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1 eet the requirements of a rapidly developing schizont.
2 parasite, in the order trophozoite > ring >> schizont.
3 then significantly diminished in late-stage schizonts.
4 trophozoite stage, but absent in late-stage schizonts.
5 s, PfPKA activity can be readily detected in schizonts.
6 they eventually develop into exoerythrocytic schizonts.
7 i apparatus and the micronemes in developing schizonts.
8 ways, while 91% are expressed in replicating schizonts.
9 multiplicity per knob on rolling adhesion of schizonts.
10 gent-insoluble skeletons of P falciparum 3D7 schizonts.
11 cifically co-purify with the 80S fraction in schizonts.
12 and showed higher cytocidal activity against schizonts.
13 pattern with an apical organization in late schizonts.
14 stage, but also occurred in trophozoites and schizonts.
15 with the nucleus of sporozoites and asexual schizonts.
16 ges of the parasite, particularly late stage schizonts.
17 MSP-1 and with each other on the surface of schizonts.
18 vel remained high in trophozoites as well as schizonts.
19 an estimate for the molecular parameters for schizont adhesion to the vascular endothelium and to pre
21 r of these acridones significantly inhibited schizont and hypnozoite formation in both prophylactic a
24 transcriptomic dataset of replicating liver schizonts and dormant hypnozoites of the relapsing paras
28 a, and PfRH2b proteins are expressed in late schizonts and merozoites and are located in apical organ
33 proteins expressed in Plasmodium falciparum schizonts and merozoites: MSPDBL1 (also termed MSP3.4) a
34 G (IgG) and IgG subclasses to P. falciparum schizonts and recombinant circumsporozoite antigen, MSP-
35 blood stages, MyoA was synthesized in mature schizonts and was located at the periphery of segmenting
37 of both GAP45 and MTIP is phosphorylated in schizonts, and we demonstrate that both proteins can be
38 otein was expressed in asexual trophozoites, schizonts, and, when present, in both male and female ga
40 staging the parasites, we find that P. vivax schizonts are largely missing in peripheral blood, with
42 The protein was found to be expressed in schizonts, be localized at the apical end of the merozoi
45 ts released during the Plasmodium falciparum schizont burst to homogeneity and tested for the activat
46 us culture indicate that 11 and 18 spare the schizont but block the progression of the parasite life
47 articipates in processing body-like mRNPs in schizonts but germ cell granule-like mRNPs in gametocyte
48 t block in rupture of erythrocytes by mature schizonts, but they did not inhibit erythrocyte invasion
50 6% of P. vivax rings/trophozoites and 46% of schizonts colocalised with 92% of immature reticulocytes
53 es remains to be proven, given that malarial schizonts contain other proinflammatory moieties, in add
54 ereas depletion of calcineurin in late-stage schizonts demonstrated its critical role in erythrocyte
55 transcripts were abundant only at the end of schizont development in a pattern most common among ebl,
56 erythrocyte cytoskeleton over the course of schizont development, our findings identify an initial s
58 ich the merozoites originating from a single schizont each express a distinct member of this multigen
59 method, we identified Plasmodium falciparum schizont egress antigen-1 (PfSEA-1), a 244-kilodalton pa
60 measured antibodies to Plasmodium falciparum Schizont Egress Antigen-1 (PfSEA-1), and related these a
61 es in vitro to malaria vaccine candidates Pf-schizont egress antigen-1 (PfSEA-1A) and Pf-glutamic aci
67 However, P. yoelii plasmei2(-) liver stage schizonts exhibited an abnormal DNA segregation phenotyp
69 culture and developed to mature liver-stage schizonts expressing P. falciparum merozoite surface pro
70 es in years and antibody reactivity to whole-schizont extract (Chonyi, risk ratio, 0.51, and 95% conf
71 crophage-activating effects of P. falciparum schizont extract (PfSE), but there was only a poor corre
76 f the erythrocyte infected with a late-stage schizont form was m = 2.94 x 10(-6) mm3 s/kg, correspond
81 s demonstrated reactivity with P. falciparum schizonts in a pattern similar to native parasite AMA1.
