ライフサイエンスコーパス: schistosome

1 asts of planarians (free-living relatives of schistosomes).

2 could increase the colonisation potential of schistosomes.

3 new drug targets in S. haematobium and other schistosomes.

4 s which mirror key features of PZQ action on schistosomes.

5 trate that SmNPP-5 is a virulence factor for schistosomes.

6 ial applications in the study and control of schistosomes.

7 of proviral MLV retrovirus in the transduced schistosomes.

8 issues of transduced schistosomula and adult schistosomes.

9 enomic DNA was extracted from the transduced schistosomes.

10 adily explains how PZQ paralyzes and damages schistosomes.

11 sease caused by parasitic flatworms known as schistosomes.

12 mmed gene editing for functional genomics in schistosomes.

13 capable of transmitting S haematobium-group schistosomes.

14 the hypothesis that the slow development of schistosome-acquired immunity is due to the slow accumul

15 luciferase transgene activity driven by the schistosome actin gene promoter was expressed in the tis

16 ed Kenyans recovered responses of B cells to schistosome Ag.

17 zation of C57BL/6 animals with bacterial and schistosome Ags also resulted in schistosome-specific IL

18 We found that crude schistosome Ags downregulate basal B cell activation lev

19 changes in IgE, IgG1, and IgG4 responses to schistosome and hookworm antigens, including the allerge

20 reens for enzyme inhibitory activity against schistosome and human HDACs.

21 we characterize 43,642 cells from the adult schistosome and identify 68 distinct cell populations, i

22 A potential role for the CCDs shared by the schistosome and invertebrates in inducing an allergy-pro

23 onship between air and water temperature and schistosome and snail development.

24 ships between these two sympatric species of schistosome and to characterise S. spindale diversity in

25 In this article, we focus on schistosomes and metastrongylids of human and animal sig

26 We focus mainly on schistosomes and other parasites with complex life cycle

27 functional genomic-phenomic explorations of schistosomes and other parasites.

28 christened SmTRPM(PZQ), present in parasitic schistosomes and other PZQ-sensitive parasites.

29 zed signalling domains called lipid rafts in schistosomes and propose that correct signalling to ERK

30 The life cycles of schistosomes and soil-transmitted helminths (STHs) sugge

31 factor critical for the optimal survival of schistosomes and successful parasitism.

32 analysis of genomic DNA from the transformed schistosomes, and hybridization signals indicated that t

33 t-ligand regulated transactivation events in schistosomes, and represent potential targets for anti-s

34 n with praziquantel and albendazole affected schistosome- and hookworm-specific humoral responses dif

35 tions in which only one organism is endemic; schistosome- and hookworm-specific responses were not as

36 they also show substantial activity against schistosomes-another hemoglobin-degrading pathogen.

37 The prophylactic efficacy of a schistosome antigen (Sm-p80) was tested in a nonhuman pr

38 Our data indicate that schistosome antigens can activate proinflammatory respon

39 Human type 2 cytokine responsiveness to schistosome antigens increases after treatment; due eith

40 correlating to high antibody titres towards schistosome antigens with unknown molecular identity.

41 The recognition of specific schistosome antigens, both in terms of the diversity of

42 ls to produce additional IL-4 in response to schistosome antigens.

43 e demonstrated transplacental trafficking of schistosome antigens; however, little is known regarding

44 Schistosomes are intravascular, parasitic flatworms that

45 Schistosomes are intravascular, parasitic helminths that

46 Schistosomes are parasitic flatworms that cause schistos

47 Schistosomes are parasitic flatworms that cause schistos

48 Schistosomes are parasitic flatworms that infect over 20

49 Schistosomes are parasitic platyhelminthes that cause sc

50 Schistosomes are parasitic platyhelminths that constitut

51 Collectively, S. mansoni and several other schistosomes are responsible for the infection of an est

52 In contrast, the actin filaments of schistosomes are similar to those of smooth muscles, lac

53 The causative agents, schistosomes, are intravascular flatworm parasites that

54 Little is known regarding the mechanisms of schistosome-associated hepatic fibrosis in humans, and f

55 ollagen degradation, these data suggest that schistosome-associated hepatic fibrosis results, in part

56 used as a powerful tool to investigate adult schistosomes at the topographic molecular level.

