ライフサイエンスコーパス: secretome

1 d its cognate signaler BMP1 decreased in the secretome.

2 s significantly altered the quality of their secretome.

3 categorize the A. fumigatus putative in vivo secretome.

4 gulation and the regulation of the mammalian secretome.

5 racellular matrix components to modulate the secretome.

6 (CLIC3) is an abundant component of the CAF secretome.

7 h soluble and exosomal fractions of the hMSC secretome.

8 cardial recovery via the components of their secretome.

9 c alterations that include a proinflammatory secretome.

10 g the expression of a complex pro-metastatic secretome.

11 the role of VEGF in modifying the angiogenic secretome.

12 unstressed cells, particularly targeting the secretome.

13 ng several predicted members of the parasite secretome.

14 cells also predicts their cell-type-specific secretome.

15 through its diverse metabolite and adipokine secretome.

16 tein in mammals, is actively degraded by the secretome.

17 spectrometry of heart extracts and a fungal secretome.

18 ure from the Mycobacterium marinum bacterial secretome.

19 predominant difference in the pks2(-) mutant secretome.

20 processing of these proteins in the biofilm secretome.

21 ied 11 enriched in the mesenchymal stem cell secretome.

22 ates angiogenic components of the tumor cell secretome.

23 characterization of the B. pseudomallei T2SS secretome.

24 characterized by proteomics analysis of the secretome.

25 -directed EMT activation and Sec23a-mediated secretome.

26 hanisms, including a potent immunomodulatory secretome.

27 port the effect of InhA1 on the B. anthracis secretome.

28 zone and activated to release arrhythmogenic secretome.

29 found intracellularly, but also in the plant secretome.

30 s intracellular pathways and their resultant secretome.

31 haracterization of the polarized endothelial secretome.

32 the relationship between the TIF and plasma secretomes.

33 lineages, despite their diverse genomes and secretomes.

34 ctivation of previously identified procancer secretomes.

35 irmed the higher content of lipids in cancer secretomes.

36 cted human umbilical vein endothelial cells' secretome, 46 proteins were up-regulated: 45 were host s

37 trategy for an enrichment of bacteria with a secretome able to mobilize dietary NSP.

38 Secretome alone did, however, evoke VF in 2 sham coronar

39 ells and/or inhibiting their proinflammatory secretome also improves cardiovascular function, enhance

40 ights into the global beta-cell sheddome and secretome, an important prerequisite to uncover novel me

41 ranscription-PCR (RT-PCR), Western blot, and secretome analyses established that S. Paratyphi A expre

42 Protein microarray secretome analyses revealed angiogenin as the most robus

43 Secretome analysis and functional validation revealed MS

44 etric approach, here we perform quantitative secretome analysis in 13 cell lines that signify the dif

45 We recently performed a bioinformatic secretome analysis in bone marrow cells from patients wi

46 entified the sulfatase SULF2 in an in silico secretome analysis in bone marrow cells from patients wi

47 We established a novel secretome analysis of cardiomyocytes by combining stable

48 We performed secretome analysis of the conditioned medium from tumor-

49 Global gene expression and secretome analysis reveals that TGFss superfamily member

50 Secretome analysis suggested R. solani employs largely d

51 Our D-SCM secretome analysis yielded 144 secreted factor candidate

52 versatile tool for questions related to cell secretome analysis.

53 co pattern searches to define a pneumococcal secretome and analyzed the transcriptome of the clinical

54 ing components of the differentiating stroma secretome and designed a potential therapeutic strategy

55 Here we profiled the apoptotic metabolite secretome and determined its effects on the tissue neigh

56 We showed that an inhalation treatment of secretome and exosome exhibited therapeutic potential fo

57 mor interstitial fluid (TIF) encompasses the secretome and holds the key to several of the phenotypic

58 a-derived MCSF induces changes in microglial secretome and identified insulin-like growth factor-bind

59 ysin as a major determinant of the S. aureus secretome and identified the phenol-soluble modulins as

60 onment, including their effects on the tumor secretome and immune infiltrates, their roles in regulat

61 hemotherapy-induced alterations in the tumor secretome and immune surface proteins by high throughput

62 tant protein-1/chemokine ligand 2 in the MSC secretome and improved MSCs immunosuppressive capacity (

63 of the most abundant proteins of the CyHV-3 secretome and is structurally very similar to carp Il10

64 entification of 609 N-glycopeptides from the secretome and lysates of Huh7 cells.

