ライフサイエンスコーパス: secretory protein

1 two lectins, a protease, and a cysteine-rich secretory protein).

2 a Calmodulin binding protein and a Cys-rich secretory protein.

3 fourth type-1 repeat is a fully independent secretory protein.

4 r mutant proteins and increased synthesis of secretory protein.

5 roduces a cellulose binding protein (Hg CBP) secretory protein.

6 tive Mycobacterium tuberculosis 30-kDa major secretory protein.

7 ular matrix as well as senescence-associated secretory proteins.

8 central role in the intracellular sorting of secretory proteins.

9 ificity of ARTC2.2 from membrane proteins to secretory proteins.

10 ite of synthesis and folding of membrane and secretory proteins.

11 and thus hold promise for predicting saliva-secretory proteins.

12 ce for export that is not seen for classical secretory proteins.

13 chaperone, it does not interact with folded secretory proteins.

14 een HIV type 1 (HIV-1) and KSHV, focusing on secretory proteins.

15 assembly and transportation of membrane and secretory proteins.

16 glycoproteins, which include the bulk of the secretory proteins.

17 nal insertion, impeding the translocation of secretory proteins.

18 mbrane and promotes anterograde transport of secretory proteins.

19 ated degradation (ERAD) of multiple unfolded secretory proteins.

20 balance between demand for and synthesis of secretory proteins.

21 tively bound to the signal peptides of small secretory proteins.

22 nctions and facilitate the mass synthesis of secretory proteins.

23 ize native folding and impair trafficking of secretory proteins.

24 sential role in the production of lipids and secretory proteins.

25 manage biogenesis of specific transmembrane secretory proteins.

26 or, more importantly, to specific misfolded secretory proteins.

27 and on extracellular domains of membrane and secretory proteins.

28 n and decreased expression of genes encoding secretory proteins.

29 of the correct pattern of disulfide bonds in secretory proteins.

30 pression of genes encoding prostate-specific secretory proteins.

31 tes, but also belonged to diverse classes of secretory proteins.

32 proper folding and structural maturation of secretory proteins.

33 associations were established for 82 (9.0%) secretory proteins.

34 functional groups and majority of them were secretory proteins.

35 l surface, is utilized by trans-membrane and secretory proteins.

36 emands in the ER by degrading mRNAs encoding secretory proteins.

37 CC16 (club cell secretory protein-16), a member of the secretoglobin fam

38 nt protein D, C-reactive protein, Clara cell secretory protein-16, IL-6 and -8, and tumor necrosis fa

39 A. ceylanicum excretory-secretory protein 2 (AceES-2), a highly immunoreactive m

40 an CAP superfamily member, the cysteine-rich secretory protein 2 (CRISP2), rescues the phenotype of y

41 s to a prostate autoantigen, seminal vesicle secretory protein 2 (SVS2), which we believe to be novel

42 Human epididymis secretory protein 4 (HE4) is a newly discovered key mole

43 Out of 908 secretory proteins, 581 (63.8%) have functions related t

44 cribe novel chaperone-like functions for the secretory protein 7B2, which is widely expressed in neur

45 Here, we show that Prostatic secretory protein 94 (PSP94) levels are reduced in ovari

46 h encodes beta-microseminoprotein (prostatic secretory protein 94).

47 is and lead to the accumulation of misfolded secretory proteins, a condition referred to as ER stress

48 Adiponectin is a secretory protein abundantly secreted from adipocytes.

49 vides the driving force for the transport of secretory proteins across the cytoplasmic membrane of Es

50 mediates transport of many proteins, such as secretory proteins, across the endoplasmic reticulum (ER

51 The adipocyte-derived secretory protein adiponectin has been widely studied an

52 ases (PCs) furin, PC5, PACE4, and PC7 cleave secretory proteins after basic residues, including the H

53 Here, we compare the transport of soluble secretory proteins (albumin and alpha1-antitrypsin) with

54 Other major secretory proteins (amylase, proline-rich protein) are n

55 dentification and role of autotaxin (ATX), a secretory protein and a major source for extracellular l

56 Fetuin-A is a hepatic secretory protein and a novel risk factor for diabetes.

57 CRK1 abolished anterograde transport of the secretory protein and disrupted the localization of mult

58 he translocation of a full-length microsomal secretory protein and was cleaved as part of the signal

