ライフサイエンスコーパス: secretory pathway

1 ipid biosynthesis and the entry site for the secretory pathway.

2 ion (ERAD-R) has a role in shaping the early secretory pathway.

3 ng events in consecutive compartments of the secretory pathway.

4 shown to increase immature APP in the early secretory pathway.

5 arge numbers of kinase substrates within the secretory pathway.

6 e critical for the evolution of an efficient secretory pathway.

7 ture VLDL particles occurs through the Golgi secretory pathway.

8 tional modification in proteins entering the secretory pathway.

9 disulfide formation in proteins entering the secretory pathway.

10 ia a late endosomal/lysosomal unconventional secretory pathway.

11 n of folding-defective proteins in the early secretory pathway.

12 lly cytosolic proteins were recruited to the secretory pathway.

13 from the cell, nonbulky proteins reenter the secretory pathway.

14 d provide the entryway for proteins into the secretory pathway.

15 is secreted from cells by an unconventional secretory pathway.

16 ular specialization at an early stage of the secretory pathway.

17 the conventional endoplasmic reticulum-Golgi secretory pathway.

18 otein (APP) is trafficking through the early secretory pathway.

19 rane-bound compartment to another within the secretory pathway.

20 g and trafficking of proteins that enter the secretory pathway.

21 s, a membrane organelle in the center of the secretory pathway.

22 ant torsinA alters protein processing in the secretory pathway.

23 for copper increases, especially within the secretory pathway.

24 ng of channels to forward trafficking in the secretory pathway.

25 s copper transport from the cytosol into the secretory pathway.

26 panded repertoire of cargo that transits the secretory pathway.

27 of newly synthesized GluA3 receptors to the secretory pathway.

28 icles is crucial to homeostasis in the early secretory pathway.

29 tes Sec4p, the final Rab GTPase of the yeast secretory pathway.

30 abolic and electrical signals in the insulin secretory pathway.

31 ion to the periplasmic space via the general secretory pathway.

32 and trafficking of proteins targeted to the secretory pathway.

33 lain many observed aspects of the eukaryotic secretory pathway.

34 the bloodstream independently of the B-cell secretory pathway.

35 sential for the movement of IRAP through the secretory pathway.

36 nsport and maintain homeostasis in the early secretory pathway.

37 proximal and distal points in the regulated secretory pathway.

38 of GluR trafficking at an early step in the secretory pathway.

39 s), the prominent component in the dendritic secretory pathway.

40 t at the plasma membrane, but throughout the secretory pathway.

41 ehaviors simultaneously as they traverse the secretory pathway.

42 n from the PLC and their transit through the secretory pathway.

43 nts and is dependent on the acidic pH in the secretory pathway.

44 eventually traffic out of the ER through the secretory pathway.

45 ermines the fate of aberrant proteins in the secretory pathway.

46 d the other with a role in disruption of the secretory pathway.

47 neuropeptide hormones through the regulated secretory pathway.

48 acellular protein phosphorylation within the secretory pathway.

49 ains by sensing the organellar pH within the secretory pathway.

50 new insights into the use of red FPs in the secretory pathway.

51 ulation of their transport through the early secretory pathway.

52 organellar compartments as they transit the secretory pathway.

53 retained by cellular quality control in the secretory pathway.

54 (TANGO1) proteins play pivotal roles in the secretory pathway.

55 have a partial secretion block later in the secretory pathway.

56 erologous secretory protein to the regulated secretory pathway.

57 c membrane proteins that are targeted to the secretory pathway.

58 reticulum-to-Golgi trafficking in the early secretory pathway.

59 rograde trafficking in the constitutive-like secretory pathway.

60 on of Rab1 affects Scabrous and Delta in the secretory pathway.

61 ticulum (ER) and delivered to myelin via the secretory pathway.

62 cantly faster kinetics than the conventional secretory pathway.

63 tory for producing proteins destined for the secretory pathway.

64 disulfide bonds during transport through the secretory pathway.