57 re, we consider the consequences of this for schistosome biology, immunoepidemiology, and public heal

58 Thus, it appears that the schistosome Ca(v) channel complex has acquired a new fun

59 on rodent and primate models has shown that schistosomes can be defeated when appropriate responses

60 Schistosomes can induce functional Bregs in humans that

61 Schistosomes cause significant morbidity and mortality.

62 We show that this compound paralyzes schistosome cercariae and prevents infection and does so

63 th S. mansoni egg antigens and variably with schistosome cercarial and worm antigens.

64 ed definitively that somatic transgenesis of schistosome chromosomes had taken place and, moreover, r

65 ealed widespread retrovirus integration into schistosome chromosomes.

66 oni and delivery of reporter transgenes into schistosome chromosomes.

67 roviral integration into human compared with schistosome chromosomes.

68 investigation of transgene integration into schistosome chromosomes.

69 The deficits in lipid metabolism that make schistosomes dependent on the host are revealed, and the

70 inducing principle from Schistosoma eggs), a schistosome-derived host modulatory protein, can amelior

71 smission sites in Kenya, where comparison of schistosome detection by conventional snail surveys (sna

72 Schistosomes detoxify heme via crystallization into hemo

73 Within the human host, female and male schistosomes develop and pair as a prerequisite for egg

74 Schistosomes develop multiple body plans while navigatin

75 discuss how widely used degree day models of schistosome development may not be accurate at lower tem

76 ased or injured tissues), our data show that schistosomes display unique, constitutive, functional ex

77 s thinking on processes influencing not only schistosome diversification but also their pathogenicity

78 gain increased understanding of patterns of schistosome diversification, and their abilities to colo

79 Exposure to schistosomes during pregnancy can modulate infant immune

80 anges constitute a substantial alteration to schistosome ecology in that the parasites are more likel

81 g antigens) and culture supernatants of live schistosome egg (egg-conditioned medium), and in particu

82 Antibody responses to schistosome egg (soluble egg antigen and SmTAL2) or soma

83 f the helminth parasite Schistosoma mansoni (schistosome egg Ag (SEA)) leads to the induction of prot

84 cytokines IL-17, IFN-gamma, and TNF-alpha by schistosome egg Ag-stimulated mesenteric lymph node cell

85 ogy induced by concomitant immunization with schistosome egg Ags (SEA) in CFA (SEA/CFA), results from

86 eral blood mononuclear cells stimulated with schistosome egg antigen 4 weeks after PZQ treatment and

87 -pathology C57BL/6 mice by immunization with schistosome egg antigens (SEA) in complete Freund's adju

88 induced in C57BL/6 mice by immunization with schistosome egg antigens in complete Freund's adjuvant,

89 s study, we show that LNFPIII conjugates and schistosome egg antigens interact with APCs via a recept

90 LNFPIII conjugates and schistosome egg antigens, which contain the Lewis(x) tri

91 n glycomics approach in which N-glycans from schistosome egg glycoproteins were prepared, derivatized

92 evel, illuminating new strategies to control schistosome egg production.

93 obium-exposed participants was cultured with schistosome egg, adult worm, and cercaria antigens pre-

94 nt role in driving inflammatory responses to schistosome egg-induced hepatic granulomata reactions, a

95 polygyrus resulted in a marked reduction in schistosome egg-induced hepatic immunopathology, which w

96 t is essential for the development of severe schistosome egg-induced immunopathology, and its absence

97 a central role in the development of severe schistosome egg-induced immunopathology.

98 g two Th2 model systems, allergic asthma and schistosome egg-induced lung granulomas, we found that t

99 Interleukin-4-inducing principle from schistosome eggs (IPSE/alpha-1) is a protein produced ex

100 s DNA repair were induced by an extract from schistosome eggs (soluble egg antigens) and culture supe

101 infected animals was shown to be induced by schistosome eggs and directed largely against egg antige

102 the Lewis(x) trisaccharide that is found on schistosome eggs and in breast milk.