59 On a large test set containing 98 secretory proteins and 6601 non-secretory proteins of hu

60 s, but a direct association between granular secretory proteins and actin-remodeling molecules has no

61 ermore, the expression of several epithelial secretory proteins and antimicrobial molecules was consi

62 Therefore, identifying human saliva-secretory proteins and further detecting protein biomark

63 t mechanism that applies to a major class of secretory proteins and indicate the co-existence of mult

64 ding trafficking and sorting of membrane and secretory proteins and posttranslational modification by

65 ted by decreased plasma levels of neutrophil secretory proteins and significantly decreased tissue in

66 anslationally recognizes signal sequences of secretory proteins and targets ribosome-nascent chain co

67 article (SRP) recognizes signal sequences of secretory proteins and targets them to the endoplasmic r

68 we investigated these two ER-retained mutant secretory proteins and the selectivity of their interact

69 roscopy revealed that Cab45 colocalizes with secretory proteins and the TGN Ca(2+) pump (SPCA1) in sp

70 l of extracellular proteolytic cleavage of a secretory protein, and reveals an important mechanism th

71 decreased levels of Clara cells, Clara cell secretory protein, and surfactant proteins B and C, with

72 The mechanisms by which secretory proteins, and granins in particular, are sorte

73 erexpresses the M. tuberculosis 30-kDa major secretory protein antigen 85B, which is 85% homologous w

74 embers of the CAP superfamily (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related

75 acterization of the C-terminal cysteine-rich secretory protein/antigen 5/pathogenesis related-1 (CAP)

76 APS) domain, also known as the cysteine-rich secretory proteins/antigen 5/pathogenesis-related 1 prot

77 Many secretory proteins are activated by cleavage at specific

78 Secretory proteins are exported from the endoplasmic ret

79 Secretory proteins are exported from the endoplasmic ret

80 In bacteria, secretory proteins are generally translocated after comp

81 Certain secretory proteins are known to be critical for maintain

82 Many plant pathogen secretory proteins are known to be elicitors or pathogen

83 When membrane proteins and secretory proteins are misfolded or incompletely folded,

84 Many secretory proteins are N-glycosylated, and despite some

85 Secretory proteins are only temporary cytoplasmic reside

86 In the endoplasmic reticulum (ER), secretory proteins are packaged into COPII vesicles that

87 Terminally misfolded or unassembled secretory proteins are retained in the endoplasmic retic

88 Many secretory proteins are targeted by signal sequences to a

89 In bacteria, most secretory proteins are translocated across the plasma me

90 In bacteria most secretory proteins are transported across the plasma mem

91 In bacteria, most secretory proteins are transported post-translationally

92 studied for 30 years, the mechanism by which secretory proteins are transported post-translationally

93 Many bacterial proteins, including most secretory proteins, are translocated across the plasma m

94 AB27A pathway to regulate the trafficking of secretory proteins as exosomes.

95 the human proteome and identified over 1,050 secretory proteins as potential furin substrates.

96 lin and SPCA1/Pmr1 in sorting of the soluble secretory proteins at the TGN/late Golgi membranes in eu

97 y calcium ATPase (SPCA)-dependent sorting of secretory proteins at the trans-Golgi network (TGN).

98 are only a few methods for predicting saliva-secretory proteins based on conventional machine learnin

99 Here we discuss the key players that mediate secretory protein biogenesis and trafficking, highlighti

100 ogether, these 13 Stat3 downstream inducible secretory protein biomarkers potentially can be used for

101 xport is selective for proinsulin over other secretory proteins, but the same effect is observed for

102 nslational targeting of nascent membrane and secretory proteins by the signal recognition particle (S

103 An unexpected connection between a secretory protein called PCSK9 and Sec24A, a well known

104 nt advances in our understanding of one such secretory protein called ROP16.

105 show that the expression of a heterodimeric secretory protein can be improved by harmonizing selecte

106 e show that both in vivo and in vitro, small secretory proteins can enter the ER posttranslationally

107 Accumulation of misfolded secretory proteins causes cellular stress and induces th

108 lf-organized into distinct Clara cell 10-kDa secretory protein (CC10+) airway-like and SPC+ saccular

109 performed for two pneumoproteins, Clara cell secretory protein (CC16) and surfactant protein D (SP-D)

110 Lower levels of circulating club cell secretory protein (CC16) in childhood are also associate

111 Clara cell secretory protein (CC16) is associated with Th2 modulati

112 sed in lung epithelial cells [via Clara cell secretory protein (CCSP(cre))].

