ライフサイエンスコーパス: scute

1 the Drosophila transcription factor achaete-scute.

2 d by the proneural bHLH proteins achaete and scute.

3 r Poils au dos as a repressor of achaete and scute.

4 ctivity were mapped to a 14 kb region around scute.

5 ulatory sequences common to both achaete and scute.

6 illa, owing to the inappropriate function of scute.

7 [(40)Ca] as well as [(40)Ca] in newly-formed scutes.

8 leless limbs with a bony carapace covered in scutes.

9 crest cells give rise to osteoblasts of the scutes.

10 which are overlain by keratinous ectodermal scutes.

11 oth natural and abnormal variation in turtle scutes.

12 human NEUROD1, NEUROD2, NEUROD3, and ACHAETE SCUTE 1 (HASH1) in cerebellar and cerebral primitive neu

13 the somatic mesoderm that express lethal of scute [2].

14 atially restricted expression of the achaete-scute (ac-sc) genes in clusters of cells, mediated by th

15 ated control of transcription of the achaete-scute (ac-sc) genes which are expressed in small proneur

16 te expression of the proneural genes achaete-scute (ac-sc).

17 The study of achaete-scute (ac/sc) genes has recently become a paradigm to un

18 Hedgehog and Lethal of scute activate Engrailed in these anterior cells.

19 A mutation removing scute activity has been previously described; it causes

20 ed carbon film around the bones and marginal scutes along the edge of the carapace.

21 through analysis of TAGteam changes in Sxl, scute (an XSE), and the ;ventral repression element' of

22 served in genetic samples from the yellow-ac-scute and Adh regions of Drosophila melanogaster.

23 erate a null allele of achaete, which leaves scute and all cis-regulatory elements intact.

24 The proneural factors Lethal of scute and Asense differentially controlled progenitor su

25 n of a single Serine at the same position in Scute and Atonal proneural proteins governs the transiti

26 The proneural genes achaete, scute and lethal of scute are required for neural precur

27 rt by activating expression of the lethal of scute and tailup H-cell regulatory genes.

28 ive soft-tissue remains, including epidermal scutes and a virtually complete flipper outline, was rec

29 Drosophila orthologues of ASH1 (Achaete and Scute) and the growth factor independence-1 (GFI1) oncop

30 function of the proneural genes achaete and scute, and express elevated levels of ac protein.

31 Of the four genes at this locus, achaete and scute appear to act redundantly to specify the periphera

32 However, when the levels of Scute are limiting, then some sensory organs are missing

33 proneural genes achaete, scute and lethal of scute are required for neural precursor formation in the

34 chanosensory precursors, whereas Achaete and Scute are required for the survival of the mechanosensor

35 achaete and scute are thought to have arisen from a duplication even

36 fish dermal armor show that their scales and scutes are formed by bone, dentin, and hypermineralized

37 veals neural crest gene signature in sterlet scutes as well as bichir scales.

38 coenia, a homolog of the Drosophila achaete-scute (AS-C) genes--which encode transcription factors t

39 Achaete-Scute basic helix-loop-helix (bHLH) proteins promote neu

40 In rescue experiments, achaete or scute, but not lethal of scute, completely restored the

41 riments, achaete or scute, but not lethal of scute, completely restored the normal MP2 identity.

42 ystem (PNS) development requires the achaete-scute complex (AS-C) and the atonal (ato) genes.

43 ession of the proneural genes of the achaete-scute complex (AS-C) is required for neurectodermal cell

44 f genes of a proneural gene cluster, achaete-scute complex (AS-C), in Drosophila larvae.