65 ation of misfolded MUC1 protein in the early secretory pathway.

66 ynthesized proteins are exported through the secretory pathway.

67 nalysis of single-pass transport through the secretory pathway.

68 hondria, endoplasmic reticulum, and the late secretory pathway.

69 wide array of precursor proteins within the secretory pathway.

70 fect KOR1 transport at various stages in the secretory pathway.

71 y imaging a cargo protein as it transits the secretory pathway.

72 s across stable distinct compartments of the secretory pathway.

73 tion depends on the contractile ring and the secretory pathway.

74 vesicle formation and transport in the Golgi secretory pathway.

75 olism, including functioning of the cellular secretory pathway.

76 be extended to modulation of the anterograde secretory pathway.

77 made to dispose of misfolded proteins in the secretory pathway.

78 lfilled when FAMK-1 is retained in the early secretory pathway.

79 y mediator of protein trafficking within the secretory pathway.

80 go receptor-containing vesicles of the early secretory pathway.

81 reate a pH-dependent retrieval system in the secretory pathway.

82 n occur within the TGN compartment along the secretory pathway.

83 hibited by down-regulating components of the secretory pathway.

84 otein and its ligand within the biosynthetic secretory pathway.

85 HeLa cells to study their assembly along the secretory pathway.

86 d stress response that impinges on the early secretory pathway.

87 degrading its targets via the endocytic and secretory pathways.

88 al transduction pathways and inhibiting host secretory pathways.

89 P)-mediated trafficking in the endocytic and secretory pathways.

90 s, molecular motors, and proteins regulating secretory pathways.

91 The secretory pathway along which newly synthesized secretor

92 protein glycosylation reactions in cellular secretory pathways, also act as important extracellular

93 ch is involved in membrane remodeling in the secretory pathway and a known target of sorafenib, was f

94 patially restricted entry into the dendritic secretory pathway and accumulate in recycling endosomes

95 hese sex-related gene sets were enriched for secretory pathway and alga-specific genes.

96 which are responsible for Cu release to the secretory pathway and excess Cu efflux.

97 tein sorting and granulogenesis early in the secretory pathway and for prevention of amyloidogenesis.

98 on correlates with pronounced defects in the secretory pathway and greatly reduces the replication of

99 JAGN1 participates in the secretory pathway and is required for granulocyte colony

100 mic reticulum (ER) is the entry point to the secretory pathway and major site of protein biogenesis.

101 MORIN is independent of the COP-II-dependent secretory pathway and mediated by PI4P and sterol.

102 ird of the eukaryotic proteome traverses the secretory pathway and most of these proteins are N-glyco

103 s, ER luminal chaperones are swept along the secretory pathway and must be retrieved to maintain cell

104 estricted to the luminal compartments of the secretory pathway and on extracellular domains of membra

105 LC35 family transporters function within the secretory pathway and sheds light onto the role that mem

106 he hair bundle does so via an unconventional secretory pathway and that activation of this pathway co

107 SUPYN alters ASCT2 glycosylation within the secretory pathway and that this binding is associated wi

108 m is the port of entry for proteins into the secretory pathway and the site of synthesis for several

109 (TFG), previously known to regulate the cell secretory pathway and to be rearranged in thyroid and lu

110 tors, TTC17 and CCDC157, localized along the secretory pathway and were found to interact with reside

111 formed a comprehensive, unbiased analysis of secretory pathways and identified an unconventional lyso

112 ht to regulate protein trafficking along the secretory pathway, and demonstrate its importance for th

113 the beta-cell endoplasmic reticulum (ER) and secretory pathway, and ER stress is associated with beta

114 e partially processed precursors through the secretory pathway, and for subsequent post-translational

115 remains associated with TACE throughout the secretory pathway, and is stabilised at the cell surface

116 These genes all encode key regulators of the secretory pathway, and much of our knowledge of the secr

117 ic reticulum (ER), is trafficked through the secretory pathway, and released to generate extracellula

118 c pathway, the protein transport through the secretory pathway, and to the formation of a novel rever

