ライフサイエンスコーパス: secretory granule

1 unusually rich in endolysosomal organelles (secretory granules).

2 e and functionality of a medically important secretory granule.

3 let amyloid polypeptide, all proteins of the secretory granule.

4 enzymatic processing events in the immature secretory granule.

5 ed to be stored as amyloids within endocrine secretory granules.

6 the proteins and peptides of the beta cells' secretory granules.

7 sized and endocytosed membrane proteins into secretory granules.

8 tion of exocytosis of the insulin-containing secretory granules.

9 elease, or (d) control the pH inside insulin secretory granules.

10 o detectable return of the mutant protein to secretory granules.

11 not affect receptor localization to insulin secretory granules.

12 ompartments, including synaptic vesicles and secretory granules.

13 R distention (ER-crowding) and deficiency of secretory granules.

14 uced secretion of MUC5AC from the post-Golgi secretory granules.

15 related with the V1-V0 association status in secretory granules.

16 ic compartment after permeabilization of the secretory granules.

17 ely, and located in the cytoplasm outside of secretory granules.

18 e probe (D1-SG) to measure calcium and pH in secretory granules.

19 ss activates at pH~5.5 within the dense core secretory granules.

20 utive pathway along with their entrapment in secretory granules.

21 of GTPases that allows controlled release of secretory granules.

22 release of inflammatory mediators stored in secretory granules.

23 sion of Muc6 and Tff2 and reduced numbers of secretory granules.

24 ling of the readily releasable pool (RRP) of secretory granules.

25 ocessed to CpepGFP that is co-stored in beta-secretory granules.

26 insulin and the presence of mature endocrine secretory granules.

27 tether formation between isolated eosinophil secretory granules.

28 13-2 priming requirement for a population of secretory granules.

29 adation was properly processed and sorted to secretory granules.

30 nzyme, and the return of internalized PAM to secretory granules.

31 M though the endocytic pathway and back into secretory granules.

32 function in the lumen of peptide-containing secretory granules.

33 sors, accumulating product peptide in mature secretory granules.

34 tion in turn modulating VWF trafficking into secretory granules.

35 s to segregate from each other into distinct secretory granules.

36 more likely to distribute homogeneously into secretory granules.

37 ase in the number of membrane-docked insulin secretory granules.

38 ial/lysosome trafficking, and generate large secretory granules.

39 ria revealed a 13-fold drop in the number of secretory granules.

40 upports the glucose-dependent recruitment of secretory granules.

41 tides to other peptides present in beta cell secretory granules.

42 , and responsible for zinc accumulation into secretory granules.

43 GFP localized to the trans-Golgi network and secretory granules.

44 nce of microvillus inclusions, and subapical secretory granules.

45 Ctr2 on the storage of proteoglycans in the secretory granules.

46 Under conditions mimicking the immature secretory granule (37 degrees C, pH 6), amylin forms amy

47 ofile of platelet dense-body granules, these secretory granules act according to general biochemical/

48 Syt isoforms are usually sorted to separate secretory granules and are differentially activated by d

49 n showed that CRF-BP was localized mainly in secretory granules and CRF2alphaR in the endoplasmic ret

50 ted with a significant decrease in number of secretory granules and features of crinophagy.

51 the isoforms of Rab3, is present on insulin secretory granules and has been implicated in regulation

52 B (CGB), a calcium binding protein found in secretory granules and in the lumen of the endoplasmic r

53 This serine protease is abundant in the secretory granules and is exocytosed upon bacterial chal

54 to label and then monitor synaptic vesicles, secretory granules and other endocytic structures in a v

55 MSC-derived JG-like cells contained renin in secretory granules and released active renin in response

56 mbrane, where it accumulated specifically at secretory granules and rendered them more prone to under

57 ic pigs showed a marked reduction of insulin secretory granules and severe dilation of the endoplasmi

58 Fusion of secretory granules and synaptic vesicles with the plasma

59 cells do indeed possess distinct subsets of secretory granules and that these subsets use different

60 und that myosin 1b controls the formation of secretory granules and the associated regulated secretio

61 The discovery of atrial secretory granules and the natriuretic peptides stored i

62 actomyosin complex promote the biogenesis of secretory granules and thereby regulate hormone sorting

63 oduced by endoproteolytic cleavage of PAM in secretory granules and transit of membrane PAM though th

64 transporter, which transports zinc into the secretory granule, and type II diabetes.

