ライフサイエンスコーパス: secretion

1 ruption by decreasing the demand for insulin secretion.

2 ](i)) and high-molecular-weight glycoprotein secretion.

3 glucose-stimulated Ca(2+) influx and insulin secretion.

4 f insulin SG content and a defect in insulin secretion.

5 receptors abrogated the ATP effect on CXCL8 secretion.

6 a potentiation of glucose-stimulated insulin secretion.

7 O-fucosylation on TSR3 and impaired ADAMTSL2 secretion.

8 in subunit beta 5 (Gnb5) knockout on insulin secretion.

9 ine pH generated by transcellular HCO(3) (-) secretion.

10 mechanism of mycobacterial T7SSs in protein secretion.

11 trol to biliary cholesterol and phospholipid secretion.

12 entify 200 putative targets of LC3-dependent secretion.

13 the Delta/Notch pathway in beta-cell insulin secretion.

14 LC3-conjugation machinery for packaging and secretion.

15 determine the role of N metabolism in nectar secretion.

16 sease resulting in severely impaired insulin secretion.

17 away from the plasma membrane limits insulin secretion.

18 nism and alpha-synuclein by increasing their secretion.

19 a key regulator of pancreatic islet hormone secretion.

20 cyte clock-genes by neutrophil elastase (NE) secretion.

21 d for iron uptake, utilization, storage, and secretion.

22 , consistent with a role in exocyst-mediated secretion.

23 ond-phase dynamic glucose-stimulated insulin secretion.

24 pancreatic islet drives oscillatory insulin secretion.

25 reproglucagon peptides in regulating insulin secretion.

26 synapse and plays a crucial role in exosome secretion.

27 ecrosis factor alpha, and interleukin (IL)-6 secretion.

28 1R protein levels or GLP-1R-mediated insulin secretion.

29 ve neutrophils and promote interleukin-1beta secretion.

30 g disease associated with increased cytokine secretion.

31 d that phosphorylation was essential for OPN secretion.

32 show impaired glucose tolerance and insulin secretion.

33 lux in octuple mutant ovules rescues LURE1.2 secretion.

34 sulted in a 3 to 16-fold increase in exosome secretion.

35 negative impact islet viability and insulin secretion.

36 that primary cilia directly regulate insulin secretion.

37 ue for storage and triggered greater insulin secretion.

38 lipopolysaccharide (LPS) result in IL-1beta secretion.

39 how the barrel pore is primed for CdiA toxin secretion.

40 First-phase insulin secretion (0-10 min) increased by 70%, while second-phas

41 -membrane acts at distinct stages of protein secretion: (1) SecA-driven translocation through SecYEG

42 dian IgG measured in OriCol-collected rectal secretions (986 ng) was lower than secretions from spong

43 ection for efficient autotransporter protein secretion, a necessary prerequisite for virulence.

44 Increases in CFTR chloride secretion also induced YAP signaling and cellular prolif

45 eting several critical regulators of insulin secretion and beta cell proliferation.

46 ce of N-linked glycosylation of ACLP for its secretion and contribute to our understanding of ACLP-de

47 d by high levels of proinflammatory cytokine secretion and cytotoxic activity.

48 press EBV-LMP2-specific TCRs showed IFNgamma secretion and cytotoxicity towards EBV-LMP2-expressing m

49 that correlates with enhanced islet insulin secretion and decreased glucagon secretion at the study

50 ntagonist NCS-382 had no effects on glucagon secretion and did not affect stimulation of secretion in

51 tivity of TMEM16A increases epithelial fluid secretion and enhances mucus clearance independent of CF

52 test) enriched in pathways linked to insulin secretion and extracellular matrix-receptor interaction.

53 toantibodies stimulated DSG3-CAART IFN-gamma secretion and homotypic clustering, consistent with an a

54 the preferential secretion model of insulin secretion and identify how granule aging is affected by

55 ive activities, modulating in vitro cytokine secretion and in vivo gene expression for effectors asso

56 the misfolded C-Pro domain itself to prevent secretion and initiate clearance.

57 sporter decreases glucose-stimulated insulin secretion and intracellular insulin content, particularl

58 sive interest in increasing endogenous GLP-1 secretion and L-cell abundance.

