ライフサイエンスコーパス: secretory

1 ated paracellular HCO(3) (-) flux was weakly secretory.

2 calculated paracellular HCO(3) (-) flux was secretory.

3 of CAFs with diverse roles, fibrogenic, and secretory.

4 in almost all species and, in the majority, secretory.

5 for an unappreciated degree of cellular and secretory activity in the steady state venom gland relat

6 These networks appear to govern the secretory activity of the whole islet and be affected in

7 ate lineages that develop into surface mucus secretory and ciliated cells and then contrasts these to

8 cellular traffic between compartments of the secretory and endocytic pathways is mediated by vesicle-

9 line governs important intestinal epithelial secretory and immune functions through its actions on ep

10 Translocation of secretory and integral membrane proteins across or into

11 ructure called the conoid that organizes the secretory and invasion machinery critical for the parasi

12 c reticulum (ER) is the site of synthesis of secretory and membrane proteins and contacts every organ

13 s as well as the changes that occur in these secretory and signalling pathways in obesity.

14 on between identical cell types (suprabasal, secretory, and multiciliated cells) from the nose (MUC4,

15 ase of virions in extracellular vesicles via secretory autophagy.

16 ab GTPases and SNARE complexes implicated in secretory but not degradative autophagy and occur with s

17 n vitro, while in vivo they generated highly secretory but poorly proliferating and hypocellular tumo

18 and CXCR2 signaling alter CAFs, producing a secretory CAF phenotype with low fibrogenic features; an

19 trate that oncogenic Kras is associated with secretory CAFs and that CXCR2 inhibition promotes activa

20 of endodermal origin are composed of highly secretory cancer cells that must adapt endoplasmic retic

21 YRF was expressed in the well-differentiated secretory cancer cells, but not in the poorly differenti

22 n, islet macrophages also impair the insulin secretory capacity of beta-cells.

23 ATP sensing in macrophages may reduce their secretory capacity.

24 uman intestinal organoids and elevated GLP-1 secretory capacity.

25 mpanies loss of beta-cell functional insulin secretory capacity.

26 patients, possibly explaining their impaired secretory capacity.

27 stion, we modified a regulatable fluorescent secretory cargo by adding a vacuolar targeting signal.

28 r this purpose initially block export of the secretory cargo from the endoplasmic reticulum (ER) and

29 ors, such as myosin XI, associate with their secretory cargo to support the ubiquitous processes of p

30 etory protein ESCargo (Erv29/Surf4-dependent secretory cargo) and demonstrate its utility not only in

31 f maturation, significantly before exit of a secretory cargo.

32 hanisms controlling the sorting of regulated secretory cargoes (soluble and transmembrane) away from

33 However, previously developed regulatable secretory cargoes are often tricky to use or specific fo

34 dding kinetics of constitutive and regulated secretory cargoes.

35 ing during TANGO1-mediated transfer of bulky secretory cargos from the ER to the ERGIC/Golgi via a tu

36 Here, we discovered that transmembrane secretory cargos, such as interleukin 2 receptor alpha s

37 Asic1 was detected in all secretory cell types, Asic2 in gonadotrophs, thyrotrophs

38 The Drosophila tubule has 2 main secretory cell types: active cation-transporting princip

39 ing smoking decreases the abundance of these secretory cells and reduces ACE2 levels.

40 ss GPR68 gene and protein, whereas excitable secretory cells express ASIC genes and proteins.

41 g additional omics data, we find that highly secretory cells have adapted to reduce expression and se

42 strate that ACE2 is expressed in a subset of secretory cells in the respiratory tract.

43 e deregulation of marker genes for basal and secretory cells upon CS exposure.

44 a gene expression signature associated with secretory cells, and generated more cells in the secreto

45 ailors the transcriptome during formation of secretory cells, boosting their protein production and s

46 generation following a near complete loss of secretory cells, however, may involve cellular plasticit

47 ing and locomotive behavior and other likely secretory cells, suggesting contributions to regulated e

48 ivity to signals that mobilise ER calcium in secretory cells.

49 eal absorptive enterocytes, and nasal goblet secretory cells.

