ライフサイエンスコーパス: scratch

1 to the ability to truly design genomes from scratch.

2 en of starting the construction process from scratch.

3 available, we do not try to bin contigs from scratch.

4 eory predicts herein enzymatic activity from scratch.

5 significantly worse than trees inferred from scratch.

6 effort than writing sequential programs from scratch.

7 ritating sensation that triggers a desire to scratch.

8 ce of the model over training the model from scratch.

9 ls in Java, while not starting entirely from scratch.

10 uld be used to design pattern formation from scratch.

11 sive sensation that elicits a strong urge to scratch.

12 ending with the ability to create fire from scratch.

13 n aversive sensation that evokes a desire to scratch.

14 y stated, "There is pleasure when an itch is scratched.

15 e anisotropic ones covered in long, parallel scratches.

16 pothalamus of mice that displayed contagious scratching.

17 mice scratched after observing a conspecific scratching.

18 l A1 (TRPA1) gene deletion blocks CQ-induced scratching.

19 ing are a peculiarity for motoneurons during scratching.

20 eviously shown for spinal motoneurons during scratching.

21 and the flexion components of locomotion and scratching.

22 shown previously for cat walking and turtle scratching.

23 fied during cat and human walking and turtle scratching.

24 studies of cat and human walking and turtle scratching.

25 n spinal neurons and prevented BA-stimulated scratching.

26 moval of a spatial constraint rather than by scratching.

27 an opposing manner during chloroquine-evoked scratching.

28 efects, dysbiosis, and skin injury caused by scratching.

29 ns (aggression, grooming, and play) and self-scratching (a proxy indicator of anxiety) at 11-14 month

30 subjected to tape stripping, a surrogate for scratching, a cardinal feature of AD.

31 aggravated by mechanical injury inflicted by scratching, a T(H)2 cell-dominated immune response, and

32 For the same task, a network trained from scratch achieved an AUC of 0.680 (95% CI: 0.538, 0.811),

33 d assessments or by objective measurement of scratching activity and scratching-induced skin changes.

34 prior training or reward, we found that mice scratched after observing a conspecific scratching.

35 How do you touch yourself, for instance, to scratch an itch?

36 If the DNA parts must be generated from scratch, an additional 2-5 d are necessary.

37 intrathecal injection of GRP led to intense scratching, an effect largely reduced by either GRPR ant

38 of water flushing, and after repeated knife scratch and sandpaper abrasion under 570 kPa.

39 sed conductance in spinal motoneurons during scratch and swim network activity.

40 parison of laser induce damage resistance of scratched and non-scratched fused silica surfaces after

41 used silica (e.g. photosensitive impurities, scratches and redeposited silica compounds) were mitigat

42 ne-responsive amygdala neurons affected both scratching and anxiety-like behavior.

43 n in Active Populations system enhanced both scratching and anxiety-like behavior.

44 eurons receive intense synaptic input during scratching and behave like neurons in the hindlimb enlar

45 Tgfbr1(f/f) CD11c-Cre mice exhibited reduced scratching and decreased Il31 expression in wounds in vi

46 strated a substantial reduction of excessive scratching and dramatic resolution of skin lesions.

47 t two peculiar interactive behaviors (social scratching and groom slapping) transmitted socially thro

48 rent from the previous findings in low speed scratching and high speed grinding, in which there is an

49 matitis, whereas their inhibition attenuated scratching and inflammatory responses in mouse atopic de

50 and compared the cerebral mechanism of self-scratching and its correlation with pleasurability in 10

51 mid-thoracic segments contribute to hindlimb scratching and may be part of a distributed motor networ

52 lts in an itchy phenotype with constant skin scratching and multi-organ inflammation.

53 w that IL-23 is released in human skin after scratching and polarizes human skin DCs to drive an IL-2

54 d dibutylester evoked persistent spontaneous scratching and significantly aberrant cutaneous and syst

55 mice lacking HTR7 or TRPA1 displayed reduced scratching and skin lesion severity.