65 ease in the readily releasable pool (RRP) of secretory granules, and decreased stimulus-evoked Ca(2+)

66 unofluorescence shows PtdIns(3,4)P(2) at the secretory granules, and fluorescent PtdIns(3,4)P(2) can

67 in response to glucose, package insulin into secretory granules, and secrete quantities of insulin co

68 mers, how this relates to their packaging in secretory granules, and their molecular form in mucus re

69 steps are often observed and suggesting that secretory granules are preferentially released by compou

70 Thus, these secretory granules are tethered to their target plasma m

71 eptides stored in large dense core vesicles (secretory granules) are released through calcium-regulat

72 is likely to permit protein "packing" in the secretory granule at approximately 50% higher density th

73 he behavior of individual insulin-containing secretory granules at the plasma membrane of living cell

74 lts indicate that the ATPase activity of the secretory granule Atp8a1 is activated by phospholipids b

75 s document a process whereby the contents of secretory granules become available to the immune system

76 wed insights into the behavior of individual secretory granules before and during exocytosis.

77 n be stored as amyloid fibrils within acidic secretory granules before release into the blood stream.

78 Insulin is also stored within the secretory granules before secretion, and has been shown

79 in a functional amyloid state within acidic secretory granules before they are released into the blo

80 We show that F-actin is also involved in secretory granule biogenesis and that myosin 1b cooperat

81 etogranin III (SgIII) protein is involved in secretory granule biogenesis in mast cells.

82 Chromogranin A (CgA) may be critical for secretory granule biogenesis in sympathoadrenal cells.

83 Chromogranin A (CHGA) triggers catecholamine secretory granule biogenesis, and its catestatin fragmen

84 , a CgA-SgIII complex may play a key role in secretory granule biogenesis.

85 th the cis-Golgi, mucin O-glycosylation, and secretory granule biosynthesis.

86 to recruit F-actin to the Golgi region where secretory granules bud.

87 o-localized with insulin in Min6B1 beta-cell secretory granules but did not undergo plasma membrane t

88 essential for the recruitment of NMII to the secretory granules but plays a key role in the assembly

89 e signal peptide), were normally targeted to secretory granules, but nonetheless caused substantial E

90 propose that CgA promotes the biogenesis of secretory granules by a mechanism involving a granulogen

91 eptide, and proinsulin together with insulin secretory granules by electron microscopy.

92 ZCs, suggesting that MIST1 establishes large secretory granules by inducing RAB transcription.

93 go on the basis of their readily discernible secretory granules by routine histology, these cells are

94 Willebrand factor, which is stored in unique secretory granules called Weibel-Palade bodies (WPBs).

95 Secretory granules carrying fluorescent cargo proteins a

96 BH) within the lumen of the Golgi network or secretory granules, catalyzing the conversion of dopamin

97 e plane parallel to the plasma membrane that secretory granules change position within several hundre

98 Both CTSL and CTSB colocalize to the secretory granule compartment of skin mast cells.

99 e development and a deficiency in a specific secretory granule component.

100 ionic proteoglycans, these data suggest that secretory granule composition in mast cells is dependent

101 hat cell death was accompanied by leakage of secretory granule compounds into the cytosol and that th

102 GBF1 and the trafficking of VWF into forming secretory granules confirmed GBF1 is a limiting factor i

103 Their secretory granules contain four cytotoxic proteins, incl

104 cathepsin D, whereas regulated exocytosis of secretory granules containing histamine and TNF-alpha wa

105 as limited to the subpopulation of mast cell secretory granules containing serotonin and cathepsin D,

106 prohormones widely distributed in dense-core secretory granules (DCGs) of endocrine, neuroendocrine,

107 esses underlying the formation of dense core secretory granules (DCGs) of neuroendocrine cells are po

108 t cells are characterized by an abundance of secretory granules densely packed with inflammatory medi

109 ings implicate histone proteolysis through a secretory granule-derived serglycin-tryptase axis as a n

110 Consequently, secretory granules did not mature.

111 transition, DeltaPsi and ROS increased, and secretory granules disappeared.

