ライフサイエンスコーパス: secondary amine

1 ted base (a primary or, in selected cases, a secondary amine).

2 he well-characterized reaction of CO2 with a secondary amine.

3 de from cyclohex-2-en-1-one and a primary or secondary amine.

4 on the (E)-4-heterocrotonate and size of the secondary amine.

5 ination of the carbamate and liberation of a secondary amine.

6 by nucleophilic activation with a primary or secondary amine.

7 ween the resulting hemiaminal and primary or secondary amine.

8 rimary amines, as well as cyclic and acyclic secondary amines.

9 aldehydes, propiolates, sulfonyl azides, and secondary amines.

10 regioselective ring-opening with primary or secondary amines.

11 mechanism of a metal-free alpha-amination of secondary amines.

12 esulting from the adsorption of CO2 onto the secondary amines.

13 g of 1,3-dihydro-1H-benzimidazol-2-ones with secondary amines.

14 ureas and oxalamides from either primary or secondary amines.

15 rging of CO(2) or trapping with nucleophilic secondary amines.

16 idinium salts and the allylic or homoallylic secondary amines.

17 ns of benzo[d]oxazol-2(3H)-ones with acyclic secondary amines.

18 , ketones, esters, free hydroxyls, and basic secondary amines.

19 transamidation of tertiary carboxamides with secondary amines.

20 le and show no signs of deprotonation of the secondary amines.

21 the most sensitive to detection, followed by secondary amines.

22 ving a side chain introduced onto one of the secondary amines.

23 and irreversibly with nitroxides to produce secondary amines.

24 mination at C5 with a variety of primary and secondary amines.

25 cycloaliphatic or substituted cycloaliphatic secondary amines.

26 with a broad selection of alkene-containing secondary amines.

27 the construction of alpha-tertiary and alpha-secondary amines.

28 bioremediation of EDTA and the metabolism of secondary amines.

29 idation of primary amines in the presence of secondary amines.

30 r alpha-branched aliphatic primary amines or secondary amines.

31 ch for the alpha-functionalization of cyclic secondary amines.

32 group tolerance with a range of primary and secondary amines.

33 catalytic advantage over simple primary and secondary amines.

34 he cross-coupling of unprotected primary and secondary amines.

35 In the EAE model, the secondary amine 12 and the triazole 14 were able to amel

36 Because of their high polarity, the secondary amines 14a (log D7.4=0.26) and 14b (log D7.4=0

37 The neat secondary amines 2-(methylamino)ethanol, 2-(ethylamino)e

38 gerodt-Kindler routes, using the primary and secondary amines 2a-k resulted in a simple, efficient th

39 ons were applied to the Schiff base to yield secondary amine 3, which is also a highly effective hydr

40 tain either one, two, or three Boc-protected secondary amines (7a, 7b, or 7c, respectively).

41 at could simplify the synthesis of aliphatic secondary amines, a class of small molecules that are pa

42 NOate, DEA/NO (Na[Et(2)NN(O)NO]), which is a secondary amine adduct.

43 olid phase extraction clean-up using primary secondary amine along with zirconia-coated silica partic

44 minal and internal aminoalkenes (primary and secondary amines), aminoalkynes (primary and secondary a

45 secondary amines), aminoalkynes (primary and secondary amines), aminoallenes, and aminodienes.

46 employs a bifunctional catalyst comprising a secondary amine and a low-valent rhodium complex capable

47 spersive solid phase extraction with primary secondary amine and acidified with 0.1% formic acid.

48 litates an intramolecular reaction between a secondary amine and aldehyde to form the D ring of the e

49 d the extracts were purified through primary secondary amine and graphitized carbon black.

50 th ethyl acetate and cleaned up with primary secondary amine and graphitized carbon black.

51 rsive solid phase extraction using a primary secondary amine and graphitized carbon is described.

52 enzylisoquinoline intermediates possessing a secondary amine and leading to the key branch-point inte

53 proteinogenic amino acids, only proline is a secondary amine and only proline has a saturated ring.

54 lead to an apparent balance in reactivity of secondary amine and thiols toward 2-oxoaldehydes.