113 Clara cell secretory protein (CCSP) and interleukin 8 levels were a

114 oximal airways of the fetus; both Clara cell secretory protein (CCSP) and MUC5AC/5B mRNA and protein

115 orged and Clara cells accumulated Clara cell secretory protein (CCSP) in Munc13-2-deficient mice.

116 Clara cell secretory protein (CCSP) is specifically expressed in pu

117 lung fluid protein expression of Clara cell secretory protein (CCSP), a marker for Clara cells, in l

118 1), the alveolar stem cell marker Clara cell secretory protein (Ccsp), and the epithelial cell marker

119 ar microinjection, were bred with Clara cell secretory protein (CCSP)-rtTA activator mice.

120 These studies used bi-transgenic Clara cell secretory protein (CCSP)/IL-1beta mice that conditionall

121 nsgenic overexpression of Vegfc in club cell secretory protein (CCSP)/VEGF-C mice reduced macrophage

122 In contrast, an integral membrane secretory protein (CD8alpha) is not enriched in these ca

123 Club cell secretory protein (Clara) (CC16) is produced mainly by b

124 total proteins) were identified as putative secretory proteins containing signal peptides.

125 n is a truncated member of the Cysteine-Rich Secretory Protein (CRISP) family, whose members include

126 CAP protein superfamily [i.e. cysteine-rich secretory proteins (CRISP), antigen 5, and pathogenesis

127 To determine effects of conceptus secretory proteins (CSP) containing IFN-delta and IFN-ga

128 Combining the secretory protein database with RNA-sequencing and quant

129 RAD are involved in degradation of malfolded secretory proteins, depending on the localization of the

130 The secretory protein Dickkopf-1 (DKK-1) is a known Wnt anta

131 Secretory proteins drive these processes, so we screened

132 Selective overexpression of Human epididymal secretory protein E4 (HE4) points to a role in ovarian c

133 Beet cyst nematodes depend on a set of secretory proteins (effectors) for the induction and mai

134 Here we term this regulatable secretory protein ESCargo (Erv29/Surf4-dependent secreto

135 Eukaryotic secretory proteins exit the endoplasmic reticulum (ER) v

136 olutionarily conserved, approximately 34-kDa secretory protein expressed in the brain.

137 th inducible expression of p52 in Clara cell secretory protein-expressing airway epithelial cells.

138 To enhance secretory protein folding and promote adaptation to stre

139 synthetic inhibitors of essential processes (secretory protein folding or sterol biosynthesis) in the

140 N-linked glycans commonly contribute to secretory protein folding, sorting, and signaling.

141 nstellation of correctly folded membrane and secretory proteins for efficient degradation by cytosoli

142 The fluorescent secretory protein forms aggregates in the ER lumen and c

143 Adiponectin is an adipocyte-specific secretory protein found in circulation in several differ

144 CapsNet-SSP by comparison with human saliva-secretory proteins from existing studies and known saliv

145 This report shows that secretory proteins from neuroendocrine cells will activa

146 required for the concentration and export of secretory proteins from the endoplasmic reticulum (ER).

147 erved mechanism to remove misfolded membrane/secretory proteins from the endoplasmic reticulum (ER).

148 complex II-coated vesicles, which transport secretory proteins from the endoplasmic reticulum to the

149 The transport of secretory proteins from the endoplasmic reticulum to the

150 Transport of secretory proteins from the endoplasmic reticulum to the

151 e the large scale prediction and analysis of secretory proteins from the Puccinia helianthi transcrip

152 ed on CapsNet is proposed to identify saliva-secretory proteins from the sequence information; (2) th

153 of Eps15, significantly reduced the exit of secretory proteins from the TGN.

154 complex, the SecA ATPase, and a segment of a secretory protein fused into SecA.

155 Overexpression of the secretory protein glyceraldehyde-3-phosphate dehydrogena

156 the intracellular bacteria and receives host secretory proteins important for bacterial development.