65 ting in successful pregnancy differ in their secretome and metabolism compared to embryos that fail t

66 estigate the changes in the global proteome, secretome and phosphoproteome of adipocytes under chroni

67 Analysis of the secretome and receptome of the alveolar niche reveals fu

68 atherosclerotic-MSCs underlies their altered secretome and reduced immunopotency.

69 e increased ER-Golgi trafficking, an altered secretome and sensitivity to the retrograde transport in

70 pha3beta1 as a regulator of the keratinocyte secretome and skin tumor microenvironment and as a poten

71 rgoing glutathionylation and apply it to the secretome and the proteome of human monocytic cells.

72 termine interactions between the immune cell secretome and the TRACER-identified active transcription

73 d plasma protein profiles with ex vivo islet secretome and transcriptome analyses.

74 Analyses of the melanoma secretome and validation in clinical specimens showed th

75 -infected human small airway epithelial cell secretome and was differentially expressed in smaller ai

76 54-Gsalpha(KO) ) to delineate the osteocyte "secretome" and its regulation by Gsalpha.

77 ted with the initial growth medium, isolated secretome, and living bacteria, and characterized for th

78 ructure, was observed in the presence of the secretome, and the rate limiting step of the reaction wa

79 glucanases that are integral to cellulolytic secretomes, and their ability to break down cellulose ha

80 s that a large number of the proteins of the secretome are not secreted out of the cell, but instead

81 sis, but the components of the niche and its secretome are only partially understood.

82 located on the outer membrane and within the secretome are responsible for Mn(II) oxidation.

83 The adipose tissue function and secretome are tightly controlled by complex homeostatic

84 human cells (collectively referred to as the secretome) are important not only for the basic understa

85 strate the feasibility of harnessing the MSC secretome as a defined, noncellular strategy to improve

86 nderstanding of the properties of the cancer secretome, as its clinical evaluation may change the the

87 Both components of the gastric gland secretome associate non-covalently and show increased ex

88 usly investigated the nature of the invasive secretome by using a comparative proteomic approach.

89 -IL-6) or mimicking (IGF-1) the cardiac hMSC secretome can rescue arrhythmia substrates.

90 inhibition of oncogenic drivers induces vast secretome changes in drug-sensitive cancer cells, parado

91 The functional effect of the LVCP secretome changes throughout the lifespan, with activate

92 SCs v/s DMSCs (DPSC, SCAP & DFSC) along-with secretome characterization.

93 ing capability, one with a transcriptome and secretome closer to normal fibroblasts (CAF-N) and the o

94 cid bacteria communicate with host cells via secretome components to influence immune responses but l

95 of this tRNA specifically drive synthesis of secretome components, resulting in a type II collagen-ri

96 atory properties are highly variable and the secretome composition following infusion is uncertain.

97 srupting lysosomal function and generating a secretome comprising exosomes with unique cargo and solu

98 otic mesenchymal stromal cells or with their secretome (conditioned medium) in a transwell system.

99 Proteome analyses of the neutrophil secretome confirmed that ATP inhibits pneumolysin-depend

100 This secretome consists of a highly interconnected network en

101 poptotic SH-SY5Y cells, suggesting that PMSC secretome contributes to neuronal survival after injury.

102 transiently controlled antiinflammatory MSC secretome could be achieved at target sites of inflammat

103 Furthermore, treatment with the MSC secretome could circumvent hurdles associated with cellu

104 associated with breast cancer progression in secretome-cultured TNBC cells.

