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3 h the activation of innate immunity, through secretion of a cytokinome that elicits recruitment and p
4 munication is mediated by the production and secretion of a hexapeptide (AimP) during lytic cycle.
5 model successfully predicts the increase in secretion of a monoclonal antibody after silencing a hig
6 elta-proteobacterium Myxococcus xanthus, the secretion of a novel biosurfactant polysaccharide (BPS)
8 the inhibition of mutated EGFR promotes the secretion of a potent vasoconstrictor, endothelin-1 (EDN
9 cells to inflammatory M1 phenotype with the secretion of a proinflammatory chemokine CXCL10 due to a
10 r, our results demonstrate that the exosomal secretion of a psychosis-altered and glial-enriched miRN
12 ption may lead to defects in trafficking and secretion of a subset of proteins required for parasite
13 eased APP processing, resulting in increased secretion of Abeta peptides and an increased Abeta38 to
18 early (within 5-10 s following stimulation) secretion of ADP specifically dependent on SERCA3 stored
20 cient in deconstructing plant biomass by the secretion of an arsenal of plant cell wall-degrading enz
22 production of proinflammatory cytokines and secretion of anti-inflammatory cytokines that limit immu
23 increased TLR3 gene expression and increased secretion of anti-viral and pro-inflammatory cytokines (
24 paired spiral artery remodeling and abnormal secretion of antiangiogenic factors are thought to be im
25 gest that starvation-specific unconventional secretion of antioxidants and Acb1-like activities maint
27 om the intestine and liver via synthesis and secretion of apolipoprotein B (apoB)-containing lipoprot
28 can serve as a stand-alone signal to trigger secretion of autoreactive and class-switched IgG in vivo
30 genesis is type 4b secretion system-mediated secretion of bacterial effectors into host cells that su
31 re essential for nuclear positioning and for secretion of basement membrane components via retrograde
32 ment epithelial (RPE) cells showed increased secretion of bFGF and conditioned medium from these cell
34 novel cancer-suppressing mechanism, via the secretion of bioactive factors by mammary cells, that is
36 5, Na(+) channels to control Ca(2+)-mediated secretion of both mucin 2 (MUC2) and MUC5AC from HT29-18
37 tor (G-CSF)-induced HSC mobilization via the secretion of calcitonin gene-related peptide (CGRP).
41 ed protein glycosylation, leading to reduced secretion of cancer-promoting growth factors, such as ch
42 VC treatment reduced activation and cytokine secretion of CD8(+) T cells via a CCR5-independent pathw
43 Pollen tube tip growth depends on balancing secretion of cell wall material with endocytic recycling
44 conditions increased apical and basolateral secretion of cGMP relative to the level under static con
46 The size of the lumen is dependent on apical secretion of chloride ions, most notably by the CFTR cha
50 at these proteolytic maturations occur after secretion of collagen VI tetramers and during microfibri
52 shape pathogen-specific immunity by inducing secretion of costimulatory cytokines during T-cell activ
53 injury, the neuroendocrine system increases secretion of counterregulatory hormones that promote rap
54 , IL-1beta, Ec-LPS, or Pg-LPS, increased the secretion of CSF-1 (P < 0.05) and Ec-LPS stimulation inc
56 ation of the model resulted in the polarized secretion of CXCL10, IL-8 and CCL-20 by IEC and could ef
58 elial cell height and apical and basolateral secretion of cyclic GMP (cGMP) under baseline, unstimula
59 HLA suppresses lipopolysaccharide-stimulated secretion of cytokines and expression of pro-inflammator
61 the proinflammatory response, leading to the secretion of cytokines that help to orchestrate the immu
65 We identify Lyn as a critical component for secretion of Dengue and Zika infectious particles and th
66 sponses, such as target cell killing and the secretion of different cytokines, that collectively cont
68 otes many of the hallmarks of cancer via the secretion of diffusible factors that can affect cancer c
69 ncreas, exocrine and endocrine cells control secretion of digestive enzymes and production of hormone
73 ion system (T3SS), which engages in one-step secretion of effectors(4), despite possessing a Sec sign
74 n in Hep3B cells also caused a defect in the secretion of endogenous EPO under conditions mimicking h
75 nt tau expressing primary neurons, while the secretion of endogenous wild-type tau was not affected.
