ライフサイエンスコーパス: seasonal influenza

1 ILI) reports to create a weekly forecast for seasonal influenza.

2 r significantly when comparing pandemic with seasonal influenza.

3 ck/sepsis, and organ failure than those with seasonal influenza.

4 H1N1pdm09 than persons of the same ages with seasonal influenza.

5 ansmission patterns previously described for seasonal influenza.

6 ss hospitalizations that are attributable to seasonal influenza.

7 increase was not greater than observed with seasonal influenza.

8 in lessening the impact of both pandemic and seasonal influenza.

9 casting and vaccination strategies to combat seasonal influenza.

10 g of the much more predictable occurrence of seasonal influenza.

11 e important settings for the transmission of seasonal influenza.

12 erica: respiratory syncytial virus (RSV) and seasonal influenza.

13 ted to institutional outbreak management for seasonal influenza.

14 les in postmortem samples from patients with seasonal influenza.

15 ncidence and rates of antigenic evolution of seasonal influenza?

16 serial passage in MDCK cells inoculated with seasonal influenza A (H1N1) viruses at a low multiplicit

17 The strategy was validated on thousands of seasonal influenza A and B virus-positive specimens usin

18 [HA], neuraminidase [NA], and matrix [M]) of seasonal influenza A and B viruses for next-generation s

19 o the high morbidity and mortality caused by seasonal influenza A virus (IAV) infections in older ind

20 vity between these viruses and current human seasonal influenza A virus strains.

21 valent influenza vaccine (sTIV) containing a seasonal influenza A virus subtype H1N1 (A[H1N1]) compon

22 Seasonal influenza A viruses (IAV) originate from pandem

23 ting influenza virus pathogenesis.IMPORTANCE Seasonal influenza A viruses (IAVs) are among the most c

24 proteases are critical for activating HAs of seasonal influenza A viruses (IAVs) in humans.

25 Seasonal influenza A viruses cause annual epidemics of r

26 Seasonal influenza A viruses of humans evolve rapidly du

27 iod, with 20 discrete introductions of human seasonal influenza A viruses showing sustained onward tr

28 pdm09 were cross-reactive with M2 protein of seasonal influenza A viruses.

29 aused by individual influenza strains (i.e., seasonal influenza A(H1N1), pandemic A(H1N1), A(H3N2), a

30 ic cross-reactivity among humans primed with seasonal influenza A(H3N2) (sH3N2), using postinfection

31 0 swine-origin influenza A(H3N2) variant and seasonal influenza A(H3N2).

32 ate its performance using historical data on seasonal influenza A/H3N2 virus.

33 mismatch on IAV reassortment using the human seasonal influenza A/Panama/2007/99 (H3N2) and pandemic

34 estimate was similar in magnitude to that of seasonal influenza, a marked shift toward mortality amon

35 , a method to identify the period of highest seasonal influenza activity.

36 rs for Disease Control and Prevention (CDC), seasonal influenza affects 5% to 20% of the U.S. populat

37 The effects of weather variability on seasonal influenza among different age groups remain unc

38 reat due to unpredictable antigenic drift in seasonal influenza and antigenic shifts caused by the em

39 tive as a broadly protective vaccine against seasonal influenza and emerging pandemic threats.IMPORTA

40 ntial for the treatment of both pandemic and seasonal influenza and has a distinct advantage over the

41 o assess human B cell responses to trivalent seasonal influenza and monovalent pandemic H1N1 vaccinat

42 level to quantify the relationships between seasonal influenza and monthly minimum temperature (MIT)

43 Seasonal influenza and the 2009 pandemic strain were cha

44 ntification of known risk factors for severe seasonal influenza and the more protracted clinical cour

45 Globally, these phenomena are observed with seasonal influenza and with the current coronavirus dise

46 associations between weather variability and seasonal influenza, and growth rates of seasonal influen

47 <5 years of age, the mean annual numbers of seasonal influenza- and RSV-associated all-respiratory d

