ライフサイエンスコーパス: sclera

1 ted human cornea and 0.001% penetrated human sclera.

2 he posterior chamber and finally through the sclera.

3 in stresses and strains in the midposterior sclera.

4 myelinated optic nerve axons adjacent to the sclera.

5 f the lamina cribrosa (LC) and peripapillary sclera.

6 edictive of a stiffer response and a thinner sclera.

7 pigmented epithelium, iris/ciliary body, and sclera.

8 s) in the healthy human retina, choroid, and sclera.

9 nt-yielding a fiber orientation map for each sclera.

10 eason for an ARP is the birefringence of the sclera.

11 (ECM) that controls the extensibility of the sclera.

12 tance to enzymatic degradation of the rabbit sclera.

13 eling that controls the extensibility of the sclera.

14 eratan sulfate (KS) was detected only in the sclera.

15 the material properties of the peripapillary sclera.

16 ng treatments that strengthen the cornea and sclera.

17 nitrate and nitrite reductase, in cornea and sclera.

18 terior (outward) bowing of the peripapillary sclera.

19 ometry and material properties of the LC and sclera.

20 atment prevented expansion of the cornea and sclera.

21 ructural organization of the human posterior sclera.

22 simultaneous indentation and marking on the sclera.

23 r orientation were mapped for each posterior sclera.

24 ical behavior in porcine and human posterior sclera.

25 propagates across all ocular tissues to the sclera.

26 ization of the choroid, lamina cribrosa, and sclera.

27 egulating this biomechanical property of the sclera.

28 glycosaminoglycan synthesis in the posterior sclera.

29 sulcus; in 2 eyes it had been sutured to the sclera.

30 cornea and (6.18 +/- 1.08) x 10(-6) cm/s in sclera.

31 e biomechanical property (creep rate) of the sclera.

32 ly displaced relative to the more peripheral sclera.

33 egulated in adult relative to juvenile mouse sclera.

34 n tissues of the irido-corneal angle and the sclera.

35 solutes and in a more dramatic way than does sclera.

36 ignificant barrier to drug transport than is sclera.

37 rough the RPE and infiltrate the choroid and sclera.

38 s, and global layers (GLs), inserting on the sclera.

39 corneal endothelium, corneal stroma and the sclera.

40 lthy monolayer of RPE resting on choroid and sclera.

41 ng or in ocular inflammatory diseases of the sclera.

42 yde also increased magnetization transfer in sclera.

43 to 120 Gy aiming to deliver >=250 Gy to the sclera.

44 uced corneal thickness, keratoconus and blue sclera.

45 y transmission of light through the iris and sclera.

46 n in retina, retinal pigment epithelium, and sclera.

47 rface and arose with a gentle slope from the sclera.

48 ion, and age-related changes in the anterior sclera.

49 oidal location, and higher radiation dose to sclera.

50 val of TM and obvious injury to the adjacent sclera.

51 nts of fiber orientation in whole normal rat scleras.

52 er tensile strain (1.2%) than mid-peripheral sclera (0.95%) for a 40 mm Hg IOP elevation (P < 0.00001

53 using discs of porcine and human cornea and sclera (5 mm diameter) to assess penetration of a candid

54 The melanocytosis involved the sclera (92%), iris (17%), choroid (12%), eyelid (8%), an

55 CsA implants placed in the deep sclera adjacent to the suprachoroidal space resulted in

56 ells of the conjunctiva, cornea, retina, and sclera after subconjunctival delivery.

57 , high IOP induced up to an 8% strain in the sclera and a 15% strain in the cornea of rabbit kit eyes

58 e I collagen, subunit alpha1 was assessed in sclera and choroid by Western blot analysis.

59 y into the suprachoroidal space, between the sclera and choroid, is an alternative delivery technique

60 Partitioning of the solutes into bovine sclera and choroid-Bruch's layer was also determined.

61 ss the optic nerve canal at the level of the sclera and consisted of collagen types I, III, IV, V, an

62 Tissues from sclera and cornea (type I collagen) and lens capsule (ty

63 cation of diffusion of different analytes in sclera and cornea of rabbit eyes.