50 de in the pars intercerebralis (PI), a neuro-secretory center in the brain involved in homeostatic co

51 of diabetes and leads to a revised model of secretory changes in the diabetogenic process.

52 corpora lutea formation, as well as lack of secretory changes in the endometrium.

53 acokinetic study to compare GFR with tubular secretory clearance for predicting kidney drug eliminati

54 ght linkage between GFR and proximal tubular secretory clearance in stable outpatients provides some

55 with similar predictive accuracy of iGFR and secretory clearances.

56 cannot transport xylose precursors into the secretory compartment is severely attenuated in virulenc

57 EC16A and could localize to the juxtanuclear secretory compartment.

58 where the N-terminal domain of pIgR, termed secretory component (SC), is proteolytically cleaved and

59 the polymeric Ig-receptor ectodomain, called secretory component (SC).

60 e joining chain (JC) and in complex with the secretory component of the pIgR.

61 an be competitively inhibited by recombinant secretory component protein.

62 protein compositions, and package different secretory contents alongside insulin.

63 agic defects at permissive temperature and a secretory defect at restrictive temperature.

64 d metabolic dysfunction of beta-cells elicit secretory defects associated with type-1 or type-2 diabe

65 Chronic cholestasis results from bile secretory defects or impaired bile flow with few effecti

66 aganglionosis, and nonrecoverable congenital secretory diarrhea.

67 tion results in intestinal fluid loss during secretory diarrheas, whereas CFTR mutations underlie cys

68 oxigenic Escherichia coli (ETEC) cause acute secretory diarrhoea in pigs, posing a great economic los

69 t evidence that NOTCH3 functions to restrain secretory differentiation.Conclusions: Basal cells are d

70 imated, is a useful surrogate for predicting secretory drug clearances in such patients.

71 nti-inflammatory, anti-nociceptive, and anti-secretory effects.

72 mune disease characterized by dysfunction of secretory epithelia with only palliative therapy.

73 Both secretory epithelial and stromal cells expressed Ki67 th

74 miR-181a is able to transform fallopian tube secretory epithelial cells through the inhibition of RB1

75 n that the precursors of HGSC originate from secretory epithelial cells within the Fallopian tube, wh

76 nsporter may explain the observed defects in secretory epithelium function in NGLY1 deficiency patien

77 P explants, we observed calcium activity and secretory events that increased in frequency following d

78 ytic Mt-derived HN could act as a beneficial secretory factor, including when transported within Mt t

79 Tumor-derived secretory factors orchestrate splenic hematopoietic and

80 associated with KS formation has focused on secretory factors.

81 lated islets to nobiletin enhanced beta-cell secretory function in a Bmal1-dependent manner.

82 male gametophyte, governing the conventional secretory function of the exocyst, analogous to EXO70A1

83 Salivary glands exert exocrine secretory function to provide saliva for lubrication and

84 A control, but instead accompanies increased secretory functions.

85 The secretory granule has an acidic pH but, on exocytosis, t

86 ower insulin content and abnormal dense-core secretory granule morphology.

87 the covalent cross-linking of proinsulin and secretory granule peptides.

88 tly linked to one another or to fragments of secretory granule proteins or other islet-derived protei

89 amyloid the pH increases from acidic in the secretory granule to neutral level in the blood, thus it

90 ally active molecules stored in long-lasting secretory granules (SGs) are secreted in response to ext

91 Within the pancreatic beta-cells, insulin secretory granules (SGs) exist in functionally distinct

92 ion of neuropeptides and peptide hormones by secretory granules (SGs) is central to physiology.

93 Insulin secretory granules (SGs) mediate the regulated secretion

94 The discovery of atrial secretory granules and the natriuretic peptides stored i

95 n be stored as amyloid fibrils within acidic secretory granules before release into the blood stream.

96 in a functional amyloid state within acidic secretory granules before they are released into the blo

97 ively stained in the Golgi apparatus, and no secretory granules formed for this variant, impairing it

98 egulating Zn(2+) accumulation in the insulin secretory granules of pancreatic beta cells.