59 of TMEM16A potentiation on epithelial fluid secretion and mucociliary clearance.Methods: The effects

60 p, to measure simultaneously the kinetics of secretion and other cellular characteristics, including

61 e impact of Malpighamoeba infection on fluid secretion and P-glycoprotein-dependent detoxification by

62 is by which drug-induced upregulation of sEV secretion and PTX3 protein cargo primes the premetastati

63 xamined the subcellular localization of SlpA secretion and S-layer growth; observing formation of S-l

64 Nasal symptoms, Th1/Th2 cytokines in nasal secretion and serum were evaluated.

65 d is involved in the regulation of adipokine secretion and the differentiation of osteoblasts and ost

66 DNA (dsRNA/dsDNA) followed by IFNalpha/beta secretion and transcriptional activation of IFN-stimulat

67 mmunicate through extracellular vesicle (EV) secretion and uptake.

68 enesis allowed for the exploration of tissue secretions and signalling pathway activation as well as

69 sion of SAR1B but not of SAR1A could restore secretion, and a divergent cluster adjacent to the SEC31

70 that coordinate conoid protrusion, microneme secretion, and actin polymerization, to initiate gliding

71 Mast cell degranulation, cytokine secretion, and early signaling events in the FcepsilonRI

72 naling pathway that governs protein folding, secretion, and energy production and serves to maintain

73 erance, increased glucose-stimulated insulin secretion, and hyperglucagonemia.

74 copy, cell degranulation, prostaglandin D(2) secretion, and proteases gene transcription.

75 vely reduces neutrophil migration, TNF-alpha secretion, and tissue inflammation in mice (female BALB/

76 c exposure to stress causes impaired insulin secretion, apoptosis, and loss of cell identity, and a c

77 The first and essential steps in Wnt secretion are their O-palmitoleation and subsequent load

78 Here we examined the role of vesicular SOCS3 secretion as a mechanism by which AMs restrain allergic

79 ic Chagas' disease patients, using IFN-gamma secretion as a readout.

80 s for the synthesis of proteins targeted for secretion as EV-associated proteins.

81 Secretion-associated Ras-related GTPase 1 (SAR1) is a sm

82 vigabatrin also failed to influence glucagon secretion at 1 mm glucose and did not prevent the suppre

83 miRNAs) are associated with residual insulin secretion at diagnosis and predict the severity of its f

84 uncated protein SYP121(DeltaC), which blocks secretion at the plasma membrane.

85 let insulin secretion and decreased glucagon secretion at the study end.

86 ) had higher virus-induced IFN-lambda airway secretion; (b) subjects with RSV infection showed the hi

87 nscription factor MAFA and abolished insulin secretion, both in vitro in primary human islets and in

88 cemia for 72 h 1) increases absolute insulin secretion but impairs beta-cell function, 2) causes insu

89 Exosome secretion by cells is a complex, poorly understood proce

90 leased by Vdelta2(+) cells upregulates IL-12 secretion by DCs in a positive feedback loop.

91 lodextrin also blocked ATP release and IL-33 secretion by decreasing the level of VDAC-1 expression i

92 ansion of human gammadelta T cells and IL-17 secretion by human CD4 T cells.

93 otect mice from sepsis, and prevent IL-1beta secretion by monocytes from patients with CAPS.

94 We tested 17 proteins important for DNA secretion by N. gonorrhoeae for protein interactions.

95 their proinflammatory cytokine and ferritin secretion by negatively regulating Erk1/2 and p38 activa

96 Increased tau secretion by VAMP8 was also observed in murine hippocamp

97 es NGSIS, but not glucose-stimulated insulin secretion, by increasing mitochondrial proton leak.

98 annels, including but not limited to insulin secretion, cardiac protection, and blood flow regulation

99 recruitment to the curli pore, CsgG, and the secretion chaperone, CsgE.

100 alcium deposition, phenotypic change and sEV secretion compared to WT CASMCs, which was associated wi

101 ls showed enhanced CD40 expression and IL-12 secretion compared with DCs cocultured with CD4(+) conve

102 ormation, and pro-inflammatory interleukin-8 secretion compared with ST31 isolates.

