ライフサイエンスコーパス: second generation

1 .3 and ZC410.7 manifest larval arrest in the second generation.

2 -ureido)-pentanedioic acid ((18)F-DCFPyL), a second-generation (18)F-labeled PSMA ligand.

3 amino]-pentyl)-ureido)-pentanedioic acid], a second-generation (18)F-PSMA-ligand) in patients with PC

4 STOP second generation (2G)-tyrosine kinase inhibitor (TKI) i

5 The purpose of this study was to develop a second-generation (99m)Tc-labeled PSMA-targeted tracer i

6 Second-generation ABL1 kinase inhibitors induce more pot

7 unctional theory calculations, combined with second-generation absolutely localized molecular orbital

8 an optimization process that has produced a second-generation acridone series with significant impro

9 ion aphids had cross-generational impacts on second-generation adults, and the impact on fecundity wa

10 The second-generation agent, dolutegravir (DTG), has enjoyed

11 ion in advSM, and the efficacy and safety of second-generation agents, such as the switch-control inh

12 role of ensartinib in patients in whom other second-generation ALK inhibitors have been unsuccessful

13 stant to currently available TKIs, including second-generation ALK TKIs, and is being investigated in

14 Here, we show that a second-generation amino-acyl tRNA synthetase (aaRS)/tRNA

15 ent the design, synthesis, and evaluation of second-generation analogues, which led to the discovery

16 ynthesis, and pharmacological evaluation of "second generation" analogues of 1 whereby subtle modific

17 Enzalutamide, a second-generation androgen receptor (AR) antagonist, has

18 Enzalutamide (MDV3100) is a potent second-generation androgen receptor antagonist approved

19 elationship also persisted in experiments on second-generation animals, and larval lipid consumption

20 Inhibition of the androgen receptor (AR) by second-generation anti-androgens is a standard treatment

21 d safety of idelalisib in combination with a second-generation anti-CD20 antibody, ofatumumab, in a s

22 Olanzapine is a second-generation anti-psychotic drug used to prevent ne

23 K activation as a mechanism of resistance to second-generation antiandrogen therapy, highlighting the

24 r NRG1 activity have an inferior response to second-generation antiandrogen therapy.

25 Enzalutamide (MDV3100) is a second-generation antiandrogenic drug that was approved

26 Despite the development of second-generation antiandrogens, acquired resistance to

27 er recommend initial treatment with either a second-generation antidepressant (SGA) or cognitive beha

28 ly significant difference in the efficacy of second-generation antidepressants (SGAs) versus most oth

29 , double-blind, placebo-controlled trials of second-generation antidepressants adjunctive to a mood s

30 Second-generation antidepressants are the first-line opt

31 tween either cognitive behavioral therapy or second-generation antidepressants to treat patients with

32 Second-generation antidepressants were associated with a

33 For the most commonly used second-generation antidepressants, the lower range of th

34 A second generation antigene peptide oligonucleotide targe

35 The efficacy of second-generation antihistamines was evaluated on the da

36 The second included studies on second-generation antipsychotic combination therapies (S

37 Second-generation antipsychotic drugs (SGAs) are essenti

38 acebo-controlled dose-finding studies for 20 second-generation antipsychotic drugs and haloperidol (o

39 ering 12 weeks of prospective treatment with second-generation antipsychotic drugs.

40 In particular, second generation antipsychotics, like first generation

41 ed hazard ratio, 3.06; 95% CI, 1.32-7.05) or second-generation antipsychotics (adjusted hazard ratio,

42 es not support routine use of haloperidol or second-generation antipsychotics for prevention of delir

43 ipolar disorder over the past 20 years, with second-generation antipsychotics in large measure suppla

44 There is limited evidence that second-generation antipsychotics may lower delirium inci

45 There is limited evidence that second-generation antipsychotics may lower the incidence

46 creased over the past 20 years, with several second-generation antipsychotics receiving regulatory ap

47 es not support routine use of haloperidol or second-generation antipsychotics to treat delirium in ad

48 e SOE), or mortality between haloperidol and second-generation antipsychotics versus placebo.

49 Several second-generation antipsychotics were superior to halope

50 andomised controlled trials (RCTs) comparing second-generation antipsychotics with placebo.

