ライフサイエンスコーパス: scarring

1 improved and finally turned to conjunctival scarring.

2 thout scarring; and (4) non-keratoconus with scarring.

3 r of aHSCs induced by injury but suppressing scarring.

4 ormal healing and prevention of hypertrophic scarring.

5 evaluating myocardial function, volumes, and scarring.

6 ion, in association with tarsal conjunctival scarring.

7 ts in the prevention and treatment of keloid scarring.

8 from the epidermis is associated with dermal scarring.

9 he profibrotic response leading to excessive scarring.

10 atory-mediated podocyte death and glomerular scarring.

11 currently available to stratify the risk of scarring.

12 is a potential therapeutic target for dermal scarring.

13 9-14.38) were also associated with new renal scarring.

14 L/MpJ 'healer' mice heal similar injuries by scarring.

15 cs, bowel and bladder dysfunction, and renal scarring.

16 to minimise the development of hypertrophic scarring.

17 nephrectomy (SNx) model of progressive renal scarring.

18 station and markers of myocardial injury and scarring.

19 al of 35 children (7.2%) developed new renal scarring.

20 cacious except in 1 case with severe orbital scarring.

21 raft detachments may reattach with interface scarring.

22 ion, in association with tarsal conjunctival scarring.

23 of 28 patients had mild tarsal conjunctival scarring.

24 tually leading to myocardial hypertrophy and scarring.

25 cal trials that promote organ repair without scarring.

26 baseline retinal dysfunction and subsequent scarring.

27 nologic advancement in the treatment of acne scarring.

28 2 inhibitor results in a marked reduction in scarring.

29 aneous wounds might contribute to pathologic scarring.

30 ural circuits or extensive right ventricular scarring.

31 e-related disease featuring progressive lung scarring.

32 ll exercise capacity, and greater myocardial scarring.

33 ound healing results in diminished cutaneous scarring.

34 CNS, which has decreased cell plasticity and scarring.

35 d widespread and confluent right ventricular scarring.

36 e that MC1R genotype may influence post-burn scarring.

37 esulting in submucosal tissue remodeling and scarring.

38 were at risk of progression of trachomatous scarring.

39 e are associated with post-burn pruritus and scarring.

40 ue repair due to accelerated closure without scarring.

41 analyses to evaluate inflammation and renal scarring.

42 ibrogenic cell in the liver, and drive liver scarring.

43 ract can lead to irreversible fallopian tube scarring.

44 ns (pannus and/or HPs) plus any conjunctival scarring.

45 y epidermal appendage neogenesis and lack of scarring.

46 al signs and moderate or severe conjunctival scarring.

47 st patients respond well to steroids without scarring.

48 recent rigid contact lens wear, and corneal scarring.

49 prognosis characterized by unrelenting lung scarring.

50 % vs. 15%; P = 0.01) and less likely to have scarring (17% vs. 36%; P < 0.001) or SHRM (36% vs. 48%;

51 were categorized as (1) keratoconus without scarring; (2) keratoconus with scarring; (3) non-keratoc

52 d markedly reduced both fibrotic and gliotic scarring 3-fold.

53 conus without scarring; (2) keratoconus with scarring; (3) non-keratoconus without scarring; and (4)

54 complications were hearing loss (5.4%), skin scarring (5.4%), amputation (3.4%), renal dysfunction (2

55 c membrane exerts anti-inflammatory and anti-scarring actions, we hypothesized that HC-HA/PTX3 could

56 nd known to exert anti-inflammatory and anti-scarring actions.

57 croptosis and apoptosis, followed by cardiac scarring after antibiotic therapy, in an NHP model of se

58 b GOF and inhbaa LOF both lead to unresolved scarring after cardiac injury.

59 ilizing drug, epothilone B (epoB), decreased scarring after rodent spinal cord injury (SCI) by abroga

60 ingly, a pericyte subset is essential during scarring after spinal cord injury, and its arrest result

61 l autofluorescence resolved without clinical scarring after treatment.

62 Importantly, high temperature and scarring alone had the greatest effect on changing micro

63 l alopecia (CCCA) is the most common form of scarring alopecia among women of African ancestry.

