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1 bolism) as well as stress response pathways (secondary metabolism).
2 Os, and during idiophase (after the onset of secondary metabolism).
3 genes and three gene deletions that enhance secondary metabolism.
4 ed the potential for feed-back regulation of secondary metabolism.
5 -CoA/propionyl-CoA intracellular balance and secondary metabolism.
6 ways to supply more aromatic amino acids for secondary metabolism.
7 and to other studies of natural variance of secondary metabolism.
8 evelopment, as well as amino acid, iron, and secondary metabolism.
9 arbon skeleton rearrangements in primary and secondary metabolism.
10 l for functional analysis of tandem genes in secondary metabolism.
11 odelling, autophagy, signal transduction and secondary metabolism.
12 ricarp transcriptome in stress responses and secondary metabolism.
13 first studies of a UGDH homolog involved in secondary metabolism.
14 are a well-established feature of microbial secondary metabolism.
15 ism and the subsequent changes in downstream secondary metabolism.
16 S) known to influence biological control and secondary metabolism.
17 pected recruitments, such as MutS ATPases in secondary metabolism.
18 te rapid and irreversible development of the secondary metabolism.
19 arbon metabolism, amino acid metabolism, and secondary metabolism.
20 how decreased virulence coupled with reduced secondary metabolism.
21 r biosynthetic pathways in plant specialized/secondary metabolism.
22 by natural variation in Arabidopsis thaliana secondary metabolism.
23 remains one of the key unsolved problems of secondary metabolism.
24 important condensation enzymes in microbial secondary metabolism.
25 erating at the interface between primary and secondary metabolism.
26 sis and as an arginine in those dedicated to secondary metabolism.
27 ease, presumably to enable higher flux, into secondary metabolism.
28 sulfur partitioning between the primary and secondary metabolism.
29 own for their role in organisms' primary and secondary metabolism.
30 It has very few genes associated with secondary metabolism.
31 ngoing evolution of biosynthetic pathways in secondary metabolism.
32 pathway, reflecting the plasticity of plant secondary metabolism.
33 uptake, vesicle trafficking, and hormone and secondary metabolism.
34 ing, and elaboration of complex molecules in secondary metabolism.
35 substances (hairs, waxes) derived from plant secondary metabolism.
36 ly of NADPH-dependent reductases involved in secondary metabolism.
37 e most common transformations in primary and secondary metabolism.
38 ltransferases (OMTs) play important roles in secondary metabolism.
39 is a critical component of both primary and secondary metabolism.
40 glucosinolate (GSL) biosynthesis, as part of secondary metabolism.
41 ies associated with gene annotation in plant secondary metabolism.
42 sue differentiation, cell cycle control, and secondary metabolism.
43 enes and large suites of enzymes involved in secondary metabolism.
44 t the control of cell buoyancy, motility and secondary metabolism.
45 n regulating carbon flux between primary and secondary metabolism.
46 al functions, and evolution of plant terpene secondary metabolism.
47 I terpene synthase paralogs involved in rice secondary metabolism.
48 ease resistance genes, and genes involved in secondary metabolism.
49 nscription, translation, cell signaling, and secondary metabolism.
50 growth, differentiation, pathogenicity, and secondary metabolism.
51 tous fungi, chromatin modifications regulate secondary metabolism.
52 le, variable, and transitory nature of plant secondary metabolism.
53 ymes required for cell wall modification and secondary metabolism.
54 hyphal growth to tissue differentiation and secondary metabolism.
55 s of SCPL acyltransferases involved in plant secondary metabolism.
56 talysts in transacylation reactions of plant secondary metabolism.
57 ified another SCPL protein involved in plant secondary metabolism.
58 mination, root hair spacing, and anthocyanin secondary metabolism.
59 reactions used in biosynthetic reactions of secondary metabolism.
60 ction relationships in a key enzyme of plant secondary metabolism.
61 iosynthetic domains, a hallmark of bacterial secondary metabolism.