55 eld was proportional to the concentration of secondary amine and was a function of CO2 loading and te

56 Cyclic secondary amines and 2-hydroxybenzaldehydes or related k

57 -EN 15662 method (150 mg MgSO4, 25mg primary secondary amines and 25mg of octadecylsiloxane for clean

58 The efficacy of several secondary amines and aniline derivatives was evaluated i

59 The use of free cyclic secondary amines and anilines as aminating agents and in

60 A range of hindered secondary amines and arylboronic esters are compatible w

61 reaction is successful with a wide range of secondary amines and can be used as a late-stage functio

62 carbamates (MTCs) were prepared from primary/secondary amines and COS as potential carbonic anhydrase

63 C salts, which can be generated in situ from secondary amines and CS2.

64 pting two hydrogen bonds from two protonated secondary amines and donating a hydrogen bond to one ami

65 f chiral building blocks such as primary and secondary amines and oxazolines, highlighting its synthe

66 itu generated from various cyclic or acyclic secondary amines and paraformaldehyde.

67 tudy expands the scope of the CEC method for secondary amines and provides a better understanding of

68 ed good results with both primary amines and secondary amines and sluggish aniline nucleophiles at 65

69 -controlled transamidation reactions between secondary amines and tertiary amides.

70 examined via the reaction of primary amine, secondary amine, and amide functionalities with high pre

71 vided alpha-amino amides from an aldehyde, a secondary amine, and an isonitrile with excellent asymme

72 ree-component coupling of a terminal alkyne, secondary amine, and sulfonamide enables efficient synth

73 c rhodium fragment binds the alkene over the secondary amine, and the olefin complex was shown to be

74 kyl, aralkyl, or substituted-alkyl type from secondary amines, and 12 examples from cycloaliphatic or

75 A(3)-coupling of ortho-hydroxybenzaldehydes, secondary amines, and alkynoic acids is performed under

76 and chloro(hetero)arenes, primary anilines, secondary amines, and amide type nucleophiles together w

77 component in the reaction, while primary and secondary amines, and anilines, all react with high effi

78 ctive Petasis reaction of alkenyl boronates, secondary amines, and ethyl glyoxylate.

79 and proceeds in moderate-to-high yield with secondary amines, and moderate-to-low yield with primary

80 lating agents, reacting with primary amines, secondary amines, and sulfonamides to form the correspon

81 irect covalent immobilization of primary and secondary amines, and the subsequent measurement of sero

82 ne)iron; (2) Boc-protection of the resulting secondary amine; and (3) oxidative demetallation leading

83 total N-nitrosamine formation in the order: secondary amines approximately tertiary amines >> primar

84 hods for enantioselective synthesis of alpha-secondary amines are available (for example, from additi

85 C-N cross-coupling reactions, alpha-branched secondary amines are difficult coupling partners and the

86 ver tertiary amine products, even though the secondary amines are established substrates for ARC-base

87 kylation adjacent to nitrogen in unprotected secondary amines are reported.

88 Chiral secondary amines are some of the most commonly used kind

89 Secondary amines are unreactive, as is a catalyst with a

90 s of benzylic/aliphatic alcohols and primary/secondary amines are viable in this reaction, enabling b

91 nducted using morpholine as a representative secondary amine as a potential CO(2) capture solvent wit

92 riple bond, carried out in the presence of a secondary amine as external nucleophile, selectively led

93 Using reactions of CO(2) with secondary amines as an exemplary system, we demonstrate

94 a general base, removing an acetate group of secondary amines as glyoxylate.

95 he developed chemistry was extended with the secondary amines as nucleophiles to afford nitrogen-subs

96 O(2)(aq) with a series of substituted cyclic secondary amines as well as the noncyclic secondary amin

97 degradation than PEI, even while containing secondary amines, as supported by FTIR, NMR, and ESI-MS

98 the primary amine at room temperature or the secondary amine at elevated temperatures leads to the co

99 ylbis(benzotriazole) (Bt2SO2, 1) reacts with secondary amines at room temperature to afford (i) the c

100 A truncated squaraine dye, with a secondary amine attached directly to the central C(4)O(2

101 eoselective synthesis of bicyclic primary or secondary amines, based on tetralin or chroman structura

102 The fluorous tags, which are secondary amines bearing different numbers of fluorine a

103 rystallography verified the formation of the secondary amine bond mediating the conjugation in the ca

104 ltistage Rh-catalyzed dehydrocoupling of the secondary amine-borane H(3)B.NMe(2)H, to give the cyclic