64 M/Ch was cholesteryl oleate-enriched, unlike sclera and cornea.

65 lly rely on the morphologically unique human sclera and have been shown to operate even in the absenc

66 The relative contrast between the sclera and iris in all 3 species is comparable, suggesti

67 the perforating vessel's course through the sclera and its termination in the choroid, directly bene

68 Given that the biomechanics of the sclera and lamina cribrosa probably influence retinal ga

69 ssues (specifically within the peripapillary sclera and lamina cribrosa) in response to intraocular p

70 eeper ONH tissues, such as the peripapillary sclera and lamina cribrosa.

71 unctiva is a mucous membrane that covers the sclera and lines the inside of the eyelids.

72 These effects were specific to the human sclera and not seen in response to polarity-inverted eye

73 essed in all ocular tissues tested including sclera and optic nerve head.

74 nt 100-kVp photon beams entering through the sclera and overlapping on the macula cumulating in a the

75 scleritis showed increased thickness of the sclera and presence of intrascleral hyporeflective areas

76 The sclera and RPE were permeable in vitro, ex vivo, and in

77 the permeability coefficients (Papp) across sclera and sclera-choroid-Bruch's layers in bovine and p

78 The thicknesses of the sclera and SCRPE and the melanin content in choroid-RPE

79 In the region of the coloboma, sclera and Tenon's capsule could also be analyzed as a h

80 ong enough to penetrate into human cadaveric sclera and that the drug coating rapidly dissolved off t

81 changes in the mechanical properties of the sclera and the axial elongation rate.

82 e analyzed to determine the thickness of the sclera and the presence or absence of scleral hyporeflec

83 Understanding the permeability properties of sclera and underlying layers would be beneficial in desi

84 Low IOP elicited negligible creep of the sclera and very gradual creep of the cornea.

85 lthy monolayer of RPE resting on choroid and sclera) and the supernatants were removed after 24 hours

86 sile strain than the adjacent mid-peripheral sclera, and 2) strains are significantly higher in the t

87 ed in retrocorneal membranes, underneath the sclera, and adjacent to uveal tissue (ciliary body, iris

88 ocular and orbital tissues--retina, choroid, sclera, and extraocular muscles--exists.

89 were manually segmented (prelamina, choroid, sclera, and lamina cribrosa [LC]).

90 bles excellent visualization of the choroid, sclera, and lamina cribrosa.

91 e obtained: cornea, equatorial and posterior sclera, and posterior pole containing the optic nerve he

92 he concentrations of melanin in choroid-RPE, sclera, and retina of BN rats were 200 +/- 30, 12 +/- 4,

93 1a) receptor subtype in the cornea, choroid, sclera, and retina.

94 etinal vein (CRV), peripapillary choroid and sclera, and subarachnoid space around the optic nerve, w

95 rs; the inner, global layer inserts into the sclera, and the outer, orbital layer inserts into the co

96 nning, posterior bowing of the peripapillary sclera, and thinning and expansion of the scleral canal

97 lastic isotropic segments--iris, cornea, and sclera--and a two-component anisotropic segment represen

98 ; inserted into nonpreserved human cadaveric sclera; and imaged.

99 owever, at the nevus margin, the choroid and sclera appeared normal.

100 ), which lies between the retina and choroid/sclera, appears to play a crucial role in this process.

101 tal sections were collected from a region of sclera approximately midway between the limbus and optic

102 material properties of monkey peripapillary sclera are altered by exposure to moderate, short-term,

103 Animal studies of chemical cross-linking of sclera as a potential treatment for progressive myopia h

104 The transition from the cornea to sclera at the limbus was marked by a change in collagen

105 ning of the scleral flange and peripapillary sclera at the onset of confocal scanning laser tomograph

106 robulbar vessels were found to perforate the sclera at the site of the lacquer crack.

107 c lenses, with the zonule, ciliary body, and sclera attached, inside an environmental scanning electr

108 While the peripapillary sclera became thinner in both mouse types with glaucoma,

109 NH with the scleral flange and peripapillary sclera being thinnest nasally.

110 ural differences were found in the posterior sclera between African American and Caucasian donors.

111 pigment epithelium (RPE) layer and the inner sclera border.