157 oimmunoprecipitated with a newly synthesized secretory protein in vitro and stimulated protein matura

158 le to mass production of functionally active secretory proteins in a silkworm-based expression platfo

159 ugh Fgfr2(cn) prostates continued to produce secretory proteins in an androgen-dependent manner, they

160 P mobility reports on the levels of unfolded secretory proteins in individual cells, independent of U

161 eoglycan, is crucial for storage of specific secretory proteins in mast cells, neutrophils, and cytot

162 Lipid transfer proteins (LTPs) are small secretory proteins in plants with defined lipid-binding

163 Accumulation of misfolded secretory proteins in the endoplasmic reticulum (ER) act

164 After folding and assembly of nascent secretory proteins in the endoplasmic reticulum (ER), th

165 sport vesicles, function in trafficking some secretory proteins in yeast and higher eukaryotes.

166 Sec61 blockade affects a selective subset of secretory proteins including key signal-transmitting rec

167 Thus, increased plasma levels of neutrophil secretory proteins, including myeloperoxidase and elasta

168 The majority of biosynthetic secretory proteins initiate their journey through the en

169 Ss occupied a more nonpolar environment than secretory proteins inside the aqueous ribosome tunnel, w

170 Incorporation of secretory proteins into ER-derived vesicles involves rec

171 import of small or intrinsically disordered secretory proteins into the ER based on their ability to

172 Translocation of secretory proteins into the lumen of the endoplasmic ret

173 or previously described and newly identified secretory proteins is confirmed in vivo and in vitro.

174 s of the disease-associated mutations in the secretory proteins is connected with defects in their tr

175 how plants exert quality control over their secretory proteins is less clear.

176 is triggered by cytosolic mislocalization of secretory proteins, is mediated by multiple signaling pa

177 em, known for its role in quality control of secretory proteins, is unexpectedly responsible for the

178 ctoferrin (LF), and reduced expression of SV secretory protein IV (SVS IV).

179 sion of the major estrogen-inducible uterine secretory protein lactoferrin (LF), and reduced expressi

180 Because hLAL is a secretory protein, lal(-/-) phenotypes in other compartm

181 here uncover a mechanism by which defects in secretory proteins lead to a dramatic reduction in their

182 These proteins, termed leaderless secretory proteins (LLSPs), comprise proteins directly o

183 potent GC, dexamethasone (Dex) increased the secretory protein load of ECM proteins in the ER of TM c

184 y of the endoplasmic reticulum (ER) with the secretory protein load of the cell.

185 In addition to promoting secretory protein maturation, enveloped viruses also uti

186 When Clara cell secretory protein-membrane hen egg lysozyme/hemoglobin t

187 ERAD of a portion of secretory proteins might occur via signal-dependent regu

188 To identify affected secretory proteins, miR-144 treated endothelial cell cul

189 novel and powerful tool for reporting global secretory protein misfolding levels and investigating th

190 s, including a number of known components in secretory protein modification and sorting.

191 overlaid on navigation between non-reactive secretory protein molecular depots patterned at the plas

192 previously characterized two SNARE proteins, secretory protein (MoSec22) and vesicle-associated membr

193 r knockdown of SRP54 promoted degradation of secretory protein mRNA.

194 rmed that NS1 can promote the translation of secretory protein mRNAs based on the nucleotides within

195 Thus, SRP protects secretory protein mRNAs from degradation.

196 A primary function of 5' regions in many secretory protein mRNAs is to encode an endoplasmic reti

197 een shown to secrete a protease termed major secretory protein (Msp).

198 ed removal of a dominant-inherited misfolded secretory protein, mucin1-frameshifted, from an intracel

199 Folding of transmembrane and secretory proteins occurs in the lumen of the endoplasmi

200 In the current study, we found that a secretory protein of M. tuberculosis PPE2 disrupted the

201 ontaining 98 secretory proteins and 6601 non-secretory proteins of human, our classifier achieved app

202 f ASP-like proteins, proteases, or excretory-secretory proteins of unknown function.

203 bility to limit deleterious effects of other secretory proteins on the ER.

204 Out of the 12 genes, three code for secretory proteins; one is homologous to effector gene R

205 sized convolution kernels to identify saliva-secretory proteins only from sequence information.