112 techolamine release from cells as individual secretory granules discharge their contents during the p

113 the processes of movement and exocytosis of secretory granules do not significantly contribute to AT

114 -cell secretory machinery and contributes to secretory granule docking, most likely through interacti

115 eracts with membrane-bound components of the secretory granule-docking machinery and with the granule

116 telets based on several types of cytoplasmic secretory granules, each sequestering distinct chemical

117 of membrane-enclosed compartments, including secretory granules, endosomes, and lysosomes.

118 ssion and effector-cell responses, including secretory granule exocytosis and cytokine production.

119 Our findings imply that secretory granule exocytosis pathways in other cell type

120 r accumulated in the trans-Golgi network and secretory granule exocytosis was more responsive to secr

121 In cells lacking secretory granules, expression of exogenous PAM led to t

122 t cells is their high content of cytoplasmic secretory granules filled with various preformed compoun

123 esent CMV antigen to TH1 cells, co-opting MC secretory granules for antigen processing and presentati

124 MCs co-opt their secretory granules for antigen processing and presentati

125 otein family proposed to function in priming secretory granules for exocytosis.

126 e native disulfide bonds, and is exported to secretory granules for processing and secretion.

127 ecular events leading to hormone sorting and secretory granule formation at the level of the TGN are

128 ively stained in the Golgi apparatus, and no secretory granules formed for this variant, impairing it

129 The secretory granule-forming activity of a series of human

130 m defective formation and secretion of large secretory granules from Paneth and goblet cells.

131 During this process, secretory granules fuse with the plasma membrane and del

132 utant GCK proteins with a sensor for insulin secretory granule fusion also revealed that blockade of

133 jor Ca(2+) sensor for exocytosis, triggering secretory granule fusion and insulin secretion.

134 translocation occurs at the vicinity of the secretory granule fusion sites.

135 ing expression of beta-cell genes regulating secretory granule fusion.

136 The secretory granule has an acidic pH but, on exocytosis, t

137 ions of both proteins cluster at sites where secretory granules have docked.

138 investigate the fusion of individual natural secretory granules (i.e., chromaffin granules (CGs)) on

139 sistent with this, they lacked the prominent secretory granules identified by histochemistry and immu

140 The state of secretory granules immediately before fusion with the pl

141 their release of cognate neuropeptides from secretory granules in axon terminals.

142 es was an important step in the evolution of secretory granules in ciliates.

143 alyses confirmed that WFS1 also localizes to secretory granules in human neuroblastoma cells.

144 or the first time that DENV localizes within secretory granules in infected skin mast cells.

145 fluorophore) within the lumen of individual secretory granules in living chromaffin cells, and relat

146 zes formation and cargo storage of regulated secretory granules in neuroendocrine cells, contributes

147 the expression of CgA reduced the number of secretory granules in normal sympathoadrenal cells (PC12

148 Zymogen secretory granules in pancreatic acinar cells express tw

149 transmembrane protein that also localizes to secretory granules in pancreatic beta cells.

150 This was associated with the loss of secretory granules in PC, suggesting an increase in degr

151 te and release the contents of intracellular secretory granules in response to the cross-linking of F

152 destly enlarged acinar cells and accumulated secretory granules in salivary glands of Atg5(f/f);Aqp5-

153 sites of expression within A. caninum L3 to secretory granules in the glandular esophagus and the ch

154 produced as a component of Paneth cell (PC) secretory granules in the small intestine.

155 nduction of cytotoxic effector molecules and secretory granules, in situ motility, or ability to form

156 a plethora of bioactive compounds from their secretory granules, including mast cell-restricted prote

157 ecretion at millimolar concentrations within secretory granules inside the beta-cells.

158 The results show that secretory granules interact stochastically with a target

159 lg1 in controlling the formation of specific secretory granules involved in VWF exocytosis in endothe

160 oreover that 7B2-dependent routing of PC2 to secretory granules is cell line-specific.