105 The impaired monocyte secretome demonstrated a distinct cytokine/chemokine foo

106 in patients with ileal CD, because the PBMC secretomes derived from patients with CD were unable to

107 BEC secretome did not promote Th1 cell generation.

108 identified alterations to the mosquito cell secretome during DENV infection by performing liquid chr

109 The resulting MDK-modulated secretome educated macrophages towards tolerant phenotyp

110 id cancer cells controls an immunomodulatory secretome, enabling the recruitment of monocytes and the

111 In senescent cells, p95HER2 elicits a secretome enriched in proteases, cytokines, and growth f

112 Il-6, and of senescence-associated phenotype secretome, followed by RPE and PRC demise, and that ELVs

113 cretion were significantly increased in CAFs secretome following radiotherapy.

114 argeting senescent cells or modulating their secretome for anti-aging therapy may have negative conse

115 3-mediated regulation of IL-8 and epithelial secretome for chemotaxis.

116 stance lead to a shift in the adipose tissue secretome from anti-inflammatory and anti-atherogenic to

117 ogenesis indicates the potential role of the secretome from differentiating ASCs in the vascular deve

118 Secretomes from 95% of Serratia marcescens, 71% of Pseud

119 Bacterial cells and secretomes from a subset of tested species of bacteria i

120 To explore this issue, we analyzed secretomes from glucose-deprived cells, which revealed u

121 usion protein was challenged with normalized secretomes from wild-type and mutant S. marcescens deriv

122 Secretome gene analysis revealed a highly connected netw

123 ontrol of secreted factors, and we show that secretome genes are preferentially controlled by synergi

124 onditioned medium, the latter containing the secretome, greatly decreased the proinflammatory respons

125 gation into the therapeutic potential of the secretome has enabled researchers to replicate the anti-

126 l fluids secreted from the tissues (named as secretome) has attracted a lot of attention.

127 mesenchymal stem cells (MSCs), known as the secretome, has demonstrated considerable therapeutic ben

128 to remodel in disease and have an extensive secretome, has recently been isolated from the human hea

129 Historically, studies of the adipose secretome have predominantly focused on polypeptide adip

130 In this study, we characterized the secretome (i.e., the global pattern of secreted proteins

131 A proteomic analysis of the PPMS NPC secretome identified high-mobility group box-1 (HMGB1),

132 Global quantitative analysis of the hypoxic secretome identified lysyl oxidase (LOX) as significantl

133 Characterization of the LEC secretome identified the extracellular protein reelin (R

134 sponses but less is known about gut-pathogen secretomes, impact of lactic acid bacteria secretomes on

135 cells confirmed reduced levels of CFD in the secretome, implicating the complement system in prostate

136 reversed the DEGs, including those encoding secretome; improved cardiac function; abrogated cardiac

137 CSp-EMVs alter fibroblast phenotype and secretome in a salutary positive-feedback loop.

138 2 gene products from the wildtype M. marinum secretome in a single CZE-tandem mass spectrometry (MS/M

139 have reported on central effects of S aureus secretome in allergy.

140 te arrhythmia substrates by remodeling their secretome in disease.

141 igated the effects of mutations on the Abeta secretome in human neurons generated in 2D and 3D.

142 nstrated the therapeutic benefits of the MSC secretome in models of stress urinary incontinence, rena

143 igating the therapeutic potential of the MSC secretome in regenerative urology.

144 de further insight into stem cells and their secretome in regenerative urology.

145 vivo and observed significant changes to the secretome in response to let-7 therapy.

146 rcted heart by flow cytometry and macrophage secretome in vitro.

147 served between the TIF and plasma angiogenic secretomes in triple negative MDA-MB-231 breast cancer x

148 ke cells when exposed to autologous melanoma secretomes in vitro.

149 The Bacillus anthracis secretome includes protective antigen, lethal factor, an

150 We discuss the placental secretome including glycoproteins, microRNAs and extrace

151 open-access knowledge resource of the human secretome, including body-wide expression data, spatial

152 s a substantial fraction of the keratinocyte secretome, including fibulin-2 and macrophage CSF1; RNA

153 ubstrates of ADAMTS7 in the human fibroblast secretome, including proteins with a wide range of funct

154 roblasts was also inhibited by S. marcescens secretomes indicating that the effect is not cornea spec

155 Functionally, the apoptotic metabolite secretome induced specific gene programs in healthy neig

156 Atrial myocardium secretome induces the adipogenic differentiation of adul

157 of fibroblasts with distinct phenotypes and secretomes inhabit the stroma, and that targeted depleti

158 issue explants, we could show that the total secretome inhibited preadipocyte differentiation.