48 In addition, we estimated the seasonal influenza- and RSV-associated deaths among HIV-

49 There are few longitudinal studies of seasonal influenza associated neurological disease (IAND

50 childbearing age, the majority of estimated seasonal influenza-associated deaths occurred in HIV-inf

51 gnant women experienced an increased risk of seasonal influenza-associated mortality compared with no

52 nonpregnant women, the estimated mean annual seasonal influenza-associated mortality rate was 41.2 (8

53 During 1999-2009, the estimated mean annual seasonal influenza-associated mortality rates were 12.6

54 ng pregnant women, the estimated mean annual seasonal influenza-associated mortality rates were 74.9

55 There are few longitudinal studies of seasonal influenza-associated neurological disease (IAND

56 We estimated that 291 243-645 832 seasonal influenza-associated respiratory deaths (4.0-8.

57 accination is a potential solution to reduce seasonal influenza burden.

58 ss analysis, we used a transmission model of seasonal influenza calibrated to 14 seasons of weekly co

59 suggest that previous exposure of humans to seasonal influenza can poise them to respond to avian H7

60 Seasonal influenza carrying key hemagglutinin (HA) head

61 ain outcome is the percentage of prospective seasonal influenza cases identified by the ALERT algorit

62 Seasonal influenza causes >200 000 annual hospitalizatio

63 Seasonal influenza causes substantial morbidity and mort

64 when a group-mismatched HA subtype dominates seasonal influenza circulation.

65 We applied JRFR to human H3N2 seasonal influenza data from 1968 to 2003.

66 Here we present weekly forecasts of seasonal influenza developed and run in real time for 10

67 In this large cohort, we also show that seasonal influenza does not result in significant alloan

68 Adults hospitalized for seasonal influenza during the period were used for compa

69 in hospitalized children aged <18 years with seasonal influenza (during 2003-2009) and 2009 pandemic

70 Winter holidays delay seasonal influenza epidemic peaks and shift disease risk

71 and seasonal influenza, and growth rates of seasonal influenza epidemics among different age groups

72 of reduced air traffic and the asynchrony of seasonal influenza epidemics among West African countrie

73 Seasonal influenza epidemics and occasional pandemics th

74 vention and treatment for management of both seasonal influenza epidemics and pandemics are desirable

75 Seasonal influenza epidemics cause consistent, considera

76 Seasonal influenza epidemics cause high economic loss, m

77 query data, this study investigated whether seasonal influenza epidemics in China, the US and the UK

78 evelopment of systems capable of forecasting seasonal influenza epidemics in temperate regions in rea

79 Seasonal influenza epidemics lead to 3-5 million severe

80 Seasonal influenza epidemics offer unique opportunities

81 et represents a powerful tool for monitoring seasonal influenza epidemics thanks to aid of self-selec

82 stems that are able to predict irregular non-seasonal influenza epidemics, using either the ensemble

83 ans in defining the community-level onset of seasonal influenza epidemics.

84 igher rates of illness and death than annual seasonal influenza epidemics.

85 's magnitude was similar to that seen during seasonal influenza epidemics.

86 ethnic disparities in vaccination rates for seasonal influenza exist.

87 e Control and Prevention (CDC) has organized seasonal influenza forecasting challenges since the 2013

88 eronegative and experimentally infected with seasonal influenza H1N1 A/Brisbane/59/07 virus.

89 Asn 177, but not Asn 71 and Asn 104) from a seasonal influenza H1N1 virus, A/Solomon Islands/2006 (S

90 ledge, this is the first time predictions of seasonal influenza have been made in real time and with

91 es was sequence divergence between avian and seasonal influenza hemagglutinin proteins, thus limiting

92 Our findings characterize seasonal influenza hospitalizations among pregnant women

93 Pregnant women are at increased risk of seasonal influenza hospitalizations, but data about the

94 These results support the safety of seasonal influenza immunization during pregnancy and sug

95 xtending the established benefits of current seasonal influenza immunizations.

96 ng oseltamivir with placebo for treatment of seasonal influenza in adults regarding symptom alleviati

97 model, we simulate transmission dynamics of seasonal influenza in England from 2012 to 2018.