206 The secretory proteins participate in motility, invasion, an

207 trols, but increased apoptosis of Clara cell secretory protein-positive airway epithelial cells was o

208 (WNT) signaling pathway, is one endometrial secretory protein potentially involved in maternal-embry

209 performs existing models; and (3) the saliva-secretory proteins predicted by our model are statistica

210 wild-type or mutated signal sequences of the secretory protein preprolactin by in vitro translation o

211 In the current study, secretory proteins present in the cultured supernatants

212 Here we demonstrate that many secretory proteins produced by hematopoietic stem cells

213 s a ubiquitous organelle that plays roles in secretory protein production, folding, quality control,

214 in-producing pancreatic beta-cells with high secretory protein production.

215 impaired ligand binding also interfered with secretory protein production.

216 use neural progenitor cells (NPCs) to have a secretory protein profile distinct from other brain cell

217 tope tag under the control of the Clara cell secretory protein promoter, which largely limited transg

218 eport that the soluble cargo protein Parotid Secretory Protein (PSP) is bound to the membranes of sec

219 -carbonic anhydrase 6 (CA6) and anti-parotid secretory protein (PSP), which occur early in the course

220 anti-carbonic anhydrase 6 (CA6) and parotid secretory protein (PSP).

221 the Mycobacterium tuberculosis 30-kDa major secretory protein (r30/antigen 85B [Ag85B]) (rLm30) as h

222 elle maturation as the redistribution of the secretory proteins Rab27a or Munc13-4 in response to LPS

223 )-associated degradation (ERAD) of misfolded secretory proteins, reflecting the fact that some level

224 Chromogranins are pro-hormone secretory proteins released from neuroendocrine cells, w

225 stasis, yet the function of many circulating secretory proteins remains unknown.

226 In eukaryotic cells, newly synthesized secretory proteins require COPII (coat protein complex I

227 Gene ontology analysis of the secretory proteins revealed an enrichment of hydrolase a

228 Administration of doxycycline to Clara cell secretory protein-reverse tetracycline-controlled transa

229 ence that DCG biogenesis is dependent on the secretory protein secretogranin (Sg) II, a member of the

230 ary to induce lactoferrin, an E(2)-regulated secretory protein selectively synthesized in the uterine

231 The secretory protein Slit2 and its receptors Robo1 and Robo

232 ecific for antibody secretion, because other secretory proteins such as IL-6 are released normally fr

233 (2+) These Cab45 oligomers specifically bind secretory proteins, such as COMP and LyzC, in a Ca(2+)-d

234 s and (ii) computational prediction of blood-secretory proteins supported by experimental validation.

235 of specialized cellular processes, including secretory protein synthesis and processing, exocytosis,

236 Restoration of normal rates of secretory protein synthesis and secretion may be a new t

237 Secretory protein synthesis begins in the endoplasmic re

238 hermore, the negative effect of BiP(T46G) on secretory protein synthesis was rescued by increased lev

239 drives acinar differentiation by maximizing secretory protein synthesis, stimulating mitochondrial m

240 te a maximum of membrane-bound polysomes for secretory protein synthesis.

241 of an isolated ATPase domain interfered with secretory protein synthesis.

242 slocation and folding machinery to influence secretory protein synthesis.

243 These results suggest new roles for secretory protein tertiary structure in hormone and tran

244 previous study showed that expression of the secretory protein TgMIC5 suppresses TgSUB1 activity, the

245 Dickkopf1 (DKK1) is a secretory protein that antagonizes oncogenic Wnt signali

246 Fetuin-A is a hepatic secretory protein that binds the insulin receptor and in

247 eptide attached to ChEL makes an independent secretory protein that binds to I-II-III, stabilizing it

248 recently optimized an artificial fluorescent secretory protein that exits the ER with the aid of the

249 Fetuin-A is a hepatic secretory protein that inhibits arterial calcium deposit

250 Fetuin-A is a multifunctional hepatic secretory protein that inhibits dystrophic vascular and

251 SPLUNC1 is a 25 kDa secretory protein that is expressed in nasal, oropharyng

252 The AGR2 gene encodes a secretory protein that is highly expressed in adenocarci

253 10A06 is a cyst nematode secretory protein that is most likely secreted as an eff

