ライフサイエンスコーパス: secretion system

1 ella pathogenicity island 1 (SPI-1) type III secretion system.

2 tip complex (DeltaPcrV) supernatant] type 3 secretion system.

3 tivation of a Pseudomonas aeruginosa type VI secretion system.

4 gionella contact is dependent on the Icm/Dot secretion system.

5 was independent of the status of the type 3 secretion system.

6 s from destruction by the Y. pestis type III secretion system.

7 s components of the virulence-critical ESX-1 secretion system.

8 ified the mRNA for the regulator of type III secretion system.

9 the presence of a novel chromosomal type IV secretion system.

10 ane as unfolded amyloid precursors through a secretion system.

11 , and lapE operons, encoding a LapA-specific secretion system.

12 d into the host cell via the Dot/Icm type IV secretion system.

13 ivered into plant cells through the type III secretion system.

14 it suggested a defect in the ESX-1 type VII secretion system.

15 and G35/A36 during export through the type I secretion system.

16 for iron acquisition and a functional type 9 secretion system.

17 rotein PrgI from the S. Typhimurium type III secretion system.

18 Secretion of the enzyme requires a Type II secretion system.

19 n boxes or affecting components of the ESX-1 secretion system.

20 eography of the substrate moving through the secretion system.

21 mbrane via a variant of the classical type I secretion system.

22 ch the main virulence factor is the Type III Secretion System.

23 ane spanning structures such as flagella and secretion systems.

24 , providing insights into the F-like type IV secretion systems.

25 karyotic microvesicles and bacterial surface secretion systems.

26 ems work by cryoEM, with a focus on type III secretion systems.

27 e contact-dependent lysis of other bacterial secretion systems.

28 he virulence-associated type III and type II secretion systems.

29 ary cryoEM techniques for studying bacterial secretion systems.

30 activation of pathogen-associated type three secretion systems.

31 monella via the invasion-associated Type III Secretion System 1 (T3SS1).

32 These processes depend on type 6 secretion system 1 (T6SS-1), which is required for virul

33 s, and virulence in humans requires type III secretion system 1 (TTSS-1), encoded on Salmonella patho

34 Da early secretory antigenic target (ESAT-6) secretion system 1] is required for both virulence and h

35 f effector proteins delivered by its Dot/Icm secretion system(1).

36 ulence factors that are secreted by type VII secretion systems(1).

37 intracellular pathogen that uses its type 3 secretion system 2 (T3SS2) to invade and replicate insid

38 because T6SS-1 and some effectors of type 3 secretion system 3 (T3SS-3), which is also required for

39 ia an unknown mechanism by bacterial type VI secretion system 5 (T6SS-5), which is an essential virul

40 acellular life cycle at the point of type VI secretion system 5 (T6SS-5)-mediated cell-cell spread.

41 induces host cell fusion through its type VI secretion system 5 (T6SS5) as an important part of its p

42 lague, and typhoid fever, rely on a type III secretion system - a multi-membrane spanning syringe-lik

43 ive T6SS but also the Gram-positive type VII secretion system, a pathway recently implicated in inter

44 completely overcome the repression of type 3 secretion system activity normally associated with expos

45 ab rivals with poisoned needles (the type VI secretion system) after being stabbed themselves.

46 Such specialized secretion systems allow a variety of bacteria to thrive

47 V tag, which can pass through the type three secretion system, allowed visualization and quantificati

48 ntly, endosymbiont genes encoding a type III secretion system and a flagellum apparatus are transient

49 The Cdz system uses a type I secretion system and is unrelated to previously describe

50 m and is actively suppressed by the type III secretion system and its effector proteins.

51 that the enzyme is secreted via the type II secretion system and results in higher extracellular act

52 ole through activation of a Dot/Icm-type IVB secretion system and subsequent translocation of effecto

53 (apoplast), while genes involved in type III secretion system and syringomycin synthesis were primari

54 ion Substance, PrgC) and the Prg/Pcf type IV secretion system and, in turn, conjugatively transfer th

55 tile bacteriophage tails, bacterial type six secretion systems and R-pyocins is rapidly increasing, s

56 unts of LcrV enclosed in OMVs by the type II secretion system, and eliminated harmful factors like pl

57 hat function in cell wall synthesis, diverse secretion systems, and antibiotic efflux pumps.