51 s in the use of mood stabilizers, first- and second-generation antipsychotics, and antidepressants am

52 For direct comparisons of different second-generation antipsychotics, there was no differenc

53 functioning (low SOE) for haloperidol versus second-generation antipsychotics, with insufficient or n

54 rther increased by both first-generation and second-generation antipsychotics.

55 enia, but we found little difference between second-generation antipsychotics.

56 scanned at baseline prior to treatment with second-generation antipsychotics.

57 Although second-generation antiseizure medications have not subst

58 Since 1989, 18 second-generation antiseizure medications have reached t

59 Some second-generation antiseizure medications have shown adv

60 els following treatment with volanesorsen, a second-generation antisense drug targeting apoC-III, wer

61 Custirsen is a second-generation antisense oligonucleotide that inhibit

62 Among the first- and second-generation APDs that we tested, clozapine exhibit

63 ive to circumvent this issue, we developed a second-generation approach for the synthesis of PODs by

64 Additionally, we prepared a second-generation barcoded SIVmac239 stock (SIVmac239M2)

65 n this study, we report the development of a second-generation BET protein degrader, BETd-246, which

66 than one year after the introduction of this second generation beta-lactam antibiotic into clinical p

67 Second-generation beta-lactamase inhibitors containing a

68 One of the drawbacks during second-generation biofuel production from plant lignocel

69 , which are valuable characteristics for the second-generation biofuels industry.

70 ss (Panicum virgatum), a strategic plant for second-generation biofuels.

71 scular leak induction yields a fully active, second-generation biologic, s-DAB-IL-2(V6A), which elici

72 The performance of the microneedle array, second generation biosensor for lactate detection was as

73 persisted upon propagation of aggregation to second-generation biosensor cells.

74 rate the capability of microneedle arrays as second generation biosensors we have functionalized gold

75 e C terminus of CA are potently inhibited by second-generation BVM analogs.

76 We recently reported a series of "second-generation" BVM analogs that display markedly imp

77 This second-generation cancer co-therapeutic protein is optim

78 elihood of reversion and enhance safety in a second-generation Candid#1 vaccine.

79 elihood of reversion and enhance safety in a second-generation Candid#1 vaccine.IMPORTANCE The live-a

80 and P removal coupled to N2O generation in a second generation CANDO process, CANDO+P.

81 ) light chain kappa or lambda, we designed a second-generation CAR targeting Igkappa, IGK CAR.

82 TRuC-T cells kill tumor cells as potently as second-generation CAR-T cells, but at significant lower

83 lls to that in T cells transduced to express second-generation CARs and found that cell expansion enh

84 These results suggest that second-generation CARs can activate additional sources o

85 vivo antitumor efficacy, we found that only second-generation CARs induced the expression of a const

86 ral constraints imparted by the structure of second-generation CARs(2).

87 ss-linked via olefin metathesis using Grubbs second generation catalyst.

88 (DFT), the reactivity of the Hoveyda-Grubbs second-generation catalyst 2 with allylbenzene, and disc

89 bis(allyoxy)methyl derivatives using Grubbs second-generation catalyst followed by olefin isomerizat

90 , using only 2.5 mol % of the Hoveyda-Grubbs second-generation catalyst in both metathesis and transf

91 nt in dichloromethane using a Hoveyda-Grubbs second-generation catalyst.

92 ABL001 and second-generation catalytic inhibitors have similar cell

93 l report clinical trial results evaluating a second-generation CD19-directed chimeric antigen recepto

94 A second-generation CDI, APT-6K, exerted bactericidal acti

95 of the CD3epsilon cytoplasmic domain into a second-generation chimeric antigen receptor (CAR) improv

96 ion or pharmacologic blockade with the novel second-generation CHK1 inhibitor prexasertib (LY2606368)

97 In this study, we report the development of second-generation cobalt- and maleimide-based liposomes

98 A second-generation cocktail, MBP134(AF), engineered to ef

99 ern settings, asthma is more prevalent among second-generation compared to first-generation migrants.

