ライフサイエンスコーパス: sculpt

1 ections to the monolayer from which they are sculpted.

2 tifying cues by which neural architecture is sculpted.

3 he basement membrane's active role in tissue sculpting.

4 ntrolled separations of 0.9 nm primed for re-sculpting.

5 remodeling and BAR domain-dependent membrane sculpting.

6 as a molecular canvas for three-dimensional sculpting.

7 ns, we show that alpha-tubulin isotype TBA-6 sculpts 18 A- and B-tubule singlets from nine ciliary A-

8 4 (Bmp2/4), and Six3-dependent pathways then sculpt a complex ciliary band territory that is defined

9 generation during development is required to sculpt a functional nervous system and is also a hallmar

10 he TRAPPI core indicates that these subunits sculpt a second RAB binding site on TRAPP apparently ind

11 proteins (EAPs) generate curvature needed to sculpt a sufficiently narrow neck to trigger Dyn2 assemb

12 ed with trophic deprivation are critical for sculpting a functional nervous system.

13 s to rationally devise schemes for precisely sculpting a great variety of elementary shapes by diffus

14 a CRISPR-associated Rossmann fold domain(6), sculpting a powerful antiviral response(7-10) that can d

15 process underlies post-learning information sculpting, a novel and essential consolidation step in t

16 standing the dual host-protective and tumour sculpting actions of immunity on cancer and establishing

17 arkedly depressing and were more powerful to sculpt activity of postsynaptic neurons.

18 he main olfactory bulb (MOB) are presumed to sculpt activity reaching the cortex via inhibition of mi

19 modulin in regulating the intrinsic membrane-sculpting activity of endocytic N-BAR domains.

20 e examined the role of sensory experience in sculpting an inhibitory circuit in the primary somatosen

21 uit mapping and show that sensory experience sculpts an intrinsically developing template network, wh

22 ironmental cues and inflammatory stimuli can sculpt and agitate homeostasis, provides a frame of refe

23 otion detection, while most neurons serve to sculpt and enhance these feedforward pathways.

24 ted, homeostatic actions of microglia, which sculpt and refine neuronal circuitry.

25 om studying excitatory maps is that maps are sculpted and refined throughout development and/or throu

26 e central functional site of the ribosome is sculpted and suggest how the formation of translation-co

27 viruses use noncanonical routes for membrane sculpting and LC3 recruitment.

28 nal apoptosis, suggesting a role in cortical sculpting and plasticity.

29 synapse elimination plays a critical role in sculpting and refining neural connectivity throughout th

30 However, the evolutionary processes that sculpt antibody repertoires remain poorly understood.

31 that the importance of rigidified, precisely sculpted architectures increases with increasing pi acid

32 hort-duration signals from extrinsic cues to sculpt axon arbors within the CNS.

33 eld of drug discovery, with the potential to sculpt biological response to favor therapeutically bene

34 Our results indicate that dopamine sculpts bipolar cell performance in a type-dependent man

35 ignalling to intercellular adhesion and that sculpts both tubular and planar epithelial shape.

36 and the physical mechanisms that are used to sculpt branched tissues.

37 phur-doped pnictogen chalcogenide nanoplates sculpted by a scalable microwave-stimulated wet-chemical

38 surroundings, and reveals a complex surface sculpted by a succession of ice-sheet configurations sub

39 w the circuitry of the developing PFC can be sculpted by a wide range of pre- and postnatal factors.

40 iling view that many developing circuits are sculpted by activity-dependent competition among converg

41 ked to CD4 T cell functionality and could be sculpted by blockade of specific inhibitory receptors.

42 tions (i.e., viral mutant swarms), which are sculpted by different evolutionary mechanisms, such as m

43 omprise many oscillator loops that have been sculpted by evolution over two trillion day-night cycles

44 tructure and function of which may have been sculpted by evolutionary selection to provide a highly t

45 Organs are sculpted by extracellular as well as cell-intrinsic forc

46 anet systems that are not flat and have been sculpted by Kozai-Lidov oscillations.

47 eloping organisms, tissues architectures are sculpted by mechanical forces during morphogenesis(2).