161 The lipid composition of insulin secretory granules (ISG) has never previously been thoro

162 Our recent study of insulin secretory granules (ISG) suggested that phosphatidylseri

163 The intracellular life of insulin secretory granules (ISGs) from biogenesis to secretion d

164 In neuroendocrine PC12 cells, immature secretory granules (ISGs) mature through homotypic fusio

165 inc-sequestrating transporter in the insulin-secretory granules (ISGs) of pancreatic beta-cells.

166 y Protein (PSP) is bound to the membranes of secretory granules isolated from rat parotids.

167 l-Palade bodies within endothelial cells are secretory granules known to release von Willebrand Facto

168 chinery for sorting proteins into mucocysts, secretory granule-like vesicles in the ciliate Tetrahyme

169 ecovered in subcellular fractions containing secretory granule-localized proteases.

170 coinciding with that of a mast cell-specific secretory granule marker, mouse mast cell protease 6.

171 Myo5c puncta colocalize with secretory granule markers such as chromogranin A and Rab

172 de that Syt IV is an essential component for secretory granule maturation.

173 hat other factors, such as the low pH of the secretory granule, may also play a role.

174 ammatory mediators in Paneth cell dense core secretory granules mediate tumor necrosis factor-alpha-i

175 regulates the rapid exocytosis of preformed secretory granule mediators.

176 ors use a proteomic approach to identify the secretory granule membrane glycoprotein 2 as a marker fo

177 e to secretion, the sudden appearance of the secretory granule membrane in the plasma membrane.

178 Our analysis identifies the pancreatic secretory granule membrane major glycoprotein 2 (GP2) as

179 lpha-amidating monooxygenase (PAM), a type I secretory granule membrane protein, as a gamma-secretase

180 ssential for neuropeptide biosynthesis, is a secretory granule membrane protein.

181 hereas transmitter release was not affected, secretory granule membrane recapture after exocytosis wa

182 It is often assumed that upon fusion of the secretory granule membrane with the plasma membrane, lum

183 ssed by measuring dopamine-beta-hydroxylase (secretory granule membrane) internalization is severely

184 ysis of purified whole secretory granules or secretory granule membranes uncovered their association

185 anule phenotypes) based on lysozyme-positive secretory granule morphology.

186 ower insulin content and abnormal dense-core secretory granule morphology.

187 esicles was unchanged by TCF7L2 suppression, secretory granule movement increased and capacitance cha

188 binds specifically to ISGs and not to mature secretory granules (MSGs), and Syt IV binds to syntaxin

189 ra cell ultrastructure (except for increased secretory granule numbers) were all normal.

190 romogranin A (CHGA), a protein released from secretory granules of chromaffin cells and sympathetic n

191 me peptides derived from proteins present in secretory granules of endocrine cells, and a number were

192 dly aggregates and forms fibrils, yet within secretory granules of healthy individuals, IAPP does not

193 Human beta-tryptase is stored in secretory granules of human mast cells as a heparin-stab

194 ode tetramer-forming tryptases stored in the secretory granules of mast cells (MCs) ionically bound t

195 zed with tryptases in the heparin-containing secretory granules of mast cells.

196 egulating Zn(2+) accumulation in the insulin secretory granules of pancreatic beta cells.

197 critical element for insulin storage in the secretory granules of pancreatic beta cells.

198 Insulin is stored within the secretory granules of pancreatic beta-cells, and impairm

199 testinal symptoms and seroreactivity against secretory granules of Paneth cells.

200 APC present exogenous peptides derived from secretory granules of the beta-cell, giving rise to uniq

201 ZnT8 mediates zinc enrichment in the insulin secretory granules of the pancreatic beta cell.

202 polypeptide (proIAPP), and processed in the secretory granules of the pancreatic beta-cells.

203 Efficient sorting and packaging into the secretory granules of the regulated secretory pathway in

204 It is stored in secretory granules of vascular endothelial cells, the We

205 Our proteomic analysis of purified whole secretory granules or secretory granule membranes uncove

206 n directing endocytosed membrane PAM back to secretory granules or to a degradative pathway.