103 ar release sites, together encoding stimulus-secretion coupling over a large range of synaptic Ca(2+)

104 le turnover, causing increased basal insulin secretion, depleting insulin vesicles from the cytoplasm

105 line phosphatase (IAP) regulates bicarbonate secretion, detoxifies lipopolysaccharide (LPS), regulate

106 re in part driven by aberrant glucocorticoid secretion during development, with strongest effects on

107 increased by 70%, while second-phase insulin secretion during the first (10-80 min) and second (90-16

108 al structure of N2, combined with monitoring secretion efficiency in cell culture of selected N2 sing

109 e central core of the domain severely affect secretion efficiency.

110 6SS assembly, although they greatly increase secretion efficiency.

111 ound subject variability and correlated with secretion elicited by compound 48/80 or substance P but

112 of endosomal pH to ensure strong type I IFN secretion exclusively during infection, avoiding autoimm

113 speptin modulates glucose-stimulated insulin secretion, food intake and/or energy expenditure in anim

114 ays necessary for glucose stimulated insulin secretion for protection from viral lysis.

115 avir analogues were synthesized and cytokine secretion from abacavir/abacavir analogue-responsive CD8

116 The protein is unusual in its poor secretion from cells and its intracellular activity; it

117 also investigated how preventing Wnt ligand secretion from endothelial cells affects zonation patter

118 CSF-1 and IL-34 secretion from GF was evaluated in response to tumor nec

119 hese findings confirm macrophage miR-106b-5p secretion from impaired vitamin D receptor signaling cau

120 tner insulin are dually linked in both their secretion from islet cells and their action in the liver

121 of either sEV uptake in secondary organs or secretion from primary tumor cells may be promising ther

122 sted by measuring glucose-stimulated insulin secretion from single and groups of murine and human isl

123 own to regulate endothelial quiescence after secretion from the liver and right atrium, whereas a dir

124 ed rectal secretions (986 ng) was lower than secretions from sponges (Weck-Cel: 8588 ng, p < 0.0001;

125 These functions, which include insulin secretion, gastric emptying, satiety, and the hedonic as

126 Glucose-stimulated insulin secretion (GSIS) is regulated by calcium (Ca(2+) ) entry

127 slets, T enhanced glucose-stimulated insulin secretion (GSIS).

128 ed with decreased glucose-stimulated insulin secretion (GSIS).

129 Each type of secretion has a unique composition of proteins, salts, a

130 se that the molecular machinery for dopamine secretion has evolved to support fast and slow signaling

131 pathway, autophagy also facilitates cellular secretion; however, the mechanisms underlying these proc

132 0.016) and recurrent accumulation of airway secretions (HR 2.614, p = 0.001).

133 The authors identified GM-CSF secretion in a rare population of CD11c(+) CD4(+) T cell

134 This reduced the input thresholds for IL-2 secretion in a sensitizer-like fashion.

135 Galanin signalling suppresses insulin secretion in animal models (but not in humans), is poten

136 minotransferase (AlaAT), were induced during secretion in C. pepo nectaries.

137 Notably, FAM134B is required for protein secretion in chondrocytes, and cartilage growth and bone

138 was also shown to significantly improve the secretion in coumaric acid production strains.

139 )-activated Cl(-) channel activity and anion secretion in human bronchial epithelial (HBE) cells from

140 ynthesis was modulated to facilitate protein secretion in macrophages in response to LPS.

141 ult in truncated RIMS2 and decreased insulin secretion in mammalian cells.

142 ivery, indicating the pivotal role of meibum secretion in ocular surface health that should be target

143 r ligand that targets somatotroph adenoma GH secretion in patients with acromegaly, inhibited cAMP an

144 e results demonstrate that increased insulin secretion in people with obesity is associated with exce

145 ffect of diet-induced weight loss on insulin secretion in people with obesity who did not improve ins

146 Loss of ADAMTSL2 secretion in POFUT2 (-/-) but not in B3GLCT (-/-) cells

147 current in mediating Ca(2+)-induced insulin secretion in response to ER stress.

148 ole for microbiome-dependent circadian GLP-1 secretion in the maintenance of 24-h metabolic homeostas

149 UDCA and 4PBA attenuated MMP9 expression and secretion in the presence of TNFalpha.

150 Typhimurium induced cell death and cytokine secretion in THP-1 cells and primary human monocyte-deri

151 inated electrical activity (and thus insulin secretion) in the rest of the islet.

152 ere associated with differences in chemokine secretion including chemokines influencing the permeabil

153 secretion and did not affect stimulation of secretion induced by a drop in glucose from 7 to 1 mm In

154 st-evoked calcium activation and cytoplasmic secretion into CSF.

