ライフサイエンスコーパス: seeding

1 residues and can be propagated through cross-seeding.

2 y play a key role in modulating toxicity and seeding.

3 d obesity has consequences on intestinal IEL seeding.

4 human laminin was enhanced following serous seeding.

5 of scrapie prions using ultrasensitive prion seeding.

6 ansthyretin tetramer does not hinder amyloid seeding.

7 ysically by ultrasonication or chemically by seeding.

8 through sequence-directed CENP-A nucleosome seeding.

9 ithm of RRS secures the efficiency of random seeding.

10 ons and adjacent brain regions by prion-like seeding.

11 to polymeric scaffold materials before cell seeding.

12 itreous injections of melphalan for vitreous seeding.

13 was treated with radiation or enucleated for seeding.

14 re suitable for biological colonisation from seeding.

15 ort significantly aggravates alpha-synuclein seeding.

16 medulloepithelioma with aqueous and vitreous seeding.

17 x 10(5) m(3) (275 ac ft) for 24 min of cloud seeding.

18 s of the population-level phenomenon of mast seeding.

19 ymorph-dependent and concentration-dependent seeding.

20 microfluidic device fabrication (2 d), cell seeding (1 d), and progressive development of the microf

21 le 27-mm(2) microfluidic chamber) 15 d after seeding ~1,500 cells per independent chamber and under x

22 x 10(5) m(3) (100 ac ft) for 20 min of cloud seeding, 2.4 x 10(5) m(3) (196 ac ft) for 86 min of seed

23 a show that Xist forms the Xi compartment by seeding a heteromeric condensate that consists of ubiqui

24 n then progress to the final stage by either seeding a metastasis or acquiring a driver mutation.

25 ced in T2D potentiates AD pathology by cross-seeding Abeta, providing a molecular explanation for the

26 The aggregation propensity and seeding ability of this amyloid-forming segment were mod

27 trating ciliary body medulloepithelioma with seeding achieved with only a small number of intracamera

28 scalable cell-based tool to investigate mHTT seeding activities in HD CSF, and demonstrated that the

29 t to quantitatively detect such pathological seeding activities in patient biosamples, e.g. cerebrosp

30 Mechanistically, we showed that mHTT seeding activities in patient CSF could be ameliorated b

31 s appear to be associated with both enhanced seeding activity and worse clinical outcomes, whereas ot

32 e; RT-QuIC assay reveals earliest skin prion-seeding activity at 3 wpi in hamsters and 20 wpi in Tg40

33 This seeding activity can be ameliorated by targeting specifi

34 osome rupture and have significantly reduced seeding activity compared to recombinant alphaS aggregat

35 Tau seeding activity correlates with the aggressiveness of t

36 inhibits 1) its aggregation in vitro, 2) its seeding activity in cells, 3) its binding to microtubule

37 tes from 263K-infected cells exhibited prion seeding activity in the RT-QuIC assay and were infectiou

38 Detection of prion seeding activity in vitro by protein misfolding cyclic a

39 Here, we intend to analyze the seeding activity of dementia with Lewy bodies (DLB) and

40 C-BSE prion seeding activity was also detected in brain tissue of ov

41 PrP(L-BSE) associated seeding activity was detected at early time points after

42 tion and minimal set of PTMs associated with seeding activity was further defined by analysis of size

43 F), most recently, the measurements of prion seeding activity with second-generation real-time quakin

44 soluble fractions of MSA extracts had robust seeding activity, whereas only the insoluble fractions o

45 insoluble fractions of PD extracts displayed seeding activity.

46 uely toxic fibrils with modulated prion-like seeding activity.

47 Little is known about the risk of tumor seeding after different routes of biopsy.

48 The risk of needle tract seeding after transcutaneous biopsy was low.

49 e more potent than those of idiopathic PD in seeding aggregation.

50 The random-seeding algorithm of RRS is based on the hidden-Markov-m

51 trary neurite structures, while the reaction-seeding algorithm of RRS secures the efficiency of rando

52 haS fibrils are intrinsically inefficient at seeding alphaS inclusion pathology.

