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1 at DAF-2B is expressed in vivo and is likely secreted.
2 lastic respiratory cell that is RALDH(-) and secretes a mucin-like mucus barrier protein (FcgammaBP).
3 stimuli and are capable of synthesizing and secreting a large range of molecules, including unique g
4 across the plasma or intracellular membrane, secreting acids to the lumen or acidifying intracellular
5 ry of ~450-900 IgG sequences from ~2,200 IgG-secreting activated human memory B cells, activated ex v
7 ather than mutation is a hallmark of hormone-secreting adenomas and that SCNAs correlate with adenoma
9 ammation, with a focus on IL-1beta, which is secreted after processing of its biologically inactive p
10 onsiderable evidence indicates that glucagon secreting alpha cells are critically involved in disease
11 eukin-6 (vIL-6) is a cytokine that is poorly secreted and localized largely to the endoplasmic reticu
12 s establish a modular strategy for directing secreted and membrane proteins for lysosomal degradation
13 chanisms by which EVs within the GBM TME are secreted and target recipient cells may offer an indispe
16 , but in B cell-sufficient mice incapable of secreting antibodies, suggesting a predominant antigen p
18 triggers ROS production and cells respond by secreting antioxidants and the lipogenic signaling prote
19 lence factor EsxA and its chaperone EsxB are secreted as a heterodimer (EsxA:B) and are crucial for m
22 ead of becoming tolerized and repressed from secreting autoantibody, Pik3cd gain-of-function B cells
23 pse of the unfolded ensemble of pertactin, a secreted autotransporter virulence protein from Bordetel
24 il activation was assessed by measurement of secreted azurophilic granule protein resistin and profil
25 s and to confer resistance to lysostaphin, a secreted bacteriocin that cleaves the pentaglycine cross
26 epatitis E virus (HEV) progeny particles are secreted basolaterally as quasi-enveloped particles and
32 r overlaps despite the fact that each valve, secreted by 2 mantle lobes, may present antisymmetric or
33 ostin domain-containing protein 1 (SOSTDC1), secreted by a subpopulation of follicular helper T (T(FH
35 cles (OMVs) are spherical liposomes that are secreted by almost all forms of Gram-negative bacteria.
38 ellular vesicles (EVs) are membrane vesicles secreted by cells and can modulate biological activities
40 otein in the vertebrate immune system and is secreted by cytotoxic T lymphocytes and natural killer c
43 monooxygenases (LPMOs) are microbial enzymes secreted by fungal saprotrophs involved in carbon recycl
45 from the saliva of HIV-positive patients and secreted by HIV-infected T-cell lines promote KSHV infec
47 lated enzyme acid sphingomyelinase (ASM) are secreted by irradiated endothelial cells and act as byst
49 hly enriched in small extracellular vesicles secreted by many cell types-reduces the expression of th
51 ep approach, we identified IGFBP7, a protein secreted by monocytes in response to parasite stimulatio
54 how that the ascaroside ascr#18, a pheromone secreted by plant-parasitic nematodes, is metabolized by
56 we show that the adipokine, adiponectin, is secreted by primary mouse adipocytes and protects fibrob
57 protein (IRBP) is a highly expressed protein secreted by rod and cone photoreceptors that has major r
58 l wall polysaccharides, are adhesive factors secreted by root axes, and that they contribute to the f
61 6 was identified as a soluble factor that is secreted by T cells and is important for antibody produc
63 e previously characterised the HpARI protein secreted by the model intestinal nematode Heligmosomoide
64 ighly expressed FhKT genes (group FhKT1) are secreted by the newly excysted juveniles (NEJs), the sta
65 Growth hormone (GH), a pleiotropic hormone secreted by the pituitary gland, regulates immune and in
66 t later regarded as artifactual and probably secreted by the resinous trees, although their origin re
70 was expressed (mRNA and protein levels) and secreted by trophoblastic cells, mostly by the syncytiot
75 rne, facultative intracellular pathogen that secretes c-di-AMP and activates STING, yet the in vivo r
76 ed IgG switching and differentiation into Ab-secreting cells (ASC)-a finding that coincided with incr
78 ent of Mp-specific immunoglobulin M antibody-secreting cells (ASCs) by enzyme-linked immunospot assay
81 hope for self-renewal of functional insulin-secreting cells following beta-cell failure, a historica
82 SARS-CoV-2 nucleocapsid protein-specific Ab-secreting cells in all 20 COVID-19 patients using a mult
85 an average of 3253 IgA and 1227 IgG antibody-secreting cells per million peripheral blood mononuclear
86 faces, act locally as 'professional cytokine-secreting cells' and thereby establish peri-vascular mic
89 se of exocrine zymogen and endocrine hormone secreting cells; and (ii) elevated presence of innate im
91 cally inhibits the enzymatic activity of the secreted chorismate mutase Cmu1, a virulence-promoting e
94 th potent antiviral function: memory T cells secreted cytokines and expanded upon antigen re-encounte
95 This effect was further narrowed down to the secreted cytolysin ShlA and the biologically active pigm
99 ogy searches reveal no other cell-surface or secreted domains in vertebrates that resemble the CC dom
100 sing platform for in situ monitoring of cell-secreted dopamine using Au-coated arrays of micropyramid
101 , which normally respond to TKI treatment by secreting EDN1, promoting vasoconstriction, and limiting
102 were accompanied by the corresponding type 3 secreted effector repertoires associated with the co-occ
103 sphoprotein (Tarp) is a multidomain type III secreted effector used by Chlamydia trachomatis In aggre
104 ce factors in xanthomonads, such as type III secreted effectors including transcription activator-lik
105 ing a Ca(2+)-sensitive promoter to express a secreted embryonic alkaline phosphatase (SEAP) reporter.