62 re represents a junction between primary and secondary metabolism.
63 to the needs for both protein synthesis and secondary metabolism.
64 with a single plasmid carrying two genes of secondary metabolism.
65 lkaloid biosynthesis as it links primary and secondary metabolism.
66 xample of convergent functional evolution in secondary metabolism.
67 ons in photorespiration, detoxification, and secondary metabolism.
68 lso play critical roles in the regulation of secondary metabolism.
69 ciated with divergent reactivity and altered secondary metabolism.
70 ast number of transformations in primary and secondary metabolism.
71 of oxygenases that are rarely identified in secondary metabolism.
72 nanticipated breadth and intricacy in animal secondary metabolism.
73 inically used antibiotics has been microbial secondary metabolism.
74 le has yet to be described in the context of secondary metabolism.
75 oduce a wide range of chemical compounds via secondary metabolism.
76 capacity with the precursors of primary and secondary metabolism.
77 menable to the study of photoautotrophic and secondary metabolism.
78 portant insights into the evolution of plant secondary metabolism.
79 aminoacyl-tRNA-dependent enzymes involved in secondary metabolism.
80 great intraspecific variability in mulberry secondary metabolism.
81 brassinosteroids and related to primary and secondary metabolism.
82 tics including pathogenesis, development and secondary metabolism.
83 unravel its role in the regulation of plant secondary metabolism.
84 e influences range from biofilm formation to secondary metabolism.
85 and has become a useful model for studies of secondary metabolism.
86 tress responses, hyphal growth, and possibly secondary metabolism.
87 thway into the interface between primary and secondary metabolism.
88 e development, stress response pathways, and secondary metabolism.
89 nzymes have diverse functions in primary and secondary metabolisms.
90 defense, defense signaling, oxidative burst, secondary metabolism, abiotic stress, cell maintenance,
93 nly 18% of P450s are found to be involved in secondary metabolism and 89 P450s that function in the s
94 pt for a higher number of AraCyc pathways in secondary metabolism and a 1.5-fold increase in carbohyd
95 regulator), serves as a global gatekeeper of secondary metabolism and a repressor of numerous BGCs.
96 at PPO plays a novel and fundamental role in secondary metabolism and acts as an indirect regulator o
97 ansform carboxylic acids in both primary and secondary metabolism and are of great interest due to th
98 er in the regulatory circuit that integrates secondary metabolism and cellular response to oxidative
99 mary metabolism genes, the genes involved in secondary metabolism and certain nutrient utilization pa
100 riched in field CA; carbohydrate metabolism, secondary metabolism and circadian rhythm pathways were
102 attacking each other with toxic products of secondary metabolism and defending themselves via an ars
103 s analyzed to provide a holistic overview of secondary metabolism and defense processes in the model
105 ' regulator, suppressing central metabolism, secondary metabolism and developmental pathways until su
106 sociated with cyanobacterial photosynthesis, secondary metabolism and fatty acid and lipid transport.
107 ide enzymes for many pathways of primary and secondary metabolism and for the conjugation of hormones
109 phering molecular mechanism of regulation of secondary metabolism and gene expression in the glandula
111 y of proteins that have specialized roles in secondary metabolism and in normal cell development.
112 ty associated with several key regulators of secondary metabolism and morphological development in S.
113 A-factor regulatory cascade, controlling the secondary metabolism and morphological differentiation o
114 endent synthesis of proteins associated with secondary metabolism and oxidative and thermal stress re
115 l identity, sexual and asexual reproduction, secondary metabolism and pathogenesis in F. graminearum.
117 Gly and Ser reflected growing commitments to secondary metabolism and photorespiration, respectively.
118 proteins involved in other processes such as secondary metabolism and protein biosynthesis were gener
119 link between the transition to flowering and secondary metabolism and provide a potential target for
122 l reactions in D. rerio for both primary and secondary metabolism and the implementation of methods f
123 thogenicity, genes for secreted proteins and secondary metabolism and the pathogen-host interaction d
124 associated with a transition from primary to secondary metabolism and the production of antibiotics.