48 ks represents optimized solutions, precisely sculpted by natural selection; their common features are

49 ling, we demonstrate that the septin ring is sculpted by polarized exocytosis, which creates a hole i

50 l enables highly localised flow-fields to be sculpted by precisely piloting the motion of optically-t

51 one (GnRH) neurons controls fertility and is sculpted by sex-steroid feedback.

52 e molecular repertoire of mature neurons was sculpted by SOC-related up- and down-regulation of volta

53 ganization suggests that their morphology is sculpted by specific cell to cell interactions with neur

54 composition of the postsynaptic membrane is sculpted by synaptic activity.

55 e discovered that the midget private line is sculpted by synaptic remodeling beginning early in fetal

56 These structures are sculpted by the combined actions of transcription and st

57 cess initiates in the ER, where vesicles are sculpted by the essential COPII coat.

58 These inclusions are often sculpted by the plant into shapes required to support fu

59 The primary antigen receptor repertoire is sculpted by the process of V(D)J recombination, which mu

60 of five enhancers, even-skipped stripes are sculpted by the same kinetic phenomena: a coupled increa

61 on its differential additive and subtractive sculpting by two isoforms of a single auxiliary subunit.

62 res and are distinguished by their elegantly sculpted calcium carbonate exoskeletons (coccoliths), re

63 select products based on safety, lifting or sculpting capability and rheological properties, such as

64 and-binding site that include the ability to sculpt cellular signaling and to respond differently in

65 light on the stage-dependent mechanisms that sculpt chamber-specific cardiomyocytes and, therefore, h

66 competition between diffusive processes that sculpt convex hillslopes and advective processes that ca

67 beliefs exert their influence on behavior by sculpting cortical latent dynamics.

68 The basal ganglia thalamic output sculpts cortical activity by interacting with signals fr

69 isms exist that may interact to persistently sculpt corticostriatal circuits, potentially influencing

70 imply a 24-h metronome: specific populations sculpt critical features of the sleep-wake cycle.

71 show that synNotch receptors can be used to sculpt custom response programs in primary T cells: they

72 Consequently, NIRs sculpt cytoplasmic membraneless organelles and regulate

73 type-specific activity-dependent manner for sculpting dendritic arbors during early-use, critical pe

74 Spontaneous network activity is believed to sculpt developing neural circuits.

75 Synaptic rearrangements are shown to help sculpt developing retinal circuits, although the mechani

76 roteins of the kinetochore are repurposed to sculpt developing synapses and dendrites and thereby con

77 ing for microglia in the healthy brain, from sculpting developing neuronal circuits to guiding learni

78 al mechanism for regulating cell numbers and sculpting developing organs.

79 O functions specifically in leaves, where it sculpts developing leaflets by repressing growth at thei

80 ving the inverse problem of designing a flow sculpting device for a desired fluid flow shape remains

81 ins limited, and it is unknown whether it is sculpted differentially by primary versus metastatic dis

82 ontribute to long-term plasticity capable of sculpting direct and indirect pathway output.

83 anner in which distinct circuits interact to sculpt diverse rhythms remains unresolved.

84 FEN1 sculpts DNA with diffusion-limited kinetics to test DNA

85 ves neuronal activity, and neuronal activity sculpts domain formation.

86 l an XPG homodimer that binds, unstacks, and sculpts duplex DNA at internal unpaired regions (bubbles

87 l and basolateral dendrites are coordinately sculpted during development.

88 Tissue sculpting during development has been attributed mainly

89 d by the protein; however, how APE1 uniquely sculpts each substrate within a single rigid active site

90 mers of a biperylene derivative by precisely sculpted electromagnetic fields.

91 ations are thought to play a central role in sculpting embryonic tissues, maintaining organ architect

92 s transmitted between cells are critical for sculpting epithelial tissues.

93 site modification may be an effective way of sculpting epitope presentation in Env-based vaccines.

94 t 2AG in the VTA regulates reward seeking by sculpting ethologically relevant patterns of dopamine re

95 Numerous surveillance pathways sculpt eukaryotic transcriptomes by degrading unneeded,

96 In addition to sculpting eukaryotic transcripts by removing introns, pr

97 fer, a process considered to be a strong and sculpting evolutionary force in microbial environments.

98 ally, generating a functional diversity that sculpts excitatory transmission and behavioral function.