159 herapeutic cells for TBI, and lncRNAs in the secretome is an important mechanism of cell therapy.

160 Mechanistically, the apoptotic metabolite secretome is not simply due to passive emptying of cellu

161 However, how the secretome is regulated remains incompletely understood.

162 ates but also by modulating the B. anthracis secretome itself.

163 ate in astrocytes that alters the astrocytic secretome, leading to loss of synaptogenic function in v

164 at the genome, transcriptome, proteome, and secretome levels.

165 By screening a secretome library, we found that the human immunorecepto

166 ed transcriptional program that alters their secretome, limiting neurogenesis both in vivo and in vit

167 impact of the Lactobacillus rhamnosus R0011 secretome (LrS) on TNF-alpha and Salmonella enterica sub

168 ries of studies utilizing lung spheroid cell-secretome (LSC-Sec) and exosomes (LSC-Exo) by inhalation

169 present preliminary evidence that the liver secretome may be directly suppressed by PPARalpha, but i

170 Thus, analyzing the effects of the astrocyte secretome may provide valuable insight into these neurop

171 upregulated MAPK signaling in the pancreatic secretome may reflect the pathophysiological development

172 lex multifaceted mechanisms of action behind secretome-mediated interdomain communication at the gut-

173 Whether cells and secretomes mediating MF represent therapeutic targets in

174 an et al. propose that ribosomes translating secretome messenger RNAs (mRNAs) traffic from the cytoso

175 levels can provide insights into regulation, secretome, metabolism, and human diseases.

176 n of alpha-l-arabinofuranosidases within the secretome of A. niger grown on arabinan.

177 Here we define the complete secretome of A. nosocomialis strain M2 in minimal medium

178 rometry was used to identify proteins in the secretome of aCPCs and nCPCs, and the literature-based n

179 A proteomic analysis of the secretome of adult mouse cardiac fibroblasts upon digest

180 ST266, the biological secretome of Amnion-derived Multipotent Progenitor cells

181 ete protein spots was altered in the biofilm secretome of an mep72 mutant, including type III secreti

182 Finally, evaluation of the secretome of astrocytes grown in monolayer identified a

183 related pathways were overrepresented in the secretome of ATP-stimulated cells.

184 Finally, the secretome of B. subtilis might be used for the green syn

185 The secretome of cancer and stromal cells generates a microe

186 Here, we show that the secretome of cancer cells is by itself able to induce co

187 be found with much higher concentrations in secretome of cancer tissues vs. normal ones.

188 hypothesize that in disease the inflammatory secretome of cardiac human MSCs (hMSCs) remodels and can

189 cytometry to profile protein expression and secretome of cells from patients with pulmonary fibrosis

190 t and angiogenesis due to alterations in the secretome of CMV-infected cells.

191 identified specific pathways affected by the secretome of CPCs in the setting of myocardial infarctio

192 NF-kappaB activation, we have dissected the secretome of cultured cHL cells by chromatography and su

193 The secretome of ERK3-deficient cells is defective in chemot

194 detected as novel candidate proteins in the secretome of HEK-293 cells.

195 ences the phenotypic characteristics and the secretome of human cardiac progenitor cells (CPCs), and

196 Here we compare the secretome of human mammary normal and cancer-associated

197 The secretome of hypoxic palmitate-treated macrophages promo

198 Furthermore, the secretome of MaR1-treated bone marrow-derived macrophage

199 The tumour-promoting secretome of melanoma cells treated with the kinase inhi

200 we demonstrate that PGC-1alpha modulates the secretome of mouse embryonic fibroblasts.