53 failure due to waterlogged conditions after seeding and allows water to be used as a means of weed c

54 ation studies demonstrate MDPs block amyloid seeding and directly bind misfolded, seeding-capable IAP

55 s breast cancer liver metastasis by enabling seeding and early cancer cell survival.

56 air edge growth, by contrast, involves local seeding and edge reconstruction and thus contrasts with

57 ltra-thin FEP foil cuvettes are suitable for seeding and growing organoids over a time period of at l

58 ent fashion, which subsequently enhances PCa seeding and growth in the bone marrow.

59 c administration of CpG-C reduced tumor cell seeding and growth in the brain in three tumor models in

60 including exosomes, that can facilitate the seeding and growth of metastatic cancer cells in distant

61 KDM4B also regulates seeding and growth of peritoneal tumors in vivo, where i

62 ations to the substrate surface optimise the seeding and growth processes for the fabrication of diam

63 g environment more vulnerable to tumour cell seeding and growth.

64 ar metastatic niche that promotes tumor cell seeding and identifies COX-1/TXA2 signaling as a target

65 d mixtures, application of manure soon after seeding and low-intensity grazing) allowed the ecosystem

66 have compared the combined effects of prion seeding and mutations of prion protein (PrP) on the stru

67 ary body medulloepithelioma with concomitant seeding and neovascular glaucoma in the right eye was se

68 eight eyes were eligible and showed vitreous seeding and normal intraocular pressure.

69 he susceptibility of the liver to metastatic seeding and outgrowth.

70 extracellular tau has been implicated in the seeding and propagation of tau pathology and is the prim

71 und amyloid-beta plaques and facilitates the seeding and spreading of neuritic plaque tau aggregates.

72 y Abeta plaques enhance endogenous alpha-syn seeding and spreading over time post-injection with mpff

73 We tested whether ISF/CSF tau and tau seeding and spreading were influenced by the sleep-wake

74 applying high-pressure gas could affect air-seeding and the generated VC.

75 Seeding and ultrasound-assisted pre-crystallization can

76 n electron microscopy, thioflavin-T binding, seeding, and immunoblot assays.

77 erve obscuration, macular involvement, tumor seeding, and serous retinal detachment [RD] >1 quadrant)

78 In a tau seeding-and-spreading model, chronic SD increased tau pa

79 This seeding approach represents a substantial reduction in c

80 cipitation unambiguously attributed to cloud seeding are isolated from natural precipitation (<1 mm h

81 nal weather modification methods, like cloud seeding, are being used to counteract increasing water s

82 Here, we demonstrate the existence of cross-seeding as a crucial step in the formation of the yeast

83 dence points to the importance of prion-like seeding as a mechanism for the pathological spread in ta

84 Using a cell-based inclusion seeding assay, we recently reported that only a few tau

85 al-time quaking-induced conversion (RT-QuIC) seeding assay, which detects minute amounts of the disea

86 fectivity in cultured slices using sensitive seeding assays such as real-time quaking-induced convers

87 We developed fluorescent, morphology-based seeding assays that allow the formation of pathological

88 BD) preferentially show endocytosis-mediated seeding associated with endo-lysosome rupture and have s

89 water- and gas-filled conduits to avoid air seeding at low water potentials.

90 Toward this goal, we further developed a seeding-based model of alpha-syn fibrillization to gener

91 We observed pathological cross-seeding between DISC1 and mutant HTT aggregates in the b

92 drives systemic metastasis, where polyclonal seeding between sites is common.

93 We also revealed potential barriers in cross-seeding between three-repeat and four-repeat Tau isoform

94 When seeding biological networks with known drug targets, mac

95 71 days); cryoablation site infection, tumor seeding, bleeding, and severe hypotension were each obse

96 iency of M204-scFv antibodies to inhibit the seeding by brain tissue extracts from different donors w

97 polymorphs, whereas inhibitors that blocked seeding by extracts from all of the tauopathies tested c

98 inhibitors also show efficacy in preventing seeding by human patient-derived alpha-syn fibrils.

99 gle-chain variable fragment (scFv) inhibited seeding by IL15-induced tau oligomers and pathological e

100 ex vivo fibrils efficiently inhibits amyloid seeding by impeding self-association of the amyloid-driv

101 hies tested could be used to broadly inhibit seeding by multiple disease-specific tau polymorphs.