106 lucose homeostasis is coordinated by hormone-secreting endocrine cells in the pancreas, as well as gl
109 associated eip locus which encodes putative secreted ETT2 effectors as well as eilA, a gene encoding
115 ogenetic proteins BMP2 and BMP4, is a muscle-secreted factor (a myokine) that is induced by nutrient
116 owed a stable and predictable metabolite and secreted factor profile during several days of perfusion
117 flammatory stimuli reproducibly switched MSC secreted factor profiles and altered microvesicle compos
118 tial expression of prognostically associated secreted factors and cell surface genes, and computation
121 nstitutive PI3K/AKT/MTOR pathway activation, secreted factors from fibroblasts can maintain this path
122 his lineage switch alters the composition of secreted factors influencing DA axonal tract formation a
125 de arrays showed that cardiac adipose tissue-secreted factors slowed conduction velocity and containe
127 tissue led to the identification of several secreted factors that underlie the observed guidance def
128 is expressed mainly inside T cells, and its secreted form is barely detected under physiological con
130 suppress the growth of lung cancer cells by secreting four factors negatively regulating the cell gr
132 sequencing and drop-out screening identified secreted frizzled-related protein 2 (SFRP2) as a key med
133 n the presence or absence of defensive odors secreted from (1) eastern leaf-footed bugs (Leptoglossus
136 port evidencing that orexin is expressed and secreted from chicken hepatocytes, and that orexin induc
139 r proteins that are actively and selectively secreted from living cells independently of the classica
143 pathway more slowly than the constitutively secreted GLUT1 transporter and localize CHC22 to the ER-
144 tty acids and, unexpectedly, little glucose; secreted glutamine and other nitrogen-rich amino acids,
145 strain isolated from papaya, we identified a secreted glycoprotein of 15 kDa, designated as Ppal15kDa
146 protein 1 (NS1) is a membrane-associated and secreted glycoprotein that functions in flavivirus repli
147 ebrospinal fluid (CSF) lipocalin 2 (LCN2), a secreted glycoprotein that has been suggested as mediati
149 ell types, including basal stem cells, mucus-secreting goblet cells, motile ciliated cells, cystic fi
150 cytosolic plus-strand RNA, but subsequently secreted HCV RNA derives equally from the cytoplasm and
151 ected with HCV, suggests that initially most secreted HCV RNA derives from intracellular cytosolic pl
152 receptor stimulated macrophages from KI mice secreted high levels of IL-1beta, IL-18, and IL-1alpha b
153 ion and activation of allogeneic T cells and secreted higher levels of inflammatory cytokines than th
154 owed that AVM-brain endothelial cells (BECs) secreted higher VEGF (vascular endothelial growth factor
160 charides (HMO) are a diverse range of sugars secreted in breast milk that have direct and indirect ef
161 study, we investigated how HIV-1 protein Nef secreted in extracellular vesicles (exNef) impairs neuro
163 inantly an intraneuronal protein but is also secreted in physiological and pathological conditions.
164 n of the endocervix by host-derived factors, secreted in response to BV, as a potential cause of HIV
166 proteolytic enzyme that is overexpressed and secreted in the tumour microenvironment of many solid tu
168 plexus (ChP) regulates brain development by secreting instructive cues and providing a protective br
169 better mimics the endogenous kinetics of co-secreted insulin and amylin, and holds promise as a dual
174 Osteopontin (OPN) is a phosphoglycoprotein secreted into the extracellular matrix upon liver injury
176 st to the well-characterized function of the secreted isoform, the biological role of the intracellul
177 of late endosomes and lysosomes that can be secreted; it exhibits maximal activity in acidic environ
178 fficiently motivated generate and memorize a secret key in less than 1 h (including all rehearsals) a
183 e initiated upon the perception of rhizobium-secreted lipochitooligosaccharides (LCOs), called Nod fa
186 herules (FKS) stimulate mouse macrophages to secret macrophage inflammatory protein 2 (MIP-2), which
187 Moreover, crude supernatant containing the secreted Malibu-Glo reagent can directly be used for det
188 d-reconstituted immunodeficient, hu cytokine-secreting, mice that have large numbers of activated hu
190 l methods we identify multiple components in secreted microvesicles, including mature PV virions; pos
192 r, little is known about the role of exosome-secreted miRNAs in the regulation of glutamate receptor
196 oduce an intact mucus layer comprised of the secreted mucin MUC2, revealed bacteria at the epithelial
197 ies of bronchiectasis mucus; 2) identify the secreted mucins contained in bronchiectasis mucus; 3) re
199 ression of modified Sia in mouse tissues, on secreted mucus in saliva, and on erythrocytes, including
201 om luteinizing/follicle-stimulating (LH/FSH)-secreting (n = 24), prolactinomas (n = 14), and non-func
203 a PEG molecule (ICG-PEG45) as a renal-tubule-secreted near-infrared-emitting fluorophore for hyperflu
204 rscore multiple spatiotemporally dynamic Wnt-secreting niches that regulate functionally distinct pha
207 R2/HER3 axis by cancer-associated fibroblast-secreted NRG1 mediates castration resistance, recommendi
209 ngle most abundant acquired immune component secreted onto mucosal surfaces and, via the process of i
210 s imply that, before the emergence of silica-secreting organisms, elevated SiO(2)(aq) concentrations
212 progenitor proliferation and increases acid-secreting parietal cells (PCs) in mice and organoids.