103 patic schistosomiasis, pathology arises when schistosome eggs become lodged in the host liver, evokin

104 Conversely, stimulation with schistosome eggs in the presence of exogenous IL-23 and

105 us, the natural shotgun glycan microarray of schistosome eggs is useful in identifying antigenic glyc

106 f malaria parasites through livers harboring schistosome eggs may alter host immune responses and inf

107 3 by substances released from tissue-trapped schistosome eggs may be important factors contributing t

108 Schistosome eggs promoted proliferation of the urothelia

109 Schistosome eggs provoke the formation of granulomas, or

110 ripts in schistosome-infected mice, and that schistosome eggs selectively stimulate production of IL-

111 We now report that live schistosome eggs stimulate dendritic cells from high pat

112 We first demonstrate that schistosome eggs stimulate production of IL-22 transcrip

113 Cell growth of cells co-cultured with schistosome eggs was monitored in real time, and gene ex

114 Schistosome eggs were exposed to Cas9 complexed with gui

115 ins, suggested that substances released from schistosome eggs were responsible for the observed effec

116 significantly downregulated when exposed to schistosome eggs, and downregulation of estrogen recepto

117 ced Th17 cell differentiation in response to schistosome eggs.

118 hich produce IL-17 when stimulated with live schistosome eggs.

119 or regulation of an inflammatory response to schistosome eggs.

120 lpha-1, the major component secreted by live schistosome eggs.

121 escence titration analyses demonstrated that schistosome eIF4E has similar binding specificity for bo

122 rison of NMR chemical shift perturbations in schistosome eIF4E on binding m(7)GpppG and m(2,2,7)GpppG

123 intrinsic conformational flexibility in the schistosome eIF4E that enables binding to m(2,2,7)G cap.

124 ers in human reproduction, we speculate that schistosome estrogen-like molecules may contribute to in

125 Simultaneous stimulation of schistosome-exposed C57BL/6 dendritic cells with a heat-

126 adult worm antigens by serum antibodies from schistosome-exposed Zimbabweans aged 5-18 years.

127 ovaries and testes from paired and unpaired schistosomes for comparative RNA-seq analyses.

128 o accumulation of infections with long-lived schistosomes from early life.

129 ansgenic lines of schistosomes, to elucidate schistosome gene function and expression, and to advance

130 o encode firefly luciferase under control of schistosome gene promoters was introduced along with 7-m

131 s feasible, given the sequencing of multiple schistosome genomes.

132 us, RGS16-mediated confinement of T cells to Schistosome granulomas mitigates widespread cytokine-med

133 Introduction of exogenous transposons into schistosomes has not been reported but transposon-mediat

134 t genome sequences of two of the major human schistosomes has underscored the pressing need to develo

135 Infection with schistosome helminths is associated with granulomatous i

136 ion role during hematophagy, we propose that schistosome hemozoin also provides a potent immunomodula

137 sing factors associated exclusively with the schistosome host-parasite interface, a structure called

138 n had significantly increased levels of anti-schistosome IgE and CD23(+) B cells after receiving > or

139 B cell activation and anti-schistosome IgE are associated with resistance to S. man

140 ole of specific fucosylated glycan motifs of schistosomes in parasite-host interactions.

141 Strikingly, schistosomes in the bloodstream have this same set of AT

142 ely influences survival and/or maturation of schistosomes in the host to patency, as we reproducibly

143 development of techniques for investigating schistosomes in their human and snail hosts and the deve

144 -enantiomers are highly active against adult schistosomes in vitro (IC50 0.08-0.13 muM), whereas both

145 were consistent with known effects of PZQ on schistosomes, including (i) nanomolar sensitivity to PZQ

146 Thus, schistosome-induced IFN-gamma had a prominent antiviral

147 which result in significant amelioration of schistosome-induced immunopathology.