102 e two VQIVYK interfaces blocked proteopathic seeding by patient-derived fibrils.

103 Our findings point to inhibition of amyloid seeding by peptide inhibitors as a potential therapeutic

104 We observed that cross-seeding by sRPT fibrils accelerates the rate of lRPT agg

105 xperiments support the hypothesis that tumor seeding can occur during colonoscopy via the working cha

106 on, surfactant activity, fibrillization, and seeding capability.

107 amyloid seeding and directly bind misfolded, seeding-capable IAPP species.

108 taS are less cytotoxic, exhibit reduced cell seeding capacity and are more resistant to fibril sheddi

109 lize the faster aggregation kinetics, higher seeding capacity in biosensor cells and greater cytotoxi

110 cancer cells that promote stemness and tumor-seeding capacity.

111 prestrain on cell mechanics was evaluated by seeding cells both on substrates with no prestrain and o

112 a metastasis to the diversity in the pool of seeding cells.

113 ing to putative amyloidogenic regions formed seeding-competent amyloid fibrils.

114 These data suggest that desmin forms seeding-competent amyloid that is toxic to myofibers.

115 We showed that the seeding-competent mHTT species in HD CSF are significant

116 s, which are hypothesized to be the earliest seeding-competent species, M204-scFv may have potential

117 ospinal fluid of AD-affected individuals are seeding-competent.

118 Self- and cross-seeding data show that surface catalysis is only efficie

119 of soluble oligomeric aggregates capable of seeding de novo rPrP aggregation.

120 s work demonstrates that at low and moderate seeding densities AR-BP sidedness significantly impacts

121 At low and moderate seeding densities hAEC proliferation was significantly i

122 anagement treatments (two row spacing, three seeding densities).

123 At moderate seeding densities, hAEC production of human laminin was

124 only occurs as a consequence of varying cell-seeding densities, it can also be observed within a smal

125 or the optimisation of electrostatic diamond seeding densities.

126 Clonal homogeneity can be obtained with low seeding densities; however, this leads to low yield and

127 efore important to quantitatively assess how seeding density affects clonality loss so that experimen

128 In this study, the effects of seeding density and a change in YAP signaling on 3D card

129 ing the growth of hESC colonies from a given seeding density based on stochastic exponential growth.

130 The spheroids with high seeding density exhibited more alpha-actinin(+) cells an

131 -management practices (e.g., row spacing and seeding density).

132 Here, using a human cell system for seeding-dependent tau aggregation, we demonstrate that t

133 ggregation of alpha-syn in vitro and prevent seeding-dependent toxicity.

134 artitions into oligomeric forms that inhibit seeding differently, and crystal structures of the M204-

135 We investigated whether tumor seeding during colonoscopy (iatrogenic implantation of t

136 ient records, we estimated the risk of tumor seeding during colonoscopy to be 0.3%-0.6%.

137 Seeding effects are hypothesized to be important in the

138 to the wild-type fibrils, with higher cross-seeding efficiency and thermodynamic stability.

139 mber alterations, the occurrence of multiple seeding events among tumor sites during metastatic tumor

140 ity could be one of the molecular mechanisms seeding evolutionary co-option.

141 Seeding experiments demonstrate that the output variatio

142 n decades ago in Vonnegut's pioneering cloud seeding experiments, it remains unclear what makes a mat

143 Using in vitro cross-seeding experiments, we show that alpha-syn fibrils stim

144 Loss of the synaptic seeding factors Syd-1 and Liprin-alpha leads to a loss o

145 r filopodia through competition for synaptic seeding factors.

146 ey events leading to LB formation, including seeding, fibrillization, and the formation of inclusions

147 Seeding from the nontumor hemisphere may attenuate asymm

148 For over half a century, cloud seeding has been evaluated as a technology to increase w

149 -binding repeat (MTBR) domains essential for seeding have been shown to undergo active secretion and

150 s bubbles and provides insights into the air-seeding hypothesis.

151 we developed automated protocols for CaMiRi seeding, image acquisition, and analysis to enable the m

152 ent a critical step toward quantifying cloud seeding impact.