155 Intravital imaging revealed impaired bile secretion into the bile canaliculi, which was secondary

156 of rhizosheaths at root surfaces and for the secretions involved in host plant infection by parasitic

157 We find that synchronous dopamine secretion is abolished in acute brain slices of conditio

158 mbrane conductance regulator)-mediated anion secretion is an attractive therapeutic approach for the

159 Our results show that ion secretion is an important regulator of morphogenesis and

160 IL-1beta, IL-18, and IL-37 maturation and secretion is governed by inflammatory caspases within si

161 (-/-) cells suggested that impaired ADAMTSL2 secretion is not responsible for skeletal defects in PTR

162 tion on the specific composition of the oral secretion is scarce.

163 Chemical signature of femoral pore secretions is important for intra- and inter-specific ch

164 ll response because of expeditious synthesis/secretion kinetics (CCL3/4/5) and low activation thresho

165 acked platelet-dense granules, dense granule secretion machinery, glycoprotein (GP) VI, or the GPVI s

166 , a beta-cell line, to repurpose the insulin secretion machinery, which enables the glucose-dependent

167 Our results indicate that collagen secretion may be intimately linked to a hypoxic microenv

168 ure in North and South America, and its oral secretion may be responsible for the damage it causes in

169 f unconventional secretory pathways for LLSP secretion may shed light on their evolution and could he

170 V) production has been proposed as a general secretion mechanism that could facilitate the delivery o

171 ts suggest that mIBG undergoes renal tubular secretion mediated by hOCT2 and hMATE1/2-K, and hOCT1 an

172 tein for FgRab8 which is required for apical secretion-mediated growth and pathogenicity.

173 Our results suggest a secretion model in which PE35/PPE68_1 determines the sys

174 in, we aimed to investigate the preferential secretion model of insulin secretion and identify how gr

175 suppression in pulsatile luteinizing hormone secretion observed in control mice.

176 e CNS axon regeneration in vivo, in part via secretion of a cocktail of growth factors.

177 h the activation of innate immunity, through secretion of a cytokinome that elicits recruitment and p

178 elta-proteobacterium Myxococcus xanthus, the secretion of a novel biosurfactant polysaccharide (BPS)

179 the inhibition of mutated EGFR promotes the secretion of a potent vasoconstrictor, endothelin-1 (EDN

180 r, our results demonstrate that the exosomal secretion of a psychosis-altered and glial-enriched miRN

181 Each ESX system mediates the secretion of a specific set of Esx, PE, and PPE proteins

182 ption may lead to defects in trafficking and secretion of a subset of proteins required for parasite

183 Secretion of activin A is known to be higher in tissues

184 Active secretion of bile salts into the canalicular lumen drive

185 ed protein glycosylation, leading to reduced secretion of cancer-promoting growth factors, such as ch

186 conditions increased apical and basolateral secretion of cGMP relative to the level under static con

187 Secretion of ECM protein fibronectin (FN) by BM stromal

188 PE35/PPE68_1 determines the system-specific secretion of EsxB_1/EsxA_1.

189 ermeabilization and inflammation through the secretion of exosomal damage-associated molecular patter

190 Mechanistically, secretion of exosomes by these spheres was essential for

191 ere, we present a method for stimulating the secretion of exosomes.

192 Their activation leads to robust secretion of exosomes.

193 ipid metabolism, unfolded protein responses, secretion of extracellular matrix proteins, and cell pro

194 :C significantly enhanced the expression and secretion of IFNgamma, IDO, and HLA-G.

195 play an important role in allergies through secretion of IgE.

196 the NLRP3-caspase-1-mediated processing and secretion of IL-1beta and IL-18 and induces the inflamma

197 tivity did not attenuate CD11c expression or secretion of IL-1beta and MCP-1.

198 nzyme to the cellular surface and stimulated secretion of IL1beta.

199 bility of CTB 100,000 g EVs to increase dESF secretion of IL8.

200 e-up of human EEC subtypes and the regulated secretion of individual hormones.

201 In response to secretion of inflammatory cytokines (e.g., IL1B) from im

202 of NFkappaB, followed by the expression and secretion of inflammatory cytokines (IL [interleukin] 1B

203 Failing hMSCs exhibited increased secretion of inflammatory cytokines IL (interleukin)-1be

204 SMase in monocytes/macrophages inhibited the secretion of inflammatory mediators IL-1beta and MCP-1.

205 s in beta-cells, including the synthesis and secretion of insulin.