105 stic investigation of the dehydrogenation of secondary amine-borane Me(2)NH.BH(3) supports a bond-met

106 Moreover, a secondary amine building block that contains all carbon

107 ibutions associated with primary amines over secondary amines, but may be due to unfavorable entropic

108 a reaction that is stimulated by primary and secondary amines, but not by tertiary amines and carbona

109 nthetic approach to the preparation of caged secondary amines by acid-catalyzed rearrangement of fuse

110 protocol that accesses directly unprotected secondary amines by intramolecular C-N bond forming dear

111 Here, we unraveled the deactivation of secondary amines by undesired aldol reaction.

112 Furthermore, we demonstrate that secondary amines can be directly used with benzoyl perox

113 Alternatively, less nucleophilic primary/secondary amines can be used as electrolytes without pol

114 lpha,beta-unsaturated aldehydes under chiral secondary amine catalysis.

115 f an electron-deficient difluoro-substituted secondary amine catalyst and the intrinsic reactivity of

116 The combination of a primary amine and a secondary amine catalyst was found to be the best choice

117 med by the condensation of an aldehyde and a secondary amine catalyst) leads to the formation of a 3p

118 A simple secondary amine catalyst, 2-methyl-l-proline, and its te

119 By the application of a chiral secondary amine catalyst, the organocatalytically activa

120 Employing a newly developed class of chiral secondary amine catalysts, alpha-diarylmethine-substitut

121 elective than with primary and less hindered secondary amine catalysts.

122 The multicatalytic process involves a secondary amine catalyzed Michael addition followed by a

123 Whereas cascade reactions catalyzed by secondary amines combine iminium- and/or enamine-catalyz

124 droxyethyl-ethylenediamine (HEEDA), and DEA, secondary amines common in MEA degradation.

125 H)OBz] were used for the synthesis of chiral secondary amines, competitive, nonproductive consumption

126 The polymers with four secondary amines (D4, G4, and M4) between the carbohydra

127 2 partial pressure for different primary and secondary amines, demonstrating that entropic contributi

128 The secondary amine dendrimer conjugates exhibited a high st

129 O release durations (>16 h) observed for the secondary amine dendrimers were significantly longer com

130 Overall, the secondary amine derivative 15a demonstrated excellent Cp

131 The treatment of a secondary amine, di-n-propylamine (DPA), provides a mild

132 tion that displays a catalytic primary amine-secondary amine diad in a specific three-dimensional arr

133 o, sMono), diamines with one primary and one secondary amines (Diamine) and triamine with one primary

134 ntly longer compared to small molecule alkyl secondary amine diazeniumdiolates, thus illustrating a d

135 , the Roush allylboronate tartrates, and the secondary amine Diels-Alder catalysts described by MacMi

136 ic secondary amines as well as the noncyclic secondary amine diethanolamine (DEA) has been investigat

137 I)([15]aneN(4))(SAr)(OOR)](+), which contain secondary amine donors.

138 ained is comparable with the LODs of primary secondary amine dSPE.

139 Primary amines react faster than secondary amines due to increased solvation of the zwitt

140 rganization of the second alkyl chain on the secondary amine during CO2 adsorption.

141 )N was derived from a library of primary and secondary amines (e.g., morpholine)].

142 )N was derived from a library of primary and secondary amines, e.g., morpholine] were placed at the 1

143 e aromatic and aliphatic amines, primary and secondary amines, electron-rich, -neutral, and -poor ami

144 As a result, among the various secondary amines employed, differing in steric bulk, ele

145 Secondary amines featuring these reactive primary amines

146 ruction of a recognition element ending in a secondary amine followed by capping with different elect

147 amino-substituted furfurals by reaction with secondary amines followed by treatment with acid in a mi

148 ive coupling of the terminal alkyne with the secondary amine, followed by hydroamidation of the ynami

149 Each track consists of n - 1 aliphatic secondary amine footholds plus a naphthylmethylamine gro

150 e a thioketene intermediate that reacts with secondary amines forming 2-(2-chloro-5-nitrophenyl)-N,N-

151 amidation of primary amides with primary and secondary amines, forming secondary and tertiary amides,

152 tabolic pathways leading to the formation of secondary amines from nitroxides are unknown.