119 Misfolded proteins of the secretory pathway are extracted from the endoplasmic ret

120 Most proteins in the secretory pathway are glycosylated.

121 onomeric, suggesting that the effects on the secretory pathway are independent of E ion channel activ

122 onomeric, suggesting that the effects on the secretory pathway are independent of E ion channel activ

123 lycosylation events that happen early in the secretory pathway are often dysregulated during tumorige

124 w conformationally defective proteins in the secretory pathway are selected from the structurally and

125 t evidence implicating proteins of the early secretory pathway as potential antiviral targets with ef

126 copper transport from the cytoplasm into the secretory pathway, as well as copper export across the p

127 e identification of a novel regulator of the secretory pathway, bactericidal/permeability-increasing

128 a synthetic lethality network focused on the secretory pathway based exclusively on mutations.

129 cts with MET during its maturation along the secretory pathway, before MET is post translationally pr

130 Glycoproteins traversing the eukaryotic secretory pathway begin life in the endoplasmic reticulu

131 In the secretory pathway, budding of vesicular transport carrie

132 in differential membrane ordering along the secretory pathway but also specifically localize diverse

133 t) accumulates on the Golgi during the early secretory pathway, but not after endocytosis.

134 oxic protein aggregates that form within the secretory pathway, but not those that form in the cytoso

135 R appears to influence the efficiency of the secretory pathway by affecting ER-mediated quality contr

136 teases have evolved to exploit the pH of the secretory pathway by altering the spatial juxtaposition

137 nc ions (Zn(2+)) are imported into the early secretory pathway by Golgi-resident transporters, but th

138 Additionally, disruption of the secretory pathway by IBV E correlates with a form that i

139 Disruption of the secretory pathway by IBV E correlates with a form that i

140 The Golgi/secretory pathway Ca(2+)/Mn(2+)-transport ATPase (SPCA1a

141 uscarinic acetylcholine receptor (M3AR), and secretory pathway Ca(2+/)Mn(2+)-ATPase isoform 1 (SPCA1)

142 L-1) is required for actin and P-type ATPase secretory pathway calcium ATPase (SPCA)-dependent sortin

143 mpartment-resident ATP-powered calcium pump (secretory pathway calcium ATPase 1 [SPCA1]) encoded by t

144 Our data suggest that GPR31 acts as a secretory pathway chaperone for KRAS4B.

145 It controls the production both of secretory pathway components and cargoes, including apol

146 and the entry of the trans-Golgi network in secretory pathway could be signal dependent.

147 complex.trappc11mutants are characterized by secretory pathway defects, reflecting disruption of the

148 atalyzed by membrane-bound enzymes along the secretory pathway, degradation takes place at the surfac

149 We show that the secretory pathway delivery of CB1R is axonally biased an

150 Removal of the H9 domain increases secretory pathway delivery to dendrites and decreases su

151 begun to uncover how different parts of the secretory pathway directly and indirectly contribute to

152 e that Gbeta5-R7 plays a role in the insulin secretory pathway downstream of signaling via all GPCRs

153 calized overexpression of Sly41 to the early secretory pathway elevates cytosolic calcium levels to s

154 brane by establishing check points along the secretory pathway, especially during the export from the

155 The unconventional secretory pathway exports proteins that bypass the endop

156 product is channelled at the Golgi into the secretory pathway for deposition into the cell wall.

157 EVs may serve as a novel secretory pathway for S. aureus to transport protected c

158 and PRV laboratories have identified a Rab6 secretory pathway for the transport of single enveloped

159 Further investigations of unconventional secretory pathways for LLSP secretion may shed light on

160 rience dramatic environmental changes in the secretory pathway, from the endoplasmic reticulum via se

161 However, the list of factors required for secretory pathway function remains incomplete, and mecha

162 Here we delineate the core secretory pathway functions and integrate them with geno

163 a the GRASP55 cargo-dependent unconventional secretory pathway (GCUSP).