98 ngly influenced the transmission patterns of seasonal influenza in households.

99 r burden than the 2009 influenza pandemic or seasonal influenza in terms of hospitalization and morta

100 We aimed to quantify mortality due to seasonal influenza in Thailand, a tropical middle-income

101 arison with a similarly standardized HFR for seasonal influenza in the same setting.

102 when there was essentially no circulation of seasonal influenza in the United States, and 2007/2008,

103 fected-recovered type transmission model for seasonal influenza, incorporating the four main strains

104 to currently circulating strains.IMPORTANCE Seasonal influenza infection remains a major cause of di

105 on, diagnosis, management, and prevention of seasonal influenza infection.

106 ly with ADCC-Abs to H7N9 NP, suggesting that seasonal influenza infections and vaccinations may induc

107 Seasonal influenza infections are associated with substa

108 such as the differences between pandemic and seasonal influenza infections.

109 Seasonal influenza infects approximately 5-20% of the U.

110 Seasonal influenza is a major cause of mortality worldwi

111 Seasonal influenza is a sometimes surprisingly impactful

112 Seasonal influenza is a vaccine-preventable disease that

113 Seasonal influenza is an annual occurrence, but it is th

114 Seasonal influenza is an important cause of acute neurol

115 Seasonal influenza is controlled through vaccination cam

116 Seasonal influenza is efficiently transmitted from human

117 showed that the antigenic evolution of H3N2 seasonal influenza is generally S-shaped while the genet

118 unger (median age, 47 years) than those with seasonal influenza (median age, 68 years; P < .01), and

119 opical and temperate zones, but estimates of seasonal influenza mortality in developing countries in

120 diagnosis codes in adults hospitalized with seasonal influenza (n = 5270) or 2009 pandemic influenza

121 Similarly, vaccines against seasonal influenza need to be updated frequently to prot

122 of the public health and economic impact of seasonal influenza on pregnant women.

123 perience of gradual or regional closures for seasonal influenza outbreaks demonstrates that logistic

124 ing, peak incidence, and total incidence for seasonal influenza outbreaks in 48 states and 95 cities

125 produced a number of methods for forecasting seasonal influenza outbreaks.

126 such as a pandemic strain versus a previous seasonal influenza, plays a crucial role in the monitori

127 nts reported assessing need for and stocking seasonal influenza; pneumococcal; tetanus and diphtheria

128 Seasonal influenza poses higher risks of hospitalization

129 Seasonal influenza poses serious problems for global pub

130 Recently, we developed a seasonal influenza prediction system that uses an advanc

131 For a seasonal influenza product, manufacturing, distribution,

132 In the models with seasonal influenza rates included, observed IPP rates du

133 lts aged 65 years and older account for most seasonal influenza-related hospital admissions and death

134 Seasonal influenza results in substantial annual morbidi

135 ipants in 15 European countries during three seasonal influenza seasons, allocated 1629 to usual care

136 However, since seasonal influenza spread has a typical spatial trend, a

137 the VaccIntDesign problem in the context of seasonal influenza spread in the United States.

138 4, H1N1pdm09 became North America's dominant seasonal influenza strain.

139 ccine containing 15 mug of each of the three seasonal influenza strains for that year, as a single do

140 ults indicate prior infection with different seasonal influenza strains leads to radically different

141 By comparing human seasonal influenza strains to avian influenza viruses, w

142 ren in Senegal against circulating, pre-2010 seasonal influenza strains, but not against A/H1N1pdm09,

143 model was applied to citywide primary school seasonal influenza surveillance and household surveys fr

144 al-time risk assessments hinging on reliable seasonal influenza surveillance and precise estimates of

145 Seasonal influenza surveillance is usually carried out b

146 ate data involving 269 ferrets infected with seasonal influenza, swine influenza, and highly pathogen

147 lutinin (HA)-specific CD4 T-cell memory with seasonal influenza to facilitate antibody production to

148 n this study, we quantified the potential of seasonal influenza to provide memory CD4 T cells that ca

149 ariability appears to be more influential on seasonal influenza transmission in younger (0-14) age gr

150 e to our knowledge in children, tonsils from seasonal influenza-vaccinated children.