148 Given that schistosome-induced, non-natural killer T (NKT) cell leu

149 Schistosomes infect 200 million individuals annually and

150 Schistosomes infect approximately 40 million women of ch

151 Schistosomes infect hundreds of millions of people in th

152 Schistosomes infect more than 200 million of the world's

153 Schistosomes infect over 200 million people.

154 Schistosome-infected animals also had significantly lowe

155 Schistosome-infected Cd14(-/-) mice showed significantly

156 Significantly, schistosome-infected IL-12p40-deficient or IL-1R antagon

157 erleukin 17 upon coculture with B cells from schistosome-infected individuals only, while the convers

158 immunoglobulin G in human serum samples from schistosome-infected individuals.

159 Treatment of schistosome-infected mice with 4-phenyl-1,2,5-oxadiazole

160 hibit accumulation of IL22-BP transcripts in schistosome-infected mice, and that schistosome eggs sel

161 We demonstrate that offspring from schistosome-infected mothers that were mated in the TH1

162 d accumulation of the CD4+ memory T cells in schistosome-infected people has implications for the dev

163 diators were elevated in the cord blood from schistosome-infected pregnancies, including insulin-like

164 on by the World Health Organization to treat schistosome-infected pregnant and lactating women.

165 or Schistosoma mansoni, one of the important schistosomes infecting man.

166 gE) responses are upregulated during chronic schistosome infection and during allergy.

167 ological theory and population-level data on schistosome infection and immune responses.

168 determines the severity of pathology during schistosome infection can be influenced not only by host

169 Protective immunity against human schistosome infection develops slowly, for reasons that

170 els and two observational studies in humans, schistosome infection during pregnancy was associated wi

171 Here we examined the effect on the schistosome infection of a third member of the IL-12 fam

172 tudy design, we found contrasting effects of schistosome infection on innate and adaptive immune resp

173 imal models indicate a deleterious effect of schistosome infection on maternal, fetal and neonatal ou

174 with the induction of Th2 responses, murine schistosome infection results in an inhibition of potent

175 produce high levels of IL-17 in response to schistosome infection show increased mortality.

176 At the transcriptome level, schistosome infection was associated with enrichment in

177 At the transcriptome level, schistosome infection was associated with enrichment in

178 Although liver pathology caused by schistosome infection was not affected by either acute o

179 To map the association of schistosome infection with responses to these motifs, we

180 ely 200,000,000 people have schistosomiasis (schistosome infection).

181 ales and females have different responses to schistosome infection, but the effect of sex on systemic

182 ae develop high levels of protection against schistosome infection, correlating to high antibody titr

183 During natural schistosome infection, the induction of T helper type 2

184 t understanding of human immune responses to schistosome infection.

185 sstalk during the different immune phases of schistosome infection.

186 ences should be included in studies of human schistosome infection.

187 e disruption as an additional consequence of schistosome infection.

188 e motility and new strategies for preventing schistosome infection.

189 single drug, praziquantel, is used to treat schistosome infection.

190 of novel therapeutic interventions to manage schistosome infections and broader interest in PZQ, whic

191 Chronic schistosome infections are associated with T-cell hypore

192 Schistosome infections are often clinically silent, but

193 Murine studies have shown that schistosome infections can induce regulatory CD1d(hi) B

194 o the debate regarding treatment of maternal schistosome infections.

195 al, but unexplored intermediary in the snail-schistosome interaction as hemolymph is in very close co

196 (ATP) released by host cells in response to schistosome intravascular migration.

197 Recently, a schistosome ion channel was discovered that is activated

198 The advent of transgenic schistosomes is explored in relation to the biology of t

199 our understanding of sexual reproduction by schistosomes is limited because normal egg production is

200 r, such 'transactivation' by host factors in schistosomes is not well defined.

201 Among the outstanding features of schistosomes is their dioecious lifestyle and the pairin

202 tions confirmed their compatibility with the schistosomes isolated from patients.