58 duction, biofilm formation, virulence factor secretion systems, and competence.

59 indicate that NLRC4 and a functional type IV secretion system are crucial for the production of IL-18

60 ing cascades regulating the activity of this secretion system are poorly understood.

61 Type III secretion systems are complex nanomachines used for inje

62 Type III protein secretion systems are essential virulence factors for ma

63 Specialized secretion systems are infamous for their contribution to

64 The ESX (or Type VII) secretion systems are protein export systems in mycobact

65 ependent inhibition (CDI) systems (a Type Vb secretion system) are a distinct subset of competition s

66 and Xanthomonas campestris, use the type III secretion system as a molecular syringe to inject type I

67 BPs detect the presence of bacterial protein secretion systems as "patterns of pathogenesis" associat

68 is structure is one of the largest bacterial secretion system assemblies ever reported and illustrate

69 g the Mycobacterium tuberculosis (Mtb) ESX-1 secretion system (BCG::RD1 and BCG::RD1 ESAT-6 Delta92-9

70 needle cap protein of the Y. pestis type III secretion system, binds to the N-formylpeptide receptor

71 omplex, IcmSW, for translocation through the secretion system, but its role in pathogenicity has rema

72 r protein (CagA) and components of a type IV secretion system (Cag T4SS).

73 One cancer-linked locus is the cag type 4 secretion system (cagT4SS), which translocates an oncopr

74 rrently, the raw expression of the bacterial Secretion Systems co-increased, but they were not over-e

75 YhaJ directly activates expression of type 3 secretion system components and effectors.

76 etracycline resistance [tet(O)], the Type IV secretion system, conjugative transfer and the Type VI s

77 Mycobacterial type VII secretion systems consist of five subtypes, ESX-1-5, and

78 response, Y. enterocolitica uses a type III secretion system consisting of an injectisome and effect

79 plants are more susceptible to the type III secretion system-deficient bacterial strain Pseudomonas

80 The Pseudomonas aeruginosa type III secretion system delivers effector proteins directly int

81 aein vitro model system for study of type IV secretion system-dependent (T4SS) pathogenesis in the Br

82 d-Ser) resulted in down-regulation of type 3 secretion system-dependent colonization, thereby avoidin

83 e phosphorylation and autophagy in a type IV secretion system-dependent fashion.

84 m invasion is promoted by O(2) in a type III secretion system-dependent manner.

85 lts reveal that the architecture of type VII secretion systems differs markedly from that of other kn

86 nscription activator-like effectors, type II secretion systems, diversity resulting in host specifici

87 vered into host cells by the Dot/Icm type IV secretion system during infection.

88 osomes induced by the E. chaffeensis type IV secretion system effector Etf-1, which traffic to and fu

89 Exoenzyme Y (ExoY) is a type III secretion system effector found in 90% of the Pseudomona

90 icans were identified, including the type VI secretion system effector Hcp1, suggesting that protein

91 onella pneumophila and identified the type 4 secretion system effector Lpg2603 as a remote member of

92 ExoU is a potent type III secretion system effector that, after secretion, localiz

93 e previously identified a bacterial type III secretion system effector, termed NleD, a metalloproteas

94 C. rodentium injects type III secretion system effectors into intestinal epithelial ce

95 This specialized secretion system employs the Dot/Icm type IVB coupling p

96 The type VII secretion system ESX-1 [6-kDa early secretory antigenic

97 The Mycobacterium tuberculosis type VII secretion system ESX-5, which has been implicated in vir

98 A type VII secretion system (ESX-1) mediated, contact-induced plasm

99 acterium tuberculosis involved in the ESAT-6 secretion system (ESX-1)-mediated virulence and pathogen

100 Type VII secretion systems (ESX) are responsible for transport of

101 ments or on the cell surface; hence, diverse secretion systems evolved to transport the hydrophilic m

102 The horizontally transferred two-partner secretion system ExlB-ExlA is instrumental in the virule

103 is usually reciprocally coordinated with T6 secretion system expression.

104 n with a broad host range, require the ESX-1 secretion system for virulence.

105 el apparatus, a widespread exopolysaccharide secretion system found in environmental and pathogenic b

106 -embedded core complex of the ESX-3/type VII secretion system from Mycobacterium smegmatis.

