ライフサイエンスコーパス: secretory phospholipase A2

1 tein lipase, secretory sphingomyelinase, and secretory phospholipase A2.

2 teins as well as HDL remodeling by group IIa secretory phospholipase A2.

3 mporally required for expression of type IIA secretory phospholipase A2.

4 underlie the pro-atherosclerotic effects of secretory phospholipase A2.

5 affolds as inhibitors of human nonpancreatic secretory phospholipase A2.

6 ipid migration into the active site of bound secretory phospholipase A2.

7 ncrease membrane order and susceptibility to secretory phospholipase A2.

8 cci proved to be a calcium-dependent enzyme, secretory phospholipase A2.

9 nfluencing the activity of the novel Group V secretory phospholipase A2.

10 es, P < .05) and modestly reduced release of secretory phospholipase A2.

11 Secretory phospholipase A2 activity in the arterial inti

12 animals with a PPARalpha activator increased secretory phospholipase A2 activity, which likely accoun

13 Secretory phospholipase A2 and cycloxygenase-2 are coexp

14 dy, we used this model to assess the role of secretory phospholipase A2 and cycloxygenase-2 in kerati

15 creased prostaglandin E2 production and both secretory phospholipase A2 and cycloxygenase-2 protein e

16 Both secretory phospholipase A2 and lipoprotein-associated ph

17 Selective inhibitors of secretory phospholipase A2 and lipoprotein-associated ph

18 for proceeding with clinical outcome trials secretory phospholipase A2 and lipoprotein-associated ph

19 h roles in host defense, including lysozyme, secretory phospholipase A2, and alpha-defensins, termed

20 proteins and peptides, including statherin, secretory phospholipase A2, and defensins, were identifi

21 eatment reduced serum fibrinogen, amyloid A, secretory phospholipase A2, and lipoprotein(a) concentra

22 or fibrinogen, serum amyloid A, haptoglobin, secretory phospholipase A2, and lipoprotein(a).

23 Tgm2, group 10 secretory phospholipase A2, and LT enzymes in NHBEs and

24 vascular cell adhesion molecule 1 (VCAM-1), secretory phospholipase A2, and malondialdehyde and hydr

25 of Paneth cell secretion: lysozyme; type II (secretory) phospholipase A2; and at least one intestinal

26 is, neutrophil degranulation, and release of secretory phospholipase A2 are predominantly mediated by

27 lipid deposition in mice, draw attention to secretory phospholipase A2 as an attractive target for t

28 ed that de novo synthesized groups IIA and X secretory phospholipase A2 can mediate arachidonic acid

29 Secretory phospholipase A2 group IIa (PLA2g2a) is associ

30 his study evaluates new emerging biomarkers, secretory phospholipase A2 group IIA (sPLA2-IIA) and com

31 Secretory phospholipase A2 group IIA (sPLA2-IIA) has bee

32 Secretory phospholipase A2 group IIA (sPLA2-IIA) plays a

33 ported that Pla2g5-null mice lacking group V secretory phospholipase A2 (gV-sPLA2) showed reduced eos

34 Group X secretory phospholipase A2 (GX sPLA2) hydrolyzes mammali

35 Group X secretory phospholipase A2 (GX sPLA2) potently hydrolyze

36 e strain with a targeted deletion of group V secretory phospholipase A2 has been developed.

37 Increased levels of human nonpancreatic secretory phospholipase A2 (hnps-PLA2) have been detecte

38 hment) technology, binds human nonpancreatic secretory phospholipase A2 (hnps-PLA2) with nanomolar af

39 ctivity as inhibitors of human nonpancreatic secretory phospholipase A2(hnps-PLA2) was developed.

40 s support the previously proposed model that secretory phospholipase A2 hydrolysis generates pro-athe

41 ave previously demonstrated up-regulation of secretory phospholipase A2 IIA (sPLA2 IIA) mRNA and prot

42 and antisense oligonucleotides (one against secretory phospholipase A2 IIa and the other against cyt

43 Altered remodeling of HDL by group IIa secretory phospholipase A2 in concert with cholesterol e

44 e presence of group IIA, group V and group X secretory phospholipase A2 in human or mouse atheroscler

45 Given the presence of secretory phospholipase A2 in tears, intestinal secretio

46 Whereas the concentration of secretory phospholipase A2 in the normal tear film excee

47 reatment with 5 microm 12-epi-scalaradial, a secretory phospholipase A2 inhibitor, caused similar cha

48 considerable light on the mechanism by which secretory phospholipases A2 interact with substrate aggr

49 levels and response to barrier disruption of secretory phospholipase A2 isoforms, enzymes that mediat