153 The synthesis of primary and secondary amines from unactivated olefins was accomplish

154 ht (<500 Da) molecules containing primary or secondary amine functional groups for MALDI-TOF MS analy

155 amples, up to 98 %), while the reaction with secondary amines furnish sulfuramidimidoyl fluoride prod

156 Reaction of 2a with primary and secondary amines furnished a number of vinamidinium salt

157 Within the secondary amine group, elevated adjusted odds ratios wer

158 reating point chirality in the vicinity of a secondary amine group.

159 ation of weakly acidic silanol/aluminol with secondary amine groups can mimic proline catalysts and a

160 lities appeared to prevent adhesion, whereas secondary amine groups promoted adhesion, in agreement w

161 where the amidate ligand was converted to a secondary amine, H1*-NiSOD, a novel strategy that retain

162 reduction of secondary amides to imines and secondary amines has been achieved using readily availab

163 rminal alkynes in the presence of metals and secondary amines, has been investigated.

164 We have synthesized a secondary amine HBr salt as the headgroup of a single-ch

165 metric Strecker reaction of aldehydes with a secondary amine in the presence of sodium fluoride using

166 mple procedure, the protocol smoothly yields secondary amines in a formal olefin hydroamination.

167 acceptor compounds discriminate primary and secondary amines in aqueous solution.

168 Secondary amines in conjunction with high nitrite intake

169 Reaction of 6 with primary or secondary amines in DMA led to regioselective opening of

170 ng unprotected anilines to provide access to secondary amines in excellent selectivity.

171 fer the ability to catalyse the oxidation of secondary amines in MAO-N-D3, Asn336Ser reduces steric b

172 cylaldehydes with dibutyl vinylboronates and secondary amines in the presence of 4 A molecular sieves

173 o benzylamines when reacted with primary and secondary amines in the presence of the Pd NPs, which al

174 lerates alcohols, carboxylic acids, and even secondary amines in the substrates.

175 synthetically valuable piperidin-4-ones from secondary amines in two steps has been achieved via a ke

176 a substoichiometric quantity of piperidine (secondary amine) in combination with cesium carbonate is

177 thod is also applicable for the synthesis of secondary amines including heterocyclic ones.

178 evaluated for 4-, 5-, and 6-membered cyclic secondary amines, including medicinally relevant compoun

179 hyl group that is adjacent to an unprotected secondary amine into a synthetically versatile nitrogen

180 Only by introducing a secondary amine into the perovskite structure to form MA

181 N-Alkylation of primary and secondary amines into tertiary amines was confirmed by F

182 the presence of the pendant NH moiety of the secondary amine is crucial for catalysis.

183 e concentration of amine during reactions of secondary amines is best attributed to catalyst decompos

184 These inhibitors feature a hydroxyethyl secondary amine isostere and a novel aromatic ring repla

185 re of BACE in complex with this hydroxyethyl secondary amine isostere inhibitor is also presented.

186 scope and functional group tolerance of the secondary amine kinetic resolution.

187 hen allowed to react further with primary or secondary amines leading, overall, to one-pot, three-com

188 d was developed to reduce the imine bonds to secondary amines, leading to fully organic covalent macr

189 reactions of a series of 1-halopolyynes with secondary amines led to novel amine end-capped polyynes

190 t by agmatine (decarboxy-arginine) through a secondary amine linkage.

191 rent amine types, strongly basic primary and secondary amine materials are shown to have essentially

192 A broad range of primary and secondary amines may be inserted by this method, includi

193 conditions and suggest that the presence of secondary amines may not mean that all aminopolymers wil

194 ma xenografts in scid mice revealed that the secondary amine metabolite is at least as active as ARC-

195 Using primary and secondary amines, model intermediates have been isolated

196 permeation chromatography (GPC) and primary/secondary amine modified silica (PSA)/graphitized carbon

197 troducing transient protecting groups on the secondary amine moieties, followed by controlled deprote

198 6- tert-butyl was replaced with aromatic and secondary amine moieties.

199 first time, leading to 3D spirocycles with a secondary amine (NH) in the spiro-ring.

200 r group to the amide nitrogen of 2 or to the secondary amine nitrogen of 1, the inhibitor molecules c

201 nors in complement to the existing series of secondary amine NONOates, which are well-characterized N

202 at formally corresponds to the reaction of a secondary amine nucleophile at C-2.

