ライフサイエンスコーパス: secretory IgA

1 and IgG antibodies, including subclasses and secretory IgA.

2 ate host defense mechanisms and secretion of secretory IgA.

3 ecretion of IgM can compensate for a lack of secretory IgA.

4 f immunization for preferential induction of secretory IgA.

5 nd male genital tracts contain more IgG than secretory IgA.

6 ed for lactadherin, butyrophilin, mucin, and secretory IgA.

7 elium and releases it into the cyst lumen as secretory IgA.

8 ous ligands C1q, mannose-binding lectin, and secretory IgA.

9 howed stronger bacterial neutralization than secretory IgA.

10 of the polymeric immunoglobulin receptor and secretory IgA.

11 e, correlating to elevated levels of urinary secretory IgA.

12 ounts of gp41-specific IgG but low levels of secretory IgA.

13 serum immunoglobulin G (IgG) and intestinal secretory IgA.

14 th substrate specificity for human serum and secretory IgAs.

15 Monomeric, dimeric, polymeric, and secretory IgA(2) derivatives of b12 reacted with gp120 a

16 in the respiratory tract, increased specific secretory IgA Ab in the vaginal and rectal tracts, and i

17 roduced higher titers of Ag-specific mucosal secretory IgA Ab levels when compared with MIP-1alpha.

18 st pathogens that complements the mucous and secretory IgA Ab-mediated system in the protection of in

19 DN elicited elevated levels of PspA-specific secretory-IgA Ab responses in external secretions and pl

20 protein A (PspA) would enhance PspA-specific secretory-IgA Ab responses, which could provide protecti

21 ectal mucosa that effectively stimulate both secretory IgA Abs and cytotoxic T lymphocytes in the gen

22 ls of BoNT-specific IgG Abs in plasma and of secretory IgA Abs in external secretions (nasal washes,

23 levels of OVA-specific IgG Abs in plasma and secretory IgA Abs in mucosal secretions (nasal washes, s

24 Both IgG and secretory IgA Abs in mucosal secretions have been implic

25 pecifically, SP contains naturally occurring secretory IgA Abs to environmental Ags of microbial orig

26 ated mice were found to contain neutralizing secretory IgA Abs.

27 Immune exclusion is performed mainly by secretory IgA, although there are back-up mechanisms in

28 ough induction of antimicrobial peptides and secretory IgA among others.

29 intranasally with the NP vaccines exhibited secretory IgA and a pronounced Th1-cell response, not se

30 by gel filtration from whole saliva or mixed secretory IgA and alpha-amylase, the high molecular weig

31 mice have fewer IgA(+) immune cells and less secretory IgA and IgA-promoting immune mediators.

32 GBOMP was an effective mucosal adjuvant for secretory IgA and IgG responses in the lungs of both mic

33 specific activity (percent inhibition/total secretory IgA and IgG) was strongly correlated with redu

34 D4+ T help, Th17, high avidity CD8+ CTL, and secretory IgA and IgG1 neutralizing Abs, at the site of

35 gens by promoting pIgR-mediated transport of secretory IgA and IgM into the airway.

36 ng potent Ab and T cell responses as well as secretory IgA and IL-17-producing resident memory T lymp

37 was inhibited while degranulation induced by secretory IgA and PMA was not inhibited.

38 se formulations also evoked antigen-specific secretory IgA and provided protection against anthrax le

39 Mepolizumab also enhanced secretory IgA and reduced tryptase in BAL fluid.

40 Here, we report that secretory IgA and secretory component preferentially act

41 contrast, neutrophils responded similarly to secretory IgA and serum IgA.

42 nt peanut allergen gene (pCMVArah2) produced secretory IgA and serum IgG2a.

43 Secretory IgA and systemic IgG converge to target gut mi

44 ficantly higher interleukin (IL)-6/IL-1beta, secretory IgA, and lower lysozyme, and histatins 1 and 5

45 oth serum immunoglobulin G (IgG) and mucosal secretory IgA anti-CFA/I; 40% of the animals produced an

46 Both CT-A/LT-B and LT-A/CT-B promoted secretory IgA anti-OVA Ab, which established their reten

47 Plasma IgA Abs as well as secretory IgA anti-PA Abs in saliva, nasal washes, and f

48 of anti-P1 serum immunoglobulin G (IgG) and secretory IgA antibodies and the subclass distribution o

49 Moreover, secretory IgA antibodies from immunized mice were shown

50 and leads to a rapid surge in maternal milk secretory IgA antibodies(5,6).