125 be utilized to characterize genes related to secondary metabolism and their regulation, and in breedi
129 red light photobiology, genes implicated in secondary metabolism, and important differences in Ca2+
130 nesis, cell division, virulence, primary and secondary metabolism, and intrinsic antibiotic resistanc
131 lumen, where microbes facilitate primary and secondary metabolism, and on mucosal surfaces, where the
132 genus' astounding dexterity and diversity in secondary metabolism, and on the genetic underpinnings o
133 nes involved in plant cell wall degradation, secondary metabolism, and secreted peptidases and effect
135 ted gene clusters are the hallmark of fungal secondary metabolism, and there is a growing body of evi
136 alance among growth, primary production, and secondary metabolism, and thus aid in the development of
137 10,000 different diterpenes of specialized (secondary) metabolism, and fewer diterpenes of general (
139 Most elucidated hydroxylations in plant secondary metabolism are catalyzed by oxoglutarate- or c
140 rovide compounding evidence that primary and secondary metabolism are differentially programmed in bo
141 e, most of the enzymatic components of plant secondary metabolism are encoded by small families of ge
143 , products of the phenylpropanoid pathway of secondary metabolism are involved in interactions with b
144 ical mechanisms underlying morphogenesis and secondary metabolism are rarely revealed, partially beca
145 ber of transcription factors associated with secondary metabolism are strain-specific while those con
146 ation, compound leaf development and profuse secondary metabolism, are absent in the typical model pl
147 late PfmaH expression in melanin production, secondary metabolism as well as fungal development.
148 assess the interconnectivity of primary and secondary metabolism as well as to compare and contrast
149 revealed a novel cross talk in JAZ-regulated secondary metabolism, as irJAZh plants had significantly
151 the feasibility of Ag NPs to inhibit fungal secondary metabolism at nonlethal concentrations, hence
152 eactions in Arabidopsis for both primary and secondary metabolism, automatic gap-filling, and the imp
153 rimethoprim, served as a global activator of secondary metabolism by inducing at least five biosynthe
154 ana attenuata, an ecological model with rich secondary metabolism, by combining tissue-wide nontarget
155 f the debate about the role and evolution of secondary metabolism can be accommodated within the view
157 dated within the view that the possession of secondary metabolism can enhance fitness, but that many
158 small-molecule chemistry in microbes (i.e., secondary metabolism) can modulate the microbe-host resp
159 missing genes encode enzymes of primary and secondary metabolism, carbohydrate-active enzymes, and t
160 extensive gene sets involved in central and secondary metabolism, cell cycle and transcription, but
161 remarkable gene sets involved in central and secondary metabolism, cell cycle, transcription, signall
162 ated to ribosome biogenesis and translation, secondary metabolism, cell wall modification and growth.
164 and diverse number of P450s in Streptomyces secondary metabolism contributes to antibiotic diversity
165 ll, lipid metabolism, stress, transport, and secondary metabolism culminated in the differentiation z
166 nt functional classes (sugar, amino acid and secondary metabolism, defense, stress response, oxidativ
167 in numerous processes, including primary and secondary metabolism, development, and responses to abio
168 ethylene biosynthesis, fruit softening, and secondary metabolism during fruit development and ripeni
169 A, ssgB, ftsZ, whiB, whiG, smeA-ssfA) and/or secondary metabolism (e.g. nsdA, cvn9, bldA, bldC, leuA)
170 clusters encoding enzymes characteristic of secondary metabolism, eight are represented on the prote
172 te the mechanism by which light induces root secondary metabolism, extracts of mutants defective in l
173 ked to polyamine catabolism, osmoprotection, secondary metabolism (fragrance), and carnitine biosynth
174 t understanding of the genetic regulation of secondary metabolism from clustering of biosynthetic gen
175 hetic process reflects derivation of related secondary metabolism from the GA primary biosynthetic pa
178 gger compensatory transcriptional changes in secondary metabolism genes analogous to those observed i
179 isproportionately enriched in regulation and secondary metabolism genes and depleted in protein trans
180 e further show that the co-linearly arranged secondary metabolism genes are expressed, exhibit eukary
181 natorial biosynthesis involves interchanging secondary metabolism genes between antibiotic-producing
184 terpenoid synthases involved in primary and secondary metabolism have been cloned and characterized.