56 t others could use this relationship between scratching and stress as an indication of the animal's s

57 inal motoneurons during network activity for scratching and swimming in an ex vivo carapace-spinal co

58 t of motoneurons are distinctly different in scratching and swimming.

59 oral extension of type 2 immunity by evoking scratching and, in the setting of disease, can become ch

60 ctivity may be associated with the addictive scratching and/or neural hypersensitization.

61 ir water repellency after finger-wipe, knife-scratch, and even 40 abrasion cycles with sandpaper.

62 g protein nanoparticles can be designed from scratch, and provides a systematic way to investigate th

63 aversion, without affecting analgesic, anti-scratch, and sedative effects and motor incoordination.

64 FN-alpha2b , or ribavirin using intradermal, scratch, and/or patch tests, as well as lymphocyte activ

65 surfactant, as evidenced by 100 taping, 100 scratching, and 1000 bending cycles.

66 tand the relationships among sleep, itching, scratching, and chronic itch conditions and their associ

67 Coitus, biting, and scratching are transfer mechanisms for the two primary s

68 o address this issue, we use turtle hindlimb scratching as a model for fine motor control, since this

69 sought to validate and test the severity of scratching as an objective measure of itch (4-point ordi

70 actions of engineering artificial cells from scratch, as opposed to re-engineering living biological

71 ular type, the latter as a model for chronic scratching, as well as 40 matched healthy controls parti

72 ression, enzymatic assay aromatase activity, scratch assay cell migration, immunocytochemistry alpha-

73 A keratinocyte monolayer scratch assay was used to assess re-epithelialization; w

74 d healing assay, also known as the "in vitro scratch assay" as a simple, versatile, and cost-effectiv

75 Many experiments, such as a scratch assay, never display this asymptotic behaviour,

76 ity and directional migration in a monolayer scratch assay.

77 keratinocyte monolayers in an in vitro wound scratch assay.

78 reduced cell migration as determined by both scratch assays and trans-well cell migration assays.

79 ion had no impact on wound healing in normal scratch assays, but after subjecting the cells to mechan

80 , quantitative real-time PCR, western blots, scratch assays, CCK-8 assays and tubule formation assays

81 lerates re-epithelialization of keratinocyte scratch assays, potentially via chemokine receptor pairs

82 of two human cancer cell lines in monolayer scratch assays.

83 The final width and depth of the residual scratch at the onset of chip formation measured vary fro

84 High pressure phases are absent from the scratch at the onset of either chip or crack formation.

85 4A domain of murine type XVII collagen begin scratching at age 2 months and then develop erosions, su

86 zed gaps in understanding about sleep, itch, scratching, atopic dermatitis, and psoriasis.

87 h is a unique sensation that helps organisms scratch away external threats; scratching itself induces

88 exion during flexion reflex, locomotion, and scratching based on evidence from studies of cat and hum

89 e, or endothelin-1) and recorded spontaneous scratching before and after drug administration.

90 n followed by wetting in macro-scale surface scratches beginning approximately 2% below the dew-point

91 mice lacking NAAA failed to develop edema or scratching behavior after challenge with DNFB, confirmin

92 SP-induced scratching behavior and activation of cultured dorsal ro

93 ate the contribution of Mrgprs to SP-induced scratching behavior and activation of cultured dorsal ro

94 i.d.) administration of AYP elicited intense scratching behavior in mice, which was prevented by the

95 nduced calcium influx in DRG neurons and the scratching behavior in mice.

96 pport this novel concept based on attenuated scratching behavior in response to histaminergic (histam

97 resulting in reduced neuronal activation and scratching behavior in response to PAR2 agonists.

98 nt thymic stromal lymphopoietin also induced scratching behavior in the specific pathogen-free NC/Tnd

99 Injection of recombinant TSLP also induced scratching behavior in the SPF NC/Tnd mice.

100 whether autism mouse models imitate observed scratching behavior remains unknown.

101 Scratching behavior was also induced by the intrathecal

102 dermally injected into mice and itch-related scratching behavior was assessed.