164 However, it is not known where in the secretory pathway GnT1IP-L inhibits MGAT1, nor whether G

165 gi compartments, but the role of COPI in the secretory pathway has been ambiguous.

166 ornaviruses to influence the function of the secretory pathway has important implications for host de

167 n identified, the protein kinases within the secretory pathway have only recently been discovered, an

168 ease, multimerization, and polarity of the 3 secretory pathways have only been addressed separately,

169 ity control process that evolved to maintain secretory pathway homeostasis during ER protein-folding

170 reticulum (UPR(ER)) is a crucial mediator of secretory pathway homeostasis.

171 tinguished by their differential reliance on secretory-pathway homeostasis.

172 otein processing and sorting site within the secretory pathway, how it contributes to PQC has remaine

173 ed alteration in the microenvironment of the secretory pathway.IMPORTANCE Coronaviruses are important

174 ome precursors; thus, PMEL must traverse the secretory pathway in a non-amyloid form.

175 VCs and surrounding tissues, and blocked the secretory pathway in a tissue-specific manner.

176 gh the highly insulin-responsive specialized secretory pathway in adipocytes.

177 microneme protein 7 (MIC7), which enters the secretory pathway in an unconventional fashion with the

178 into the secretory granules of the regulated secretory pathway in each cell type are required for nut

179 ransition in the lipid landscape divides the secretory pathway in early and late membrane territories

180 We assessed the role of the early secretory pathway in establishing PIN1 polarity in Arabi

181 oplasmic reticulum transport of GluK2 in the secretory pathway in heterologous cells and primary neur

182 However, regulation of the secretory pathway in Leishmania is not well characterize

183 ptor trafficking follows an Rab1-independent secretory pathway in Leishmania.

184 Folding of proteins entering the secretory pathway in mammalian cells frequently requires

185 rganizes trafficking events within the early secretory pathway in response to GPCR signaling.

186 he molecular machines operating in the early secretory pathway in the biogenesis of SARS-CoV-2 and th

187 ized and recycled through a highly regulated secretory pathway in these cells.

188 ze sorting to the constitutive and regulated secretory pathways in real time.

189 NA interference-mediated inactivation of the secretory pathway inhibits bacteroid differentiation.

190 s in the endoplasmic reticulum and regulates secretory pathways, integrins, and Toll-like receptors,

191 om the endoplasmic reticulum/Golgi-dependent secretory pathway into the unconventional secretory path

192 nae) that forms the first compartment in the secretory pathway involved in protein translocation, fol

193 The secretory pathway is a major determinant of cellular hom

194 ry pathway, and much of our knowledge of the secretory pathway is based on this initial discovery.

195 To determine whether the Rab1-dependent secretory pathway is conserved in parasites, we have ana

196 are elevated and protein transport along the secretory pathway is delayed.

197 Traffic of proteins within the secretory pathway is directed by cargo-bearing vesicles

198 ns in the endoplasmic reticulum (ER) and the secretory pathway is disrupted in many protein misfoldin

199 f substrates, including lectins, in the late secretory pathway is important in embryonic and tissue c

200 hough most of the machinery acting along the secretory pathway is known and its function generally un

201 l-dependent sorting of proteins in the early secretory pathway is required for dynamic retention of e

202 ust trafficking within the constitutive-like secretory pathway is required for VAMP8- but not VAMP2-m

203 Disposal of membrane proteins in the late secretory pathway is thought to be exclusively facilitat

204 r results have shown that the Rab1-regulated secretory pathway is well conserved, and hemoglobin rece

205 ized BACE1 and APP are transported along the secretory pathway, it is not known whether BACE1 and APP

206 We recently discovered a family of secretory pathway kinases that phosphorylate extracellul

207 oat protein H (CotH), and the Fam20C-related secretory pathway kinases.