45 vey of a 110-kb region including the achaete scute complex (ASC) examined 14 polymorphic molecular ma

46 quantified the relationship between achaete-scute complex (ASC) polymorphisms and Drosophila bristle

47 nes, atonal (ato) and members of the achaete-scute complex (ASC), are required for the formation of c

48 s and R8 photoreceptors, whereas the achaete-scute complex contains proneural genes for external sens

49 These results demonstrate that the achaete-scute complex genes specify aspects of neural precursor

50 Achaete-scute complex homolog (Ascl)1(+) C cells were heterogene

51 Prior to and during this process, an achaete-scute complex homolog, CapI-ash1, is expressed in cluste

52 lly expressed imprinted gene, Ascl2 [achaete-scute complex homolog-like 2 (Drosophila)], and their de

53 elix-loop-helix transcription factor achaete-scute complex homologue 1 (ASCL1) is essential for the d

54 The achaete-scute complex of Drosophila has been the focus of extens

55 regulatory enhancer sequences at the achaete-scute complex that mediate activation at specific sites

56 sion by enhancers in the neighboring achaete-scute complex, causing an apparent absence of the block

57 is showed that AmeloD belongs to the achaete-scute complex-like ( ASCL) gene family and is a homologu

58 While the proneural factor achaete-scute complex-like 1 (Ascl1) is widely used for neuronal

59 2 (2.4-fold increase, P = .029) and Achaete-scute complex-like 1 (ASCL1; 2.7-fold increase, P = .023

60 ress the transcription factor ASCL1 (achaete-scute complex-like 1) as well as high levels of the neur

61 ller glia increase expression of the Achaete-scute complex-like 1a (Ascl1a) and Signal transducer and

62 ter that mediates transactivation by achaete-scute complex-like 1a (ascl1a) during retina regeneratio

63 (sc) works with its paralogs in the achaete-scute-complex (ASC) to direct neuronal development.

64 -helix (bHLH) proneural proteins Achaete and Scute cooperate with the class I bHLH protein Daughterle

65 Activation of SxlPm depends on the scute, daughterless, and runt transcription factors, whi

66 Here, we show that scutes develop from an array of patterned placodes and t

67 In an achaete-scute double mutant, MP2 formation was reduced (to 11-14

68 MP2 delaminates from a cluster of achaete-scute-expressing ectodermal cells.

69 To our surprise, we found that ectopic scute expression in the ato(1) mutant induces the format

70 induces chordotonal organ formation, ectopic scute expression produces external sensory organs but no

71 s au dos, is associated with ectopic achaete-scute expression that results in the additional bristles

72 hairy, to transcriptionally repress achaete-scute expression.

73 ed by genes of the NEUROD/atonal and ACHAETE SCUTE families.

74 anscription factor module expressing achaete-scute family basic helix-loop-helix transcription factor

75 m the intestinal stem-cell regulator achaete-scute family basic helix-loop-helix transcription factor

76 of-function compromises the onset of achaete-scute family bHLH transcription factor 1 (Ascl-1)(+) vom

77 Although Achaete-scute family bHLH transcription factor 1 (Ascl1) plays i

78 bilizes proactivation protein Ascl1 (achaete-scute family bHLH transcription factor 1) in proliferati

79 expression of phox2b, phox2a and the achaete-scute family member zash1a/ascl1.

80 retinoblastoma) expressed NeuroD and ACHAETE SCUTE family members.

81 ctor Neurogenin/Math/atonal and Mash/achaete-scute family members.

82 n Drosophila and in vertebrates, the achaete-scute family of basic helix-loop-helix transcription fac

83 Proteins of the achaete-scute family of transcription factors play important rol

84 l lineages, and mutations in lin-32 (achaete/scute family), vab-3 (Pax-6 homolog) and egl-5 (Abd-B ho

85 ffected by mutations that remove Achaete and Scute function.

86 nsory organs (SOs) in the absence of achaete-scute gene complex function.

87 Finally, the expression of the Achaete-Scute gene complex suggests that SoxNeuro acts upstream

88 The achaete-scute genes encode essential transcription factors in no

89 The Drosophila proneural achaete-scute genes govern neural precursor formation, but their

90 , we test the role of the Drosophila achaete-scute genes in specifying neural precursor identity, foc

91 te that cash4 can substitute for the achaete/scute genes in the fly and that it also has proneural ac

92 The number of achaete-scute genes increased during insect evolution, particula

93 e comparison indicates that the four achaete-scute genes of Drosophila result from three independent

94 of a family of proneural genes, the achaete-scute genes, and to examine their genomic organization a

95 ver, the genetic regulation of the epidermal scutes has not been investigated.