51 , prevention of SIV infection in macaques by secretory IgA antibodies, up-regulation of CC chemokines

52 ly elevated, as were total, IgG1, IgG2a, and secretory IgA antibody levels in bronchoalveolar lavage

53 the booster immunization, at which time the secretory IgA antibody levels were significantly higher

54 ines were more effective in inducing a local secretory IgA antibody response than a salivary or serum

55 e lamina propria, which give rise to mucosal secretory IgA antibody responses.

56 serum immunoglobulin G (IgG) and/or mucosal secretory-IgA antibody titers than the aroA vaccine stra

57 -low mice degrade the secretory component of secretory IgA as well as IgA itself.

58 ivery has yielded nasal vaccines that induce secretory IgA as well as serum IgG antibodies, which are

59 pes were expressed as monomeric, dimeric, or secretory IgA, as well as in an IgG1 backbone.

60 ely, IgG was detected in mucosal secretions; secretory IgA, as well as mucosal and systemic IgA Ab-se

61 barrier function was evaluated by measuring secretory IgA, bacterial adherence to the intestinal muc

62 In the gut lumen, secretory IgA binds pathogens and toxins but also the mi

63 passively protect the newborn via breastmilk secretory IgA but also actively stimulate and train the

64 nhibited by unlabeled secretory component or secretory IgA but not by serum IgA.

65 ates is monomeric; it cannot be converted to secretory IgA by T560 cells.

66 Indeed, secretory IgA can reduce in vitro budding and invasion o

67 h antigens since key host effectors, such as secretory IgA, can directly bind to such antigens in the

68 (pIgR)-binding site, which might explain why secretory IgA cannot initiate phagocytosis or bind to Fc

69 Secretory IgA (cervical IgA- and secretory piece-positiv

70 Consequently, secretory IgA competitively inhibited binding of vitrone

71 s, mucins, proline-rich proteins (PRPs), and secretory IgA complex.

72 n analysis adjusted for age at infection and secretory IgA concentration there was a significant diff

73 Secretory IgA contributes to humoral defense mechanisms

74 eosinophils were stimulated with immobilized secretory IgA, degranulation and superoxide production w

75 in vivo intracellular viral inactivation by secretory IgA during transcytosis is a mechanism of host

76 t effects and sufficient to transfer delayed secretory IgA expression.

77 specific intestinal T-cell populations, and secretory IgA expression.

78 Secretory IgA glycans bind gut bacteria, and an unusual

79 lymphoid tissue (GALT) in the production of secretory IgA has been well characterized.

80 ut microbiota composition in humans and that secretory IgA has evolved to maintain a diverse and stab

81 confers increased stability on the resultant secretory IgA; however, the effect of secretory componen

82 ncentrations of intact Abs (human serum IgA, secretory IgA, IgG, or mouse anti-HA mAb), monocytes wer

83 Eosinophils stimulated by immobilized secretory IgA, immobilized IgA, immobilized IgG, or TNF-

84 Soluble secretory IgA immune complexes also induced degranulatio

85 olonization and was correlated with a strong secretory IgA immune response.

86 Faecal secretory IgA immune responses were recorded against all

87 s that polymeric Ig receptor (pIgR)-mediated secretory IgA immunity could be impaired in chronic uppe

88 ll subsets associated with the generation of secretory IgA immunity, the regulation of mucosal commen

89 m antibody titers (log(10) mean value, 4.2), secretory IgA in bronchoalveolar lavage (BAL) fluid from

90 Geometric LS mean (95% CI) fecal secretory IgA in EG was twice that of CG [70 (57, 85) co

91 While secretory IgA in healthy controls targeted a defined sub

92 The relative importance of secretory IgA in host defense was further shown by the f

93 ic surgery regimen alters the level of fecal secretory IgA in humans.

94 The results demonstrate the critical role of secretory IgA in protection against pneumococcal nasal c

95 Despite its abundance, the precise role of secretory IgA in the intestinal lumen, where it coats a

96 The roles of IgG and secretory IgA in the protection of the respiratory tract

97 approximately one-third that of immobilized secretory IgA in the same experiments.

98 ng-lasting HIV-specific serum antibodies and secretory IgA in the secretory nasal, vaginal, and intes

99 Secretory IgA interacts with commensal bacteria, but its

100 anscytosis of IgA and increases secretion of secretory IgA into saliva.

101 Secretory IgA is important in mucosal defense, but other

102 nisms in place to induce oral tolerance when secretory IgA is lacking.