153 onal analysis reveals evidence of monoclonal seeding in 41 of 42 patients.

154 es deliver better coverage than single stage seeding in about 90% of cases.

155 minoglycans and inhibition of Tau uptake and seeding in cells.

156 ncer-related mortality, mechanisms governing seeding in distal tissues are poorly understood.

157 sed approach to quantify snowfall from cloud seeding in mountain cloud systems is presented.

158 orylation dramatically attenuated metastatic seeding in the lungs, which demonstrates the functional

159 We identify that viral seeding in tissues occurs early in a tissue- and cell ty

160 Seeding, in the context of amyloid disease, is the seque

161 n the second patient, we observed polyclonal seeding, in which two independent clones seeded the meta

162 apitulate discrete steps of early metastatic seeding, including arrest, transendothelial migration an

163 odels, we visualize all stages of metastatic seeding, including: tumor cell arrival; extravasation; g

164 Consistent with the seeding-incompetent nature of the truncated tau and supp

165 f the working electrode ensures in-situ cell seeding, incubation, and further electrochemical detecti

166 The work demonstrates that seeding induces nucleation at low temperatures accelerat

167 These maps are used as seeding information for a subsequent variographic analys

168 Inhibition of seeding initiated by brain tissue extracts differed amon

169 Mast seeding is a crucial population process in many tree spe

170 In neurodegenerative diseases, seeding is a process initiated by the internalization of

171 Mast seeding is a widespread reproductive phenomenon in plant

172 eraged this concept to show that MM systemic seeding is accelerated at relapse and appears to be driv

173 Increased seeding is accompanied by decreased microglial clusterin

174 We demonstrate that amyloid plaque seeding is increased in the absence of functional Trem2.

175 tope, and supports the hypothesis that cross-seeding is one mechanism by which amyloid is linked to t

176 volution of precipitation generated by cloud seeding is then quantified using radar observations and

177 The exact mechanism of seeding is unclear yet critical to illuminating the prop

178 Structural variances of alpha-synuclein seeding kinetics and products in DLB and PD indicated, f

179 from the brain region, we observed different seeding kinetics of alpha-synuclein in the RT-QuIC in pa

180 accelerates Abeta aggregation in vitro in a seeding-like manner and the resulting fibrils are compos

181 rger areas of the brain through a prion-like seeding mechanism.

182 pathology from cell-to-cell by a prion like seeding mechanism.

183 To decipher the seeding mechanisms of alpha-synuclein (alphaS) aggregate

184 sm underlying these changes, and to evaluate seeding methodologies as a clinical tool.

185 After seeding microalgae in the TAPP medium in a solution phas

186 on the atomic structure, we propose a local seeding model where the kinked GGA motifs in the stem re

187 tion (n = 2), infection (n = 1), tumor track seeding (n = 1), and screw displacement (n = 2).

188 ses as a driver of pollen limitation in mast seeding oaks (Quercus ilex).

189 ary tissue-engineering strategies enable the seeding of a biomaterial scaffold and subsequent implant

190 neuronal LRP1 expression and ApoE4-mediated seeding of Abeta and showed that knockout of neuronal LR

191 Finally, this segment also inhibits seeding of Abeta catalyzed by Abeta fibrils extracted fr

192 In vitro studies indicated scFvs inhibit the seeding of alpha-syn aggregation in a time-dependent man

193 t and thereby likely increasing the risk for seeding of autoimmune B cell responses.

194 oma (MM) progression is characterized by the seeding of cancer cells in different anatomic sites.

195 nd survival, circulating tumour cell number, seeding of cancer cells in distant organs and metastasis

196 During metastatic seeding of cancer cells, endothelial-tumor cell interact

197 Brain metastases are thought to occur via seeding of circulating tumour cells into the brain micro

198 all major steps of metastasis, including the seeding of disseminated tumor cells (DTCs) to bone, the

199 mphasize the role of Ncad in intraperitoneal seeding of EOC and provide the rationale for future stud

200 ed by interfollicular NKT cells triggers the seeding of germinal center cells and serves as an innate

201 IV infection is characterized by rapid viral seeding of immunologic inductive sites in the gut follow

202 Indeed, seeding of jejunal organoids onto either type of scaffol

203 intraocular infection caused by hematogenous seeding of mycotic organisms to the eye.