107 nd that gene PA2374, proximal to the type VI secretion system H3 (H3-T6SS), functions synergistically

108 This secretion system has emerged as a key player in regulati

109 A variety of protein-secretion systems have evolved to make this process high

110 Type III protein secretion systems have specifically evolved to deliver b

111 export apparatus of the Salmonella type III secretion system in association with the needle complex

112 1, we demonstrated the important role of the secretion system in facilitating bacterial colonization.

113 ases to be the substrates of the Xps type II secretion system in S. maltophilia strain K279a.

114 eview, we summarize the current knowledge of secretion systems in Acinetobacter species, and highligh

115 d homologs of this toxin are associated with secretion systems in many Gram-negative and Gram-positiv

116 port systems, and observe cross-talk between secretion systems in the pathobiology of medically relev

117 cterial activity of Vibrio vulnificus Type 6 secretion systems in vivo, revealing an important role f

118 This process is promoted by type III secretion system inactivation in infected tissues, favou

119 Helicobacter pylori type IV secretion system injects the oncoprotein CagA into epith

120 ver Yop effector proteins through a type III secretion system into host cells.

121 The H. pylori cag type IV secretion system is an oncogenic locus that translocates

122 We determined that the Llo Dot/Icm secretion system is critical for virulence.

123 The Dot/Icm-type IVB secretion system is essential for the biogenesis of the

124 he attenuation of bacteria lacking the ESX-1 secretion system is independent of surfactant levels.

125 ellulolytic enzymes suggest that the Type IX secretion system is involved in the translocation of the

126 We further show that the type II secretion system is required for translocation across th

127 Although FapF represents a unique type of secretion system, it shares mechanistic features with a

128 acts upstream of ler and not directly on the secretion system itself.

129 ding a molecular syringe known as a type III secretion system, leading to infectious colitis and infl

130 We document, herein, that the type VI secretion system locus II (H2-T6SS) of P. aeruginosa del

131 Crucial to its pathogenesis is type 4b secretion system-mediated secretion of bacterial effecto

132 retion (T4S) systems are versatile bacterial secretion systems mediating transport of protein and/or

133 of P. aeruginosa lacking a functional type 3 secretion system needle tip complex (DeltaPcrV) supernat

134 ugh complex interactions between the type VI secretion system of V. cholerae and the microbial commun

135 to the architecture of various dual membrane secretion systems of distinct function.

136 downregulates the expression of the type III secretion systems of enteropathogenic and enterohemorrha

137 rescence microscopy to image dynamic type VI secretion system processes in metabolically active Bacte

138 al entry into macrophages the ESX-1 type VII secretion system promotes phagosomal permeabilization an

139 acity of Yersinia YopB, a conserved type III secretion system protein, alone or combined with LcrV in

140 agellar machinery and alterations in type VI secretion system proteins.

141 possess sequence similarities with bacterial secretion system proteins.

142 the Liberibacter virulence traits, including secretion systems, putative effectors, and lipopolysacch

143 Bacterial type VII secretion systems secrete a wide range of extracellular

144 T4aP secretin from the type II and type III secretion system secretins.

145 part on its pathogenicity island 2 type III secretion system (SPI-2 T3SS), which is required to tran

146 njugative systems, which depend on a type IV secretion system, Streptomyces requires only TraB protei

147 ter species produce both a functional type I secretion system (T1SS) and a contact-dependent inhibiti

148 led in a heterologous Klebsiella T2SS type 2 secretion system (T2SS) by using cryo-electron microscop

149 The type II secretion system (T2SS) is a multi-protein complex used

150 The type II secretion system (T2SS) is a multiprotein envelope-spann

151 t was previously determined that the type II secretion system (T2SS) promotes the ability of Legionel

152 socomialis M2 possesses a functional type II secretion system (T2SS) that is required for full virule

153 ter membrane to the exterior using a type II secretion system (T2SS)(3,5).

154 aA is a predominant substrate of the type II secretion system (T2SS).

155 Bacterial type 2 secretion systems (T2SS), type 4 pili, and archaeal flag

156 Many Gram-negative bacteria use type 2 secretion systems (T2SSs) to secrete proteins involved i

157 Bacterial type II secretion systems (T2SSs) translocate virulence factors,

158 erfamily, comprised of type IV pili, type II secretion systems (T2SSs), archaella, and other less-wel

159 some upon sensing components of the type III secretion system (T3SS) and flagellar apparatus.