112 eability and partition coefficients of human sclera both significantly decline with increasing donor

113 roportion to accommodative amplitude and the sclera bows inward with increasing age in both species.

114 on syndrome (UES) with histologically normal sclera but responsive to scleral resection.

115 be efficiently delivered into and across the sclera by iontophoresis for drug delivery.

116 rks-Bruch's membrane opening (BMO), anterior sclera canal opening (ASCO), anterior laminar insertion

117 es in multiple eye tissues, but particularly sclera, causing progressive myopia.

118 fferent strain response in the peripapillary sclera characterized by a stiffer meridional response.

119 of photoreceptor-like cells was detected in "sclera+choroid+RPE" eyecup explants derived from adult a

120 Explant culture of "sclera+choroid+RPE" eyecup was used to examine whether c

121 ed that nonendothelial LYVE-1(+)cells in the sclera, choroid, and iris included CD11b(+)F4/80(+) macr

122 red, and celecoxib levels in ocular tissues (sclera, choroid-RPE, retina, vitreous, lens, and cornea)

123 bility coefficients (Papp) across sclera and sclera-choroid-Bruch's layers in bovine and porcine mode

124 ial cells (HCECs) and across isolated bovine sclera-choroid-RPE (SCRPE).

125 days, and retinal pigment epithelium-choroid-sclera (choroidal) flat mounts were prepared.

126 WDR36 gene expression in lens, iris, sclera, ciliary muscles, ciliary body, trabecular meshwo

127 vement was measured using surgically removed sclera clamped in a modified Ussing chamber and connecte

128 mponents of the RPE-Bruch's membrane-choroid-sclera complex were major contributors of vascular endot

129 Choroid sclera complexes, after laser-induced CNV, were examined

130 The sclera contained regions lacking TPAF and CARS fluoresce

131 ose of this study was to examine whether the sclera contains mesenchymal stem/progenitor cells.

132 This study indicates that the sclera contains multipotent mesenchymal stem cells.

133 cantly different between the two strains for sclera, cornea, and lens.

134 Da in ocular tissues including ciliary body, sclera, cornea, and retina.

135 ow-velocity ballistic trauma to the inferior sclera created a reproducible retinal injury, with centr

136 A biomechanical property of the sclera, creep rate, increases; during recovery from indu

137 Ex vivo trans-sclera drug delivery in porcine eyes is demonstrated by

138 sulfated and sulfated GAG composition of the sclera during compensation for a -5 diopter (D) lens and

139 emonstrate gene expression profiles in mouse sclera during ocular growth.

140 binding proteins secreted by the choroid and sclera during visually guided ocular growth.

141 ma and in retinal pigment epithelium/choroid/sclera, establishing that human CFH regulates activation

142 cision reduced recurrence compared with bare sclera excision alone in most studies of primary or recu

143 Evidence indicates that bare sclera excision of pterygium results in a significantly

144 Fifty-one studies comparing bare sclera excision, conjunctival or limbal autograft, intra

145 For all eyes, the posterior sclera exhibited inhomogeneous, anisotropic, nonlinear b

146 The posterior sclera exhibited inhomogeneous, anisotropic, nonlinear m

147 Overall, the peripapillary sclera exhibited significantly higher tensile strain (1.

148 Human posterior sclera exhibits complex regional mechanical behavior in

149 r collagenous layer of submacular BM-choroid-sclera explants generated from aged and AMD human donor

150 India ink to the suprachoroidal space below sclera, following injection.

151 Significant stiffening of the sclera follows exposure to moderate IOP elevations in mo

152 n were measured in strips of human cadaveric sclera for up to 1 week.

153 The sclera forms the fibrous outer coat of the eyeball and a

154 s also examined in tissue-cultured pieces of sclera from additional marmosets.

155 Trephined ONH and peripapillary sclera from both eyes of four monkeys were serially sect

156 Trephinated ONH and peripapillary sclera from both eyes of nine monkeys that were perfusio

157 Trephined ONH and peripapillary sclera from both eyes of six monkeys, each perfusion fix

158 Trephinated ONH and peripapillary sclera from both eyes of six normal monkeys were serial

159 The trephinated ONH and peripapillary sclera from both eyes of three early glaucoma (EG) monke

160 The trephinated ONH and peripapillary sclera from both eyes of three monkeys with early glauco

161 Peripapillary sclera from the early-glaucoma eyes exhibited an equilib

162 Diffusion of CsA across the sclera from the episcleral space was not a feasible meth

163 Posterior-temporal scleras from 75 right eyes were procured at an average d

164 e wall of SC with the channel going into the sclera, from which quantitative measurements were made.