96 or (FGF)-2 deprivation and mammalian achaete-scute homolog (MASH)1 transcription factor levels in an

97 ude (a) expression of the bHLH mouse achaete-scute homolog (mASH1) in normal and CR2-TAg NE cells and

98 entified two Tribolium ac/sc genes - achaete-scute homolog (Tc-ASH) a proneural gene and asense (Tc-a

99 The Achaete-scute homolog 1 (Ascl1) protein regulates a large subset

100 We determined that achaete-scute homolog 1 (ASCL1), a transcription factor required

101 neage-specific transcription factors Achaete-scute homolog 1 (ASCL1), NEUROD1 and POU2F3 have been re

102 s GLI family zinc finger 1 (Gli1) or achaete-scute homolog 1 (Ascl1).

103 e gene encoding the proneural factor Achaete-scute homolog 1 (Ascl1; also known as Mash1 in mammals)

104 ix (bHLH) transcription factor human achaete-scute homolog 1 (hASH1).

105 ral and spatial pattern of mammalian achaete-scute homolog 1 (MASH-1) expression in the developing ra

106 The mammalian achaete-scute homolog 1 (MASH1) protein is required for the earl

107 hh), its receptor ptc, and mammalian achaete-scute homolog 1 (Mash1), a pro-neuron basic helix-loop-h

108 ith other vertebrate homologs of the achaete scute homolog 1 subclass shows that the carboxyl 2/3 of

109 sed expression of the lineage marker Achaete-scute homolog 1, (ASCL1) through a positive feedback mec

110 genic transcription factor mammalian achaete-scute homolog 1, by low doses of BMP2.

111 a Japanese pufferfish, Fugu rubripes achaete-scute homolog 1, Fash1.

112 the regulatory elements of the gene Achaete-scute homolog 1.

113 Mechanisms regulating achaete-scute homolog expression outside of Drosophila are prese

114 s examined in an effort to correlate achaete-scute homolog expression with the generation of particul

115 ic helix-loop-helix (bHLH) gene, the Achaete-Scute homolog hlh-14, is expressed in a mirror image pat

116 It also inhibits the activity of the achaete-scute homolog lin-32 and an unidentified gene that we po

117 the isolation of a novel vertebrate achaete-scute homolog, cash4, which is expressed in the presumpt

118 study, we characterize a C. elegans Achaete-Scute homolog, HLH-14.

119 Human achaete-scute homolog-1 (hASH1) is constitutively expressed in a

120 dimers of the proneural bHLH protein achaete-scute homolog-1 and E12, leading to active transcription

121 lesions was reduced when CC10-human achaete-scute homolog-1 mice were crossed with matrilysin-1 null

122 an lesions and BOA in the CC10-human achaete-scute homolog-1 transgenic mouse model.

123 for gliadin homology, noteworthy was achaete scute homologous protein (DQ2-alpha-I-gliadin; BestFit q

124 lity=215 versus 100 for random); and achaete-scute homologous protein, which displays particularly hi

125 achaete-scute homologs (ash) regulate neural development in all

126 These data suggest that achaete-scute homologs functioned in the ancestral metazoan neur

127 Human ACHAETE SCUTE homologue (HASH1) was not expressed in medulloblas

128 the neurogenic transcription factors achaete-scute homologue 1 (ASCL1) and neurogenic differentiation

129 f four key transcription regulators: achaete-scute homologue 1 (ASCL1; also known as ASH1), neurogeni

130 iption factor encoding genes, ash1a (achaete/scute homologue 1a) and neurogenin1 (ngn1), in epiphysia

131 Here we show that expression of achaete-scute homologue 2 (Ascl2)--a basic helix-loop-helix (bHL

132 anscription factor Mash-2 (mammalian achaete/scute homologue 2), which is elevated in human cytotroph