76 at SURF4 overexpression results in increased secretion of EPO, suggesting a new strategy for more eff
79 res ESX-5 for virulence, it tightly controls secretion of ESX-5 substrates to avoid elimination by ho
82 ermeabilization and inflammation through the secretion of exosomal damage-associated molecular patter
83 itor, abrogated this process and cut off the secretion of exosomal PD-L1 by blocking the transcriptio
87 on of only one allele of Nischarin increased secretion of exosomes, and Rab14 activity modulated exos
91 cells (HSCs), which promotes production and secretion of extracellular matrix (ECM) proteins and hep
92 ipid metabolism, unfolded protein responses, secretion of extracellular matrix proteins, and cell pro
94 oteomes, demonstrating that ECs polarize the secretion of extracellular vesicle cargoes to the apical
95 ophagy and exosome biogenesis leading to the secretion of extracellular vesicles (EVs) in vivo and ex
96 ion in Slac2-b-mutant KCs as well as reduced secretion of extracellular vesicles containing extracell
98 autocrine growth and significantly decreases secretion of FGF2-containing exosomes, resulting in less
101 Both infection groups had higher levels of secretion of gamma interferon (IFN-gamma), tumor necrosi
104 orrect localization of GRAs into the PVM and secretion of GRA effectors into the host cytoplasm.
105 oid cells that promote tumorigenesis through secretion of growth- and survival-promoting cytokines th
106 ose and palmitate to produce Acetyl-CoA, and secretion of heparan sulfate proteoglycan (component of
107 ic acid polymers (NAPs) inhibit assembly and secretion of hepatitis B virus (HBV) subviral particles.
108 tric surgery results in increased intestinal secretion of hormones GLP-1 and anorexigenic PYY, which
112 s pathway is conserved and implicated in the secretion of hydrolytic enzymes and toxins for a range o
113 mor-infiltrating CD8(+) T cells and elevated secretion of IFN-gamma, Cxcl9, and Cxcl10 in tumor micro
114 tentially exploited to prevent inappropriate secretion of IFN-I in autoimmune diseases or promote IFN
118 ally, nonfailing hMSCs exhibited >25x higher secretion of IGF (insulin-like growth factor)-1 compared
119 to the M2 phenotype, thereby increasing the secretion of IGF-1 and CCL20, which promoted tumor progr
121 ws, whereas only clinical cows had increased secretion of IL-10, IL-12, and IL-18 upon stimulation of
122 egs provide cytoprotection for CEnCs through secretion of IL-10, indicating potentially novel therape
124 cyte integrin alpha3beta1 in controlling the secretion of IL-1alpha, a paracrine factor that regulate
125 inhibits (P < 0.0001) NT-stimulated (10 nM) secretion of IL-1beta (at 1 ng/mL) and CXCL8 (at 100 ng/
126 the NLRP3-caspase-1-mediated processing and secretion of IL-1beta and IL-18 and induces the inflamma
127 masomes, enabling processing, and facilitate secretion of IL-1beta and IL-18, as well as other signal
131 /mL) of embryonic microglia (HMC3), in which secretion of IL-1beta was undetectable, inhibits secreti
132 a(-/-) bone marrow-derived DCs show enhanced secretion of IL-1beta, whereas production of IL-10 and I
134 lp to CD11c(+) T-bet(+) B cells via the dual secretion of IL-21 and IFN-gamma in a CD40/CD40L-depende
137 he endothelium, and we identify the distinct secretion of IL-6 as the paracrine cause of PI3Kalpha(H1
139 ls of CD83, CD86, HLA-DR and CD54, increased secretion of IL12 and IL10 and higher tumour-antigen (TA
141 ells from HDM +/- DEP exposed ST2(-/-) mice, secretion of IL5, IL13, IL6 and IL17A was abrogated by a
147 of NFkappaB, followed by the expression and secretion of inflammatory cytokines (IL [interleukin] 1B
148 r potential for virulence and did not induce secretion of inflammatory cytokines by epithelial cells.