100 To understand more about how these second-generation compounds block HIV-1 maturation, here

101 The expanded chemical scaffolds of second-generation compounds mediate interactions with th

102 Recently, second-generation CRISPR/Cas9 activation systems based o

103 The photogenerated intermediate of the second-generation DASA was photo-accumulated at low temp

104 First and second-generation DASAs share a common photoisomerizatio

105 nogashira coupling into a methoxy-terminated second generation dendrimer with persistent globular sha

106 zed, is critical to the development of their second-generation derivatives to improve drug potency to

107 significantly lower in patients treated with second-generation DES (odds ratio, 0.51; 95% confidence

108 Patients receiving second-generation DES for the treatment SVG disease have

109 We aimed to compare efficacy and safety of second-generation DES over BMS in large coronary culprit

110 P<0.001) were lower in patients treated with second-generation DES, but not with first-generation DES

111 eived first-generation DES, and 47% received second-generation DES.

112 The second-generation design relies on the use of the Henry

113 Moreover, the second-generation design was also associated with strong

114 s relative to input H2O2 concentrations, the second-generation dihydroxy hydroperoxy peroxy radical (

115 ric protein with reduced vascular leak, is a second-generation diphtheria-toxin-based fusion protein

116 based therapies including paclitaxel and the second-generation docetaxel are currently limited by sev

117 al structure of PDE5 complexed with the sole second generation drug avanafil.

118 eriority of thin-strut biodegradable polymer second-generation drug-eluting stent to the first-genera

119 ere is a paucity of contemporary data on the second-generation drug-eluting stent use within SVG, and

120 -metal stents (BMS) and first-generation and second-generation drug-eluting stents (DES1 and DES2, re

121 st-generation drug-eluting stents (DES1) and second-generation drug-eluting stents (DES2).

122 eds to be assessed individually, but overall second-generation drugs are less likely to cause pharmac

123 mography myocardial perfusion imaging with a second-generation dual-source scanner.

124 ion, which mediates resistance to first- and second-generation EGFR TKI, and recent clinical trials h

125 Although second generation endocrine therapies have significantly

126 r laparoscopic supracervical hysterectomy or second generation endometrial ablation.

127 ose in the saccharification of cellulose for second-generation ethanol production, and due to this im

128 We describe a second-generation EWAS approach, which focuses on the po

129 reduced insulin secretion in first- (F1) and second-generation (F2) C57BL/6J male mice offspring.

130 of ferrocene cored polyamidiamine dendrimers second generation (Fc-PAMAM (G2)), after which electrode

131 The activation of second-generation fluorinated oxazaborolidines by the st

132 In addition, we transferred second generation (G2) tert blastula cells into WT to pr

133 A second-generation ("Gen 2") device capable of surface-in

134 Phylogenomics based on second-generation genomics and transcriptomics has furth

135 Herein, we report the discovery of second-generation GluN2C/D-selective NMDAR-positive allo

136 ile suppressing desallyl products using both second-generation Grubbs and second-generation Hoveyda-G

137 oup significantly outperformed the benchmark second-generation Grubbs catalyst in the ethenolysis of

138 pooled meta-analyses showed that nonsedating second-generation H(1)-antihistamines (nsAHs) are effect

139 s' first generation (G1) and Hoveyda-Grubbs' second generation (HG2) catalyst under identical conditi

140 Herein we describe the discovery of second-generation HIF-2alpha inhibitor PT2977 with incre

141 e addressed these obstacles by engineering a second-generation, high-affinity AXL decoy receptor with

142 Custirsen (OGX011) is a second generation highly specific antisense oligonucleot

143 Although second-generation HIV integrase strand-transfer inhibito

144 thesis-active Ru intermediates formed by the second-generation Hoveyda and Grubbs catalysts.

145 ucts using both second-generation Grubbs and second-generation Hoveyda-Grubbs catalysts.

146 ation: HR, 0.90; 95% CI, 0.68-1.20; P = .49; second generation: HR, 1.19; 95% CI, 0.82-1.73; P = .36)

147 compared the performance of three available second-generation human genome-wide CRISPR-KO libraries

148 GSK3532795 is a second-generation human immunodeficiency virus type 1 (H

149 cular outflow [Trabectome, iStent (first and second generations), Hydrus microstent, Kahook Dual Blad

150 Second-generation IGRAs had a sensitivity of 94.0% (90.0

151 cy and utility of commercially available and second-generation IGRAs in the diagnostic assessment of

152 89.4) for T-SPOT.TB to 80.0% (75.6-83.8) for second-generation IGRAs.