64 ter, adult Pparg(Delta/Delta) mice developed scarring alopecia and severe perifollicular inflammation

65 ures, which modelled the details of fibrotic scarring an order of magnitude below the MRI scan resolu

66 Corneal scarring and blindness are consequences of the immune re

67 infections caused by HSV-1 can cause corneal scarring and blindness.

68 Notably, myocardial scarring and cardiac dimensions, among other variables,

69 diated inflammatory responses promoted renal scarring and compromised renal function, as indicated by

70 of the quadrant depended upon the amount of scarring and conjunctival mobility.

71 ent understanding of purinergic signaling in scarring and discuss its potential to prevent or decreas

72 s used clinically in ophthalmology to reduce scarring and enhance wound resolution after surgery.

73 sex, and the presence of preoperative apical scarring and environmental allergies in a multivariable

74 l target of TGF-beta1 and mediates excessive scarring and fibrosis in several tissues.

75 that knocking down MRTF can lead to reduced scarring and fibrosis.

76 ragility and nonhealing wounds aggravated by scarring and fibrosis.

77 with subcortical calcifications; (3) macular scarring and focal pigmentary retinal mottling; (4) cong

78 functional muscle, human hearts are prone to scarring and hypertrophy, which can often lead to fatal

79 s, we quantified the prevalence of permanent scarring and identified clinical features predictive of

80 y response in some individuals that leads to scarring and in-turning of the eyelids in later life.

81 benefits were associated with suppression of scarring and infiltration of inflammatory/immune cells i

82 ing concern because it poses a risk of renal scarring and irreversible loss of kidney function.

83 mulation reveals a novel mechanism of genome scarring and is critical to exploring therapies to count

84 derived from skin biopsy studies that cause scarring and may be impractical in large-scale clinical

85 plicates many chronic liver diseases causing scarring and organ failure.

86 ounts of extracellular matrix, which induces scarring and organ failure.

87 characterized by confluent right ventricular scarring and patchy left ventricular scarring capable of

88 Microtubule stabilization reduces scarring and promotes axon growth.

89 tissue exposed to WNT-974 exhibits decreased scarring and reduced Col6 production.

90 fully regenerate as evidenced by persistent scarring and reduced wall motion.

91 or ductular regeneration, demonstrating that scarring and regeneration can be uncoupled in adult bili

92 mate human biology, as well as comparison of scarring and regenerative phenotypes to uncover master r

93 bullous keratopathy, postinfectious corneal scarring and thinning and keratoconus were the most comm

94 The fibrotic group had marked bleb scarring and vascularization and worse logMAR visual acu

95 owing a recurrent episodes, it progresses to scarring and visual impairment.

96 d receive urgent AMT to decrease the risk of scarring and visual sequelae.

97 Due to the substantial improvement in skin scarring and well-established clinical safety profile, l

98 ling in limiting the genital tract fibrosis, scarring, and chronic inflammation often associated with

99 es are invasive and result in pain, anxiety, scarring, and disfigurement of patients, which can add a

100 Peripheral neovascularization, stromal scarring, and features of limbal stem cell deficiency (L

101 traditional circumcision, home birth, tribal scarring, and hepatitis B virus coinfection.

102 e common and can lead to extensive fibrosis, scarring, and loss of function.

103 to extracellular matrix accumulation, organ scarring, and loss of kidney function.

104 any, effective treatments to prevent excess scarring, and new treatment strategies are needed.

105 a significant difference in symptom control, scarring, and occurrence of vulvar carcinoma between com

106 es remain poor secondary to corneal melting, scarring, and perforation.

107 s with scarring; (3) non-keratoconus without scarring; and (4) non-keratoconus with scarring.

108 an's layer level, and the absence of stromal scarring are associated with a high risk of developing c

109 reatment of febrile UTIs and permanent renal scarring are associated.

110 crobial therapy and the development of renal scarring are inconsistent.

111 uring open revision which lead to additional scarring around the stent and subsequent raised intraocu

112 undescribed pattern of interface astroglial scarring at boundaries between brain parenchyma and flui

113 h reduced mycobacterial growth but increased scarring at the vaccination site.