133 ue of the fly proneural genes (chick achaete-scute homologue 4, cash4), which is expressed heterogene

134 These medial cells do not express achaete scute homologue in proneural clusters, but express colli

135 The transcription factor achaete-scute homologue-1 (ASH1) is essential for neural differe

136 The Achaete-Scute Homologue-1 (ASH1) transcription factor is critica

137 We show here that human achaete-scute homologue-1 (hASH1) is selectively expressed in no

138 elix-loop-helix transcription factor achaete-scute homologue-1 (hASH1) may stimulate both proliferati

139 ix (bHLH) transcription factor human achaete-scute homologue-1 (hASH1).

140 by increased expression of mammalian achaete/scute homologue-2 (Mash-2), which increases levels of up

141 dent evolution of multiple copies of achaete-scute homologues and argue that this might have contribu

142 Vertebrate achaete-scute homologues are expressed early during neurogenesis

143 melanogaster and Tribolium castaneum achaete-scute homologues are initially expressed in clusters of

144 In all euarthropod groups, achaete-scute homologues are required for neuroblast/neural prec

145 specified by elevated levels of the achaete-scute homologues CsASH1 and CsASH2.

146 he expression of spalt, iroquois and achaete-scute homologues from elytron-like to more typical wing-

147 r results raise the possibility that achaete-scute homologues may help specify neural precursor ident

148 to its homologs, the proneural genes achaete-scute in Drosophila.

149 s expression of the proneural gene lethal of scute in the most anterior midline daughter cells of the

150 ineralogy, and organic content of shells and scutes in juvenile Tridacna squamosa giant clams.

151 es that are responsible for the evolution of scutes in turtles, and the regulation of these centers h

152 Remarkably, many scute-induced ommatidia lack R8 although they contain ou

153 Thus, when Scute is absent, the activity of achaete allows formatio

154 We demonstrate that Scute is phosphorylated by Sgg on a serine residue and t

155 e expression of the proneural gene lethal of scute (l'sc) is required for the development of the majo

156 sion pattern of the proneural gene lethal of scute (l'sc), as well as the pattern of brain neuroblast

157 late H-cell fate revealed that the lethal of scute [l(1)sc], tailup and SoxNeuro transcription factor

158 Achaete-scute like (ASCL)2 is a basic helix-loop-helix transcrip

159 Proneural genes, including Achate-scute-like 1 (Ascl1) and Neurogenin 3 (Neurog3) are wide

160 omoter activity of a newly described Achaete-scute-like gene hlh-3.

161 s Sgn1, is a member of the mammalian achaete scute (Mash) gene family of transcription factors, which

162 The difference between achaete and scute null flies is surprising and raises the question o

163 thodenticle, by the proneural gene lethal of scute or by tailless itself.

164 conserved bHLH transcription factors achaete-scute or neurogenin, is located outside the central brai

165 ariety of skin structures: keratinous dermal scutes, protospines composed of hair-like tubules, and c

166 of developing fruit flies, achaete (ac) and scute (sc) expression defines a group of neurally-compet

167 by ectopic expression of the proneural gene scute (sc) misdirect hemocytes to these ectopic location

168 In flies, scute (sc) works with its paralogs in the achaete-scute-

169 c flies expressing chimeric genes of ato and scute (sc), a member of ASC, and found that the informat

170 sion of the proneural genes achaete (ac) and scute (sc).

171 (h) and the proneural genes achaete (ac) and scute (sc).

172 mutants, Tufted is epistatic to achaete and scute, the proneural genes that normally control the dev

173 -length polymorphism 97 bp downstream of the scute transcript.

174 e absent from a soft-shelled turtle in which scutes were lost secondarily.

175 In contrast, Atonal and Scute, which are thought to heterodimerize with Daughter

176 by inducing the proneural genes achaete and scute, which downregulate the mitosis-inducing phosphata

177 repressing the action of the proneural gene Scute, which is essential for EE differentiation.

178 estigial, Serum Response Factor, and achaete-scute, whose products regulate morphological features th