213 e EPIDERMAL PATTERING FACTOR (EPF) family of secreted peptides: EPF1 enforces stomatal spacing, where
218 e AMR requires rapid elimination of antibody-secreting plasma cells (PC) with a proteasome inhibitor,
219 ither esIgG(4) or esIgD; indicating that IgE-secreting plasma cells could originate from either seque
222 ether, these data reveal the central role of secreted polysaccharides in the intricate behaviors coor
224 was used to identify surface-associated and secreted products generated by the opportunistic pathoge
225 acrophages, myeloid-lineage cells, and their secreted products perpetuate inflammation, whereas OA wa
228 Here we report that both hormones induce the secreted protease Adamts18 in myoepithelial cells by con
233 s against Sec-delivered effector 1 (SDE1), a secreted protein biomarker, for the detection of HLB.
235 virulence of M. tuberculosis ESAT-6, a 6-kDa-secreted protein of region of difference 1, is known to
236 show that the pinhead (pnhd) gene encodes a secreted protein that is essential for the activation of
237 onveniently produced in mammalian cells as a secreted protein that retains the functional activity of
239 nes (connective tissue growth factor [CTGF], secreted protein, acidic and rich in cysteine), crosslin
240 cription of genes encoding highly expressed, secreted proteins and an overall reduction in translatio
241 (ER) serves both as a hub for maturation of secreted proteins and as an intracellular calcium storag
242 ns attached to lipids and membrane-bound and secreted proteins and peptides mediate many important ph
243 g all the secreted proteins, 'non-classical' secreted proteins are difficult to identify as they lack
244 ated a preferential interaction of PscN with secreted proteins or protein-chaperone complex rather th
246 vidual cells and, in particular, analysis of secreted proteins such as cytokines and antibodies.
249 n-1 (Nrp-1) and granulin (Grn) as osteocytic-secreted proteins upregulated in Ocy454-Gsalpha(KO) cell
251 the SASP, typically assessed by a few dozen secreted proteins, has been greatly underestimated, and
253 cilitate the discovery of such non-classical secreted proteins; however, the existing methods are bas
257 oroid plexus (ChP) epithelium is a source of secreted signaling factors in cerebrospinal fluid (CSF)
258 nd bone homeostasis is that regulated by the secreted signaling proteins, myostatin (MSTN) and activi
261 at increased risk of developing preeclampsia secreted significantly more STC-1 than normal tissue und
267 cus aureus-caused endocarditis, the pathogen secretes staphylocoagulase (SC), thereby activating huma
268 hanced antifungal activity against aflatoxin secreting strain of Aspergillus flavus (AF-LHP-S1) and 1
271 , including prophage PhiHKU.vir encoding the secreted superantigens SSA and SpeC and the DNase Spd1.
272 and gave rise to the three major classes of secreted SVMP toxins by sequential removal of a membrane
273 ain selection, pairing phototrophic, sucrose-secreting Synechococcus elongatus with heterotrophic Esc
274 in the spleen, and enhanced overall cytokine-secreting T cell percentages upon antigen restimulation.
275 n frequencies of F-specific interferon gamma-secreting T cells also increased substantially from base
278 frequency of RSV-F-specific interferon gamma-secreting T-cells after a ChAd155-RSV high dose was 108.
282 ansient endocrine gland that synthesizes and secretes the steroid hormone, progesterone, which is vit
285 hat express only membrane-associated but not secreted TNF revealed that CrmD is critically dependent
287 lar, bacteria use virulence factors, such as secreted toxins and effector proteins, to manipulate hos
289 repurposed to improve drug delivery in VEGFA-secreting tumors, which normally respond to TKI treatmen
292 3 was found to be enriched in astrocytes and secreted via exosomes, and antipsychotics were shown to
296 secreted when homologously expressed, it was secreted when co-expressed together with the PE35/PPE68_
297 inum Although this substrate pair was hardly secreted when homologously expressed, it was secreted wh