208 te that the mutation inhibits the ameloblast secretory pathway leading to ER stress and an activated

209 ith machinery to tackle perturbations in the secretory pathway, like the unfolded protein response pa

210 re retained in the early compartments of the secretory pathway: mainly the endoplasmic reticulum, but

211 ich occur frequently in the cytoplasm and in secretory pathways, may induce the formation of betaS fi

212 Therefore, secretory pathway-mediated assemblage and excretion of i

213 In the secretory pathway, misfolded asparagine (N)-linked glyco

214 king for egress rather than the biosynthetic secretory pathway more commonly used by other enveloped

215 bserve that GLUT4 transits through the early secretory pathway more slowly than the constitutively se

216 ollicular lumen of the thyroid gland via the secretory pathway, multiple tyrosine residues can become

217 l, this study shows that the perturbed Golgi secretory pathway of chondrocytes of the epiphyseal grow

218 he main catalysts for membrane fusion in the secretory pathway of eukaryotic cells.

219 ng the molecular basis of the unconventional secretory pathway of FGF2.

220 nt secretory pathway into the unconventional secretory pathway of FGF2.

221 translocation as part of the unconventional secretory pathway of FGF2.

222 Within the secretory pathway of higher eukaryotes, the core of thes

223 t a complex set of interactions occur in the secretory pathway of infected cells to ensure proper gly

224 To understand the role of LdRab1 in the secretory pathway of Leishmania, we have generated trans

225 Mutant CALRs determine traffic via the secretory pathway of partially immature TpoR, as they pr

226 coprotein prM during virus maturation in the secretory pathway of the infected cell, explaining its c

227 ort the hypothesis that TG processing in the secretory pathway of TSHR-hyperstimulated thyrocytes alt

228 NHE8 regulates pH homeostasis in the protein secretory pathways of RPE.

229 holipids, we observed that the endocytic and secretory pathways of the parasite converge, and endocyt

230 reticulum to folding and trafficking via the secretory pathway, optimization of antigenic cargo, fina

231 little is known about the filamentous fungal secretory pathway or how it might be manipulated for imp

232 recently characterized protein kinase in the secretory pathway, phosphorylates HRC on Ser96.

233 ide the first insight into the regulation of secretory pathway phosphorylation.

234 To study secretory pathway physiology during such "ER stress," we

235 Our results establish Fam20C as the major secretory pathway protein kinase and serve as a foundati

236 In eukaryotic cells, secretory pathway proteins must pass stringent quality c

237 e of the sharpest evolutionary signatures of secretory pathway proteins, and was therefore critical f

238 ion of proteins, most of which are not ER or secretory pathway proteins.

239 ation triggered a dual selection pressure on secretory pathway proteins: while sequons were positivel

240 When secretory pathway quality-control pathways fail, stress

241 t2 vacuoles, MIC2 accumulated earlier in the secretory pathway rather than localizing to micronemes.

242 recognized by different chaperones along the secretory pathway, realizing reliable assembly control b

243 mmalian proteome that traverses the cellular secretory pathway, regulating glycoprotein folding and f

244 ate maintenance of organelle identity in the secretory pathway relies on retention and retrieval of r

245 The secretory pathway remains a central paradigm of modern c

246 The exocyst is an essential component of the secretory pathway required for delivery of basolateral p

247 sn-linked oligosaccharides in the eukaryotic secretory pathway requires the trimming of nascent glyca

248 FSH released from the LH secretory pathway rescued ovarian defects in Fshb-null m

249 ntrol the early and late stages of the yeast secretory pathway, respectively.

250 FAM20C is a newly identified kinase on the secretory pathway responsible for the phosphorylation of

251 ion in viral egress by targeting VCP and the secretory pathway, resulting in a buildup of virions wit

252 2 within the ER (scFv4B12KDEL) and along the secretory pathway (scFv4B12) reduced the intracellular p

253 g and reveal that a GNL1/GNOM-mediated early secretory pathway selectively regulates PIN1 basal polar

254 Specifically, within the secretory pathway, significant populations of FPs misfol

255 However, only B5 traffics through the secretory pathway, suggesting that F13 uses another rout

256 ient to BFA than functioning of the cellular secretory pathway, suggesting that the role of GBF1 in t

257 produce a higher flux of copper through the secretory pathway that balances copper in the cytosol an

258 vered that IL-1beta and IL-18 share a common secretory pathway that depends upon membrane permeabilit

259 A10 may form a complex with neurexins in the secretory pathway that facilitates surface transport of

260 somatic mutations in proteins handled by the secretory pathway that impede their folding.