151 Recent receipt of seasonal influenza vaccination and older age were associ

152 Similarly, the serological responses to seasonal influenza vaccination are also determined large

153 Rates of seasonal influenza vaccination are modestly but signific

154 ccines are approved in the United States for seasonal influenza vaccination every year.

155 In a randomized, controlled trial of seasonal influenza vaccination in 773 children aged 6-17

156 Seasonal influenza vaccination in humans primarily stimu

157 Safety and immunogenicity data of seasonal influenza vaccination in transplanted patients

158 Seasonal influenza vaccination is recommended for patien

159 t this hypothesis, we examined the effect of seasonal influenza vaccination on NK cell function and p

160 e optimal target age groups when extending a seasonal influenza vaccination programme of at-risk indi

161 3N2)v] highlights the need to assess whether seasonal influenza vaccination provides cross-protection

162 ic H1N1 vaccination, as well as pre-pandemic seasonal influenza vaccination to elucidate the effect o

163 Here, we report that unadjuvanted seasonal influenza vaccination via intratumoral, but not

164 Seasonal influenza vaccination with either LAIV4 or IIV3

165 Pregnant women are prioritized for seasonal influenza vaccination, but the evidence on the

166 ages frequently underperform in response to seasonal influenza vaccination, despite virologic contro

167 After 21 d, subjects received the seasonal influenza vaccination.

168 ansplant recipients before and 1 month after seasonal influenza vaccination.

169 B-cell responses get boosted in humans after seasonal influenza vaccination.

170 d clinically significant increase in rate of seasonal influenza vaccination.

171 ith previous estimates of the disorder after seasonal influenza vaccination.

172 cs to healthy adults prior and subsequent to seasonal influenza vaccination.

173 to reconsideration of the optimal timing of seasonal influenza vaccination.

174 SIMON to data from five clinical studies of seasonal influenza vaccination.

175 el vaccine platforms have been developed for seasonal influenza vaccination: a recombinant HA vaccine

176 Formulation of the seasonal influenza vaccine (injectable trivalent inactiv

177 antibody response to a trivalent inactivated seasonal influenza vaccine (TIV) and a large number of i

178 Prior receipt of a trivalent seasonal influenza vaccine (TIV) can affect hemagglutina

179 l investigation of 274 children who received seasonal influenza vaccine (trivalent inactivated vaccin

180 y, and diabetic subjects vaccinated with the seasonal influenza vaccine across five consecutive seaso

181 determine the effectiveness of the 2010-2011 seasonal influenza vaccine against laboratory-confirmed

182 Compared with those receiving the seasonal influenza vaccine alone, subjects receiving the

183 hildren previously vaccinated with 2009-2010 seasonal influenza vaccine also showed greater expansion

184 e effectiveness (VE) estimates for 2015-2016 seasonal influenza vaccine are reported from Canada's Se

185 nd adaptive response to vaccination with the seasonal influenza vaccine during early childhood, and i

186 We sought to determine the seasonal influenza vaccine effectiveness (VE) against la

187 Seasonal influenza vaccine formulas change almost every

188 Seasonal influenza vaccine formulation efforts struggle

189 a substantial burden worldwide, and current seasonal influenza vaccine has suboptimal effectiveness.

190 s were stratified by documented receipt of a seasonal influenza vaccine in each Medicare beneficiary.

191 experimental studies of the effectiveness of seasonal influenza vaccine in older adults have found 40

192 Antibody responses to the inactivated seasonal influenza vaccine in patients with atopic derma

193 The seasonal influenza vaccine is an important public health

194 The seasonal influenza vaccine is recommended for all person

195 ed, the medical community's understanding of seasonal influenza vaccine performance remains limited.

196 would be difficult to capture during routine seasonal influenza vaccine programmes, which have extens

197 hy control (HC) participants selected from a seasonal influenza vaccine responsiveness study.