103 We further demonstrate that mucosal secretory IgA is not recognized by FCRL4 and that system

104 r aim in this study was to determine whether secretory IgA is sufficient for protection of Peyer's pa

105 gen, how they favor isotype switching to the secretory IgA isotype, and how their GC responses may un

106 Spike-specific secretory IgA level was also quantified at selected time

107 Urinary secretory IgA levels also correlated to the degree of tu

108 subclasses), IgA (including subclasses), or secretory IgA levels were seen, regardless of HIV status

109 Bona fide multimeric secretory IgA levels were significantly higher in indivi

110 mesenteric lymph node/body weight ratio, and secretory IgA levels.

111 and a subsequent increase in airway IgM and secretory IgA levels.

112 n devoid, assembled multivalent dimeric, and secretory IgA-like antibodies.

113 When converted to secretory IgA, MAb326 also neutralizes authentic SARS-Co

114 However, secretory IgA may be preferred because the polymeric com

115 Thus, our data suggest that secretory IgA may play a key role in preventing streptoc

116 ith plasma IgG Ab serving as the back-up for secretory IgA-mediated protection in the nasal compartme

117 nophil superoxide production stimulated with secretory IgA or secretory component but not with serum

118 a2 integrins in eosinophil interactions with secretory IgA or secretory component.

119 In contrast to the pronounced dominance of secretory IgA over other immunoglobulin isotypes in huma

120 assayed for amylase, lactoferrin, lysozyme, secretory IgA, peroxidase, and total protein.

121 IgA is represented by secretory IgA, polymeric IgA, and monomeric IgA.

122 humoral effector, IgG2a, and to some extent secretory IgA produce protective immunity against chlamy

123 homeostasis through their well-known role in secretory IgA production and their emerging role in muco

124 methasone-treated rats significantly impairs secretory IgA, promotes bacterial adherence to the mucos

125 The impact of secretory IgA, purified from breast milk (n = 9), on Can

126 Uremia did not affect secretory IgA release into the ileum lumen or mucosal le

127 In some cases, both a serum IgG and secretory IgA response are induced to the recombinant pr

128 ects, in contrast, developed a serum IgG and secretory IgA response to a 22 kD protein, whereas 7 of

129 chi10057(pYA5199) resulted in a significant secretory IgA response to LcrV.

130 influences the abundance and quality of the secretory IgA response toward commensal bacteria.

131 now show that the specificity of the mucosal secretory IgA response was also influenced by this MAb.

132 minant at all stages in the development of a secretory IgA response.

133 that the magnitudes of breast milk total and secretory IgA responses against a consensus HIV-1 envelo

134 t, the magnitudes of the breast milk IgA and secretory IgA responses against HIV-1 envelope proteins

135 The intestinal secretory IgA responses to FrgC were very similar in the

136 ization with LT via the skin induced mucosal secretory IgA responses to LT, protection could also be

137 Mucosal secretory IgA responses to oral or nasal vaccines were n

138 iter T1-SP10MN(A)-specific fecal and vaginal secretory IgA responses were observed, and the response

139 and consistent B pertussis-specific mucosal secretory IgA responses, whereas Tdap did not induce con

140 1 and type 2 biased vaccines induced similar secretory IgA responses.

141 ereas Tdap did not induce consistent mucosal secretory IgA responses.

142 th TS plus CpG induce TS-specific T-cell and secretory IgA responses.

143 n correlated with a reduction in CT-specific secretory-IgA responses in nasal passages and reproducti

144 immunoglobulin, breast milk (as a source of secretory IgA), ribavirin, and the anti-picornaviral age

145 high p.o. QS-21 doses triggered Ag-specific secretory IgA (S-IgA) Ab responses.

146 ol mice, but exhibited no IgE and negligible secretory IgA (S-IgA) Ab responses.

147 esponses with systemic IgG1, IgE and mucosal secretory IgA (S-IgA) antibodies (Abs).

148 affinity-purified immunoglobulin G (IgG) and secretory IgA (S-IgA) from immune secretions were adjust

149 Capsule-specific secretory IgA (s-IgA) in breast milk may enhance protect

150 Secretory IgA (S-IgA), a major humoral mediator of mucos

151 , including secreted immunoglobulins such as secretory IgA (S-IgA), which can bind and agglutinate ba

152 tors was identified to be the heavy chain of secretory IgA (S-IgA).

153 is study was designed to investigate whether secretory-IgA (S-IgA) Abs induced by a pneumococcal surf

154 e proportion of participants achieving nasal secretory IgA seroconversion against at least one B pert

155 with oral or nasal immunization enhanced the secretory IgA, serum IgG, and T cell responses.

156 IgG, but reduced IgA as well as low anti-OVA secretory IgA (SIgA )Ab responses in saliva and nasal wa

157 Secretory IgA (sIgA) Abs are polymeric Igs comprised of

158 atch M cells selectively bind and endocytose secretory IgA (SIgA) Abs.