149 profloxacin resistance and ability to induce secretion of inflammatory cytokines by HT-29 intestinal
151 the cleavage of cysteine protease caspase-1, secretion of inflammatory cytokines, and induction of in
152 which promoted glycogen accumulation and the secretion of inflammatory cytokines, including interleuk
153 SMase in monocytes/macrophages inhibited the secretion of inflammatory mediators IL-1beta and MCP-1.
155 ues based on chemotactic cues and modulating secretion of instructive regenerative molecules in respo
158 cretory granules (SGs) mediate the regulated secretion of insulin, which is essential for glucose hom
160 nd expand APCs in the tumor and induce local secretion of interferon beta (IFNbeta), which is a pro-i
161 lls increased numbers of intracellular 11G5, secretion of interleukin (IL) 6 and IL8, and markers of
162 Activation of inflammasomes induces the secretion of interleukin (IL)-1beta and IL-18 and drives
163 entration induces proteolytic processing and secretion of interleukin (IL)-33, a critical cytokine in
164 rATG exposure further resulted in hampered secretion of interleukin (IL)-7, IL-15, and IL-6, cytoki
167 ducing activation of the NLRP3 inflammasome, secretion of interleukin-1beta and interleukin-18, and p
168 ice destabilized Nfkappab1 mRNAs and reduced secretion of interleukin-2 (IL2) and interferon-gamma (I
169 roinflammatory response characterized by the secretion of interleukin-8 (IL-8; also called CXCL8) and
171 with IPF-RC during differentiation increases secretion of IPF biomarkers and RNA sequencing (RNA-seq)
172 velopment of a complex hard tissue, from the secretion of its organic macromolecular template to the
174 s treated with drugs that block synthesis or secretion of lactate mimic the pgk1- / - phenotype, wher
178 inhibited lysosomal exocytosis, whereby the secretion of lysosomal-associated membrane protein 1 (LA
180 nisms, partly by reducing the expression and secretion of macrophage colony-stimulating factor CSF1 b
182 tributes to age-related diseases through the secretion of matrix-degrading and inflammatory molecules
183 of exocyst, Endosidin2, reversibly augmented secretion of mature WPBs containing HMW forms of VWF.
191 T, and allowed the selective translation and secretion of nerve growth factor (NGF) by PDAC cells to
192 141716A up-regulated KLF4 and STAT6, reduced secretion of Netrin-1, and increased migration toward th
195 cidual stromal cell (dESF) transcription and secretion of NF-kappaB targets, including IL8, as measur
196 d insulin ((pro)insulin) content and insulin secretion of NIT-1 cells, autophagy inhibition using baf
198 C. difficile infection is dependent on the secretion of one or more AB-type toxins: toxin A (TcdA),
202 y, SLE LL37-specific T-cells promoted B-cell secretion of pathogenic anti-LL37 antibodies in vitro.
203 tion of effector T-cell function and ensuing secretion of pathogenic cytokines (eg, IL-17, interferon
204 d DCs and monocytes from blood and bronchial secretions of patients with varying COVID-19 severity an
206 , while stage three was characterised by the secretion of phytotoxins, including colletotrichin and c
207 hormone (GnRH) leads to a marked decrease in secretion of pituitary gonadotropins LH and FSH and impa
209 l tubular epithelial cells, resulting in the secretion of pro-fibrotic cytokines, thereby promoting i
211 creased intestinal permeability and enhanced secretion of pro-inflammatory cytokines compared to NC c
212 ited effect on the viability of HBMEC or the secretion of pro-inflammatory cytokines or chemokines, e
216 ular senescence that is characterized by the secretion of pro-inflammatory molecules that promote the
217 with low fibrogenic features; and increased secretion of pro-tumor cytokines and CXCR2 ligands, util
218 lammasome assembly drives the maturation and secretion of proinflammatory cytokines and induces pyrop
219 Besides, inhibition of p38 suppressed the secretion of proinflammatory cytokines and promoted auto
220 ell lines or primary CML cells, resulting in secretion of proinflammatory cytokines and specifically
222 evelopment of inflammation by activating the secretion of proinflammatory cytokines, IL-1beta and IL-
227 chinery, which enables the glucose-dependent secretion of protective immunomodulatory factor interleu
228 tate in solution and (ii) the production and secretion of redox-active, P. aeruginosa-produced phenaz
230 ith Helicobacter pylori stimulates increased secretion of Rspo by myofibroblasts, leading to an incre
231 motes endoplasmic-reticulum localization and secretion of S100b-a protein that lacks a signal peptide