207 examerization, steps in formation of nascent secretory granules, or other unknown molecular events.

208 ibute to sorting during the formation of the secretory granules, or sorting by retention during matur

209 lar mechanisms involved in the maturation of secretory granules, organelles that store hormones and n

210 the covalent cross-linking of proinsulin and secretory granule peptides.

211 ropic hormone, growth hormone) into separate secretory granule pools.

212 or whether there is heterogeneity within the secretory granule population in mast cells.

213 ease revealed that subapical accumulation of secretory granules precedes occurrence of microvillus in

214 ons might account for the disorganization of secretory granules previously reported in Paneth cells f

215 mouse, we recently identified the beta cell secretory granule protein, chromogranin A (ChgA), as a n

216 tly linked to one another or to fragments of secretory granule proteins or other islet-derived protei

217 AL1 in INS-1 cells reduces the expression of secretory granule proteins prochromogranin A and proICA5

218 Here we show that serglycin, a secretory granule proteoglycan of hematopoietic cells, c

219 Serglycin (SG), the hematopoietic cell secretory granule proteoglycan, is crucial for storage o

220 oupled to compensatory endocytosis, allowing secretory granule recycling.

221 We conclude that Epac2A controls secretory granule release by binding to the exocytosis m

222 s of post-Golgi carriers, particularly large secretory granules, requires ongoing nucleation and repl

223 change factors (GEFs), which interact with a secretory granule resident protein, modulate cargo secre

224 ense-body granules are one prominent type of secretory granule responsible for storing small molecule

225 Copper loading decreases cleavage of PAM in secretory granules, secretion of soluble enzyme, and the

226 mice to examine the role of Syn-2 in insulin secretory granule (SG) exocytosis.

227 Secretory granule (SG) maturation has been proposed to i

228 Munc18-2 in mast cells inhibits cytoplasmic secretory granule (SG) release but not CCL2 chemokine se

229 role of MyRIP in myosin Va (MyoVa)-dependent secretory granule (SG) transport and secretion in pancre

230 n receptor) complexes that mediate fusion of secretory granule (SG) with plasma membrane (PM).

231 ated PE-induced juxtanuclear accumulation of secretory granules (SG) containing ANP propeptides (pro-

232 s from these mice had a severe deficiency of secretory granules (SGs) and insulin.

233 tors (FcepsilonRI) triggers degranulation of secretory granules (SGs) and the release of many allergi

234 Before undergoing neuroexocytosis, secretory granules (SGs) are mobilized and tethered to t

235 ally active molecules stored in long-lasting secretory granules (SGs) are secreted in response to ext

236 ells had a severe reduction in the number of secretory granules (SGs) docked onto the plasma membrane

237 flammatory mediators prestored in mast cells secretory granules (SGs) enhances immune responses such

238 Insulin secretory granules (SGs) exist in different functional p

239 Within the pancreatic beta-cells, insulin secretory granules (SGs) exist in functionally distinct

240 binding protein that localizes to and primes secretory granules (SGs) for Ca(2+)-evoked secretion in

241 of exocytosis, during which the membranes of secretory granules (SGs) fuse with each other to form a

242 ed in the biogenesis and turnover of insulin secretory granules (SGs) in pancreatic islet beta-cells.

243 hat prevent cell flattening and converge the secretory granules (SGs) in the cell center.

244 ion of neuropeptides and peptide hormones by secretory granules (SGs) is central to physiology.

245 Insulin secretory granules (SGs) mediate the regulated secretion

246 Exocytosis of secretory granules (SGs) requires their delivery to the

247 Secretory granules (SGs) sequester significant calcium.

248 cretory cells relies on the timely fusion of secretory granules (SGs) with the plasma membrane.

249 release inflammatory mediators, contained in secretory granules (SGs), which play important roles in

250 exocytosis of predocked and newcomer insulin secretory granules (SGs).

251 is found at millimolar concentrations in the secretory granule, significantly inhibits hIAPP amyloid

252 degraded via direct fusion with lysosomes, a secretory granule-specific autophagic process known as c

253 in the intestinal mucosa that do not contain secretory granules, such as brush or caveolated cells.