50 its efficacy against gram-positive bacteria, secretory phospholipase A2 lacked bactericidal activity

51 hils, where its members include lactoferrin, secretory phospholipase A2, lysozyme, and the cathelicid

52 , particularly serum amyloid A and group IIa secretory phospholipase A2, may alter reverse cholestero

53 toferrin), but did not affect the release of secretory phospholipase A2 or lipopolysaccharide-binding

54 ion in antigen-challenged allergic subjects, secretory phospholipase A2 (PI.A2) and acetyl hydrolase

55 The mechanisms by which secretory phospholipase A2 (PLA2) exerts cellular effect

56 demonstrate that in activated mast cells (i) secretory phospholipase A2 (PLA2) mediates the release o

57 V phospholipase A2 is a recently discovered secretory phospholipase A2 (PLA2) that has been shown to

58 ns of two chemically unrelated inhibitors of secretory phospholipase A2 (PLA2), bromphenacyl bromide

59 d mast cells also requires the activity of a secretory phospholipase A2 (PLA2).

60 These results suggested that secretory phospholipase A2 plays a part in keratinocyte

61 , providing the first direct evidence that a secretory phospholipase A2 plays a role in stimulation-i

62 The possibility that secretory phospholipase A2 plays a role in the pathophys

63 phage-specific expression of human group IIA secretory phospholipase A2 promotes atherosclerotic lipi

64 Secretory phospholipase A2 receptor (PLA2R) is the targe

65 pe TNF tended to be a more potent inducer of secretory phospholipase A2 release than the p55 specific

66 Secretory phospholipase A2 (sPLA(2)) and lipoprotein-ass

67 The group IIA secretory phospholipase A2 (sPLA(2)-IIA) has been studie

68 fluid LTB4 , LTE4 , PGD2 , and PGE2 , plasma secretory phospholipase A2 (sPLA2 ), and 11beta prostagl

69 Group IB secretory phospholipase A2 (sPLA2 IB), which is one of t

70 Observational studies report that secretory phospholipase A2 (sPLA2) activity is a marker

71 Likewise, SC secretory phospholipase A2 (sPLA2) activity, measured wi

72 We have previously reported that group V secretory phospholipase A2 (sPLA2) amplifies the action

73 ls of the Paneth cell antimicrobial molecule secretory phospholipase A2 (sPLA2) and the goblet cell g

74 9 lymphoma cells to exogenous group IIA or V secretory phospholipase A2 (sPLA2) caused an initial rel

75 Secretory phospholipase A2 (sPLA2) enzymes are considere

76 ing the contribution of low molecular weight secretory phospholipase A2 (sPLA2) enzymes in eicosanoid

77 Four related genes encode four different secretory phospholipase A2 (sPLA2) enzymes in mammals, n

78 Accumulating evidence indicates that secretory phospholipase A2 (sPLA2) enzymes promote ather

79 Secretory phospholipase A2 (sPLA2) generates bioactive p

80 Three inbred mouse strains with known secretory phospholipase A2 (sPLA2) genotypes [BALB/c (+/

81 Human group II secretory phospholipase A2 (sPLA2) is an enzyme found in

82 Secretory phospholipase A2 (sPLA2) is an important infla

83 Secretory phospholipase A2 (sPLA2) is the major effector

84 hidonic acid (AA) induced by the addition of secretory phospholipase A2 (sPLA2) isotypes to bone marr

85 Secretory phospholipase A2 (sPLA2) produces many inflamm

86 Group V secretory phospholipase A2 (sPLA2) rather than Group IIA

87 he acute phase of the inflammatory response, secretory phospholipase A2 (sPLA2) reaches its maximum l

88 KEGG pathways, we found expression levels of secretory phospholipase A2 (sPLA2), lysophospholipid acy

89 Because of its similarity to secretory phospholipase A2 (sPLA2), this gene was referr

90 lipase expressed by keratinocytes is group X secretory phospholipase A2 (sPLA2), which liberates larg

91 This study sought to investigate the role of secretory phospholipase A2 (sPLA2)-IIA in cardiovascular

92 ast cell activation also provokes release of secretory phospholipase A2 (sPLA2).

93 The type IIA secretory phospholipase A2 (sPLA2-IIA) is a host protein

94 Group IIA secretory phospholipase A2 (sPLA2-IIA), released during

95 se of cyclooxygenase 2, type I collagen, and secretory phospholipase A2 type IIA mRNA, but not those

96 Secretory phospholipase-A2 type X (sPLA2-X) is released

97 , whereas adult mice expressed more group 10 secretory phospholipase A2, Wnt5a, and transglutaminase