232 ssion of proteins involved in biogenesis and secretion of sEV, and triggered co-localization of multi
234 e show that Rab13 additionally regulates the secretion of sEVs corresponding to both traditional exos
235 s with loss or inhibition of PRKD1 increased secretion of sEVs; loss of PRKD1 reduced phosphorylation
236 ed mechanisms responsible for biogenesis and secretion of SGs, but how SGs mature remains poorly unde
238 coincide with cell wall synthesis, while the secretion of SlpA from the cell is relatively delocalize
241 Intercellular communication through the secretion of soluble factors plays a vital role in a wid
243 we have shown that low oxygen increased the secretion of STC-1 but it required co-stimulation with t
244 th a cell wall-editing enzyme to mediate the secretion of substrate proteins from the periplasm to th
246 manipulate stem cell homeostasis by inducing secretion of TGF-beta while protecting infected HPCs fro
247 ke, costimulatory molecule upregulation, and secretion of Th1 (IL-12)- and Th17 (IL-23, IL-1beta, and
248 ver, microbe-activated monocytes induced the secretion of Th17 and monocyte-recruiting chemokines CCL
249 ver, microbe-activated monocytes induced the secretion of Th17 and monocyte-recruiting chemokines che
250 and that this effect is counteracted by the secretion of the bacterial effector CT622/TaiP (transloc
251 In this study, we show that, in addition to secretion of the Breg immunosuppressive cytokines IL-10,
260 ellular accumulation of amyloid precipitate, secretion of the major curli subunit, CsgA, is tightly r
262 ttach to substrates and the biosynthesis and secretion of the mucilage compounds of the Arabidopsis s
264 olumella cells provide a feedback signal via secretion of the peptide CLAVATA3/ESR-RELATED40 (CLE40),
265 lved in pollen tube attraction, and promotes secretion of the pollen tube chemoattractant LURE1.2.
266 i severely damages white button mushrooms by secretion of the pore-forming toxin tolaasin, the main v
267 atory function of hypoxic CAFs by decreasing secretion of the pro-angiogenic factor VEGFA and consequ
268 ound superior to ceftriaxone in reducing the secretion of the pro-inflammatory cytokine IL-8 by endoc
269 n vitro, and attenuates chemotherapy-induced secretion of the pro-inflammatory cytokines TNFalpha, IL
271 ls within 6 days, significantly decrease the secretion of the proinflammatory cytokine IL-6, and, via
272 In turn, Fap2-dependent invasion induced the secretion of the proinflammatory cytokines IL-8 and CXCL
273 n the presence of farnesol, there is reduced secretion of the Th1-inducing cytokine, IL-12, and incre
276 induced CD62P expression; HMGB1 release; and secretions of thromboxane A(2), CXCL7, and IL-33 by mous
278 effect, as represented by a decrease in the secretion of TNFalpha, IL6 and IL12/IL23 (IL12p40) proin
279 otein that is essential for the assembly and secretion of triglyceride (TG)-rich, apoB-containing lip
280 anistically we found that TFEB regulates the secretion of truncated mutant tau lacking MTBR and this
281 tion still increases the ER stress-dependent secretion of TTR in non-native conformations under these
282 ed with CD200-coated particles decreased the secretion of tumor necrosis factor-alpha (TNF-alpha).
283 loid precursor protein in neurons and in the secretion of tumor necrosis factor-alpha from microglial
284 isms of chaperone-mediated stabilization and secretion of two distinct families of T6SS membrane prot
285 C3s) maintain intestinal homeostasis through secretion of type 3 cytokines such as interleukin (IL)-1
287 ral nucleic acids induces the expression and secretion of type I IFNs (IFN-Is), important mediators o
289 rons.IMPORTANCE Viral infection triggers the secretion of type I interferons, which in turn induce th
290 ptidase to facilitate secretion, whereas the secretion of Typhoid toxin in Salmonella enterica serova
291 ly sculpt their microenvironment through the secretion of various cytokines, chemokines, and other fa
295 can be potentially achieved by detecting the secretion of volatile sulfur compounds (VSCs) in oral ca
296 GCs) are potent anti-inflammatory drugs, the secretion of which is mediated and controlled by the hyp
297 lly, loss of p53 in cancer cells induced the secretion of WNT ligands that stimulate tumour-associate
299 r porcupine, both of which are essential for secretion of Wnts, caused misrotated sensory cells and s
300 old insulin SGs, revealing that preferential secretion of younger granules occurs in glucose-stimulat