204 osomes in some species was driven by de novo seeding of new centromeres at ancestrally gene-rich regi

205 ired to assess the relative preponderance of seeding of new metastasis by clones from primary tumors

206 e are no inhibitors that specifically target seeding of Parkinson's disease (PD)-associated alpha-syn

207 of immune functions that determine efficient seeding of peripheral tissues by a limited number of cel

208 the association kinetics via more efficient seeding of productive collisions.

209 wn what controls the formation and templated seeding of strain-specific structures associated with in

210 on, and moreover reduce aggregation and self-seeding of tau fibrils.

211 AD pathogenesis by influencing clearance and seeding of the initial aggregation of Abeta.

212 mpletely differentiated cells to prevent the seeding of the latent reservoirs that make HCMV infectio

213 ntibody titers by all vaccines, breakthrough seeding of the placenta and fetal head was observed in a

214 hanced chemokine and alarmin production, and seeding of the skin with antigen-presenting cells capabl

215 the time of HSCT enhanced T cell progenitor seeding of the thymus, T cell neogenesis and diversifica

216 iod of infection can significantly limit the seeding of viral reservoirs and modify the course of dis

217 of snowfall generated from glaciogenic cloud seeding of winter mountain cloud systems and its spatial

218 how that the combination of the SDO and self-seeding of X-rays increases the pulse energy and makes i

219 Hence, inhibitors of this seeding offer a possible route to managing tauopathies.

220 ires a long preparatory period for stem cell seeding on a scaffold and relatively invasive procedures

221 ating wall vessel (RWV) for 18 days prior to seeding on semipermeable supports to measure ion flux (t

222 on by TAK779 treatment did not affect tissue seeding or spreading, despite reduced systemic viral rep

223 different from approaches that require user seeding or well-defined training data sets.

224 tion, forming unstable aggregates capable of seeding other PSMs resulting in stable amyloid structure

225 ent with its height at the center set by the seeding particle, and the meniscus profile set by the st

226 d 0.3 mm as precipitation generated by cloud seeding passed over the instruments.

227 g the detachment, systemic dissemination and seeding phases of metastasis by limiting reactive oxygen

228 nology can affect plant reproduction of mast-seeding plants, with subsequent implications for communi

229 We sought to determine the impact of seeding point errors (SPEs) as a source of low test reli

230 uld be cognizant of false positive rates and seeding point errors as common sources of error for SFR.

231 nly because of high false positive rates and seeding point errors.

232 They are effective at seeding polyglutamine aggregation and exhibit cytotoxic

233 with increased metastatic potential and cell seeding, poor prognosis, and enhanced recruitment of tum

234 use with stem cells and usually require cell seeding post-fabrication.

235 an external source and establish the minimum seeding power required.

236 rphisms of amyloid plaques through the cross-seeding process.

237 rsor datasets identified two putative thymus seeding progenitors that varied in expression of CD7; CD

238 Our results imply that Abeta subtypes with "seeding-prone" properties may influence the polymorphism

239 aggregates with decreased hydrophobicity and seeding propensity.

240 ved embryonic stem cells for optimizing cell-seeding protocols, characterization of the resulting int

241 The total amount of water generated by cloud seeding ranged from 1.2 x 10(5) m(3) (100 ac ft) for 20

242 f transferred diversity as a function of the seeding rate between tumors.

243 Maize hybrid by seeding rate trials were conducted in 24 US states from

244 ironmental cues facilitating metastatic cell seeding remain poorly understood.

245 ulated cellular morphology, with serous side seeding resulting in a more rounded aspect ratio and int

246 without CENP-B or initial CENP-A nucleosome seeding, revealing distinct paths to centromere formatio

247 rain yield of GOC plants varied depending on seeding season and was increased significantly in the sp

248 The possibility of iatrogenic seeding seems low.

249 Bay of Bengal is known as the epicenter for seeding several devastating cholera outbreaks across the

250 ollowing long-term cell growth regardless of seeding side.

251 n HD CSF, and demonstrated that the CSF mHTT seeding species are significantly associated with certai

252 ensitivity and specificity in detecting mHTT seeding species in HD patient biosamples.