114 we introduce a noninvasive method to prevent scarring based on nonthermal partial irreversible electr

115 Cs into mice with liver injury reduced liver scarring based on picrosirius red staining (49.7% reduct

116 isease, including stromal keratitis, corneal scarring, blindness, and encephalitis.

117 ot only poised to prevent progressive tissue scarring, but also have the potential to reverse establi

118 g in oral mucosa is faster and produces less scarring, but the mechanisms involved are incompletely u

119 UWFI; P < .001) and chorioretinal atrophy or scarring by 116% (50 eyes [0.6%] by NMFP vs 101 eyes [1.

120 No case showed clinical haze or scarring by month 3.

121 schemia, tubular dysfunction, and glomerular scarring can result in CKD or ESRD.

122 ricular scarring and patchy left ventricular scarring capable of sustaining a large number of re-entr

123 severity of dryness, corneal ulceration and scarring, cataract, and glaucoma are factors associated

124 hibited an acute inflammatory response, with scarring characterized by stronger myeloperoxidase activ

125 r resolution of NASH, or develop progressive scarring, cirrhosis, and possibly liver cancer.

126 significant corneal injuries and subsequent scarring collectively represent a major global human hea

127 reater overall conjunctival inflammation and scarring compared to controls, similar to CW-TCP.

128 oma filtration surgery and other contractile scarring conditions in the eye.

129 for eye diseases and possibly also for other scarring conditions.

130 are required to exclude the other causes of scarring conjunctivitis until more sensitive and specifi

131 fibroblasts (OFs) were treated with the pro-scarring cytokine, transforming growth factor beta (TGFb

132 Trabeculectomies in eyes without previous scarring decreased 52% from 54 224 in 1994 to 25 758 in

133 New renal scarring defined as the presence of photopenia plus cont

134 Liver fibrosis, a form of scarring, develops in chronic liver diseases when hepato

135 iopathic pulmonary fibrosis is a progressive scarring disease characterized by extracellular matrix a

136 st that genetic associations with chlamydial scarring disease may be focussed on processes relating t

137 Trachoma is a conjunctiva scarring disease, which is the leading infectious cause

138 lmonary fibrosis encompasses a group of lung-scarring disorders that occur owing to known or unknown

139 Advanced UG-TB can cause renal scarring, distortion of renal calyces and pelvic, ureter

140 More eyes with CME (65.3%) developed scarring during 2 years of follow-up compared with eyes

141 Eleven showed progression of conjunctival scarring during a median follow-up of 42 months (range,

142 might be a therapeutic tool to prevent renal scarring during acute pyelonephritis.

143 val scarring on presentation or worsening of scarring during follow-up, even in the setting of negati

144 d hepatic stellate cells (aHSCs) orchestrate scarring during liver injury, with putative quiescent pr

145 irregular astigmatism from anterior stromal scarring during that period.

146 remained significantly associated with renal scarring even after adjusting for these variables.

147 distorted tracheids was associated with the scarring event.

148 all mammals studied to date exhibits spinal scarring following SCI.

149 diameter was found to significantly increase scarring for glass implants, as well as increase local B

150 diameter and cell wall thickness in the pre-scarring fossilized wood show a response similar to that

151 Chronic liver scarring from any cause leads to cirrhosis, portal hyper

152 pro-fibrotic myofibroblast phenotype, limits scarring from different hepatic insults and represents a

153 Congenital anomalies or scarring from previous surgeries, which prevents full ca

154 tologic findings suggest that improvement in scarring from this treatment goes beyond remodeling of c

155 ver, doxycycline's potential effects on skin scarring have not been explored in vivo.

156 ly, and significantly decreased fibrosis and scarring histologically.

157 q to probe unsorted cells from regenerating, scarring, homeostatic, and developing skin, we identifie

158 netic determinants of post-burn hypertrophic scarring (HTS) are unknown, and melanocortin 1 receptor

159 l peel, dermabrasion, wound healing, safety, scarring, hypertrophic scar, and keloid.