99 However, here we report that the membrane-sculpting F-BAR domain-containing Fer/Cip4 homology doma

100 t caveolins (CAV1 and CAV2) and the membrane sculpting F-BAR protein PACSIN2 promote L. monocytogenes

101 rrays with ~30 A periodicity into a membrane-sculpting filament.

102 During development, the canals are sculpted from pouches that protrude from the otic vesicl

103 We conclude that rule learning sculpts frontal cortex interconnectivity and adjusts a t

104 insight into how early environmental events sculpt functional network architecture across developmen

105 forms emerge and feed back to each other to sculpt functional organs remains unclear.

106 tive results support XPG scaffolding and DNA sculpting functions in multiple DDR processes to maintai

107 ince each hemagglutinin mutation potentially sculpts future mutation space, drift can follow many sto

108 new insights into how DNA polymerase errors sculpt genetic variation and drive evolution.

109 e should increase through time, as selection sculpts genetic variation.

110 ular pathways through which our life stories sculpt genomic function to contribute to complex behavio

111 2 transforms flat Snf7 spirals into membrane-sculpting helices.

112 c cells could be improved if we could custom sculpt immune cell responses.

113 red landscape of the prokaryotic ribosome is sculpted in this way.

114 provide mechanistic insight into how TFL1-FD sculpt inflorescence architecture, a trait important for

115 regions implement a set of learning rules to sculpt information processing in a given neural circuit?

116 We show here that organs can be sculpted instead by patterning anisotropic resistance wi

117 a spontaneously flowing active fluid can be sculpted into a static material through an active mechan

118 The brushes are easily sculpted into micropatterned landscapes by photo-deactiv

119 mmature pattern of connectivity that is then sculpted into the adult pattern via pruning.

120 llic and dielectric nanostructures precisely sculpted into two-dimensional (2D) and 3D nanoarchitectu

121 d apical dendrites that results in a gradual sculpting into a stellate morphology.

122 The early cancer-immune interaction sculpts intratumor heterogeneity through the selection o

123 onceptually appealing mechanism for membrane sculpting is really overhyped.

124 nt optical wave packet in free space through sculpting its spatio-temporal spectrum.

125 ay be the ultimate force through which Pitx2 sculpts L-R organs.

126 Continental ice sheets typically sculpt landscapes via erosion; under certain conditions,

127 Fluid-sheared granular transport sculpts landscapes and undermines infrastructure, yet pr

128 y passively adsorb to membranes but actively sculpt lipid bilayers, which would result in highly curv

129 s analogous to topological quantum states to sculpt localized buckling regions in the interior of per

130 ply seen as a cargo-recognition and membrane-sculpting machine viewable from three distinct perspecti

131 The way nature evolves and sculpts materials using proteins inspires new approaches

132 and biochemical approaches to probe the DNA sculpting mechanism of APE1, specifically by characteriz

133 This is hypothesized to occur through a DNA sculpting mechanism where structural adjustments of the

134 on, is an important step in elucidating this sculpting mechanism.

135 Numerous proteins act in concert to sculpt membrane compartments for cell signaling and meta

136 he assembly of COPI into a cage-like lattice sculpts membrane vesicles that transport cargo from the

137 nsing, bending, and stabilizing curvature to sculpt membranes with speed.

138 and PRRs emerges as a mechanism that locally sculpts microbial assemblages in plant populations.

139 Here we introduce ion beam-sculpted microcantilevers that enable precise force-feed

140 irected signal bias offers opportunities for sculpting molecular events, with the promise of better,

141 nally, we demonstrated that teratomas can be sculpted molecularly via microRNA (miRNA)-regulated suic

142 Apoptosis is an important mechanism for sculpting morphology.

143 therapies that enhance neural plasticity and sculpt motor recovery.

144 ergetic ions, often gallium (Ga(+)), FIB can sculpt nanostructures via localised sputtering.

145 itory interneurons that gate signal flow and sculpt network dynamics.

146 optimal stimulation of dopamine D1 receptors sculpts network inputs to refine mental representation.

147 ding to the list of mechanisms available for sculpting neural circuits.