206 lls increased numbers of intracellular 11G5, secretion of interleukin (IL) 6 and IL8, and markers of

207 ion of the NLRP3 inflammasome and consequent secretion of interleukin 1beta (IL-1beta).

208 hanisms to escape neutrophils, including the secretion of leucocidins (e.g. ionomycin).

209 nisms, partly by reducing the expression and secretion of macrophage colony-stimulating factor CSF1 b

210 The production and secretion of matrix proteins upon stimulation of fibrobl

211 nt dysregulation, Th2 skewing, and increased secretion of MCP-1.

212 C. difficile infection is dependent on the secretion of one or more AB-type toxins: toxin A (TcdA),

213 y, SLE LL37-specific T-cells promoted B-cell secretion of pathogenic anti-LL37 antibodies in vitro.

214 er iron deprivation that is dependent on the secretion of plant-derived coumarins.

215 Higher secretion of pro-inflammatory cytokines was seen in colo

216 xposure of Kupffer cells to gp96 induced the secretion of pro-inflammatory cytokines.

217 chinery, which enables the glucose-dependent secretion of protective immunomodulatory factor interleu

218 e show that Rab13 additionally regulates the secretion of sEVs corresponding to both traditional exos

219 ed mechanisms responsible for biogenesis and secretion of SGs, but how SGs mature remains poorly unde

220 coincide with cell wall synthesis, while the secretion of SlpA from the cell is relatively delocalize

221 Overall, AM secretion of SOCS3 within EVs serves as a brake on airwa

222 system, also resulted in redirection and co-secretion of the Esx pair via ESX-5.

223 Maximal secretion of the gonadotropin Luteinizing Hormone is sup

224 ellular accumulation of amyloid precipitate, secretion of the major curli subunit, CsgA, is tightly r

225 n vitro, and attenuates chemotherapy-induced secretion of the pro-inflammatory cytokines TNFalpha, IL

226 Secretion of these proteins also occurs from activated c

227 anistically we found that TFEB regulates the secretion of truncated mutant tau lacking MTBR and this

228 by transcriptionally repressing STAT1/2 and secretion of Type I Interferons (IFNs).

229 rons.IMPORTANCE Viral infection triggers the secretion of type I interferons, which in turn induce th

230 can be potentially achieved by detecting the secretion of volatile sulfur compounds (VSCs) in oral ca

231 The secretion of Wnt ligands, the turnover of Wnt receptors,

232 SAR1B knockdown caused loss of lipoprotein secretion, overexpression of SAR1B but not of SAR1A coul

233 We uncovered deficits in insulin secretion, partly due to reduced mitochondrial oxygen co

234 We uncovered deficits in insulin secretion, partly due to reduced mitochondrial oxygen co

235 kidney cancer arises from the fact that the secretion pathway enables ICG-PEG45 to be effectively ef

236 Genes involved in the "pancreatic secretion" pathway are the most strongly differentially

237 s show a specific transcriptome and cytokine secretion pattern demonstrating a specific immunomodulat

238 tured lymphocytes were analyzed for cytokine secretion profiles and cellular polarization by flow cyt

239 brane protein characterization, endocytosis, secretion, protein folding, quality control, and glycobi

240 a specific function for SAR1B in lipoprotein secretion, providing insights into the mechanisms of lar

241 eosinophils and IL-5 concentrations in nasal secretion (r = 0.69, P = .06) in allergic rhinitis.

242 Increased fluid secretion rate of infected tubules likely exposes locust

243 We used regional daily secretion rates and Sr marker-lines to reconstruct tooth

244 ed with inflammasome activation and IL-1beta secretion, remains poorly understood.

245 s, we generated an HPAT-targeted fluorescent secretion reporter.

246 ent K(+) channel that regulates gastric acid secretion, salt and glucose homeostasis, and heart rhyth

247 orrelated with iGFR (r=0.84) and the summary secretion score (r=0.86).