165 ayer of hyaline cartilage within the fibrous sclera giving an extra degree of support to the eyeball.

166 cted in the conditioned medium of choroid or sclera had an apparent Mr of 27,000 Da.

167 Aged human sclera had relatively high fluorescence due to nonenzyma

168 Cornea and sclera homogenates possessed a measurable amount of nitr

169 verall, the scleral flange and peripapillary sclera immediately surrounding the ONH were posteriorly

170 collagen solubility profile of the posterior sclera in a canine model of primary open-angle glaucoma

171 ral GAG synthesis in tissue-cultured primate sclera in a dose-dependent manner after several days.

172 cells regulates the growth of the equatorial sclera in a vision-dependent manner.

173 eral flap and connected them to the adjacent sclera in all 53 patients.

174 Less than ~20% of DEX was released from the sclera in approximately 2h after cathodal iontophoretic

175 Peripapillary sclera in CD1 controls had significantly greater tempora

176 anization, at five regions of the cornea and sclera in chickens developing high myopia and astigmatis

177 ed by cells in the fibrous and cartilaginous sclera in equatorial regions of the eye.

178 l strain of peripapillary and mid-peripheral sclera in normal eyes from elderly human donors.

179 ambiguous boundaries between the choroid and sclera in Optical Coherence Tomography (OCT) images.

180 OCT was performed over the anterior sclera in the inflamed area on all cases.

181 iomechanical response of the human posterior sclera in vitro and to estimate the effects of age and g

182 e-by-side diffusion cells with excised human sclera in vitro.

183 It is technically possible to stiffen the sclera in vivo using collagen cross-linking techniques a

184 (apposition group) or tightly to indent the sclera (indentation group) and (2) flexible refillable s

185 to impose small deformations on fresh bovine sclera, iris, crystalline lens, kidney fat, orbital pull

186 Drug delivery via the sclera is a promising approach to retinal disorder treat

187 Collagen cross-linking of the sclera is a promising approach to strengthen scleral rig

188 lateral diffusion of sulforhodamine in human sclera is slow and localizes to the site of administrati

189 Rat sclera is structurally anisotropic with several consiste

190 Results indicate 1) the peripapillary sclera is subjected to significantly higher tensile stra

191 m and 3.15 +/- 3.07 mum; and for the choroid-sclera junction was -3.90 +/- 15.93 mum and 21.39 +/- 10

192 position of the outer RPE border and choroid-sclera junction was consistent with the manual delineati

193 o-called bowl or convex shape to the choroid-sclera junction, and the thickest point of the choroid w

194 outer border of the RPE band and the choroid-sclera junction.

195 (LD-BM decrease) compared with the anterior sclera (LD-AS decrease) reference plane (hazard ratio, 3

196 from a Bruch's membrane (LD-BM) or anterior sclera (LD-AS) reference plane were measured with optica

197 ne activation including cells in the retina, sclera, lung, kidney, and abundant activation in the neo

198 xpression of all three genes in the superior sclera (Mann-Whitney tests, all p </= 0.05), as well as

199 2 expression in the central cornea and nasal sclera (Mann-Whitney tests, both p </= 0.05).

200 to suggest that stiffening the peripapillary sclera may be protective against the development of glau

201 control breakdown of matrix proteins in the sclera may contribute to the development of simple myopi

202 iomechanical response of normal and glaucoma sclera may represent baseline properties that contribute

203 Age-related stiffening of the sclera may significantly influence ONH biomechanics and

204 oglycan synthesis was assessed on punches of sclera obtained immediately after extraction of supracho

205 dulation of the mechanical properties of the sclera occur during lens compensation.

206 Eye-specific baseline models of the LC and sclera of both eyes of three normal monkeys were constru

207 sed to reconstruct the ONH and peripapillary sclera of four pairs of eyes fixed at 10 mm Hg.