160 P2X(7) receptors on infection-induced renal scarring in a murine model of pyelonephritis.

161 ression of CD80 by HSV-1 exacerbated corneal scarring in BALB/c mice.

162 P = 0.01) in PLTR and baseline conjunctival scarring in BLTR (OR, 1.72; 95% CI, 1.06-2.81; P = 0.03)

163 scues the phenotype of increased post-injury scarring in collagen-V-deficient mice.

164 te col4a1 in zebrafish significantly reduces scarring in cryoinjured hosts.

165 We previously showed the role of EGCG in scarring in ex vivo human scar models.

166 with a recombinant HSV-1 exacerbated corneal scarring in infected mice.

167 lational target relevant to inflammation and scarring in kidney disease.

168 idered when aiming to understand the role of scarring in limiting tissue repair and recovery.

169 we demonstrate increased latency and corneal scarring in LTalpha(-/-) infected mice, independent of t

170 hin the cutaneous lupus inflammation without scarring in MRL/lpr mice (P < 0.01).

171 resents a morphological analysis of fibrotic scarring in non-ischemic dilated cardiomyopathy, and its

172 eased 50% lethal dose, and decreased corneal scarring in ocularly infected mice compared to the NgK o

173 ranslate these findings in order to minimize scarring in patients.

174 rchitecture of the lung and drive pathologic scarring in pulmonary fibrosis.

175 P-9 in particular could play a role in tubal scarring in response to gonococcal infection.

176 ausible mechanistic triggers of pathological scarring in skin wounds.

177 to the molecular pathways underlying orbital scarring in TED.

178 y of opiate use, did not have any astroglial scarring in the brain regions analysed.

179 left ventricular dysfunction, and excessive scarring in the ischemic heart.

180 phenotype, associated with decreased implant scarring in the long-term.

181 remodeling, myofibroblast accumulation, and scarring in the orbit of affected individuals.

182 acute blast exposure showed early astroglial scarring in the same brain regions.

183 implants were found to significantly reduce scarring in vivo, compared to hard implants of identical

184 with higher 50% lethal dose and less corneal scarring in vivo.

185 Arthrofibrosis, abnormal scarring in which dense fibrous tissue prevents normal r

186 whose dysregulation may lead to pathological scarring in wounds.

187 onic tissues heal wounds rapidly and without scarring, in a process conserved across species and driv

188 etry, corneal transplantation rates, corneal scarring incidence, and patient-reported outcome measure

189 factors, such as bacterial infection, tissue scarring, inflammation, and vasculature damage, as well

190 standing why adult mammals develop extensive scarring instead of regeneration is a crucial goal for r

191 Although scarring is a component of wound healing, excessive scar

192 Scarring is a long-lasting problem in higher animals, an

193 This scarring is due to loss of podocytes, cells critical for

194 beyond the material yielding threshold, and scarring is thus a by-product of the folding dynamics th

195 y play an important role in certain forms of scarring kidney disease.

196 s replication in the eyes, levels of corneal scarring, latency-reactivation in the trigeminal ganglia

197 Myocardial scarring leads to cardiac dysfunction and poor prognosis

198 Preoperative apical scarring led to worsening haze (P = .0001), more astigma

199 on of CD80 has a detrimental role in corneal scarring, likely by increasing CD8(+) T cell recruitment

200 d neovascularization, postherpetic keratitis scarring, lipid keratopathy, and limbal stem cell defici

201 This distinctive pattern of scarring may indicate specific areas of damage from blas

202 ces of cranial implants, which include glial scarring, meningeal lymphangiogenesis, and increased gly

203 gnosis of LyP and were also required to have scarring, more than 10 lesions, or active lesions on the

204 y during regeneration (Acomys cahirinus) and scarring (Mus musculus), we found that both species exhi

205 es these diseases result in chronic ductular scarring, necessitating liver transplantation.

206 ccal ophthalmia neonatorum can cause corneal scarring, ocular perforation, and blindness as early as

207 trended towards a protective effect against scarring (odds ratio 0.71, P = 0.10).