103 In a murine itch model, ET-1-induced scratching behavior was substantially augmented by pharm

104 opeptides, activation of spinal neurons, and scratching behavior were studied using TRPA1 antagonists

105 In support of this concept we found that scratching behavior, evoked by direct intradermal activa

106 GRPR neurons in the SCN abolished contagious scratching behavior, which was recapitulated by chemogen

107 Activation of SCN GRP/GRPR neurons evoked scratching behavior.

108 lockade or PI3Kgamma inhibition reversed the scratching behavior.

109 ns in the brainstem exhibit markedly reduced scratching behavior.

110 ations of VTA GABA neurons rapidly modulated scratching behaviors through encoding itch-associated av

111 lopment of lesions, HOCl reduced lesions and scratching behaviour to a similar extent as a positive c

112 The diminished scratching behaviour was confirmed by impaired response

113 (licking or wiping) and itch-like (biting or scratching) behaviours.

114 Severity of scratching best correlated with patient-reported global

115 ild-type mice were observed in the number of scratch bouts elicited by SLIGRL and histamine.

116 as well as midge allergen-challenge-induced scratch bouts, midge allergen-induced IL-13 and IL-4 pro

117 ce exhibited significantly fewer 5-HT-evoked scratching bouts compared with wild-type mice.

118 gel prevented the development of lesions and scratching bouts during the whole observation period.

119 hibited robust reversal of histamine-induced scratching bouts in mice.

120 ited by inadequate frequency and duration of scratching bouts required for contagious itch test.

121 nductance states are present not only during scratching but also during swimming.

122 imply that new structures are not built from scratch, but rather form by co-opting preexisting gene n

123 scharge at itch nerve terminals and bouts of scratching by about 50%.

124 ions demonstrate bidirectional modulation of scratching by neurons in the PAG.

125 ation induces neuronal hyperexcitability and scratching by unknown mechanisms.

126 adermal injection of CaP into mice triggered scratching by up-regulating the IL-6 in skin and phospho

127 ssigned in a 1:1 ratio to either endometrial scratching (by pipelle biopsy between day 3 of the cycle

128 (block size 10 participants) and pre-printed scratch cards were used to reveal study group assignment

129 Tape stripping mouse skin, a surrogate for scratching, caused expansion and activation of small int

130 tion of miR-155 increased human keratinocyte scratch closure and topical inhibition of miR-155 in viv

131 ient mice exhibited significantly attenuated scratching, compared with littermate controls, after AD-

132 ation of the animal's stress state, and thus scratching could potentially have social function.

133 f circuit mechanisms of the unstoppable itch-scratch cycles and shed important insights into chronic

134 efficiency remained above 93% even after 40 scratch cycles, and the materials could be reused with a

135 bit contagious itch behavior while viewing a scratching demonstrator mouse, as opposed to an ambulati

136 ombination of two measures of variability of scratch density, namely standard deviation and coefficie

137 Endometrial scratching did not result in a higher rate of live birth

138 ved from wynyardiid-like ancestors, and that scratch-digging adaptations evolved in vombatoids prior

139 l skeleton exhibits features associated with scratch-digging, but it is unlikely to have been a true

140 origin (FUO) is a rare manifestation of cat scratch disease (CSD).

141 dination at the effective analgesia and anti-scratch doses.

142 Mechanical itch is a desire to scratch due to light mechanical stimuli.

143 mice nalfurafine produced analgesic and anti-scratch effects dose-dependently, like the prototypic KO

144 t ultimately to massively edit or write from scratch entire genomes.

145 revealed their roles in sustaining recurrent scratching episodes through signaling scratching-induced

146 xtensor activities underlying locomotion and scratching, even in the absence of brain inputs and move

147 Scratching evokes a rewarding and pleasurable sensation,

148 simpler molecular mechanisms, designed from scratch, exhibit the same range of behaviors?