208 ate [C6S], and dermatan sulfate [DS]) in the sclera of groups of tree shrews (n = 5 per group) that w

209 Posterior sclera of old monkeys is significantly stiffer than that

210 3D eye-specific models of the lamina and sclera of the eyes of three normal monkeys were construc

211 sed to reconstruct the ONH and peripapillary sclera of three pairs of unilateral EG eyes fixed at 10

212 onitored and quantified in rabbit cornea and sclera of whole eyeballs.

213 -2, MMP-3, TIMP-1, TIMP-2, and TIMP-3 in the scleras of tree shrews that had received either 1, 2, 4,

214 ice, impermeable on one side and open to the sclera on the other, that contained compressed pellets o

215 branches through the emissary canals in the sclera, or both were visualized in 120 (86%) eyes.

216 OCT, the dome-shaped lesion arises from the sclera, outer choroid, or both and the overlying choroid

217 cation, consistent with direct trauma to the sclera overlying the injured retina.

218 e inner to the outer layers of the posterior sclera (P < 0.001).

219 horoid (P = .004) and tended to have thicker sclera (P = .067) and greater bulge height (P = .079).

220 , and radiation dose >/= 400 Gy to the outer sclera (P = 0.0455).

221 study examined lateral diffusion within the sclera parallel to the scleral surface.

222 eation specimen contained tumor cells within sclera, pars plana, or pars plicata.

223 (PC5), and forces through the peripapillary sclera (PC3).

224 tissue (PC4), rotation of the peripapillary sclera (PC5), and forces through the peripapillary scler

225 Sclera, pericardium, dura mater and cornea are available

226 The most frequent sign was symmetric brown sclera pigmentation present in 82.5 percent of the patie

227 scein and CsA penetrated the in vitro equine sclera poorly; however, low but detectable levels of CsA

228 ese abnormal eyeballs, cornea anteriorly and sclera posteriorly, are regulated by region-specific mol

229 a in vitro, removed from the RPE/choroid and sclera, produces 11-cis retinoids upon light exposure, i

230 rong and consistent with the concept of "the sclera pulls the lamina taut" as IOP increases.

231 sa depth should be measured from an anterior sclera reference plane to reduce the influence of choroi

232 h the Bruch's membrane, but not the anterior sclera, reference plane (LD-BM decrease without LD-AS de

233 icrotubular-like structures found within the sclerad region of the inner nuclear layer of the retina.

234 the signal(s) relayed from the retina to the sclera remains poorly understood.

235 5.96 +/- 2.69 kJ/m(3) for porcine and human sclera respectively; P > 0.05).

236 litates diffusion of fluorescein through the sclera resulting in high levels in the retina and poster

237 However, histological studies of the excised sclera revealed no scleral architectural changes or abno

238 f retinal pigmented epithelium (RPE)-choroid sclera revealed that the expression of CFH was down-regu

239 cut from the scleral surface of the eyeball, sclera, RPE-choroid, retina, lens, and ciliary body.

240 nsport of eight beta-blockers across excised sclera/sclera-choroid-RPE (SCRPE) of albino rabbit, pigm

241 ough different in magnitude between species, sclera/SCRPE transport can be correlated between species

242 e view that the human eye with its prominent sclera serves critical communicative functions during hu

243 aucoma, and (2) Bruch's membrane or anterior sclera should be used as a reference plane when measurin

244 Porcine sclera showed a nonlinear reduction in solute permeabili

245 retinal cells are involved in the retina-to-sclera signaling cascade causing myopia.

246 ites from type I collagen chains was high in sclera, similar to tendon.

247 However, the drug delivered onto the sclera subjects to vigorous clearance by episcleral and

248 The sclera synthesizes and secretes TGFBIp, which may functi

249 troma (SCT) than the vascular lumen (VCT) or sclera (TCT).

250 umferential creep rates in the peripapillary sclera than normal eyes.

251 ion of the lamina cribrosa and peripapillary sclera that are minimal to modest in magnitude.