208 size, the GG homozygotes demonstrated worse scarring (odds ratio 1.88, P = 0.005) compared to AG het

209 multivariate analysis were keratoconus with scarring (odds ratio [OR] = 3.56, P = .02), non-keratoco

210 Epithelial shedding and scarring of fallopian tube mucosa are the main consequen

211 retion, ependymal denudation, and damage and scarring of intraventricular and parenchymal (glia-lymph

212 in whether MP-TCP may cause inflammation and scarring of the bulbar conjunctiva.

213 cell density and mitigated inflammation and scarring of the conjunctiva.

214 ent reactivation events can lead to blinding scarring of the cornea.

215 stitial lung disease characterized by patchy scarring of the distal lung with limited therapeutic opt

216 lateral canthus in each eye and 2 others had scarring of the eyelid margins and blepharitis.

217 ied by epithelial remodeling and progressive scarring of the gas-exchange region.

218 s a clinical disorder characterized by focal scarring of the glomerular capillary tuft, podocyte inju

219 ve kidney diseases are often associated with scarring of the kidney's filtration unit, a condition ca

220 lmonary Fibrosis (IPF), there is unrelenting scarring of the lung mediated by pathological mesenchyma

221 mortality that is characterized by abnormal scarring of the lung parenchyma.

222 ) is a complex lung disease characterized by scarring of the lung that is believed to result from an

223 Visual acuity, dry eye severity, and scarring of the ocular surface and eyelids were assessed

224 Three of 10 had moderate scarring of the tarsal conjunctiva and lid margins and a

225 atients who have Foster stage 3 conjunctival scarring on presentation or worsening of scarring during

226 Determining if individuals with TT had scarring or are known to the health system was critical

227 nal lesions - congenital dysplasia, acquired scarring or both - are a common cause of childhood hyper

228 of cutaneous surgery contributes to abnormal scarring or delayed wound healing is widely taught and p

229 to be unique among mammals by showing little scarring or fibrosis after skin or muscle injury, but th

230 oderate cases have a low risk of significant scarring or visual sequelae and may be monitored and tre

231 [OR] = 3.56, P = .02), non-keratoconus with scarring (OR = 5.09, P = .002), intraoperative central p

232 aCT1 has potential to improve scarring outcome after surgery.

233 The presence of corneal scarring (P < .00001; OR: 3.00), corneal ulceration (P <

234 cuity risk was 11.1-fold higher with macular scarring (p = 0.001) and 14-fold higher with optic atrop

235 tival corkscrew vessels (P < 0.001), corneal scarring (P = 0.01) and pingueculae under the age of 50

236 ildren for clinical evidence of trachomatous scarring, pannus and Herbert's pits (HPs) or limbal foll

237 re of cardiac fibroblasts, which can lead to scarring, pathological remodelling and functional defici

238 Whereas glial scarring presents a roadblock for mammalian spinal cord

239 and confluent, indicating a dense/transmural scarring process in CC.

240 nalysis allowed us to detect the presence of scarring processes resulting from the disappearance of o

241 enes that were significantly associated with scarring progression included those encoding proinflamma

242 A and PDGF were significantly upregulated in scarring progressors relative to in nonprogressors.

243 shown to contribute to myofibroblasts during scarring, promote metaplastic differentiation of airway

244 Trabeculectomies in eyes with scarring ranged from 9054 to 13 604 between 1994-2003, b

245 underlying acute pyelonephritis-driven renal scarring remain unknown.

246 Skin scarring represents a major source of morbidity for surg

247 ells involved in tissue repair, healing, and scarring respond to both ADO and ATP.

248 ic injury, corneal wound healing can cause a scarring response that stiffens the tissue and impairs o

249 Fibrosis and scarring result from chronic inflammation that interrupt

250 l acuity at referral, local therapy, macular scarring, retinal detachment, and hypotony and phthisis

251 ghts that are consistent with a compensatory/scarring scenario for brain pathological changes.

252 Conjunctival scarring score at presentation in both biopsy-positive a

253 The primary efficacy endpoint was average scarring score using visual analog scales evaluating inc

254 included patients with clinically diagnosed scarring secondary to inflammatory or cystic acne.