99 Insulin is stored in secretory granules to facilitate rapid release in respon

100 nation of pituitary glands revealed that the secretory granules were significantly decreased in pitui

101 In cells lacking secretory granules, expression of exogenous PAM led to t

102 tion of exocytosis of the insulin-containing secretory granules.

103 of GTPases that allows controlled release of secretory granules.

104 release of inflammatory mediators stored in secretory granules.

105 ria revealed a 13-fold drop in the number of secretory granules.

106 intracellular HBV RNA (44-77% reduction) and secretory HBsAg (25-81% reduction), and 12 mutants had a

107 Metabolic and secretory heterogeneity are fundamental properties of pa

108 mice, and a reduced luminal concentration of secretory IgA (SIgA) following infection with C rodentiu

109 e pilus shaft protein, by naturally acquired secretory IgA (sIgA).

110 In the gut lumen, secretory IgA binds pathogens and toxins but also the mi

111 We further demonstrate that mucosal secretory IgA is not recognized by FCRL4 and that system

112 When converted to secretory IgA, MAb326 also neutralizes authentic SARS-Co

113 s to explore the association between natural secretory immunoglobulin A (sIgA) capsular antibodies in

114 Secretory immunoglobulin A (SIgA) is the single most abu

115 Secretory immunoglobulin A (sIgA) represents the immune

116 st immunity pathway that involves intestinal secretory immunoglobulin A (sIgA).

117 Secretory KI ameloblasts also lacked Tomes' processes, c

118 etory cells, and generated more cells in the secretory lineage compared with control mice.

119 progenitor cells to differentiate along the secretory lineage.

120 ed cellular diversity via differentiation of secretory lineages.

121 ISCs, restricting their differentiation into secretory lineages.

122 e in the expression of key components of the secretory machinery of beta-cells, resulting in impaired

123 E effectors that is recognized by plant cell secretory machinery to redirect these peptides from the

124 The ability of small secretory microvesicles known as exosomes to influence n

125 cantly suppressed angiogenesis by increasing secretory miR-23c level in the exosomes.

126 We find TMPRSS2 is part of a mucus secretory network, highly upregulated by type 2 (T2) inf

127 eted, ranging from hemoglobin degradation to secretory organelle protein processing for egress, invas

128 called the apical complex to organize their secretory organelles and invasion machinery.

129 the apical complex, a structure composed of secretory organelles and specific cytoskeletal elements.

130 dependent exit route of flaviviruses in LC3+ secretory organelles that enables them to evade circulat

131 asite is modified by the parasite, using its secretory organelles.

132 mic reticulum (ER) is the entry point to the secretory pathway and major site of protein biogenesis.

133 s, ER luminal chaperones are swept along the secretory pathway and must be retrieved to maintain cell

134 (TFG), previously known to regulate the cell secretory pathway and to be rearranged in thyroid and lu

135 Most proteins in the secretory pathway are glycosylated.

136 lycosylation events that happen early in the secretory pathway are often dysregulated during tumorige

137 t evidence implicating proteins of the early secretory pathway as potential antiviral targets with ef

138 mpartment-resident ATP-powered calcium pump (secretory pathway calcium ATPase 1 [SPCA1]) encoded by t

139 e that Gbeta5-R7 plays a role in the insulin secretory pathway downstream of signaling via all GPCRs

140 EVs may serve as a novel secretory pathway for S. aureus to transport protected c

141 and PRV laboratories have identified a Rab6 secretory pathway for the transport of single enveloped

142 Here we delineate the core secretory pathway functions and integrate them with geno

143 microneme protein 7 (MIC7), which enters the secretory pathway in an unconventional fashion with the

144 oplasmic reticulum transport of GluK2 in the secretory pathway in heterologous cells and primary neur

145 he molecular machines operating in the early secretory pathway in the biogenesis of SARS-CoV-2 and th

146 king for egress rather than the biosynthetic secretory pathway more commonly used by other enveloped

147 bserve that GLUT4 transits through the early secretory pathway more slowly than the constitutively se

148 t a complex set of interactions occur in the secretory pathway of infected cells to ensure proper gly

149 ate maintenance of organelle identity in the secretory pathway relies on retention and retrieval of r

150 somatic mutations in proteins handled by the secretory pathway that impede their folding.