261 represents a knowledgebase of the mammalian secretory pathway that serves as a novel tool for system

262 nism of the folding state of proteins in the secretory pathway that targets unfolded/misfolded polype

263 iological significance of the unconventional secretory pathways that cells use to release LLSPs.

264 and from constitutive, basal, and regulated secretory pathways, the latter two via Weibel-Palade bod

265 e focus on the first two compartments of the secretory pathway: the endoplasmic reticulum and Golgi.

266 regulates the dynamics of p115 in the early secretory pathway, thereby controlling trafficking from

267 As proteins enter the secretory pathway they are decorated by a 'glycan', whic

268 uring maturation of the proteins through the secretory pathway, they are modified by the addition of

269 m lumen regulates normal proteostasis of the secretory pathway; they also support therapies targeting

270 promoting a model in which IBV E alters the secretory pathway through interaction with host cell fac

271 ssing can occur at neutral pH throughout the secretory pathway through the activity of furin-like pro

272 re extensively processed as they transit the secretory pathway to generate diverse glycans on cell su

273 et of membrane-anchored proteins through the secretory pathway to the plasma membrane.

274 where Tomt and the Tmcs interact within the secretory pathway to traffic Tmc proteins to the hair bu

275 ntional versus unconventional (Golgi bypass) secretory pathways to reach the OS.

276 ment, the cell plate, via a rerouting of the secretory pathway toward the division plane aided by a d

277 ther enterovirus, replication by controlling secretory pathway trafficking and Golgi complex morpholo

278 data implicate BPIFB6 as a key regulator of secretory pathway trafficking and viral replication and

279 the initial hub of protein biogenesis in the secretory pathway, triages misfolded proteins by deliver

280 co-factors, because Psd1p re-directed to the secretory pathway undergoes autocatalysis normally and i

281 Although altered expression of the PC secretory pathway was observed in human colon cancers, o

282 roteins in directing trafficking through the secretory pathway, we generated fluorescently tagged VSV

283 iroporin, causes disruption of the mammalian secretory pathway when exogenously expressed in cells.

284 lum (ER) represents the entry point into the secretory pathway where nascent proteins encounter a spe

285 e three P4Hs are shown to be targeted to the secretory pathway, where P4H5 forms dimers with P4H2 and

286 ral, i.e. in the pH range found in the early secretory pathway, whereas it is resolved at acidic pH a

287 dulate and augment key aspects of the entire secretory pathway, whereas maladaptive UPR outputs trigg

288 s dispensable for COPI function in the early secretory pathway, whereas the N-terminal longin domain

289 enterovirus 71 (EV71), co-opt the host cell secretory pathway, which controls the transport of prote

290 a set of interconnected organelles form the secretory pathway, which encompasses the terrain that th

291 nsport illuminated a novel adaptation of the secretory pathway, which is to transiently modulate the

292 arge amounts of membrane protein through the secretory pathway, which makes these cells particularly

293 of the intrinsic factors that act along the secretory pathway, which may compromise product integrit

294 r localization suggested localization to the secretory pathway, which was confirmed by localization s

295 gates in Alzheimer's disease form within the secretory pathway while in Huntington's disease and amyo

296 If these proteins are directed into the secretory pathway with a signal/leader sequence, they wi

297 nipulates cellular processes associated with secretory pathways within an infected cell to facilitate

298 f terminally misfolded proteins in the early secretory pathway yet spares folding intermediates from

299 lum (ER), acting as gatekeepers to the early secretory pathway, yet little is known about their cellu

300 not depend on membrane traffic in the early secretory pathway, yet requires both Sec23 and Sec24AB.