153 nce country, and their Danish-born children (second-generation immigrants), to evaluate the importanc

154 rt, 578 among first-generation and 106 among second-generation immigrants.

155 uding 1 176 419 first-generation and 184 282 second-generation immigrants.

156 These compounds are useful second-generation in vitro tools and a promising step to

157 From further computational work a second generation, in silico designed catalyst emerged,

158 d QuantiFERON-TB Gold In-Tube [QFT-GIT]) and second-generation (incorporating novel M tuberculosis an

159 subsequently applied to rationally design a second-generation inhibitor scaffold with a nearly optim

160 bitors and to the identification of refined, second generation inhibitors.

161 We therefore tested second-generation inhibitors of the 20S proteasome (dela

162 es, which highlights a need for discovery of second-generation inhibitors.

163 Although second-generation INSTIs present higher barriers to the

164 ent drug resistance (PDR) on the efficacy of second generation integrase inhibitors.

165 ed the performance of the first (PQ-CSF) and second generation (IQ-CSF) RT-QuIC assays, and investiga

166 We found that treatment with the second-generation irreversible HER-family inhibitors, pa

167 A recent clinical trial of carfilzomib (a second-generation irreversible PI) demonstrated improved

168 Dacomitinib is a second-generation, irreversible EGFR tyrosine kinase inh

169 ME-344 is a second-generation isoflavone with unusual cytotoxic prop

170 A second generation leishmanization is described here usin

171 NLC, a second-generation lipid nanocarrier, upsurges the drug p

172 B and VEGFR2 in the 7-d first generation and second generation lungs.

173 or chloroquine, often in combination with a second-generation macrolide, are being widely used for t

174 identify mutations that confer resistance to second-generation maturation inhibitors and provide nove

175 developed bevirimat analogs, referred to as "second-generation" maturation inhibitors, overcome this

176 ign and engineer artificial pathways towards second generation meroterpenoids with valuable bioactivi

177 Here, a second-generation method is described for cryopreservati

178 s of AD, and review recent studies using the second-generation mice.

179 care, who had been identified as a first or second generation migrant from a high-risk country.

180 he unique, non-Western context of Hong Kong, second-generation migrants had higher risk of hospitaliz

181 h provides means for rational development of second-generation MINIs.

182 Herein we report three new second-generation molecular motors featuring a phosphoru

183 cause additional phenotypes unrelated to AD Second-generation mouse models contain humanized sequenc

184 tution to provide highly efficient DABOs as "second generation" NNRTIs.

185 Herein, we describe second-generation NS5B inhibitors including GSK8175 (49)

186 nvestigate the safety and performance of the second generation of an implantable intraocular pressure

187 studies reported high diagnostic value of a second generation of cerebrospinal fluid (CSF) Real-Time

188 progenitor cells capable of giving rise to a second generation of odontoblasts during reparative dent

189 nt was the addition of only 3 wt.% Re in the second generation of single crystal Ni-based superalloys

190 We now present a second generation of UAS- and LexA-responsive CLIPf, SNA

191 modulator, we describe the development of a second generation of utrophin modulators, based on the b

192 In this study, we developed a second generation of vector systems for enhanced transcr

193 rtic valve replacement (TAVR) with first and second generations of transcatheter valves.

194 reprogram somatic cells to pluripotency, a "second generation" of cellular reprogramming involves li

195 way inflammation not only in first- but also second-generation offspring but does not increase suscep

196 to adulthood and transmitted the reporter to second-generation offspring.

197 hagy than all previous datasets, producing a second-generation ontology of 220 functions.

198 From the second generation onward, the lineage bred endogamously

199 in optobiology, focusing on new features of second-generation optobiological tools.

200 sed after or were refractory to at least one second-generation or later TKI or were intolerant to sec

201 eneration or later TKI or were intolerant to second-generation or later TKIs and intolerant or refrac

202 Acalabrutinib is a novel second-generation oral Bruton tyrosine kinase inhibitor

203 Duvelisib is a second-generation oral inhibitor of phosphoinositide-3 k

204 e-activity studies led to the discovery of a second-generation ozonide, artefenomel (OZ439, 2), which

205 effects in collagen-induced arthritis of the second generation PAD inhibitor, BB-Cl-amidine.