185 t catalyze transacylation reactions in plant secondary metabolism have been identified from wild toma
187 ochemical and genetic studies on primary and secondary metabolism have laid a solid foundation for th
188 0s and those predicted to be associated with secondary metabolism have revealed that different lifest
189 cts of culture geometry and growth matrix on secondary metabolism, highlighting the potential use of
195 date, little is known about the evolution of secondary metabolism in dinoflagellates as comparative g
196 and Lae1, whereas Sge1, a major regulator of secondary metabolism in F. fujikuroi, affects gibepyrone
199 possible functions of these related OMTs in secondary metabolism in M. truncatula, seven of the OMTs
200 Polyketides, the ubiquitous products of secondary metabolism in microorganisms, are made by a pr
207 -level versus pathway-specific regulation of secondary metabolism in Streptomyces species is warrante
208 genomics is providing a mechanism to assess secondary metabolism in the context of evolution and evi
209 ith the delayed morphological development or secondary metabolism in the DeltaclpP background after r
210 e resulting complexes govern development and secondary metabolism in the filamentous fungus Aspergill
211 ection between oxidative stress response and secondary metabolism in the filamentous fungus Aspergill
213 components largely modulate development and secondary metabolism in this fungus, including the rhyth
216 those involved in cell wall biosynthesis and secondary metabolism, including cyanogenic glucoside for
218 ulfur trafficking in primary metabolism, the secondary metabolism involving sulfur has long been negl
220 ay in streamlined bacteria demonstrates that secondary metabolism is an essential component of the sy
221 th sexual and asexual development as well as secondary metabolism is consistent with the dual regulat
223 itical overview of engineering approaches in secondary metabolism is presented, both in heterologous
224 thermore, the role of Xpp1 as a repressor of secondary metabolism is shown by gene expression analyse
225 lines of experimental evidence indicate that secondary metabolism is triggered by oxidative stress; h
226 how gluconisolate biosynthesis, regarded as secondary metabolism, is intricately linked with hormone
227 1) production and gene expression related to secondary metabolism (laeA) and the mechanism of virulen
228 es and at least two key global regulators of secondary metabolism, laeA and veA, with a concomitant r
229 ished by deletion of the global regulator of secondary metabolism, laeA, and to a lesser extent by de
230 under the control of the master regulator of secondary metabolism, LaeA, contains, in its entirety, t
231 -chain dehydrogenases/reductases involved in secondary metabolism (lignan biosynthesis), stress respo
233 ar evolutionary approach focused on genes of secondary metabolism may have broad implications for the
234 d plants and lichens, suggests that enhanced secondary metabolism might facilitate symbioses with phy
235 rolling important cellular processes such as secondary metabolism, motility, biofilm formation and th
236 nformation on data quality, expansion of the secondary metabolism node of the pathway ontology to acc
237 and showcases a strategy of manipulating the secondary metabolism of an organism to improve traits re
239 ethyltransferase superfamily involved in the secondary metabolism of many species across all kingdoms
240 iously, these acids were thought to arise by secondary metabolism of the major nicotine metabolite co
242 (Xpp1) in the regulation of both primary and secondary metabolism of Trichoderma reesei Xpp1 was prev
244 automated and a modeling framework capturing secondary metabolism onset will enhance the predictive p
245 to augment the supply of substrates towards secondary metabolism operating in the glandular trichome
246 sglutaminases, whereas mel(2) is involved in secondary metabolism or biosynthesis of fatty acids.