148 present results indicate that the eCB system sculpts neural activity patterns that accompany PR perfo

149 Early visual experience sculpts neural mechanisms that regulate the balance of i

150 ss functional connections between neurons to sculpt neuronal circuits during development and througho

151 ranscription programs, and synaptic activity sculpt neuronal form.

152 ynaptic and intrinsic properties interact to sculpt neuronal output.

153 elopment, experience plays a crucial role in sculpting neuronal connections.

154 Axon degeneration sculpts neuronal connectivity patterns during developmen

155 rs and scaled additive noise can interact to sculpt noise-induced stimulus encoding uncertainty to ma

156 This observation makes it possible to sculpt nucleation pathways by tuning the distribution of

157 ylate cyclases operate in close proximity to sculpt O2 responses.

158 gens drives the immunological destruction or sculpting of a developing cancer.

159 ell established that BDNF contributes to the sculpting of dendrite structure and modulation of synaps

160 s that are permissive for activity-dependent sculpting of excitatory synapses via the mechanism of NM

161 lts support a potentially general concept of sculpting of glycosylases to their targets, allowing the

162 vation of JAGGED, a key gene involved in the sculpting of lateral organs in several model species, we

163 omputer-generated holography enables precise sculpting of light and could in principle enable simulta

164 The sculpting of membranes into dynamic, curved shapes is ce

165 It is subject to complex, dynamic sculpting of morphology and composition.

166 These indicate sex related sculpting of neuroanatomy begins early in development, b

167 glial cell-dependent pathway regulating the sculpting of neuronal connectivity and synaptic circuitr

168 ork identifies key steps in the dimorphic re-sculpting of the anal depressor that are regulated by ge

169 We propose that developmental sculpting of the arcuate fasciculus determines acquisiti

170 We conclude that the ubiquitin-dependent sculpting of the chromosomal distribution of an antisile

171 framework to quantify and guide the dynamic sculpting of the curved structures that often arise in a

172 piny stellate neurons emerge by differential sculpting of the dendritic arborizations of an initial p

173 e patterns give additional insights into the sculpting of the endomembrane system.

174 ir shape and behavior to promote bending and sculpting of the epithelial sheet is not well understood

175 We find detailed sculpting of the rings by embedded masses, and banded te

176 Tissue morphogenesis involves both the sculpting of tissue shape and the positioning of tissues

177 hment of a branch from suitable vegetation; "sculpting" of a terminal hook from the nodal joint; and

178 e for shaping microfluid flow, known as flow sculpting, offers an unprecedented level of passive flui

179 nd post-mitotic cell expansion that together sculpt organ form.

180 ar matrix (ECM) regulates cell migration and sculpts organ shape.

181 Sculpting organism shape requires that cells produce for

182 Cellular forces sculpt organisms during development, while misregulation

183 he rigid junctions provide for protein shape sculpting over multiple nanometer length scales.

184 rast, stronger higher-level predictions that sculpt perception into conformity with beliefs might con

185 e these contractile networks to generate and sculpt persistent fluid flows.

186 as a smoothing process, we find that erosion sculpts pointed and cornerlike features that persist as

187 ever, how these molecules are coordinated to sculpt postsynaptic structures is less well understood.

188 ts a versatile set of tools that are used to sculpt pRb in precise, but very different, ways.

189 t to explain how GABAergic neurotransmission sculpts principal cell activity in a relevant fashion.

190 that mediate topologically similar membrane-sculpting processes, including cytokinesis, retroviral e

191 id phosphatase, actin assembly, and membrane-sculpting proteins leads to proper membrane shaping, tub

192 ns correlates with translocation of membrane-sculpting proteins.

193 These findings expand the membrane-sculpting repertoire of dynamin to include the regulatio

194 Organ sculpting requires directed physical force generation.

195 l that not only is FH an important player in sculpting retinal development but also that the developm

196 d fishes, in which males use their mouths to sculpt sand into large species-specific structures for c

197 a simple, evolutionarily labile solution for sculpting sensory bandwidth to maximize the detection of

198 y, some of the proteins that fuse cells also sculpt single cells, repair neurons, promote scission of

199 ound experience can activate and potentially sculpt subplate circuits before permanent thalamocortica

200 rent endocytic modes to generate new SVs and sculpt subsequent presynaptic performance.