201 , data suggests that DSBs inflicted by SecA2 secretome of Mtb provides survival niche through activat

202 Proteomics analysis of the secretome of murine aortic smooth muscle cells, after mi

203 First, we demonstrated that the secretome of obese adipocytes decreased the expression o

204 Mass spectrometric analysis of the secretome of P. aeruginosa derived from an acute infecti

205 results provide molecular insights into the secretome of P. destructans, and identify serine endopep

206 es of human ileal tissue, we showed that the secretome of peripheral blood mononuclear cells (PBMCs)

207 Finally, we discovered that the secretome of phagocytic microglia limits the production

208 ding enzymes, are integral components of the secretome of Pleurotus ostreatus, a white rot fungus.

209 s obtained by repeated freeze-thawing or the secretome of PRF membranes, termed PRF conditioned mediu

210 ted approach is feasible for analysis of the secretome of primary cardiomyocytes without serum starva

211 y-based approach allows investigation of the secretome of primary cardiomyocytes.

212 tative proteomics pipeline for analyzing the secretome of primary human umbilical vein endothelial ce

213 ibited the production of the proinflammatory secretome of senescent cells using a JAK inhibitor (JAKi

214 as inflammatory mediators that demarcate the secretome of senescent cells, also referred to as the se

215 We show that the secretome of senescent fibroblasts, which are selectivel

216 Furthermore, the secretome of the broad host range AG8 isolate may be sha

217 The secretome of the cellulolytic model fungus Trichoderma r

218 with genes encoding the surface proteome and secretome of the parasite.

219 R constitute a major folding machine for the secretome of this organism.

220 uantitative mass spectrometry to compare the secretome of wild-type B. thailandensis to that of a mut

221 sed a proteomic approach to characterize the secretome of X. fastidiosa, both in vitro and in planta,

222 inhibitor I9 domain was more abundant in the secretomes of a wide range of necrotising fungi relative

223 Unlike the secretomes of cellulolytic fungi, which typically compri

224 matography-mass spectrometry analysis of the secretomes of encapsulated organisms yielded detailed ge

225 eted by PEL cell lines after comparison with secretomes of human cell lines representative of diverse

226 secretion of cellular IL-10 and CCL8 in the secretomes of latently infected cells.

227 As such, the nature of the microbial secretome often influences the function of a community (

228 n secretomes, impact of lactic acid bacteria secretomes on host-pathogen interactions, and the mechan

229 ancer-associated proteins from two procancer secretomes: one that included IL-6 (in cases of mild or

230 protection by cMSCs, and suggesting the cMSC secretome or its components as potential cell-free thera

231 s and regional differences in the epithelial secretome participating in RSV lower respiratory tract i

232 With the aid of secretome phage display, we identified a highly conserve

233 As a part of PMSC secretome, PMSC exosomes were isolated and extensively c

234 assays with human BEC secretome showed that secretome polarizes CD4 T cells toward a Th17 phenotype

235 omics enabled the identification of a unique secretome pool from these lignocellulose-degrading commu

236 Trapping of platelet secretome prepared ex vivo, or platelet-sized fluorosphe

237 ation in resistin release and the neutrophil secretome profile were observed following exposure to di

238 granule marker, and by determination of the secretome profile, using mass spectrometry.

239 s in other fungal genomes and found that the secretome profiles cluster the tested basidiomycetes int

240 c efficacy via spatiotemporal monitoring and secretome profiling.

241 onstrated by morphology, gene expression and secretome profiling.

242 Our study supports that ADSC and its secretome promote favorable conditions for normal breast

243 ce-associated secretory phenotype, and their secretome promotes vascular remodeling and angiogenesis.

244 Protein Atlas in which each gene encoding a secretome protein is annotated to provide an open-access

245 alysis revealed the interaction of DPSC/SCAP secretome proteins and these proteins were found to be a

246 Approximately one third of secretome proteins are exosomal; the remainder are from

247 iversity of PCWDEs, but without elevated SSP/secretome ratios.