149 yer is formed at the topmost of the residual scratch, followed by the pristine crystalline lattice be

150 nduce damage resistance of scratched and non-scratched fused silica surfaces after HF etching with hi

151 nd traditional microwear variables (pits and scratches) generated from teeth and casts of rat molars

152 180 of 690 women (26.1%) in the endometrial-scratch group and 176 of 674 women (26.1%) in the contro

153 We performed scratch-hardness tests on hardened samples of class G ce

154 So far, such scratching has been seen as a by-product of physiologica

155 vere infections in humans after dog bites or scratches, has a lipopolysaccharide (LPS) (endotoxin) wi

156 agious behaviors such as yawning and itching/scratching have mirror-like properties and clearly defin

157 proteasome, and apoptosis either during cell scratch healing or ganciclovir-induced apoptosis.

158 Rather than starting from scratch, however, it's sometimes possible to repurpose m

159 upregulated in tape-stripped mouse skin and scratched human skin.

160 expressing, mitochondria-depleted cells from scratch in 23 d, as well as offer a variety of methods f

161 d the production of, and social responses to scratching in a group of free-ranging rhesus macaques (M

162 nels are required for generating spontaneous scratching in a mouse model of ACD induced by squaric ac

163 pletion significantly attenuated itch-evoked scratching in a mouse model of atopic dermatitis.

164 amatergic neurons resulted in attenuation of scratching in both acute and chronic pruritis.

165 ron-ablation also reduced pruritogen-induced scratching in both male and female mice.

166 as investigated the cerebral activity during scratching in chronic itch patients and whether it diffe

167 A higher activity during scratching in chronic itch patients, versus healthy cont

168 cratching in normal mice observing excessive scratching in genetically modified demonstrator mice.

169 withdrawal (flexion reflex), locomotion, and scratching in limbed vertebrates.

170 Q) stimulates itch nerves and causes intense scratching in mice by activating the G-protein coupled r

171 vates MrgprC11 and evokes receptor-dependent scratching in mice.

172 gious itch occurs in mice based on imitative scratching in normal mice observing excessive scratching

173 e studies are needed to validate severity of scratching in other pruritic disease.

174 The bouts of scratching in response to CQ were not different between

175 ls of BAs, prevented exacerbated spontaneous scratching in TGR5 overexpressing mice.

176 ergic signaling not only reduced spontaneous scratching in the IL-31Tg mice but also dramatically res

177 agonist significantly attenuated 5-HT-evoked scratching in vivo.

178 signaling in vitro and reduced IL-31-induced scratching in vivo.

179 3-drug combination regimen for children from scratch, independent of adult regimens, in <2 years.

180 Furthermore, mechanical scratching indicates that the different-n-value nanoplat

181 Scratching-induced pleasurability significantly activate

182 hat this reward system has a crucial role in scratching-induced pleasurability.

183 urrent scratching episodes through signaling scratching-induced reward.

184 ctive measurement of scratching activity and scratching-induced skin changes.

185 subjected to tape stripping, a surrogate for scratching, induces an IL-22 response that drives epider

186 iR-124-3p inhibited neuronal inflammation in scratch-injured neurons.

187 miR-124-3p promoted neurite outgrowth after scratch injury, characterized by an increase on the numb

188 In primary astrocyte cultures, hypoxia and scratch injury-induced astrogliosis was attenuated by bo

189 The Scratch Intensity and Impact Scale consisted of two fact

190 y and Impact Scale consisted of two factors (scratching intensity and impact of scratching on QOL) th

191 n this study, a novel approach of high speed scratching is carried out on silicon (Si) wafers at nano

192 The scratching is conducted on a Si wafer of 150 mm diameter

193 Because scratching is highly specialized rhythmic behavior, it i

194 ation we feel and the relief that comes from scratching, is an evolutionary warning system and defens

195 lps organisms scratch away external threats; scratching itself induces an immune response that can co

196 Laminae I/II INs drive chemical itch-induced scratching, laminae II/III INs generate paw withdrawal m

197 [very prominent] based on the observation of scratching lesions).

198 e appearance of the first abundant arthropod scratch marks in Earth evolution.