248 sport of both ions and proteins to the shell secretion site, which are required during normal shell g

249 Secretion steers the polymers toward a common exit point

250 r signalling pathways and adipokine/cytokine secretions, such as adiponectin and leptin, resulting in

251 t induction of cell death or loss of insulin secretion, suggesting that appropriate levels of Myc cou

252 Pseudomonas aeruginosa uses a type III secretion system (T3SS) to inject cytotoxic effector pro

253 Experimental overproduction of a type 3 secretion system (T3SS1) in this pathogen leads to decre

254 The cag PAI encodes a type IV secretion system (T4SS) that mediates delivery of the Ca

255 ytoplasmic entrance of the F-encoded type IV secretion system (T4SS).

256 system, conjugative transfer and the Type VI secretion system (T6SS).

257 The type VII protein secretion system (T7SS) is conserved across Staphylococc

258 intracellular pathogen that uses its type 3 secretion system 2 (T3SS2) to invade and replicate insid

259 completely overcome the repression of type 3 secretion system activity normally associated with expos

260 that the enzyme is secreted via the type II secretion system and results in higher extracellular act

261 This specialized secretion system employs the Dot/Icm type IVB coupling p

262 is usually reciprocally coordinated with T6 secretion system expression.

263 We further show that the type II secretion system is required for translocation across th

264 al entry into macrophages the ESX-1 type VII secretion system promotes phagosomal permeabilization an

265 T4aP secretin from the type II and type III secretion system secretins.

266 etracycline resistance [tet(O)], the Type IV secretion system, conjugative transfer and the Type VI s

267 for iron acquisition and a functional type 9 secretion system.

268 the presence of a novel chromosomal type IV secretion system.

269 mbrane via a variant of the classical type I secretion system.

270 eract with mammalian cells by using type III secretion systems (T3SS) to inject virulence proteins in

271 Such specialized secretion systems allow a variety of bacteria to thrive

272 ments or on the cell surface; hence, diverse secretion systems evolved to transport the hydrophilic m

273 Bacterial type VII secretion systems secrete a wide range of extracellular

274 digmatic example, Salmonella uses two type-3 secretion systems to inject effector proteins that facil

275 Gram-positive bacteria have developed secretion systems to transport proteins across their cel

276 nscription activator-like effectors, type II secretion systems, diversity resulting in host specifici

277 insights into the mechanisms of large cargo secretion that may be relevant for COPII-related disease

278 immune cells induced a differential cytokine secretion that may contribute to CRC metastasis.

279 concurrently reduces anti-inflammatory LXA4 secretion to maintain KSHV latency in infected cells.

280 racteristics like chemotaxis and biomolecule secretion to outperform conventional diagnostics and the

281 of human and porcine small intestinal mucus secretions to sub-micron sized particles have been compa

282 d measures of insulin resistance and insulin secretion) to cluster adult-onset diabetes patients into

283 epatocytes, Epo de novo synthesis led to its secretion, to splenic erythropoiesis and to dramatic ery

284 ILC2(10)s were isolated to evaluate cytokine secretion, transcription factor signaling, metabolic dep

285 NK cell synaptic secretion, triggered by ligation of NKp30 or NKG2D, incl

286 esponding to CDC with an increase in insulin secretion under control conditions were less impaired by

287 Unlike GSIS, such insulin secretion was blocked with mitochondrial antioxidant SkQ

288 In addition, CCL-2 secretion was decreased after L-type Ca(V) inhibition.

289 h-fat/high-sucrose) diet for 16 weeks, GLP-1 secretion was markedly increased but arrhythmic over the

290 y, so that directional (basal or apical) 5HT secretion was measurable.

291 (1) and vascular endothelial growth factor-A secretion was measured in serum and/or cholangiocyte sup

292 om diagnosis), during which residual insulin secretion was measured with a mixed meal tolerance test

293 Induction of cholesterol secretion was not a consequence of increased ATP-binding

294 endent on IL-18 and IL-12, whereas IFN-gamma secretion was restricted by high concentrations of IL-10

295 dditive to supra-additive effects on insulin secretion when combining SU+GIP and SU+GLP-1, respective

296 metabolism to sustain physiological citrate secretion, whereas prostate adenocarcinoma consumes citr

297 ion: NTCP inhibition increases biliary lipid secretion, which is independent of alterations in bile s

298 Thus, AmB induced IL-1beta and IL-18 secretions, which are reduced by specific inhibitors of

299 high SARS-CoV-2 burden in nasal tissues and secretions, which coincided with efficient transmission

300 xposures to persons shedding virus in bodily secretions (young children, sexual activity, household c