248 not exosome-depleted, fractions of the hMSC secretome recapitulated the effects observed with hMSC c

249 hanges such as the production of a bioactive secretome, referred to as the senescence-associated secr

250 We expect that this secretome resource will provide the foundation for futur

251 Transfer of PCSK6-depleted cardiomyocyte secretome resulted in decreased expression of collagen I

252 Analysis of the Xf secretome revealed a putative lipase/esterase (LesA) tha

253 LC-MS/MS analysis of stem cell secretome revealed the presence of different proteins re

254 sing a proteomics approach with fractionated secretome samples, we were able to identify a spectrum o

255 Electrical lipidomics of the secretome shed new lights in cell free cancer diagnosis

256 Cell culture assays with human BEC secretome showed that secretome polarizes CD4 T cells to

257 The cancer-specific lung metastasis secretome signatures (LMSSs) displayed significant progn

258 The ADSC secretome significantly upregulated normal epithelial ce

259 ADSC/ADSC secretomes significantly stimulated proliferation, trans

260 This therapy-induced secretome stimulates the outgrowth, dissemination and me

261 enterica subsp. enterica serovar Typhimurium secretome (STS)-induced outcomes in human intestinal epi

262 Through the use of secretome studies, in vitro bacterial interaction assays

263 ng, functional analyses showed that the cMSC secretome suppressed apoptosis and preserved cardiac mit

264 Using a mouse model, we unravel a secretome switch in SCs that controls lymphatic behavior

265 When lymphatics are perturbed or the secretome switch is disrupted, HFs cycle precociously an

266 Eliminating exosomes from the cancer cell secretome, targeting Rab27a, abolished differentiation a

267 l cycle arrest and a complex proinflammatory secretome, termed the senescence-associated secretory ph

268 dentify proteins from the cardiomyocyte (CM) secretome that are directly targeted by the muscle-speci

269 One component of the secretome that is gaining increasing attention is the ex

270 in mammary fibroblasts induces an oncogenic secretome that remodels the extracellular milieu acceler

271 le cell cycle arrest and produce a bioactive secretome that remodels their microenvironment and engag

272 in whole body homeostasis through its varied secretome that targets distant adipose depots, skeletal

273 he neurogenic niche through the phagocytosis secretome, thereby supporting the long-term maintenance

274 enotype is accompanied by alterations in the secretome through the increased expression of pro-inflam

275 ADD dependent and identify the TRAIL-induced secretome to drive monocyte polarization to myeloid-deri

276 ectrical impedance spectroscopy (EIS) of the secretomes to detect the cancerous samples due to the li

277 dated this approach by showing enrichment of secretome transcripts at the endoplasmic reticulum, and

278 secretomes with polymyxin B agarose rendered secretomes unable to inhibit epithelial cell migration.

279 trometry-based proteomic analysis of the CAF secretome unraveled that hypoxic CAFs contributed to blo

280 SK9-interacting proteins in the HepG2 cells' secretome using co-immunoprecipitation combined with mas

281 ranule protein resistin and profiling of the secretome, using mass spectrometry.

282 The platform enables control of cells' secretome, viability, proliferation and differentiation,

283 The ADSC secretome was analyzed from five normal breast reduction

284 oad efficacy or host specificity, a combined secretome was constructed from a monocot specific isolat

285 The adipogenic property of the atrial secretome was enhanced in AF patients.

286 We tested if the secretome was involved in BRF1-driven tumorigenesis.

287 In Experiment 4, tissue secretome was obtained from ex-vivo culture of these pai

288 relevance of the p95HER2-induced senescence secretome, we show that p95HER2-induced senescent cells

289 The secretomes were analyzed using two complementary mass sp

290 nctional classification showed that PEL cell secretomes were enriched in proteins specifically involv

291 ADSC/ADSC secretomes were tested for their influence on the functi

292 ts of glutathionylation, particularly in the secretome where the protein concentration is much lower,

293 IL-1 controls the late arm of the senescence secretome, which consists of proinflammatory cytokines i

294 The cancer secretome, which resembles the parent cell make-up, is c

295 nce of deleterious OIS- or TIS-related tumor secretomes, which can promote both drug resistance and t

296 Secretome-wide predictions and confocal microscopy revea

297 t proteomic methods used to characterize the secretome will be necessary to provide further insight i

298 mal sheath proteins in the dermal fibroblast secretome with aging.

299 ds are the main dielectric components of the secretome with respect to proteins and ions.

300 LPS depletion of S. marcescens secretomes with polymyxin B agarose rendered secretomes