201 Here we present the Gene Sculpt Suite (GSS), which comprises three tools: (i) GTa

202 for applications where wrinkles are used to sculpt surface topography, to measure properties of the

203 lised for waves confined to an appropriately sculpted surface.

204 c (3)He surface exposure dating of fluvially sculpted surfaces to determine the impact of extreme flo

205 modulation of neuronal activity required for sculpting synapses.

206 neuronal populations and can differentially sculpt synaptic transmission and plasticity.

207 microenvironment and play essential roles in sculpting synaptic connections during brain development.

208 ntaneous action potentials, thus potentially sculpting synaptic connections in an activity-dependent

209 orce for Ca(2+) entry are powerful levers in sculpting synaptic efficacy.

210 Fragile X mental retardation protein (FMRP) sculpts synaptic refinement in an activity sensor mechan

211 ping intracortical circuitry and thereby can sculpt thalamocortical connections.

212 Here we present a method based on light sculpting that enables unbiased single- and dual-plane h

213 Thus Hof1 tunes formins to sculpt the actin cable network.

214 ent a mechanism through which experience can sculpt the activation patterns within a neural circuit.

215 ignals received in the periphery promote and sculpt the adaptive immune response.

216 and synapse-specific form of plasticity may sculpt the balance of activity in basal ganglia circuits

217 Experiences during the critical period sculpt the circuitry within the neocortex, leading to ch

218 e of capabilities, we present sequences that sculpt the cross-sectional shape of a stream into comple

219 aged by delta-catenin and other effectors to sculpt the developing dendritic arbor.

220 rites and engages the autophagy mechanism to sculpt the developing dendritic arbor.

221 the experienced stimuli could instructively sculpt the emergent responses, visually naive ferrets we

222 ive cell-cell and cell-matrix adhesions that sculpt the emerging tissue architecture are guided by dy

223 riation, identified some of the factors that sculpt the epigenome, and determined its functional rela

224 secreted and membrane-associated targets to sculpt the extracellular environment and modulate interc

225 ystemic insulin- and VIP-like neuropeptides, sculpt the growth of specific tracheal subsets.

226 quired, leading to the proposal that FCHo1/2 sculpt the initial bud site and recruit the clathrin mac

227 We show how TARPs sculpt the ligand-binding domain gating ring, enhancing

228 axons, but many branches are later pruned to sculpt the mature pattern of connections.

229 tural insights into the way BAR proteins may sculpt the membrane as a high-order cooperative assembly

230 order assembly can define how these proteins sculpt the membrane.

231 rides any direct nutrient sensing in ISCs to sculpt the observed response to CR.

232 not simply to prevent over-excitation but to sculpt the output of specific circuits.

233 of loci over long periods, can dramatically sculpt the phylogenetic relationships among species.

234 from the available microbial communities to sculpt the root microbiome.

235 ects facilitate wave function engineering to sculpt the spatial distribution of charge and spin state

236 integrates with other signaling pathways to sculpt the SSCs and their sensory patches is unknown.

237 brain, indicating that microglia continue to sculpt the synaptic landscape in the postdevelopmental b

238 9:Im9 complex demonstrates that force can re-sculpt the underlying energy landscape, providing new op

239 and electrical activity has the potential to sculpt the wiring of neural circuits and to modulate the

240 ncode and to reflect the learning rules that sculpted the information-processing system within which

241 ential role for iron-mobilizing coumarins in sculpting the A. thaliana root bacterial community by in

242 lamo-nigral glutamatergic synapses (STN-SNr) sculpting the activity patterns of nigral neurons, the m

243 e and used here to illustrate the concept of sculpting the analytical volume associated with a nanopa

244 act upon neuromodulation as a mechanism for sculpting the behavioral repertoire of a species.

245 eveal that transcription plays a key role in sculpting the chromatin after DNA replication.

246 trol the polarized development of tissues by sculpting the cytoskeleton of individual cells.

247 Thus, AlkD acts by sculpting the global DNA conformation to achieve lesion

248 Patterns of neural activity are critical for sculpting the immature brain, and disrupting this activi

249 way epithelium facilitates carcinogenesis by sculpting the immune/inflammatory environment in the lun

250 ne cells protect against cancer formation by sculpting the immunogenicity of developing tumors.