203 of unactivated alkenes and vinyl arenes with secondary amines occurs readily in the presence of tanta

204 with a pKa of 6.2 accepts a proton from the secondary amine of saccharopine as it is oxidized.

205 p that originally accepted a proton from the secondary amine of saccharopine, and products are releas

206 ole, histidine amide, pyrimidine N1, and the secondary amine of the beta aminoalanine, whereas the pr

207 Modifications of the secondary amine of the C2 ethylaminomethylene side chain

208 morpholino nucleic acid (MoNA), because the secondary amine of the morpholino-nucleotides is expecte

209 s consisting of valine and basic primary and secondary amines of varying gas-phase basicity (GB) were

210 carbonylation of alkyl and aryl alcohols and secondary amines on metallic gold well below room temper

211 NHS derivatives react with primary or secondary amines on proteins to yield stable amide or im

212 sors was developed by grafting site-isolated secondary amines on silica-alumina supports.

213 reported; optically enriched products bear a secondary amine or a readily removable Cbz or acetamide

214 d derivatives at 313 nm releases primary and secondary amines or ammonia in nearly quantitative yield

215 Secondary amines or primary alcohols as the third compon

216 In general, secondary amines or tertiary amines with nonsterically d

217 either through direct trifluoroethylation of secondary amines or via a three-component coupling of pr

218 s activated as an enamine by the action of a secondary amine (organocatalysis), which then adds to an

219 Thus, IdaA is a secondary amine oxidase, and our findings improve unders

220 t least an order of magnitude higher for the secondary amine piperazine (PZ) than for the primary ami

221 t was found that design rules logD(7.4) > 2, secondary amine pK(a) > 8.0, yielded ultra-long duration

222 od for carbon capture and sequestration, but secondary amines present in all amine solvents can form

223 The stepwise reduction to secondary amine proceeds through an imine intermediate t

224 -protected amino acids with both primary and secondary amines proceeds effectively, with very low lev

225 process known to produce a wide spectrum of secondary amine products that are more readily nitrosata

226 primary alkyl amines to selectively furnish secondary amine products.

227 philes are generated in situ from aldehydes, secondary amines, proton sponge, and silyl triflate.

228 the 2,3-dialkyl substituted products, cyclic secondary amines provided the 2-alkylsubstutited product

229 While photochemical release of primary and secondary amines provides high yields in methanol, relea

230 orphyrin model compound elution from primary secondary amine (PSA) stationary phase combined with UV-

231 h as graphitised carbon black (GCB), primary secondary amine (PSA), C(18), silica, and florisil were

232 he supernatant was then cleaned by a primary-secondary amine (PSA), GCB, and MgSO4.

233 spersive solid-phase extraction with primary secondary amine (PSA).

234 ation of anhydrous CaCl2 (100mg) and primary-secondary amine (PSA, 25mg) as sorbents.

235 xample, the overall quantum yields of simple secondary amines release are 0.5 at acidic pH from 3.9 t

236 ties of copper salts to provide tertiary and secondary amines, respectively, in generally good yields

237 A detailed account on chiral secondary amine salt promoted enantioselective intramole

238 The relative reactivities of several secondary amines serving as hydride donors in propargyli

239 ocyclams with acetic acid side chains on the secondary amine sites and ethylene glycol side chains on

240 l adsorbents composed of both primary and/or secondary amine sites has been demonstrated at standard

241 orption may play a key role in adsorption at secondary amine sites, making adsorption at these sites

242 With model secondary amine solvents ranging from nonvolatile dietha

243 f graphitized carbon black (GCB) and primary-secondary amine sorbent (PSA).

244 taining anhydrous magnesium sulfate, primary secondary amine sorbent, and C-18 sorbent.

245 a mixture of magnesium sulphate and primary secondary amine sorbent.

246 iazine ring with a minimum of one primary or secondary amine substituent and either a chloride or ami

247 The synthesis of 27 cyclic, secondary amine substituted phenyl and benzyl nitrofuran

248 icient aerobic dehydrogenation of non-native secondary amine substrates, including pharmaceutically r

249 ity can be realized with challenging N-alkyl secondary amine substrates.

250 major product for reaction with primary and secondary amines such as butylamine, morpholine, and ani

251 rsity of commercially available alcohols and secondary amines, suggests broad applicability of the re

252 d primary amines suggest that tertiary amide/secondary amine systems are particularly promising for f

253 ed NSDs according to their functional group (secondary amine, tertiary amine, and amide).