151 represents a knowledgebase of the mammalian secretory pathway that serves as a novel tool for system

152 re extensively processed as they transit the secretory pathway to generate diverse glycans on cell su

153 et of membrane-anchored proteins through the secretory pathway to the plasma membrane.

154 If these proteins are directed into the secretory pathway with a signal/leader sequence, they wi

155 e partially processed precursors through the secretory pathway, and for subsequent post-translational

156 In the secretory pathway, misfolded asparagine (N)-linked glyco

157 reticulum to folding and trafficking via the secretory pathway, optimization of antigenic cargo, fina

158 lum (ER), acting as gatekeepers to the early secretory pathway, yet little is known about their cellu

159 Therefore, secretory pathway-mediated assemblage and excretion of i

160 nsport and maintain homeostasis in the early secretory pathway.

161 t at the plasma membrane, but throughout the secretory pathway.

162 (TANGO1) proteins play pivotal roles in the secretory pathway.

163 ticulum (ER) and delivered to myelin via the secretory pathway.

164 cantly faster kinetics than the conventional secretory pathway.

165 tory for producing proteins destined for the secretory pathway.

166 disulfide bonds during transport through the secretory pathway.

167 ation of misfolded MUC1 protein in the early secretory pathway.

168 ynthesized proteins are exported through the secretory pathway.

169 nalysis of single-pass transport through the secretory pathway.

170 hondria, endoplasmic reticulum, and the late secretory pathway.

171 wide array of precursor proteins within the secretory pathway.

172 fect KOR1 transport at various stages in the secretory pathway.

173 y imaging a cargo protein as it transits the secretory pathway.

174 ng events in consecutive compartments of the secretory pathway.

175 arge numbers of kinase substrates within the secretory pathway.

176 ipid biosynthesis and the entry site for the secretory pathway.

177 Further investigations of unconventional secretory pathways for LLSP secretion may shed light on

178 ze sorting to the constitutive and regulated secretory pathways in real time.

179 iological significance of the unconventional secretory pathways that cells use to release LLSPs.

180 nipulates cellular processes associated with secretory pathways within an infected cell to facilitate

181 F in the control of ER homeostasis in highly secretory PDAC cells.

182 The Vgf gene encodes a secretory peptide precursor protein that has critical ne

183 an cells that phenocopy murine CD122+Macs in secretory phase endometrium during the implantation wind

184 he p16Ink4a may induce senescence-associated secretory phenotype (SASP) and IL-6 expression.

185 senescent markers and senescence-associated secretory phenotype (SASP) components.

186 hat senescence and its senescence-associated secretory phenotype (SASP) contribute to chemotherapy-in

187 terize the age-related senescence-associated secretory phenotype (SASP) gene expression profile.

188 joint tissues, and the senescence-associated secretory phenotype (SASP) has been implicated in cartil

189 The senescence-associated secretory phenotype (SASP) has recently emerged as a dri

190 ectively decreased the senescence-associated secretory phenotype (SASP) of IVD cells.

191 P1 loss reprograms the senescence-associated secretory phenotype (SASP) of senescent tumor cells thro

192 ing therapy produces a senescence-associated secretory phenotype (SASP) that includes pro-angiogenic

193 promotes inflammatory senescence-associated secretory phenotype (SASP) through recognizing cytoplasm

194 tance, production of a senescence-associated secretory phenotype (SASP), mitochondrial dysfunction, a

195 molecules, termed the senescence-associated secretory phenotype (SASP), which is correlated with can

196 senescence through the senescence-associated secretory phenotype (SASP).

197 secretome, termed the senescence-associated secretory phenotype (SASP).

198 s or inhibitors of the senescence-associated secretory phenotype (SASP).

199 es, collectively named senescence-associated secretory phenotype (SASP).

200 me, referred to as the senescence-associated secretory phenotype (SASP).

201 entate gyrus display a senescence-associated secretory phenotype and reinforce NK cell activities and

202 ent development of the senescence-associated secretory phenotype and tumour progression.

203 ted DNA damage and the senescence-associated secretory phenotype are preferentially associated with o

204 coincided with reduced senescence-associated secretory phenotype complexity.