160 ll wall degrading enzymes (PCWDEs), type III secretion system (T3SS) and flagellar motility.

161 pression dose of the antiphagocytic type III secretion system (T3SS) and induces functions counteract

162 usion protein and secreted it via the type 3 secretion system (T3SS) at 37 degrees C under calcium-de

163 ic Escherichia coli (EPEC) uses the type III secretion system (T3SS) effector EspL to degrade the RHI

164 opathogenic Escherichia coli (EPEC) type III secretion system (T3SS) effector translocated intimin re

165 We examined the importance of type III secretion system (T3SS) effectors in the production of c

166 The type III secretion system (T3SS) is a pivotal virulence mechanism

167 The Type Three Secretion System (T3SS) is a well-studied and attractive

168 f enterocyte effacement (LEE)-encoded type 3 secretion system (T3SS) is the major virulence determina

169 tunistic pathogenic bacterium whose type III secretion system (T3SS) plays a critical role in acute i

170 mmasome activation by the conserved type III secretion system (T3SS) rod proteins from Gram-negative

171 Here, we show that AxoU is a type III secretion system (T3SS) substrate that induces cytotoxic

172 enic Gram-negative bacteria use the type III secretion system (T3SS) to deliver effector proteins int

173 ogens infect eukaryotes and use the type III secretion system (T3SS) to deliver effector proteins int

174 Pseudomonas aeruginosa uses a type III secretion system (T3SS) to inject cytotoxic effector pro

175 ages a syringe-like machinery named type-III secretion system (T3SS) to inject effectors within host

176 Many Gram-negative pathogens use a type III secretion system (T3SS) to promote disease by injecting

177 EHEC employs a type III secretion system (T3SS) to translocate 50 effector prote

178 embrane damage by components of the type III secretion system (T3SS) translocon.

179 ella pathogenicity island 1 (SPI-1) type III secretion system (T3SS)) and outer membrane (OM) (15-mer

180 yticus, can be exported through the type III secretion system (T3SS), which engages in one-step secre

181 e bacteria secrete proteins using a type III secretion system (T3SS), which functions as a needle-lik

182 ein, a component within the bacterial type 3 secretion system (T3SS), which is mainly expressed in Gr

183 greatly increased expression of the Type III secretion system (T3SS), widely considered to be the mos

184 t during colonic crypt hyperplasia, type III secretion system (T3SS)-mediated intimate epithelial att

185 rectly injected into host cells via a type 3 secretion system (T3SS).

186 ection of virulence factors through a type 3 secretion system (T3SS).

187 nella pathogenicity island 1 (SPI1) type III secretion system (T3SS).

188 e to high expression of the bacterial type-3 secretion system (T3SS).

189 ctors into the cell cytoplasm via a type III secretion system (T3SS).

190 ginosa virulence determinant is the type III secretion system (T3SS); the production of T3SS cytotoxi

191 Protein secretion through type-three secretion systems (T3SS) is critical for motility and vi

192 Pathogen type 3 secretion systems (T3SS) manipulate host cell pathways b

193 am-negative bacterial pathogens use type III secretion systems (T3SS) to inject proteins into eukaryo

194 eract with mammalian cells by using type III secretion systems (T3SS) to inject virulence proteins in

195 Experimental overproduction of a type 3 secretion system (T3SS1) in this pathogen leads to decre

196 Type III Secretion Systems (T3SSs) are structurally conserved nan

197 rates also called effectors through Type III secretion systems (T3SSs) into host cells and cause dise

198 Bacterial type III secretion systems (T3SSs) play an important role in path

199 Many Gram-negative bacteria use type III secretion systems (T3SSs) to inject virulence effector p

200 jected into host cell cytoplasm via type III secretion systems (T3SSs) to modulate interactions betwe

201 fector proteins into host cells via type III secretion systems (T3SSs).

202 to the host cell by the C. burnetii type IVB secretion system (T4BSS) are required for the inhibition

203 The Legionella pneumophila Dot/Icm type IVB secretion system (T4BSS) is extremely versatile, translo

204 Legionella pneumophila uses a type IVB secretion system (T4BSS) to export a large number of pro

205 /intracellular multiplication (Icm) type IVB secretion system (T4BSS).