203 Intriguingly, schistosomes lacking the esophageal gland die after tran

204 ed significant dose-dependent killing of the schistosome larvae and markedly impaired egg laying of a

205 patibility experiments by exposing snails to schistosome larvae recovered from the urine of a locally

206 itionally screened for lethality against the schistosome larval stage using a fluorescence-based assa

207 emonstrate that SPRM1hc is expressed in each schistosome life stage examined (eggs, cercariae, schist

208 How schistosomes maintain their longevity in this immunologi

209 rted but transposon-mediated transgenesis of schistosomes might supersede current methods for functio

210 hlight future interventions towards stopping schistosome morbidity and transmission within this conse

211 Schistosome mRNAs have either the typical monomethylguan

212 We conclude that schistosome muscles are hybrids, containing striated mus

213 supported by sequence comparison between the schistosome myosin II heavy chain and known striated mus

214 and alpha-1,3-fucose are antigenic motifs on schistosome N-glycans, as well as prominent IgE targets

215 ene expression profiling, we find that these schistosome neoblast-like cells express a fibroblast gro

216 ion in individuals chronically infected with schistosomes or hepatitis C virus (HCV).

217 urification and chemical characterization of Schistosome Paralysis Factor (SPF), a novel tetracyclic

218 challenges in the pilot-scale production of schistosome paramyosin have hampered further studies of

219 Schistosome parasites exhibit separate sexes and with th

220 udy provides a solid basis for investigating schistosome parasites in chemical detail at the whole-wo

221 Schistosome parasites kill 250,000 people every year.

222 ht into the intravascular lives of the major schistosome parasites of humans.

223 Likewise, the remaining important human schistosome parasites, S. japonicum and S. hematobium, a

224 argeting the freshwater snails that transmit schistosome parasites.

225 dditionally, the proteolytic secretions from schistosome parasitic flatworm larvae and a pancreatic c

226 kines, whereas HBV coinfection did not alter schistosome pathogenicity.

227 In this report, we characterize this schistosome permease heavy chain (SPRM1hc) gene and prot

228 ing and functional characterisation of other schistosome/platyhelminth genomes continues to expedite

229 ity, and chromosomal assignment, of existing schistosome/platyhelminth genomes.

230 ught, and flooding could impact on snail and schistosome population dynamics.

231 The eDNA method furthermore detected schistosome presence at two additional sites where snail

232 We propose this as one mechanism by which schistosomes prevent their hosts from focusing immunolog

233 hared by free-living ancestors to modern-day schistosomes probably contributed to the success of thes

234 ances in our understanding of the genomes of schistosomes, progress in the development of functional

235 4E.m(7)GpppG structure demonstrates that the schistosome protein binds monomethyl cap in a manner sim

236 ts, and a chemogenomic screen has pinpointed schistosome proteins for which existing drugs may be act

237 dings that rBgGal selectively recognizes the schistosome-related sugar, lacNAc, and strongly binds to

238 Female schistosomes rely on a unique male-induced strategy to a

239 Female schistosomes rely on continuous pairing with male worms

240 l gene expression between S. mansoni-exposed schistosome-resistant and susceptible snail lines will i

241 Infection with schistosomes results in a CD4 T cell-mediated inflammato

242 footprints in the vicinity of the endogenous schistosome retrotransposons Boudicca, SR1, and SR2.

243 , and others, as well as near the endogenous schistosome retrotransposons, the fugitive and SR1.

244 Schistosomes reveal a surprising ability to switch into

245 isation between S haematobium and the cattle schistosome S bovis had a putative role in this outbreak

246 several decades that rotifers colonizing the schistosome's snail intermediate host produce a water-so

247 Among the schistosomes, Schistosoma haematobium is responsible for

248 Fragments of the MLV transgene and flanking schistosome sequences recovered using an anchored PCR-ba

249 we describe culture conditions that support schistosome sexual development and sustained egg product

250 ells from M. tuberculosis-infected humans to schistosome soluble egg antigen (SEA) and then profiled

251 Data were analyzed according to schistosome species (Schistosoma mansoni or S. haematobi

252 sites, evolutionary conservation among other schistosome species and differential expression across f

253 Whether IPSE homologs are expressed in other schistosome species has not been investigated.

254 cuss recent findings regarding how different schistosome species infect and manipulate immune respons

255 compound was active against the three major schistosome species infecting humans.