254 Secretory granules, such as neuronal dense core vesicles

255 which TTX occurs exclusively in distinctive secretory granules, suggesting a relationship between gr

256 oA activity polarizes around JFC1-containing secretory granules, suggesting that it may control direc

257 Knockdown of Kv2.1 expression reduces secretory granule targeting to the plasma membrane.

258 l-Palade bodies (WPBs), endothelial-specific secretory granules that are central to primary hemostasi

259 in Weibel-Palade bodies (WPBs), cigar-shaped secretory granules that are generated in a wide range of

260 ore an array of proinflammatory mediators in secretory granules that are rapidly released upon activa

261 Weibel-Palade bodies (WPBs) are secretory granules that contain von Willebrand factor an

262 ic protein-protein interaction on individual secretory granules that is linked to a specific granule

263 Sperm contain a large dense-core secretory granule (the acrosome) whose contents are secr

264 a2+ stores in the endoplasmic reticulum, the secretory granules, the lysosomes, and the endosomes all

265 amounts of mMCP-6.heparin complexes in their secretory granules, the passive cutaneous anaphylaxis re

266 etrieval of the compound membrane of several secretory granules through a single membrane fission eve

267 amyloid the pH increases from acidic in the secretory granule to neutral level in the blood, thus it

268 elaying information about secretion from the secretory granule to the nucleus.

269 naling molecule that relays information from secretory granules to both cytosol and nucleus.

270 Insulin is stored in secretory granules to facilitate rapid release in respon

271 eviously unreported mechanism for delivering secretory granules to the immunological synapse, with gr

272 actin bundled by annexin A2 connected docked secretory granules to the plasma membrane and contribute

273 uiring the continued mobilization of insulin secretory granules to the plasma membrane.

274 ll on P-selectin after its mobilization from secretory granules to the surfaces of platelets and endo

275 ef(-/-) colon, including genes implicated in secretory granule traffic and functions.

276 otein known to be involved in melanosome and secretory granule trafficking to the plasma membrane in

277 f Myo5c and indicate that Myo5c functions in secretory granule trafficking.

278 organelle, not the plasma membrane, and that secretory granules use a JFC1- and GMIP-dependent molecu

279 Multiple Rabs are associated with secretory granules/vesicles, but how these GTPases are c

280 -stimulated exocytosis: fusion of individual secretory granules (Weibel-Palade bodies [WPBs]) and sub

281 iability, reactive oxygen species (ROS), and secretory granules were assessed with parameter-indicati

282 apical vesicles that normally support mature secretory granules were dispersed.

283 PC secretory granules were released, and Crp-3/-5 mRNA expr

284 nation of pituitary glands revealed that the secretory granules were significantly decreased in pitui

285 he high concentrations that are found in the secretory granule where it is stored.

286 f the normal component of pre-docked insulin secretory granules, whereas cells with elevated levels o

287 expression of RAB26 and RAB3D to form large secretory granules, whereas control, non-MIST1-expressin

288 Hormone secretion relies on secretory granules which store hormones in endocrine cel

289 Pancreatic beta cells store insulin within secretory granules which undergo exocytosis upon elevati

290 driving the remodeling of membranes of large secretory granules, which are integrated into the plasma

291 rgic stimulation elicits exocytosis of large secretory granules, which gradually collapse with the ap

292 To study this mechanism, we used eosinophil secretory granules, which undergo stimulated homotypic f

293 peripheral tissues wherein the appearance of secretory granules with a particular protease phenotype

294 les (GUVs) and smaller liposomes or purified secretory granules with high temporal and spatial resolu

295 and Vamp7 are all required for the fusion of secretory granules with lysosomes.

296 ikely formed by cumulative fusion of several secretory granules with the cell membrane.

297 n to this system which relies on loading the secretory granules with the false transmitter dopamine,

298 ased secretion of a product stored in mature secretory granules, with no effect on basal secretion; a

299 e of Trpm5 and that does not contain typical secretory granules yet expresses endogenous opioids (bet

300 ymorphisms in the SLC30A8 gene, encoding the secretory granule Zn(2)(+) transporter ZnT8, are associa