206 he cell decrease the activity of the Type IV secretion system (T4SS) and subsequently the capacity of

207 indicated that the cell biology and type IV secretion system (T4SS) dependence of B. neotomae intrac

208 A (CagA), which is translocated by a type 4 secretion system (T4SS) into gastric epithelial cells an

209 We also demonstrate that the Coxiella type 4 secretion system (T4SS) is critical for the formation of

210 The Dot/Icm type IV secretion system (T4SS) is one of the key virulence fact

211 ion systems are members of the large type IV secretion system (T4SS) superfamily.

212 The cag PAI encodes a type IV secretion system (T4SS) that mediates delivery of the Ca

213 equent pathology require the Dot/Icm Type IV Secretion System (T4SS) to deliver effector proteins int

214 tracellular multiplication (Dot/Icm) type 4b secretion system (T4SS) to silence the host innate immun

215 he, C. burnetii requires the Dot/Icm type IV secretion system (T4SS) to translocate a cohort of effec

216 ext-dependent human pathogens, use a type IV secretion system (T4SS) to translocate effectors directl

217 often leads to downregulation of the type IV secretion system (T4SS), typically by recombination in c

218 that augments cancer risk is the cag type 4 secretion system (T4SS), which translocates the oncoprot

219 ns is paired with a highly conserved type IV secretion system (T4SS).

220 ytoplasmic entrance of the F-encoded type IV secretion system (T4SS).

221 s cag pathogenicity island (cag PAI) type IV secretion system (T4SS).

222 o the host cytoplasm using a Dot/Icm type IV secretion system (T4SS).

223 ry of CagA into host cells through a type IV secretion system (T4SS).

224 his transfer is often facilitated via type 4 secretion systems (T4SS), which frequently are encoded o

225 Bacterial type IV secretion systems (T4SSs) are molecular machines that ca

226 Bacterial type IV secretion systems (T4SSs) can mediate conjugation.

227 obile genetic elements (MGEs) encode type IV secretion systems (T4SSs) known as conjugation machines

228 A large subfamily of the type IV secretion systems (T4SSs), termed the conjugation system

229 chia coli secreted by the Type V, subtype a, secretion system (T5aSS) and belonging to the family of

230 that Rhs effectors are essential for type VI secretion system (T6SS) activity in Enterobacter cloacae

231 potent antibacterial activity of the type VI secretion system (T6SS) against specified target cells.

232 Further, we report that the type 6 secretion system (T6SS) and type 1 fimbriae are importan

233 etically distinct, harboring a unique type 6 secretion system (T6SS) effector (TseC).

234 jugative plasmids that represses the type VI secretion system (T6SS) in multiple Acinetobacter strain

235 The Type VI secretion system (T6SS) is a bacterial nanomachine that

236 The type VI secretion system (T6SS) is a bacterial nanomachine used

237 The type VI secretion system (T6SS) is a contact-dependent bacterial

238 The type 6 secretion system (T6SS) is a dynamic organelle encoded b

239 The type VI secretion system (T6SS) is a nanomachine used by many ba

240 The type VI secretion system (T6SS) is a proteinaceous weapon used b

241 The type VI secretion system (T6SS) is a weapon of bacterial warfare

242 The P. chlororaphis type VI secretion system (T6SS) is activated upon contact with B

243 The type VI secretion system (T6SS) is one of the largest dynamic as

244 The bacterial type VI secretion system (T6SS) mediates antagonistic cell-cell

245 Moreover, inactivation of the type VI secretion system (T6SS) of a competitor annuls the respo

246 killing adjacent competitors via the Type VI secretion system (T6SS) precipitates phase separation vi

247 rains harbor a constitutively active type VI secretion system (T6SS) that is employed to kill nonkin

248 Each type has a contact-dependent type VI secretion system (T6SS) that kills neighbouring competit

249 competent Vibrio cholerae use their type VI secretion system (T6SS) to actively acquire DNA from non

250 brio cholerae deploys a harpoon-like type VI secretion system (T6SS) to compete against other microbe

251 phagosomal escape, the F. tularensis Type VI Secretion System (T6SS) was required for vacuole escape.