254 carboxyl groups (amino acids), but not from secondary amines, tertiary amines, sterically hindered p

255 ar hydroamination/cyclization of primary and secondary amines tethered to conjugated dienes.

256 patible primary amino alcohols into hindered secondary amines that are capable of undergoing a steric

257 Rate analysis reveals that for primary and secondary amines, the aza-Michael addition to ethyl acry

258 in, and a conjugate addition of the hindered secondary amine to acrylonitrile.

259 Using a cyclic secondary amine to form the C-28 amide bond increased th

260 s of the aza-Michael addition of primary and secondary amines to acrylates in an aprotic solvent.

261 unctionalized olefins react with primary and secondary amines to give the corresponding secondary and

262 ding derivatization to transform primary and secondary amines to less reactive carbamate functional g

263 th aminosilanes and subsequent conversion of secondary amines to N-diazeniumdiolate NO donors.

264 ature with diversely substituted primary and secondary amines to produce N-monoalkyl or N,N-dialkyl b

265 hemoselective dehydrogenation of primary and secondary amines to the corresponding nitriles and imine

266 contain two differentiated sites (protected secondary amines) to allow for further functionalization

267 amine) and triamine with one primary and two secondary amines (TRI) as well as different impregnated

268 mination of the alkene with simple exogenous secondary amines under extraordinarily mild reaction con

269 arenes, has been performed using thiols and (secondary) amines under base-free and metal-free conditi

270 g-opening reactions of pyridinium salts with secondary amines, undergo a fascinating thermal rearrang

271 develop a CuH-catalyzed synthesis of chiral secondary amines using a variety of amine coupling partn

272 alyzed synthesis of amides from alcohols and secondary amines using the oxygen in air as the terminal

273 livery of molecules that contain primary and secondary amines via an amide or carbamate bond; however

274 The remaining secondary amine was introduced with a catalyst-controlle

275 es with anions generated from the primary or secondary amines was developed.

276 4-Cyanobenzenesulfonamides of secondary amines were found to cleave to the parent amin

277 All N-acylated products of primary and secondary amines were isolated in good to excellent yiel

278 of polymers comprising pendant or main-chain secondary amines were observed for an array of TAC deriv

279 Aliphatic and aromatic secondary amines were obtained in up to 99 % conversion,

280 unctional groups, indicated that primary and secondary amines were the dominant chloropicrin precurso

281 The compounds studied, primary and secondary amines, were introduced at a concentration of

282 ate-assisted deprotonation of the glyphosate secondary amine, whereas another active site residue, Ty

283 +) mainly because the water interacts with a secondary amine, whereas for Gly-Trp+H(+), DeltaH(o) is

284 adation has been ascribed to the presence of secondary amines, which, when oxidized, lose their CO2 c

285 Primary or secondary amine will allow for an intramolecular additio

286 Reaction of cyclic secondary amines with 1-alkynes and copper(I) chloride a

287 on of a range of fused- and bridged-bicyclic secondary amines with a broad set of heteroarenes.

288 A broad range of aldehydes, secondary amines with a cheaper ethyne equivalent, 2-met

289 onstraint, via the coupling of aldehydes and secondary amines with alkyl halides.

290 onoacetate, iminodiacetate and sarcosine are secondary amines with at least one N-acetyl group.

291 bamates were prepared by reaction of primary/secondary amines with carbon disulfide in the presence o

292 rch on the synthesis of biobased primary and secondary amines with current available biobased resourc

293 Microwave reactions of primary and secondary amines with imidoylbenzotriazoles 6a-w gave di

294 meric excess up to 84% of the desired chiral secondary amines with minimal side products.

295 has been discovered that couples primary or secondary amines with N-aryl-substituted lactams to deli

296 ne as representative examples of primary and secondary amines with pinacol allenylboronate is present

297 -catalyzed one-pot alkylation of primary and secondary amines with simple alcohols was carried out un

298 onyl compounds with a variety of primary and secondary amines with up to >98% conversion and with up

299 h provided a selective pathway to synthesize secondary amines without using a catalyst.

300 ospholane tetraacyl fluoride with primary or secondary amines yields a small library of tetracarboxam