198 The unadjuvanted 2012-2013 seasonal influenza vaccine was administered to 81 kidney

199 Receipt of the 2010-2011 seasonal influenza vaccine was associated with a 42% (95

200 Receipt of seasonal influenza vaccine was associated with an adjust

201 study there was no evidence to suggest that seasonal influenza vaccine was associated with major mal

202 The 2016-2017 seasonal influenza vaccine was updated to include a clad

203 Influenza C is not included in the annual seasonal influenza vaccine, and has historically been re

204 tudy, 51 healthy adults were vaccinated with seasonal influenza vaccine, and PBMC were collected befo

205 ple, we analyse CD4+ T-cell responses to the seasonal influenza vaccine, establishing a frequency hie

206 es, are selected for inclusion in the annual seasonal influenza vaccine.

207 infected children who received the 2012-2013 seasonal influenza vaccine.

208 before and after vaccination with trivalent seasonal influenza vaccine.

209 tional, and immunologic data in humans given seasonal influenza vaccine.

210 , highlights the need to improve our current seasonal influenza vaccine.

211 Antibody responses to seasonal influenza vaccines are defective during older a

212 riable epitopes in the HA head; (ii) current seasonal influenza vaccines are efficient in inducing B-

213 Egg-based seasonal influenza vaccines are the major preventive cou

214 Seasonal influenza vaccines are transitioning to quadriv

215 We argue that seasonal influenza vaccines can be dramatically improved

216 Finally, we confirm that currently licensed seasonal influenza vaccines can boost preexisting memory

217 from adults ages 48-64 who received multiple seasonal influenza vaccines from 2004 to 2009 for cross-

218 Current seasonal influenza vaccines have highly variable efficac

219 d for both nonadjuvanted and MF59-adjuvanted seasonal influenza vaccines in elderly recipients.

220 contribute to lower vaccine effectiveness of seasonal influenza vaccines in humans.

221 Seasonal influenza vaccines lack efficacy against drifte

222 Effectiveness of seasonal influenza vaccines mainly depends upon how well

223 Seasonal influenza vaccines prevent influenza-related il

224 Both natural influenza infection and current seasonal influenza vaccines primarily induce neutralizin

225 Although annual seasonal influenza vaccines provide some protection agai

226 barriers, the adjuvant MF59 has been used in seasonal influenza vaccines to increase antibody titers

227 hould be specifically dedicated to improving seasonal influenza vaccines while developing entirely ne

228 Here, we review the history of seasonal influenza vaccines, describe challenges associa

229 ly in the MF59 adjuvant, a component in some seasonal influenza vaccines, in stockpiled, emulsion-bas

230 he inclusion of both influenza B lineages in seasonal influenza vaccines.

231 s from studies with the yellow fever and the seasonal influenza vaccines.

232 nsitions is critical to developing effective seasonal influenza vaccines.

233 slightly higher than that seen with previous seasonal influenza vaccines; however, additional results

234 nogenic influenza A epitopes as putative non-seasonal influenza vaccines; one specifically targets th

235 effectiveness against illness caused by the seasonal influenza virus (presumed to all be drifted A/H

236 Seasonal influenza virus causes significant morbidity an

237 We applied this model into H3N2 seasonal influenza virus data.

238 Seasonal influenza virus epidemics represent a significa

239 tential of D1-8 for therapeutic treatment of seasonal influenza virus H3 infection.

240 The antigenic distance between current seasonal influenza virus H3 strains in humans and those

241 nza A virus is less stable than other recent seasonal influenza virus HAs, but the molecular interact

242 nogenicity to provide better protection from seasonal influenza virus infection and improve pandemic

243 Seasonal influenza virus infection presents a major stra

244 Seasonal influenza virus infections can cause significan

245 Seasonal influenza virus infections cause mild illness i

246 Seasonal influenza virus infections continue to cause si

247 In healthy adults, seasonal influenza virus infections result in mild disea

248 ens contributing to a significant portion of seasonal influenza virus infections worldwide.

249 protective neutralizing Abs, as seen during seasonal influenza virus infections, can be expected to

250 ual vaccinations, there are few remedies for seasonal influenza virus infections.