199 Severity of scratching may be a useful endpoint in clinical trials a

200 P channels participate in pruritogen-induced scratching may involve sites of action other than the pr

201 promoting cutaneous sensitization to foods, scratching may promote food anaphylaxis in AD by expandi

202 mpared with control animals, MRGPRX4(+) mice scratched more upon acute injection of BAs and in a mode

203 The comparison of scratches morphology after static etching and high-frequ

204 CI1) in locusts that performed natural aimed scratching movements.

205 Intense synaptic transmission during scratch network activity increases conductance and induc

206 are functionally integrated in the hindlimb scratch network.

207 key spinal interneurons with locomotion and scratching networks across limbed vertebrates generally.

208 idities) and disease prognosis (by promoting scratching of itchy skin).

209 ed to a significant reduction in spontaneous scratching of the hapten-challenged nape of the neck of

210 lags behind GABA neurons and is dependent on scratching of the itchy site.

211 se of a randomisation schedule that required scratching off an opaque layer to reveal assignment.

212 factors (scratching intensity and impact of scratching on QOL) that accounted for 64.59% of the vari

213 The median score for pain from endometrial scratching (on a scale of 0 to 10, with higher scores in

214 d, the simplest way, offline introduction of scratched or cut pieces of strips into the IMS injection

215 gh-conductance state is a select feature for scratching or a property that goes with spinal motor net

216 ction independently, as in behaviors such as scratching or searching, or be used in coordinated patte

217 n the skin evokes itch- but not pain-related scratching or wiping behaviors.

218 The cumulative sum of scratching over all pruritogens confirmed a leading role

219 In contrast, the scratching persisted and skin lesions worsened over time

220 postnatally, at ~3-5 wk they elicit a severe scratching phenotype.

221 To create new enzymes and biosensors from scratch, precise control over the structure of small-mol

222 ow environmental representations emerge from scratch provided a new window into the information proce

223 Na(V)1.7(-/-) showed substantial scratch reduction mainly towards strong pruritogens.

224 The itch-scratch reflex serves as a protective mechanism in every

225 In addition, there is no scratch related damage initiations found on the samples

226 y performances that can be "engineered" from scratch, remain elusive.

227 interface attachment with Cu, improving the scratch resistance and oxidation resistance of Cu.

228 , the low friction coefficient and excellent scratch resistance make them attractive as solid lubrica

229 d PDA (LAPDA) was shown to be >100-fold more scratch resistant than pristine PDA and even better than

230 tes mediate itch by evoking a Tgr5-dependent scratch response in mice.

231 ic acid (0.2 mol/L) pH-dependently induced a scratching response in mice when applied intradermally t

232 1, is involved in the acidic citrate-induced scratching response.

233 A1 and TRPV1 channels may be involved in the scratching responses to intradermal pruritogens, this is

234 id-thoracic segments leads to a weakening of scratch rhythmicity.

235 ming of (i.e., reset) cat walking and turtle scratching rhythms; in addition, reflex responses to leg

236 The Sleep-Related Itch and Scratch Scale consisted of one factor that accounted for

237 There was a significant decrease in scratching severity for patients experiencing itch impro

238 Patients experiencing improvement of scratching severity of 1 point or greater had significan

239 on reflex, multiple forms of locomotion, and scratching share key components.

240 croarray analysis of L. rhamnosus GG treated scratches showed increased expression of multiple genes

241 Severity of scratching showed responsiveness over time.

242 Scratching significantly attenuated the itch sensation (

243 Secondly, when macaques scratched, subsequent interactions were less likely to b

244 sol, but not stress-related behaviors (e.g., scratching), suggesting the possibility of some anxiolyt

245 whereas cell motility was assessed using the scratch test and confocal microscopy.

246 phage migration by using Boyden chambers and scratch tests, characterized its contribution to experim

247 EM), transmission electron microscopy (TEM), scratch tests, MTT reduction cytotoxicity, HOS cell bioa

248 In nano-scratch tests, the TFMG coatings achieved a coefficient

249 litative 'happy/active' scores, play, ground-scratching) than birds in Conditions 1-3.