206 s of oncolytic PVs, including development of second-generation parvoviruses with enhanced oncolytic a

207 Here, we show that a second-generation PC-positive (PC(+)) DISC (DISCII) vacc

208 Second generation peptides were then designed to further

209 The binding of second-generation peptides to Ral proteins was quantifie

210 iodegradable polymer DES generations against second-generation permanent polymer DES needs to be expl

211 ent and the noninferiority to the thin-strut second-generation permanent polymer drug-eluting stent.

212 the third-generation IMiD pomalidomide, the second-generation PIs carfilzomib and ixazomib, the DACI

213 Platelet-rich fibrin (PRF), a second-generation platelet concentrate, has been the foc

214 GSK2838232 is a second-generation, potent, small-molecule, oral human im

215 Herein, we show that first generation and second generation progeny from gestationally SS-exposed

216 ic valve implantation in BAV and analyze the second-generation prostheses geometry postimplantation.

217 Second-generation prostheses similarly reshape the aorti

218 nical progress has been made with the use of second-generation proteasome inhibitors (PIs).

219 highly effective drugs, including first- and second-generation proteasome inhibitors, immunomodulator

220 SPO), a biomarker of neuroinflammation, most second-generation radioligands are sensitive to the sing

221 Profiling of second-generation RAF inhibitors confirmed their improve

222 MR of the inserted species of both first and second generation RCM catalysts are reported and discuss

223 The first option is second-generation real-time quaking-induced conversion (

224 measurements of prion seeding activity with second-generation real-time quaking-induced conversion (

225 Currently, there exist no data on second-generation recurrence rates among families affect

226 3 months, or an e-cigarette starter pack (a second-generation refillable e-cigarette with one bottle

227 O of the TCRbeta chain in combination with a second-generation retroviral CAR transduction including

228 e bipolar cell-selective photoswitch DAD and second-generation RGC-targeting photoswitch PhENAQ, we i

229 y or assemble full-length mRNA isoforms from second-generation RNA-seq data, it remains a challenge t

230 Compared with SAVR, the second-generation SAPIEN XT balloon-expandable valve has

231 The SOLVE-TAVI (Comparison of Second-Generation Self-Expandable Versus Balloon-Expanda

232 igh-accuracy, and high-throughput short-read second-generation sequencer to generate over 100 kb of l

233 Generation Sequencing (TGS) long reads with Second Generation Sequencing (SGS) short reads, the accu

234 Second generation sequencing technologies are being incr

235 ctively address the read length issue of the second generation sequencing technology, but contain app

236 in order to attain bacterial diversity from second generation sequencing, Hill number can be a good

237 g reads can be corrected by the high-quality second-generation sequencing (SGS) short reads, which is

238 pmental disorders has been revolutionized by second-generation sequencing combined with international

239 ariations rely on short, accurate reads from second-generation sequencing devices.

240 Second-generation sequencing technologies have been exte

241 ing reads that are substantially longer than second-generation sequencing technologies.

242 ata from long DNA molecules using economical second-generation sequencing technology.

243 Massively parallel or second-generation sequencing-based genomic studies conti

244 tellite arrays not accessible to single-cell second-generation sequencing.

245 A second-generation series improved on affinity by incorpo

246 rise to the development of a more efficient second-generation set of olefin cross-coupling condition

247 We then expanded the barcoding approach in a second-generation SIVmac239 stock (SIVmac239M2) with ove

248 Here, we report an improved, second-generation SPARK2 that incorporates a luciferase

249 t inhibition of SRC-3 and SRC-1 with SI-2, a second-generation SRC-3/SRC-1 small-molecule inhibitor,

250 ned from this maturation were used to design second-generation stapled peptides based on RLIP76 that

251 A second-generation strategy was then developed to access

252 n effect estimates were found for RCTs where second-generation sulfonylureas were used as a proxy for

253 ive real-world risk of SCA/VA among users of second-generation sulfonylureas: glimepiride, glyburide,