255 gard to visual acuity, dry eye symptoms, and scarring sequelae at least 3 months after the acute illn

256 No other scarring sequelae occurred.

257 (BCVA) of 20/20, no dry eye symptoms, and no scarring sequelae.

258 10 had only mild or no dry eye symptoms and scarring sequelae.

259 ata were analyzed in relation to progressive scarring status between baseline and the final time poin

260 ould be more effective in treating excessive scarring than modulation of either therapeutic target al

261 a(-/-) mice had significantly higher corneal scarring than WT mice, and adoptive T cell transfer did

262 ive explanation for some forms of pathologic scarring that are now attributed to truncated telomeres.

263 y development of cardiac fibrosis, a form of scarring that increases muscular tissue rigidity and dec

264 c blast exposure showed prominent astroglial scarring that involved the subpial glial plate, penetrat

265 ealing response that generates collagen-rich scarring that is at first protective but if inappropriat

266 g corneal edema can lead to anterior stromal scarring that may limit visual acuity following Descemet

267 vere cases of pyelonephritis can cause renal scarring that subsequently can lead to progressive failu

268 eta 2 adrenergic receptor (beta2AR) in wound scarring, the ability of beta 2 adrenergic receptor agon

269 imicrobial therapy was associated with renal scarring; the median (25th, 75th percentiles) duration o

270 t eCRT attenuates TGF-beta-mediated fibrosis/scarring to achieve tissue regeneration.

271 conjunctival fibroblasts from patients with scarring trachoma and matching control individuals, and

272 ntly no treatment to halt the progression of scarring trachoma due to an incomplete understanding of

273 We further demonstrate that scarring trachoma fibroblasts can promote Akt phosphoryl

274 We show that scarring trachoma fibroblasts substantially differ from

275 ered a distinctive molecular fingerprint for scarring trachoma fibroblasts, and identified IL-6- as a

276 FA) is a recently described inflammatory and scarring type of hair loss affecting almost exclusively

277 ), central corneal disease (vascularization, scarring, ulceration, and conjunctivalization), history

278 tubes can lead to damaging inflammation and scarring, ultimately resulting in infertility.

279 as determined by the degree of conjunctival scarring (using Tauber staging), central corneal disease

280 At 1 year, CDVA associated with the scarring was 20/40 versus 20/20 for the fellow-eye prima

281 otic therapy in those with and without renal scarring was 72 (30, 120) and 48 (24, 72) hours, respect

282 eal hydrops, whereas the presence of corneal scarring was a preventive factor.

283 wound inflammation, angiogenesis, and wound scarring was explored in HDFs, zebrafish, chick chorioal

284 Scarring was measured using the Vancouver Scar Scale (VS

285 Left ventricular scarring was patchy with a predilection for the basal se

286 Chorioretinal scarring was present in 3 patients (7%).

287 healing to attenuate or prevent hypertrophic scarring, well-designed trials to confirm treatment effi

288 inal pigment epithelial atrophy, and macular scarring were associated with increased risk of MVL; and

289 trick skin types I through V and facial acne scarring were enrolled.

290 CVA, topography, refraction, CCT, and apical scarring were significant predictors of outcomes.

291 mal fibroblast (HDF ) function contribute to scarring, whereas hyperpigmentation negatively affects s

292 findings contrast with the current model of scarring, whereby collagen deposition is exclusively att

293 position of neural tissue and leads to glial scarring, which inhibits the regrowth of damaged axons.

294 ncentrations of mitomycin C (MMC) to prevent scarring with trabeculectomy surgery.

295 cutive keratoconic eyes without deep stromal scarring, with at least 1 postoperative examination 1 mo

296 epidermis can be selectively removed without scarring, with complete healing within 2 weeks.

297 aracterized by progressive, unrelenting lung scarring, with death from respiratory failure within 2-4

298 3A)-responsive cells in driving trachomatous scarring, with potential key mechanistic roles for PDGFB

299 dentifies a trend between COMT genotype with scarring, with rs4680 genetic variation constituting an

300 Tracheids in the post-scarring wood are initially smaller, and then become lar