82 ng in peripheral blood, with the presence of schizonts in circulation correlating with a high reticul
83 , and sporozoites developed into liver-stage schizonts in culture.CONCLUSIONWe have demonstrated the
84 virus-expressed RII recognized P. falciparum schizonts in immunofluorescence assays and also gave sim
85 the transcript level of one gene, encoding a Schizont Infected Cell Agglutination (SICA) protein, her
86 sites was discovered in P. knowlesi, using a schizont-infected cell agglutination (SICA) assay to det
93 o flip due to their biconcave shape, whereas schizonts (late-stage iRBCs) tend to roll due to their a
94 d by ELISA for Abs to an extract of malarial schizonts (MA), recombinant apical merozoite Ag 1 (AMA-1
95 standard medium, which manifested as delayed schizont maturation accompanied by reduced formation of
97 te synthetase, ribonucleotide reductase, the schizont multigene family, and erythrocyte binding antig
98 th through to the synthetic and reproductive schizont phase, which ends with production of new invasi
99 tion of species-specific transcripts in late schizonts, possibly associated with the specificity of e
101 t, in contrast to the prevailing model, many schizonts produced mixed plaques containing both asexual
102 d merozoite and ends, 48 hours later, with a schizont releasing newly formed merozoites, all committe
103 e stage-specific expression of CyRPA in late schizonts resembles that of proteins known to be involve
105 sulted in a severe egress defect, preventing schizont rupture and blocking the erythrocytic cycle.
106 decreased parasite replication by arresting schizont rupture, and conditional disruption of PfSEA-1
107 helial cells, which encounter hemozoin after schizont rupture, respond to sHz by releasing IL-6 and t
109 how that sexually committed, AP2-G(+) mature schizonts specifically upregulate additional regulators
110 se proteins are synthesized in the preceding schizont stage (PTEX150 and HSP101) or even earlier in t
111 ttern of expression, which peaked during mid-schizont stage and then significantly diminished in late
113 n P. vivax but its association with the late schizont stage suggests some of its significance for gen
115 VOR in enabling infected erythrocytes at the schizont stage to form rosettes and in promoting merozoi
117 iquitin conjugates were also detected at the schizont stage, consistent with a cell activity slowdown
119 per physiological parasite-host cell ratios, schizont-stage P. falciparum-IE induced low levels of ce
121 d to localize expression in trophozoite- and schizont-stage parasites and demonstrate extracellular r
125 erent transfection methods and revealed that schizont-stage transfection limited the tendency for par
126 al activity in vitro against blood and liver schizont stages and show good efficacy in Plasmodium fal
127 cupancy analysis during both trophozoite and schizont stages of development demonstrates that PfMORC
129 cetylation increased in late trophozoite and schizont stages, while H4-K16 acetylation peaked in mid-
138 er of merozoites released from an individual schizont, termed the "intraerythrocytic multiplication f
140 to drug-induced conversion of intracellular schizonts to merozoites that lack the ability to maintai
142 n of mature stage parasites (trophozoite and schizonts) to vascular endothelium is well established,
144 o differentiate hypnozoites from liver stage schizonts using a transgenic P. cynomolgi parasite line
145 Growth and maturation of trophozoites and schizonts was markedly inhibited in the presence of the
146 Merozoites physically released from stalled schizonts were capable of invading new erythrocytes, sep
147 n a panel of 50 vivax malaria patients where schizonts were completely absent in 27 isolates, and few
148 rythrocytes containing Plasmodium falciparum schizonts were cultured in the presence of the cysteine
151 to the arrest of global protein synthesis in schizonts, where ontogeny of daughter merozoites takes p
153 ites deficient in PfCDPK5 arrested as mature schizonts with intact membranes, despite normal maturati