar/WAVE's activity and that phosphorylation acts as a

284 Here we show that Scar/WAVE's proline-rich domain is polyphosphorylated af

285 nt modifications of the cell wall, driven by SCAR/WAVE, are important in balancing cell wall developm

286 Two isoforms of SCAR/WAVE, WAVE1 and WAVE2, reside at the leading edge,

287 CVA, topography, refraction, CCT, and apical scarring were significant predictors of outcomes.

288 h), although the majority of the sharks with scars were adult and subadult males (n = 9; 64%).

289 uble coxsackievirus and adenovirus receptor (sCAR) were similar with and without FBS, but FBS amplifi

290 findings contrast with the current model of scarring, whereby collagen deposition is exclusively att

291 certain cultivars, in contrast with the stem scar, which healed relatively rapidly.

292 Adduction deficits indicate a stretched scar, which must be treated with resection and advanceme

293 Children with presumed foveal toxoplasmosis scars who underwent amblyopia treatment.

294 o cells expressing phosphorylation-deficient Scar, with longer-lived pseudopods and patches of Scar r

295 epidermis can be selectively removed without scarring, with complete healing within 2 weeks.

296 3A)-responsive cells in driving trachomatous scarring, with potential key mechanistic roles for PDGFB

297 dentifies a trend between COMT genotype with scarring, with rs4680 genetic variation constituting an

298 ealing (ie, full epithelialisation or stable scar) without recurrence at 52 weeks after start of anti

299 rate instead of only repairing wounds with a scar, without perturbing development and homeostasis.

300 Tracheids in the post-scarring wood are initially smaller, and then become lar