247 idating this important reaction of the plant secondary metabolism our study provides a foundation for
248 include genes involved in carbon metabolism, secondary metabolism, P scavenging and remobilization, p
249 kinin on genes encoding proteins involved in secondary metabolism, particularly those acting in flavo
250 son is the discovery of a vast repertoire of secondary metabolism pathways and of numerous small cyst
251 ans reveals that the products of many of the secondary metabolism pathways in these fungi have not be
253 ded in antioxidant (flavonoid synthesis) and secondary metabolism pathways, adapting to ultraviolet r
254 the other (OsCPS2ent) is involved in related secondary metabolism producing defensive phytochemicals.
257 n of carrier-protein activity in primary and secondary metabolism, providing insight into pathways th
258 tly repressing genes involved in central and secondary metabolism, redox balancing, and the consumpti
259 or carbon storage regulator and regulator of secondary metabolism, respectively; hereafter called Csr
260 lla microbiome and its impact on primary and secondary metabolism, revealing a remarkable versatility
263 esults indicate that FgSSN3 is important for secondary metabolism, sexual reproduction, and plant inf
265 own to function as acyltransferases in plant secondary metabolism: sinapoylglucose:malate sinapoyltra
266 sm, the model includes the full known potato secondary metabolism, spanning over 566 reactions that f
267 suggested that CaMYB31 could be involved in secondary metabolism, stress and plant hormone responses
268 cts of fungal biology, including primary and secondary metabolism, stress response, biomass degradati
269 g nutrient availability: growth, adaptation, secondary metabolism, survival, persistence, cell divisi
270 ed into three distinct lineages in bacterial secondary metabolism systems and these were precursors o
272 terplay of two powerful enzymatic classes in secondary metabolism: the coupling of nonribosomal pepti
273 the draft genome are putatively dedicated to secondary metabolism, this is far too few to encode a la
274 exist to exploit these unique properties of secondary metabolism to enhance secondary product divers
275 ere primary metabolites of tamoxifen undergo secondary metabolism to form DNA adducts, which are dete
276 found in proteins are shunted into microbial secondary metabolism to form peptide antibiotics by spec
277 some of the sulfate is partitioned into the secondary metabolism to synthesize a variety of sulfated
279 d form, deoxynivalenol-3-O-glucose (D3G), by secondary metabolism UDP-glucosyltransferases (UGTs).
280 th important substrates for both primary and secondary metabolism via the oxidation of glucose-6-phos
281 gest that ScmR is a pleiotropic regulator of secondary metabolism, virulence, biofilm formation, and
282 lation plays a prominent role in central and secondary metabolism, virulence, transcription, and tran
283 sulfur partitioning between the primary and secondary metabolism, we analysed plants in which activi
284 pergillus, a fungal genus known for its rich secondary metabolism, we characterize the effects of cul
285 rder to advance the exploration of microbial secondary metabolism, we developed the largest publicall
287 Heritability analyses revealed that mQTLs of secondary metabolism were less affected by environment t
288 ganic remediation, antibiotic resistance and secondary metabolism were shown to significantly vary be
289 ly sets of proteins related to transport and secondary metabolism were upregulated, while in the pres
290 (c-di-GMP) signalling, iron homeostasis and secondary metabolism, were influenced by one or both reg
291 mology with polyketide synthases involved in secondary metabolism, whereas VdDf7 shared homology with
292 lex interactions with downstream branches of secondary metabolism, which is currently poorly understo
293 ysaccharide degradation, nutrient uptake and secondary metabolism, which may result from adaptations
294 ive to such inhibition than those devoted to secondary metabolism, which presumably limits flux towar
295 r normal growth conditions (e.g., lipids and secondary metabolism), while changes in amino acid-, car
296 of genes including many that are involved in secondary metabolism, while downregulating a smaller num
298 n enhance fitness, but that many products of secondary metabolism will not enhance the fitness of the