250 in design is to build protein scaffolds from scratch that allow precise control over metal coordinati

251 ive science-centered information system from scratch that has been afforded by the Sidra Medical and

252 ome motility in melanocytes, and have barely scratched the surface in our understanding of melanin tr

253 asts, mitochondria and nucleus, we have only scratched the surface of this multilayered control and h

254 basic biological processes, but we have only scratched the surface of what they have to offer as rese

255 Paradoxically, scratching the itch also produces a hedonic experience.

256 Scratching the skin of healthy adults and tape stripping

257 elopment, has restricted researchers to only scratching the surface of this inherently challenging su

258 spontaneously using a small wooden stick to scratch their bodies.

259 Primary human keratinocyte monolayers were scratched then exposed to lysates of Lactobacillus (L) r

260 een noxious and pruritic pathways, and allow scratch to inhibit itch.

261 rophysiologic reflexes, such as coughing and scratching, to expel invading pathogens and noxious envi

262 Scratching upregulated IL13 expression in human skin, an

263 mparable to networks refined or trained from scratch using additional manually segmented images.

264 trypsin, SLIGRL, beta-alanine, BAM8-22), and scratching was assessed using a magnet-based recording t

265 Firstly, we found that the likelihood of scratching was greater around periods of heightened soci

266 Two scales related to sleep and/or scratch were recently developed and assessed in 137 pati

267 nd hyperactive behaviors such as jumping and scratching were recorded.

268 Primates (including humans) scratch when stressed.

269 methods, which recompute the hierarchy from scratch when the network topology changes, our method ad

270 dently elicit the same degree of robust itch scratching, which can be inhibited by mu-opioid peptide

271 1.8(-/-) impaired histamine and 5-HT-induced scratching while Na(V)1.9 was involved in itch signallin

272 e competitive performance with learning from scratch with a significantly larger number of samples.

273 ide range of structures can be designed from scratch with atomic-level accuracy.

274 Endometrial scratching (with the use of a pipelle biopsy) is a techn

275 both beta-endorphin- and GRP-elicited robust scratching without affecting pain processing.

276 Scratch wound and proliferation assays revealed that cul

277 bladder cancer cell migration in a modified scratch wound assay and invasion through Matrigel.

278 In the scratch wound assay of cell spreading, HIF stabilization

279 Importantly, in vitro scratch wound assays demonstrate that the positive role

280 so increase closure of epithelial cells in a scratch wound by 1.2- and 1.5-fold, respectively, compar

281 The application of glycomimetic improved scratch wound closure in vitro in patient ECFCs (p < 0.0

282 tions of AS II to assess cell proliferation, scratch wound closure, L-arginine uptake, cationic amino

283 However, for claudin-1 effects on scratch wound healing were more pronounced when TJs coul

284 xpression resulted in significantly impaired scratch wound healing, with delayed migration and reduce

285 An in vitro scratch wound initiated the release of thymic stromal ly

286 migrate and repopulate areas subjected to a scratch wound.

287 on through measurements of cell migration in scratch-wound assays.

288 n migrating SKCO-15 cells was assessed using scratch-wound assays.

289 Analysis of single-cell migration and scratch-wound closure clearly demonstrated that hERG1-ex

290 Additionally, Erdr1 accelerates scratch-wound closure in vitro, increases Lgr5(+) intest

291 d epithelial cell migration and repair after scratch-wound healing assay that was associated with red

292 on EA.hy926 cell migration was determined by scratch-wound healing assay.

293 Cultured keratinocytes were scratch wounded and expression levels of the B2AR and ca

294 Immunofluorescence analysis of scratch-wounded cells reveals that P2X7 inhibition resul

295 Accordingly, in a scratch-wounded epithelium, TGFbeta provokes cilium loss

296 njured paclitaxel-treated zebrafish skin and scratch-wounded human keratinocytes (HEK001) display red

297 The induction of cellular migration by scratch-wounding confluent cell cultures, culturing unde

298 en implicated, e.g., 2D cell migration after scratch-wounding, invasion of cancer cells, and finally,

299 oblasts could accelerate closure of in vitro scratch wounds by 1.8-fold and epithelial growth capacit

300 less proliferative and failed to seal linear scratch wounds.