256 Of the three main human schistosome species, only S. mansoni is sensitive to oxa

257 issue origin of the epithelial cells and the schistosome species.

258 Interferon (IFN)-gamma secreting, HBV- and schistosome-specific CD8 T cells acted in synergy to red

259 ects were associated with distinctly altered schistosome-specific cytokine and gene expression profil

260 haematobium infection resulted in increased schistosome-specific cytokine responses that were negati

261 haematobium infection resulted in increased schistosome-specific cytokine responses which were negat

262 el treatment markedly alters polarization of schistosome-specific cytokine responses, and these chang

263 Schistosome-specific IgE from resistant, occupationally

264 sociated with a significantly lower ratio of schistosome-specific IgE/IgG4 (marker for resistance to

265 In this article, we demonstrate that schistosome-specific IL-17 induction by dendritic cells

266 This schistosome-specific IL-17 was dependent on IL-6 product

267 cterial and schistosome Ags also resulted in schistosome-specific IL-17, and this response was enhanc

268 had significantly higher baseline levels of schistosome-specific immunoglobulin E (IgE) than did chi

269 he development of natural or vaccine induced schistosome-specific protective immunity as well as for

270 the esophageal gland, which is essential for schistosome survival and pathogenesis.

271 n of host immune cell responses by viral and schistosome T2 enzymes, and neurological development and

272 reveal a heretofore unrecognized role of the schistosome tegument in controlling water and drug movem

273 nes and/or novel drugs targeting TEMs in the schistosome tegument.

274 Recent proteomic analysis of the schistosome tegumental membranes revealed the presence o

275 n this study we cloned and characterized the schistosome tegumental phosphodiesterase SmNPP-5 and eva

276 To explore such a role, we examine schistosomes that lack the esophageal gland due to knock

277 ide, is caused by flatworms (blood flukes or schistosomes) that live in the bloodstream of humans.

278 hologies exacerbated by the long lifespan of schistosomes, that can thrive in the host for decades.

279 es, and represent potential targets for anti-schistosome therapy aimed at reducing parasite survival

280 to treat infection caused by all species of schistosome to combat emerging resistance to current the

281 ntegrates data on 13 cytokines elicited by 3 schistosome to examine how praziquantel treatment alters

282 the cells that enable parasitic worms called schistosomes to reproduce inside snails could lead to ne

283 ers a means to establish transgenic lines of schistosomes, to elucidate schistosome gene function and

284 ng infection of their human definitive host, schistosomes transform rapidly from free-swimming infect

285 Here, we demonstrate that PZQ activates a schistosome transient receptor potential (TRP) channel,

286 Indeed, local schistosome transmission appears firmly engrained for in

287 limitations of current models of climate and schistosome transmission, and substantial gaps in empiri

288 Schistosomes use aquatic snails as intermediate hosts.

289 nhibitors showed potency against both larval schistosomes (viability) and adult worms (pairing, egg l

290 esent, particularly among understudied avian schistosomes, we gain increased understanding of pattern

291 ycans isolated from different life-stages of schistosomes, we studied the anti-glycan immunoglobulin

292 data analysis also showed that the Corsican schistosomes were closely related to those from Senegal

293 Lower susceptibility was documented on adult schistosomes, with most hit compounds being tricyclic mo

294 the first time, permit visualization of live schistosomes within their living hosts.

295 reatment or were unchanged, whereas those to schistosome worm antigens (soluble worm antigen and SmTA

296 ttreatment increases in the levels of IgE to schistosome worm antigens were associated with lower Sch

297 In the present study, we show that schistosome worms also elicit systemic, antigen-specific

298 first report of killing of established adult schistosome worms by a vaccine.

299 Adult schistosome worms colonise human blood vessels for years

300 Together, our data show that schistosome worms establish an immunologic milieu where

301 Schistosome worms infect over 200 million people worldwi