205 The activation of the senescence-associated secretory phenotype fuels further 'inflammatory storms',

206 Investigations into the mixed muscle-secretory phenotype of cardiomyocytes from the atrial ap

207 -derived IL1beta promoted the activation and secretory phenotype of quiescent pancreatic stellate cel

208 to the activation of a senescence-associated secretory phenotype, amplify the impact of cell-intrinsi

209 ent and induction of a senescence-associated secretory phenotype, and provides an overview of cellula

210 er reverse organ fibrosis nor the associated secretory phenotype, favoring the exciting notion that t

211 lly accompanied by the senescence-associated secretory phenotype, which modulates tissue homeostasis.

212 ine manner through the senescence-associated secretory phenotype.

213 s (HSCs), exhibiting a senescence-associated secretory phenotype.

214 This complexity of beta-cell secretory physiology establishes a direct link between g

215 both currents increased the excitability of secretory pituitary cells, consistent with their potenti

216 transfers paucimannose structures to nascent secretory polypeptides.

217 cifically biased toward the expansion of the secretory primed basal cell subset in IPF.

218 Secretory primed basal cells include an overlapping mole

219 nd that basal cells included multipotent and secretory primed subsets in control adult lung tissue.

220 tered adipocyte gene expression and cytokine secretory profiles, which were also associated with bioe

221 tion, with contributions from absorptive and secretory progenitors.

222 racterized by stable cell-cycle arrest and a secretory program that modulates the tissue microenviron

223 nsgenic overexpression of Vegfc in club cell secretory protein (CCSP)/VEGF-C mice reduced macrophage

224 Human epididymis secretory protein 4 (HE4) is a newly discovered key mole

225 Combining the secretory protein database with RNA-sequencing and quant

226 Here we term this regulatable secretory protein ESCargo (Erv29/Surf4-dependent secreto

227 N-linked glycans commonly contribute to secretory protein folding, sorting, and signaling.

228 The fluorescent secretory protein forms aggregates in the ER lumen and c

229 In addition to promoting secretory protein maturation, enveloped viruses also uti

230 recently optimized an artificial fluorescent secretory protein that exits the ER with the aid of the

231 Beet cyst nematodes depend on a set of secretory proteins (effectors) for the induction and mai

232 These proteins, termed leaderless secretory proteins (LLSPs), comprise proteins directly o

233 Therefore, identifying human saliva-secretory proteins and further detecting protein biomark

234 Many secretory proteins are activated by cleavage at specific

235 In the endoplasmic reticulum (ER), secretory proteins are packaged into COPII vesicles that

236 are only a few methods for predicting saliva-secretory proteins based on conventional machine learnin

237 CapsNet-SSP by comparison with human saliva-secretory proteins from existing studies and known saliv

238 ed on CapsNet is proposed to identify saliva-secretory proteins from the sequence information; (2) th

239 sized convolution kernels to identify saliva-secretory proteins only from sequence information.

240 performs existing models; and (3) the saliva-secretory proteins predicted by our model are statistica

241 profiles and protein sequences, 76 mosquito secretory proteins that are highly expressed in midguts

242 PORTANCE N-linked glycans are transferred to secretory proteins upon entry into the endoplasmic retic

243 is and lead to the accumulation of misfolded secretory proteins, a condition referred to as ER stress

244 To identify affected secretory proteins, miR-144 treated endothelial cell cul

245 encoding highly glycosylated, cysteine-rich secretory proteins, thus preventing ER overload.

246 ular matrix as well as senescence-associated secretory proteins.

247 and thus hold promise for predicting saliva-secretory proteins.

248 een HIV type 1 (HIV-1) and KSHV, focusing on secretory proteins.

249 sine induced a robust CFTR-mediated chloride secretory response together with cAMP-mediated inhibitio

250 of SGLT2 protein and variability in glucagon secretory responses contribute to interindividual differ

251 ntinuous glucose monitoring (CGM), beta cell secretory responses from a glucose-potentiated arginine

252 T C-peptide groups did not exhibit beta cell secretory responses to hyperglycemia, whereas the high C

253 Organellar and secretory RNases, associated with different cellular com

254 sphingolipid metabolism turned out to be the secretory route of newly synthesized Rhodopsin, a major

255 Secretory (S) Immunoglobulin (Ig) A is the predominant m

256 Secretory solute clearance measurements can predict kidn

257 secretion score as the scaled average of the secretory solute clearances.