254 Ym1/Ym2 is a chitinase-like secretory protein that is transiently induced in alterna

255 PRADC1: a novel metabolic-responsive secretory protein that modulates physical activity and a

256 o regions II-III also makes for an efficient secretory protein that neither demonstrably interacts no

257 is mediated under the positive regulation of secretory protein that possesses a cysteine and histidin

258 amined the production of p40, an LGG-derived secretory protein that protects intestinal epithelial ce

259 profiles and protein sequences, 76 mosquito secretory proteins that are highly expressed in midguts

260 associated proteins (PAP) are stress-induced secretory proteins that are implicated in immunoregulati

261 Thirteen secretory proteins that are Stat3 downstream gene produc

262 ty control protein ERp44 allows retrieval of secretory proteins that contain free thiols via a disulf

263 Membrane and secretory proteins that fail to pass quality control in

264 ast growth factor 23 (FGF-23) and Klotho are secretory proteins that regulate mineral-ion metabolism.

265 nd DeltatatC strains identified 73 predicted secretory proteins that were present in reduced amounts

266 in the delivery of basolateral membrane and secretory proteins, the basolateral targeting of syntaxi

267 Like all other secretory proteins, the HIV-1 envelope glycoprotein gp16

268 can be rationalized by lower trafficking of secretory proteins through their ERs.

269 encoding highly glycosylated, cysteine-rich secretory proteins, thus preventing ER overload.

270 to act as an escort factor by binding to the secretory protein thyroglobulin (Tg) in the ER, thereby

271 mutant proteins stimulated secretion of the secretory protein thyroglobulin with an efficiency simil

272 nals by efficiently directing a heterologous secretory protein to the regulated secretory pathway.

273 We observed the large majority of secretory proteins to be cotranslationally translocated,

274 -A) inserts or signal peptides from membrane/secretory proteins to explore the influence of nascent c

275 reciated heterogeneity in the recruitment of secretory proteins to the COPII vesicles that extends to

276 nery responsible for delivering membrane and secretory proteins to the proper cellular destination.

277 Two distinct pathways deliver secretory proteins to the Sec61 protein translocase in t

278 ally delivers newly synthesized membrane and secretory proteins to the target cellular membrane.

279 GA expression, by siRNA, disrupted regulated secretory protein traffic by approximately 65%, while ta

280 oplasmic reticulum (ER) is rate-limiting for secretory protein trafficking because protein folding/as

281 lex II (COPII) mediates the initial steps of secretory protein trafficking by assembling onto subdoma

282 cargo and coat subunits to promote efficient secretory protein transport.

283 After leaving the endoplasmic reticulum, secretory proteins traverse several membranous transport

284 logy employing disulfide bond formation of a secretory protein, trypsinogen (TG), that behaves in vit

285 Secretory proteins unable to assemble into their native

286 PORTANCE N-linked glycans are transferred to secretory proteins upon entry into the endoplasmic retic

287 cell model and found that the key mast cell secretory protein VAMP8 becomes phosphorylated by PKC at

288 ression of some, but not all, genes encoding secretory proteins was inhibited by injection of xbp1 mo

289 ng associated with the discharge of parasite secretory proteins was not sufficient to induce this swi

290 ally expressed human growth hormone (hGH), a secretory protein, was packaged into DFV.

291 ht into ER homeostasis and the biogenesis of secretory proteins, we screened a genomewide collection

292 Additionally, 143 putative secretory proteins were categorized into 27 functional g

293 y A member 2 (BPIFA2), also known as parotid secretory protein, which we identified via a multiplex q

294 ite of synthesis and folding of membrane and secretory proteins, which, collectively, represent a lar

295 (ERAD), monitors the folding of membrane and secretory proteins whose biogenesis takes place in the e

296 d domain-containing 1 (PRADC1), an enigmatic secretory protein widely expressed in humans and mice.

297 toxin (EDN) is an eosinophil granule-derived secretory protein with ribonuclease and antiviral activi

298 It encodes ubiquitous, highly conserved, secretory protein with the poorly defined function.

299 which encodes ubiquitous, highly conserved, secretory protein with unknown function, leads to activa

300 Here, we demonstrate for several secretory proteins with disease-associated mutations tha