252 cal response, likely due to a less compliant sclera that limits corneal motion and reduces energy dis

253 model yielded 3-D deformations of posterior sclera that matched well with those observed experimenta

254 fillable silicone exoplants also open to the sclera that were secured by suturing, to form a sealed e

255 other conditions, such as for thin and stiff sclera, the association was opposite to the tautening.

256 In recent studies using sclera, the authors observed that short-chain aliphatic

257 human, facilitated by our depigmented, white sclera-the pale area around the colored iris-and to unde

258 g studies of transverse diffusion across the sclera, this study examined lateral diffusion within the

259 M experiments conducted with conjunctiva and sclera tissue in Franz diffusion cells suggested vasodil

260 Imaging proceeded from the surface of the sclera to a depth of approximately 60 mum.

261 rate of delivery of bioactive factors to the sclera to regulate the rate of glycosaminoglycan synthes

262 cribrosa, scleral flange, and peripapillary sclera, to determine the position and thickness of these

263 roid stroma, and (3) the inner border of the sclera, to measure the vascular choroidal thickness (VCT

264 omal CT [StCT]), and (3) inner border of the sclera (total CT [TCT]).

265 se types with glaucoma, the remainder of the sclera uniformly thinned in CD1, but thickened in B6.

266 antenna of the implant were sutured onto the sclera using an encircling silicone band.

267 he stretched scar and muscle fixation to the sclera using non-absorbable sutures significantly correc

268 scar tissue with muscle re-attachment to the sclera using non-absorbable sutures.

269 Sclera was also clamped between two hemichambers, and tr

270 ent ratio of bovine choroid-Bruch's layer to sclera was approximately 1, 1.5, 1.7, 2, and 3.5, respec

271 Inflation testing of posterior sclera was conducted, and circumferential and meridional

272 scent signal from collagen fibers within the sclera was evident in the TPAF channel; the scleral coll

273 or small eyecup but angle narrowing when the sclera was indented by a large eyecup.

274 Each posterior sclera was mounted on a pressurization apparatus, IOP wa

275 weaker and biochemically distinct posterior sclera was observed in dogs with the G661R missense muta

276 Human sclera was permeable to compounds with a molecular weigh

277 Sclera was reconstructed with allogenic scleral grafts.

278 Drug release from the sclera was significantly prolonged with the micellar car

279 The sclera was significantly thinner (P = 0.038) and tangent

280 Starting at 0 load, the sclera was symmetrically stretched to 2 mm in 0.25-mm st

281 Our case was unique in that, although the sclera was thick, no abnormal microscopic scleral archit

282 tion of (35)SO4 into CPC-precipitable GAG in scleras was taken as a measure of the rate of synthesis

283 ces of the lamina cribrosa and peripapillary sclera were delineated in 40 serial radial (4.5 degrees

284 Only desired areas of the sclera were marked during the same indentation session.

285 he lens, capsule, zonules, ciliary body, and sclera were mounted in an optomechanical lens-stretching

286 he lens, capsule, zonules, ciliary body, and sclera were mounted in an optomechanical lens-stretching

287 es from the conjunctiva, cornea, retina, and sclera were performed to determine the distribution and

288 terior laminar surface and the peripapillary sclera were reconstructed from serial horizontal EDI-OCT

289 The scleras were cleaned of intra- and extraorbital tissues

290 and inferior quadrants of the peripapillary sclera, which may contribute to the increased prevalence

291 uscle anlage and establish insertions in the sclera, which sets these muscles apart from classical mu

292 epending on the properties of the lamina and sclera, which shows that it is critical to consider the

293 Physical examination revealed icterus sclera with abdominal tenderness.

294 Select studies were performed using porcine sclera with and without choroid-Bruch's layer.

295 regulation of 4884 gene transcripts in mouse sclera with less than 5% false-discovery rate (FDR) was

296 stroma, near the limbus, and throughout the sclera, with lower expression in the TM.

297 n the bovine and porcine eyes) more than the sclera, with the impedance increasing with lipophilicity

298 nic), were determined across freshly excised scleras, with or without the underlying choroid-Bruch's

299 the tumor periphery directly adjacent to the sclera within the eye, more often in tumors of the epith

300 edles were designed to penetrate through the sclera, without penetrating into the choroid/retina, in