252 genetic architectures (GA1-3) of the type VI secretion system (T6SS), an effector delivery pathway th

253 aling includes downregulation of the type VI secretion system (T6SS), and prevents T6SS-dependent bac

254 ative order Bacteroidales encode the type VI secretion system (T6SS), which facilitates the delivery

255 that this strain harbors 2 putative type VI secretion system (T6SS)-encoding gene clusters.

256 lized by Gram-negative cells against type VI secretion system (T6SS)-wielding competitors, including

257 tivation of a Pseudomonas aeruginosa type VI secretion system (T6SS).

258 system, conjugative transfer and the Type VI secretion system (T6SS).

259 tition systems have been described: type six secretion systems (T6SS); contact dependent inhibition (

260 Type VI secretion systems (T6SSs) are nanomachines widely used b

261 Type VI secretion systems (T6SSs) deliver antibacterial effector

262 Both P. aeruginosa and Bcc use type VI secretion systems (T6SSs) to mediate interbacterial comp

263 The Staphylococcus aureus type VII secretion system (T7SS) exports several proteins that ar

264 The type VII protein secretion system (T7SS) is conserved across Staphylococc

265 The type VII secretion system (T7SS) of Staphylococcus aureus is a mu

266 In mycobacteria, type VII secretion systems (T7SSs) are dedicated protein transpor

267 Type VII secretion systems (T7SSs), originally described in mycob

268 ion sigma factors, components of the type IX secretion system (T9SS), and CRISPR and cas genes.

269 ds on a secretory apparatus known as type IX secretion system (T9SS).

270 protein of a Salmonella Typhimurium type III secretion system that are involved in the regulation of

271 Here, we describe a protein secretion system that uses a holin membrane protein in t

272 D and IpaD of Gram-negative bacterial type-3 secretion systems that breach immune barriers and delive

273 pathogenesis due to the presence of type IVA secretion systems that cause higher mortality due to ove

274 pumps that export small molecules and type I secretion systems that export a range of bacterial virul

275 for extracellular survival and the type III secretion system-the symbiont's primary virulence mechan

276 icking/Intracellular multiplication) type IV secretion system to enable its replication in target cel

277 e a syringe-like apparatus called a type III secretion system to inject virulence factors into host c

278 P. aeruginosa uses its type III secretion system to secrete various effector proteins di

279 of plague, Yersinia pestis, uses a type III secretion system to selectively destroy immune cells in

280 Legionella pneumophila, rely on the type IV secretion system to translocate a repertoire of effector

281 ny Gram-negative pathogens utilize dedicated secretion systems to export virulence factors such as ex

282 digmatic example, Salmonella uses two type-3 secretion systems to inject effector proteins that facil

283 erial pathogens utilize virulence-associated secretion systems to inject, or translocate, effector pr

284 ttaching and effacing pathogens use type III secretion systems to introduce effectors targeting key s

285 Mycobacteria use type VII secretion systems to secrete proteins across their highl

286 Gram-positive bacteria have developed secretion systems to transport proteins across their cel

287 ropose that the pathway be named the Type 10 Secretion System (TXSS).

288 ulence in the absence of large, multiprotein secretion systems (Types I, II, III, IV, and VI), which

289 he bacterium Brucella abortus uses a type IV secretion system (VirB T4SS) to generate a replication-p

290 ribed findings were dependent on the type IV secretion system (VirB) and the secreted BPE005 protein,

291 that S. maltophilia also encodes a type IVA secretion system (VirB/VirD4 [VirB/D4] T4SS) that is hig

292 which is activated by flagellin or bacterial secretion systems, was shown to be dispensable for H. py

293 n ethanolamine catabolism or in the type VII secretion system were attenuated in persisting during va

294 luding membrane transport from which type VI secretion systems were in particular upregulated.

295 cuoles is dependent on the bacterial Dot/Icm secretion system, whereas the delivery of GBP2 to Yersin

296 umented that the bacterium encodes a type II secretion system which triggers detachment-induced apopt

297 ces global expression of the EHEC type three secretion system, which is a key virulence factor requir

298 One such mechanism involves type VI secretion systems, which bacteria can use to inject anti

299 SPI-2 encodes a type three secretion system whose effectors modify the vacuole, dri

300 with examples of insights provided into how secretion systems work by cryoEM, with a focus on type I