258 l hazards regression to test associations of secretory-solute clearances with CKD progression and mor

259 urine concentrations of endogenous candidate secretory solutes at baseline, using targeted liquid chr

260 oncomitantly, we quantified eight endogenous secretory solutes in plasma and urine using liquid chrom

261 ficance of the kidney's clearance of tubular secretory solutes is uncertain.

262 This suggests that tubular clearance of secretory solutes provides additional information about

263 secretion score (24.1%); MPEs for individual secretory solutes ranged from 27.3% to 48.0%.

264 found lower kidney clearances of endogenous secretory solutes to be associated with CKD progression

265 Delta-like canonical Notch ligand and other secretory-specific transcription factors.

266 d may therefore convey information about the secretory state of beta-cells via vagal afferent nerves.

267 tein convertases (PCs) form a family of nine secretory subtilisin-like serine proteases, seven of whi

268 ross broad time scales, but how the dopamine secretory system is built to support fast and slow neuro

269 Among many glycoproteins within the plant secretory system, KORRIGAN1 (KOR1), a membrane-anchored

270 f U21 from the ER as it traffics through the secretory system.

271 with lipid droplets within the endomembrane-secretory system.

272 of 72 patients with symptomatic GOR off anti-secretory therapy was conducted.

273 e steady state venom gland relative to other secretory tissues and identify vacuolar ATPases as the l

274 ers of the pancreas, mammary gland and other secretory tissues, as well as an interferon-inducible pr

275 idylinositol 4-phosphate (PI4P), coordinates secretory trafficking and plasma membrane function.

276 dicate a novel role for CRT in promoting the secretory trafficking of a protein that forms polymers a

277 nderstanding of the factors that control the secretory trafficking of ATZ and their regulation by CRT

278 Inefficient secretory trafficking of ATZ in the absence of CRT is co

279 um (ER) glycoprotein chaperone, promotes the secretory trafficking of ATZ, enhancing the media:cell r

280 ated chaperone calnexin does not enhance ATZ secretory trafficking, despite the higher cellular abund

281 r disrupt the endoplasmic reticulum (ER) and secretory transport, but their role in infection is unkn

282 erform overlapping functions in vacuolar and secretory transport.

283 ork (TGN) is a central trafficking hub where secretory, vacuolar, recycling, and endocytic pathways m

284 rns or organizing 'elements' that facilitate secretory vesicle fusion and the subsequent exocytosis o

285 cally, amisyn interferes with the priming of secretory vesicles and the sizes of releasable vesicle p

286 Here, we show that Rab6-positive secretory vesicles are transported from the Golgi appara

287 -formed specific and gelatinase granules and secretory vesicles contained complex N- and O-glycans wi

288 Dense-core vesicles (DCVs) are secretory vesicles found in neurons and endocrine cells.

289 c42-directed GTPase-Activating Proteins with secretory vesicles increases the distance moved.

290 lated release of neurotransmitters stored in secretory vesicles through SNARE-mediated exocytosis.

291 ut the essential Sec4-dependent transport of secretory vesicles to sites of polarized growth.

292 n, is a Rab effector responsible for docking secretory vesicles to the plasma membrane before exocyto

293 omplex responsible for specific targeting of secretory vesicles to the plasma membrane.

294 nd high-affinity docking of large dense core secretory vesicles to the plasma membrane.

295 n, retention of synaptotagmin-1-positive EYS secretory vesicles within the outer nuclear layer, and d

296 icles that, while distinct from constitutive secretory vesicles, are dependent on actin and Myo2 func

297 anuphilin is involved in membrane docking of secretory vesicles.

298 , serving as a signal for cargo loading into secretory vesicles.

299 exit) and control the binary fate decision (secretory vs enterocyte lineage) by repressing genes reg

300 on +4/5 regulates their specification toward secretory vs enterocyte lineages (binary fate).