254 A catalytic asymmetric second generation synthesis of (4S,5S)-4,8-dihydroxy-3,4

255 A concise and scalable second generation synthesis of HIV maturation inhibitor

256 synthetic strategy, which also resulted in a second-generation synthesis of amphilectolide, confirms

257 The key innovation in this second-generation synthesis of illudinine is the use of

258 The application to a second-generation synthesis of the C15-C24 northern port

259 In addition, we describe a second-generation synthesis of the clinical candidate BM

260 armacophore and assessed binding efficacy of second-generation TDZD analogs (TDZD-10 and Tideglusib)

261 t discovery and modified base detection than second generation technologies.

262 Second-generation tests, however, might have sufficientl

263 50-85% of patients with TNBC and developed a second-generation TF-targeting antibody-like immunoconju

264 nd provide a means for rationally developing second-generation therapies.

265 ear) with the potential benefit in favour of second-generation TKI (willingness to pay $200 000 per Q

266 case 0.89, range 0-1) and the annual cost of second-generation TKIs (base case US$152 814 [ie, the pr

267 Considering the current prices of second-generation TKIs and of generic imatinib under dif

268 lower cost of generic imatinib, the value of second-generation TKIs as frontline therapy for this par

269 btained an ICER of $22 765 208, meaning that second-generation TKIs as frontline therapy to achieve s

270 ion of patients achieving such response with second-generation TKIs at 66%, 88%, and a near-perfect r

271 n the USA, Europe, and developing countries, second-generation TKIs at current prices do not offer go

272 showed potential treatment value for use of second-generation TKIs at the current prices in the USA

273 ange 0-240 000) on the cost-effectiveness of second-generation TKIs compared with generic imatinib.

274 was approved for pediatric CML in 2003, the second-generation TKIs dasatinib and nilotinib were rece

275 Highly priced second-generation TKIs might offer deep molecular respon

276 ditionally, the frontline CML treatment with second-generation TKIs produces deeper molecular respons

277 pay of $50 000 per QALY, the annual price of second-generation TKIs should not exceed $10 000 per yea

278 We aimed to assess the potential value of second-generation TKIs used as frontline therapy in pati

279 ple, considering a scenario in the USA using second-generation TKIs versus imatinib (annual price $44

280 ty of the chronic phase of 0.1), the cost of second-generation TKIs would need to be less than $25 00

281 estimated at 26% with imatinib and 44% with second-generation TKIs.

282 (18)F-DPA-714 is a second-generation tracer for PET imaging of the 18-kDa t

283 of this study was to compare (18)F-DPA714, a second-generation translocator protein tracer, with (11)

284 tection of certain ions, we have developed a second-generation transmission mode (TM) AP-MALDI imagin

285 ion in daytime ASBP was observed with RSD in second-generation trials (6.12 mm Hg vs. 2.14 mm Hg; p i

286 The intravenous solutions of both second-generation triazoles showed characteristics that

287 herapy, aerosolized delivery with one of the second-generation triazoles was considered.

288 g and can potentially be addressable through second-generation TRK inhibitors(9-11).

289 resonance imaging (MRI) brain scan with the second-generation TSPO ligand [(11)C]PBR28.

290 The present study uses the novel second-generation TSPO PET radioligand [(18)F]FEPPA to e

291 Human PET imaging using the second-generation TSPO radiotracer [(11)C]DPA-713 reveal

292 mission tomography (MR-PET) scanner with the second-generation TSPO radiotracer [(11)C]PBR28.

293 is study was to directly compare 2 promising second-generation TSPO tracers, (11)C-DPA-713 and (18)F-

294 It is a high-quality second-generation TSPO-binding PET radiotracer.

295 I] (1) with potassium graphite produces the "second-generation" uranocene [(eta(5) -C(5) (i) Pr(5) )(

296 Efforts to develop second-generation vaccine candidates may concentrate on

297 Similar patterns were observed for the second-generation vaccine.

298 red that nearly 10% of candidate DNMs in the second generation were post-zygotic, and present in both

299 tion and generational status (i.e., first or second generation) with death among children of immigran

300 n embryo viability was carried over into the second generation without further selection and was equa