253 astrocytic apoE4, but not apoE3, during the seeding stage of amyloid development enhanced amyloid de

254 logical advances are required regarding cell seeding strategies and functional assessment.

255 of the seed ranking method used, sequential seeding strategies deliver better coverage than single s

256 Formed by an initial CENP-A nucleosome seeding strategy, a construct lacking repetitive centrom

257 lic school enrolment records, as part of the Seeding Success study.

258 ted advantage at initial steps of metastatic seeding, suggesting that Rab27a may alter cell-autonomou

259 toxic in vitro due to their capacity towards seeding tau misfolding, thereby propagating the tau path

260 ranules are hypothesized to be a conduit for seeding TDP-43 proteinopathy, we demonstrate pathologica

261 ticles is key to biomedical applications and seeding techniques.

262 ters, promoting a miliary mode of peritoneal seeding that complicates surgical removal and is associa

263 mblies showed differential neurotoxicity and seeding that were correlated with disease duration of FT

264 Mounting evidence implicates PAR in seeding the abnormal localization and accumulation of pr

265 ss-border travel might have played a role in seeding the disease in the population.

266 rotection, contributing to pathogenesis, and seeding the human placenta.

267 splantation (OR, 2.48) increased the risk of seeding the infection into the eye.

268 Seeding the networks with genes associated to disease by

269 h gliomas 40 mm or less from the IHM region, seeding the nontumor hemisphere yielded less asymmetric

270 brils) are capable of growing on the ends by seeding the refolding and incorporation of the normal fo

271 nable to generate tumors after independently seeding the skeleton of mice.

272 ng in zebrafish, we find that cardiomyocytes seeding the trabecular layer actively change their shape

273 c hand motor resting-state connectivity than seeding the tumor hemisphere (connectivity seeded:contra

274 nts between survival at 14 and 21 days after seeding, the correlation across environments was low.

275 ts and beating synchronously within 1 day of seeding; the speeds of contraction and relaxation and th

276 , 2.4 x 10(5) m(3) (196 ac ft) for 86 min of seeding to 3.4 x 10(5) m(3) (275 ac ft) for 24 min of cl

277 as well as facilitating cancer invasion and seeding to distal sites.

278 specimen can remain in the same cuvette from seeding to fixation, clearing and observation, without t

279 tracellular matrix remodeling, and increased seeding to the liver and lymph node work as interconnect

280 likely subsequent aspiration-mediated virus seeding to the lung in SARS-CoV-2 pathogenesis.

281 Ciliary tumor and seeding totally regressed after a total of 3 combined in

282 Dust classification was the most prevalent seeding type of the 9 enucleated eyes.

283 By pre-seeding uniform magnetic fields on the kilotesla order,

284 omic changes in rare metastatic cells during seeding using single-cell RNA sequencing and patient-der

285 e assess possible interventions to halt this seeding, using biochemical and EM assays.

286 Polyclonal seeding was common in untreated lymph node metastases (n

287 Remarkably, cytoplasmic aggregate seeding was detected earlier for the A315T and M337V var

288 In total, tumor seeding was suspected as the most likely etiology of met

289 This cross-seeding was unidirectional, as RPT fibrils did not influ

290 ition of the Arabideae subclades, centromere seeding was usually confined to long chromosome arms, tr

291 for their own replication, a process termed "seeding." We have previously observed that heparan sulfa

292 nal 432 contrived specimens were prepared by seeding well-characterized carbapenem-susceptible and -n

293 e ascribed the most likely etiology to tumor seeding when endoscopic manipulations, such as biopsies

294 utations is consistent with early metastatic seeding, which we estimated occurred 2-4 years before di

295 ity of individual cells for up to 1 hr after seeding, while collective forces on longer timescales ar

296 nt self-propagating isoform in vitro despite seeding with at least 12 different infectious prions fro

297 ons responsible for the observed hIAPP cross-seeding with beta-amyloid.

298 Interestingly, seeding with exogenous fibrils also induces cytoplasmic

299 s involving ejection from stress granules or seeding with exogenous fibrils.

300 d bind Tau and block its cellular uptake and seeding, without exhibiting anticoagulation activity.