159 mice immunized with Hcbetatre produced weak secretory IgA (sIgA) and plasma IgG Ab response.

160 lear to what extent antigen specific mucosal secretory IgA (SIgA) antibodies are induced by mRNA vacc

161 Endocervical secretions were analyzed for secretory IgA (sIgA) antibody against the B subunit of c

162 Mucosal IgA or secretory IgA (SIgA) are structurally equipped to resist

163 to IgA and secretory component revealed that secretory IgA (SIgA) dominated in all saliva samples.

164 mice, and a reduced luminal concentration of secretory IgA (SIgA) following infection with C rodentiu

165 ication or production of large quantities of secretory IgA (SIgA) for potential mucosal application h

166 tissue in rabbits, bind and retro-transport secretory IgA (sIgA) from the tear film.

167 Recent elucidation of the structure of secretory IgA (SIgA) has begun to shed light on SIgA fun

168 d to as p24 in the text) HIV antigen through secretory IgA (SIgA) in nasal mucosae in mice.

169 From very early in life, secretory IgA (SIgA) is found in association with intest

170 Secretory IgA (SIgA) is the primary mucosal Ig and has b

171 molecular weight salivary antigen and (iii) secretory IgA (sIgA) light chain and alpha-amylase.

172 We examined the relationship between secretory IgA (SIgA) on the mucosal surface of small air

173 Secretory IgA (sIgA) plays a critical role in providing

174 High and moderate oral fluid anti-spike (S) secretory IgA (SIgA) postinfection was associated with s

175 In mucosal sites, secretory IgA (SIgA) protects the host through immune-ex

176 e no significant differences for tear IgA or secretory IgA (sIgA) reactivity to hsp60 or for tear sIg

177 n contrast, all immunization routes elicited secretory IgA (sIgA) responses at multiple mucosal sites

178 Stimulation of FlaA-specific intestinal secretory IgA (sIgA) responses required immunization wit

179 tracts contain the immunoglobulins (Ig)G and secretory IgA (sIgA) that function together in host defe

180 , EDN (eosinophilic derived neurotoxin), and secretory IgA (sIgA) underwent comparative paired analys

181 ched mAbs that express well as monomeric and secretory IgA (SIgA) variants with high antigen-binding

182 s host proteins, including factor H (FH) and secretory IgA (sIgA) via the secretory component.

183 hat the aggregation of E. coli K-12 by human secretory IgA (SIgA) was dependent on the presence of th

184 calcium, iron, and zinc bound to human milk secretory IgA (sIgA) was investigated.

185 ycoprotein B (gB) neutralize, levels of IgG, secretory IgA (sIgA), and mucosal IgA1 antibodies to HCM

186 nflammatory markers fecal calprotectin (FC), secretory IgA (sIgA), beta-defensin 2 (HBD-2), fecal ela

187 Secretory IgA (SIgA), the most abundant antibody in huma

188 specific deficiency of B-lymphocyte-produced secretory IgA (sIgA), the primary effector molecule of m

189 mic changes in the levels of SFB coated with secretory IgA (sIgA), which resulted from the significan

190 dducts and have decreased levels of anti-MAA secretory IgA (sIgA).

191 e pilus shaft protein, by naturally acquired secretory IgA (sIgA).

192 al tract of suckling mammals, in the form of secretory IgA (SIgA).

193 omeric IgA [mIgA], polymeric IgA [pIgA], and secretory IgA [SIgA]) on OPC and susceptibility to cleav

194 he treated mice developed both serum IgG and secretory IgA specific for rNV.

195 IgG converges with nonoverlapping secretory IgA specificities to target the same bacteria.

196 th the functional importance of this natural secretory IgA, the mutant animals were more resistant to

197 IgA, were used to assess the contribution of secretory IgA vs total IgA in the induction of allergic

198 TS-specific secretory IgA was detectable in the tears of vaccinated

199 Although secretory IgA was found to be important for protection a

200 nd concentrations of butyrophilin, mucin, or secretory IgA was found.

201 Secretory IgA was less active than serum IgA1 and simila

202 HIV-specific secretory IgA was present in CVS of 10 (42%) of 24 women

203 n of at least one B pertussis-specific nasal secretory IgA was recorded in 79 (94% [95% CI 87-98]) of

204 ficantly lower at 4 mo (P < 0.0001), whereas secretory IgA was significantly higher at 12 mo of age (

205 knockout mice, which are devoid of serum and secretory IgA, were infected and then rechallenged with

206 cosal epithelium where it is cleaved to form secretory IgA, were used to assess the contribution of s

207 Secretory IgA, which targets enteric bacteria, regulates