251 Seasonal influenza virus is a common cause of acute lowe

252 Seasonal influenza virus is associated with high morbidi

253 or without CLDC, and challenged with a human seasonal influenza virus isolate, A/Memphis/7/2001(H1N1)

254 which exhibit unusual features compared with seasonal influenza virus NA proteins, are ill-defined.

255 In the temperate regions, seasonal influenza virus outbreaks correlate closely wit

256 tions about the makeup of the future A(H3N2) seasonal influenza virus population, and we compare pred

257 ragine or threonine in over 99% of all human seasonal influenza virus pre-2009 H1N1, H2N2, and H3N2 s

258 ich prior infection with specific strains of seasonal influenza virus protect from lethal H5N1 challe

259 Thus, in primate cells, MxA inhibits human seasonal influenza virus replication at a step prior to

260 Seasonal influenza virus routinely causes epidemic infec

261 satory effect of E214D is applicable in both seasonal influenza virus strain A/New Caledonia/20/1999

262 sed to determine when sequence variations in seasonal influenza virus strains have affected regions r

263 cross-reactivity between strains in pigs and seasonal influenza virus strains in humans is also impor

264 h or without prior exposure to either of two seasonal influenza virus strains, H1N1 and H3N2.

265 dm09] is less stable than the HAs from other seasonal influenza virus strains.

266 thesized that it is possible to make a human seasonal influenza virus that is specifically attenuated

267 ed with the outbreak strain had received the seasonal influenza virus vaccination.

268 orating NA, including PIV5-NA, could improve seasonal influenza virus vaccine efficacy and provide pr

269 Seasonal influenza virus vaccines can prevent infection,

270 mmunodominance of the HA over the NA in many seasonal influenza virus vaccines.

271 ns of emergence and circulation of new human seasonal influenza virus variants is a key scientific an

272 In Figure 4, seasonal influenza virus was erroneously indicated as ha

273 As a dominant seasonal influenza virus, H3N2 virus rapidly evolves in

274 immunity" to represent ongoing evolution of seasonal influenza virus.

275 Seasonal influenza viruses are a common cause of acute r

276 Seasonal influenza viruses are a major cause of human di

277 nza and emerging pandemic threats.IMPORTANCE Seasonal influenza viruses cause considerable morbidity

278 Although seasonal influenza viruses circulate globally, preventio

279 Seasonal influenza viruses constantly change through ant

280 Seasonal influenza viruses continuously drift, which all

281 Seasonal influenza viruses create a persistent global di

282 Seasonal influenza viruses evolve rapidly, allowing them

283 Human seasonal influenza viruses evolve rapidly, enabling the

284 s of 9,604 haemagglutinin sequences of human seasonal influenza viruses from 2000 to 2012.

285 Human-to-swine transmission of seasonal influenza viruses has led to sustained human-li

286 in the proteolytic activation and spread of seasonal influenza viruses in humans.IMPORTANCE Influenz

287 Antigenic drift of circulating seasonal influenza viruses necessitates an international

288 In comparison to seasonal influenza viruses of lesser virulence, the 1918

289 rule out cross-reactive antibodies to other seasonal influenza viruses to determine whether addition

290 Increased antibody diversity to seasonal influenza viruses was associated with low-level

291 owever, the specific proteases that activate seasonal influenza viruses, especially H3N2 viruses, in

292 way epithelial cells was on par with that of seasonal influenza viruses, mild-to-moderate disease was

293 For seasonal influenza viruses, protection is correlated wit

294 A(H3N2)v viruses transmit as efficiently as seasonal influenza viruses, raising concern over the pan

295 role of H5N1 PA in altering the virulence of seasonal influenza viruses, we generated a recombinant s

296 nces in the immune responses to pandemic and seasonal influenza viruses.

297 exclude cross-reactive antibody responses to seasonal influenza viruses.

298 Immunological memory to seasonal influenza was established in mice, through stra

299 In a year with minimal seasonal influenza, we found no evidence that confoundin

300 volution allows the continual circulation of seasonal influenza, while novel influenza viruses invade