251 vidually optimized illumination settings; 2) sculpting the light-sheet to trace complex sample shapes

252 We propose that Robo3 evolution was key to sculpting the mammalian brain by converting a receptor f

253 lements and the simple architectures play in sculpting the response dynamics of the network.

254 cell death, are the principal mechanisms of sculpting the sexually dimorphic abdomen of Drosophila.

255 afB/cJun heterodimers promoted apoptosis for sculpting the shape of the limbs.

256 As such, it is a potent mechanism for sculpting the synapse.

257 to-maturation transition in mouse oocytes by sculpting the transcriptome to degrade RNAs encoding gro

258 Branching morphogenesis sculpts the airway epithelium of the lung into a tree-li

259 Kat-60L1 thus sculpts the class IV dendritic arbor through microtubule

260 eurons as spatial learning in the water maze sculpts the dendritic arbor of adult-born neurons even w

261 The directed migration of cells sculpts the embryo, contributes to homeostasis in the ad

262 rsus basket cell GABAergic neurotransmission sculpts the firing properties of Purkinje cells.

263 e provide the first description of how Pitx1 sculpts the forming hindlimb skeleton by localised modul

264 ridylation of mRNA mediated by TUT4 and TUT7 sculpts the mouse maternal transcriptome by eliminating

265 findings suggest that knowledge accumulation sculpts the neural networks associated with successful m

266 Evolution sculpts the olfactory nervous system in response to the

267 nderstanding how the PINK1-PARKIN pathway re-sculpts the proteome to support mitochondrial homeostasi

268 the 'even-toed' camel, extensive cell death sculpts the tissue around the remaining toes.

269 t that an exosome-associated RNase, EXOSC10, sculpts the transcriptome to facilitate the growth-to-ma

270 man learners use estimates of uncertainty to sculpt their learning.

271 his work reveals a mechanism by which plants sculpt their lipid pool in response to pathogens and pro

272 Cancer cells can functionally sculpt their microenvironment through the secretion of v

273 d indirect pathway MSNs and are important in sculpting their output to downstream basal ganglia nucle

274 d reassembling it, playing an active role in sculpting their surrounding environment and directing th

275 structure is set by competing energies which sculpt them.

276 stable levels of activity, while experiences sculpt them.

277 ructures are dynamic and self-organize: they sculpt themselves and change their own architecture, and

278 The factors that dynamically sculpt these inter-regional correlation patterns are poo

279 eview how activity and visual experience can sculpt this exquisite connectivity.

280 on but the molecules in the active zone that sculpt this function are poorly understood.

281 it remains unclear which factors dynamically sculpt this topography as a function of brain state.

282 n II is a major driver of the movements that sculpt three-dimensional organs from two-dimensional epi

283 ize of individual astrocytes are dynamically sculpted through inhibitory or competitive astrocyte-ast

284 mouse models, we show that blood vessels are sculpted through the generation of stereotyped avascular

285 oproteinases (MMPs) are crucial mediators in sculpting tissue architecture and are required for many

286 ustness and versatility of this strategy for sculpting tissue interfaces by directing the morphogenes

287 s in our understanding of how cells actively sculpt tissues and how forces are involved in specific m

288 inated cell shape changes and cell divisions sculpt tissues.

289 uit and illustrate how a circuit is flexibly sculpted to guide behavioral decisions in a context-depe

290 pe of disordered mechanical materials can be sculpted to show desired force-response behaviors by a l

291 dular nanostructures that can be dynamically sculpted to stabilize and tune both local and global syn

292 the aim is to provide some lift, support and sculpting to the treated area.

293 The focused ion beam can also be used as a sculpting tool to create specific specimen shapes such a

294 r transformation, promotes tumour growth and sculpts tumour cell immunogenicity, but also as an extri

295 phase of the process, where immunologically sculpted tumours begin to grow progressively, become cli

296 Yet, how tissues are sculpted under challenging conditions is unknown.

297 additional temporal regulators may exist to sculpt vascular topology.

298 s, two new studies show that arousal already sculpts visual information as it first enters the brain.

299 hesia impairs normal synapse development and sculpting, which are crucial elements of developmental s

300 tified the optimal lattice type for membrane sculpting, which matches closely the lattices seen throu