ライフサイエンスコーパス: selective

1 Whole cell CRAC current is Ca(2+) -selective.

2 host, singlet fission can be strongly state-selective.

3 Surface-selective (133)Cs solid-state NMR spectra show the prese

4 Selective ablation of any of these subtypes in mice did

5 The impact of atrial/SAN-selective ablation of Galpha(o) or Galpha(i2) was consis

6 Notably, selective abrogation of EGFR signaling in myeloid cells

7 Altogether, selective activation of MC(1) is a viable strategy to in

8 have documented the importance of direction-selective activity in the areas that are active during m

9 ber of these enzymes are responsible for the selective addition of specific modifications to the asca

10 a model that virulent X. nematophila have a selective advantage and accumulate in aging IJs in advan

11 Deletion of Trp53 in gastric cells confers a selective advantage and promotes the development of dysp

12 ke protein variant D614G are suggestive of a selective advantage but may also be due to a random foun

13 g antigen stimulation-a mechanism conferring selective advantage during B-cell lymphoma development.

14 s can ensure correlated gene expression, the selective advantage of maintaining adjacent gene pairs r

15 e failures were largely due to a lack of MMP-selective agents; accordingly, it has become important t

16 al TLR7 activation via administration of the selective agonist imiquimod (5.0 mg/kg) induces a phenot

17 This effect is mirrored by subunit-selective agonists and heteromeric receptors that contai

18 aling mechanism, the structural basis of CB2-selective agonists design, and the unexpected interactio

19 ak KO mice or forebrain glutamatergic neuron-selective Ahnak KO mice display a depression-like behavi

20 ntroduce a new alignment methodology, called selective alignment, to overcome the shortcomings of lig

21 Herein, a metal-free domino synthesis of Z-selective alpha,beta-diphenylthio enones is developed fr

22 oltage-gated sodium channels comprise an ion-selective alpha-subunit and one or more associated beta-

23 Sorption of HAs to DAX-8 was less selective and caused only slight changes in electron exc

24 s through molecular self-assembly for highly selective and fast separations.

25 ic substitution, providing a mechanistically selective and irreversible scaffold for cysteine conjuga

26 In parallel, collagen I and III showed a selective and progressive increase over time.

27 We report the first examples of selective and regiodivergent opening of unsymmetrical ph

28 We designed a very selective and sensitive colorimetric sensor using synthe

29 ruthenium(II) vinyl probes allows the rapid, selective and sensitive detection of endogenous carbon m

30 med in our precursors' design rely on highly selective and sequential activations of carbon-bromine (

31 ium uniporter complex in metazoans, a highly selective and tightly controlled Ca(2+) channel of the i

32 we disclose our efforts to identify potent, selective, and orally bioavailable inhibitors of FXIa.

33 ased PDGF-BB aptasensor is highly sensitive, selective, and robust.

34 l-molecule thiophenes resulted in potent and selective antagonism of human Complement C3a receptor.

35 rdings, we found that the alpha3beta4* nAChR-selective antagonist alpha-conotoxin AuIB almost complet

36 ly bind A(2B)AR, with a number of potent and selective antagonists further confirmed by functional cy

37 e of M(1)AChR in complex with MT7, a subtype-selective anti-M(1)AChR snake venom toxin.

38 will be aided by the discovery of potent and selective antibodies against relevant viral epitopes.

39 Selective area thermal etching (SATE) of gallium nitride

40 ctional organization of neighboring category-selective areas may enable a dynamic and flexible repres

41 -level visual cortex is composed of category-selective areas that reside in nearby locations.

42 A direct and selective aromatic nitration reaction may be useful in b

43 onal click chemistry ensures fast and highly selective attachment onto a variety of biomolecular targ

44 e investigate how reinforcement learning and selective attention interact during learning from trial

45 othesis that the neural mechanisms of visual selective attention involve focal cortical changes in al

46 investigations provide direct evidence that selective attention relies on rhythmic temporal coordina

47 n catastrophizing and the ability to inhibit selective attention to pain-related faces (attentional b

48 ing impairment may impair the ability to use selective attention to suppress distracting speech in si

49 s the yeast SAR that mediates mitophagy, the selective autophagic capture of mitochondria.

50 We also observed that mitophagy (i.e., selective autophagic degradation of mitochondria) is als

51 Selective autophagic elimination of aggregates is critic

52 lein into autophagosomes for degradation via selective autophagy (termed synucleinphagy).

53 A number of selective autophagy receptors (SARs) have been character

54 The success of clinical trials of selective B-cell depletion in patients with relapsing mu

55 hology could be a risk factor for failure of selective biliary cannulation (SBC) and post endoscopic

56 ar docking model was used to rationalize the selective binding between a macrocyclic analogue and the

57 for applications involving the strong and/or selective binding of O(2).

58 type I receptor kinase-1 (IRAK-1) as a Nck1-selective binding partner, demonstrating that IRAK-1 act

59 has been associated with more effective and selective binding to target proteins compared to planar

60 anti-influenza IgG monoclonal antibodies for selective binding to the activating Fcgamma receptor Fcg

61 a significant fluorescence enhancement upon selective binding to the transport protein serum albumin

62 in a specific amino acid context that allows selective binding.

63 blished as a biocompatible reaction for site-selective biomolecular labeling and imaging.

64 oid-responsive chemokine receptor CXCR4, and selective blockade of CXCR4 reduced or eliminated the ea

65 ore exploration to identify a highly potent, selective, brain penetrant TORKi.

66 Selective breakdown of lipid droplets (LDs) by autophagy

67 inhibitor, with zanubrutinib, a novel highly selective BTK inhibitor, in patients with WM.

68 e Pd-based catalyst system to promote a para-selective C-H functionalization reaction from benzylic e

69 e intensity of interactions and the rates of selective carbonyl reduction.

70 ials have recently been identified as highly selective catalysts for the oxidative dehydrogenation (O

71 ide, have recently been identified as highly selective catalysts for the oxidative dehydrogenation of

72 AZD6738 (ceralasertib), in vitro, leading to selective cell death in ATM-deficient cells.

73 bility to excess prooxidant loads leading to selective cell death, a therapeutically exploitable diff

74 that intracortical inhibition of a direction-selective cell is spatially inhomogeneous and therefore

75 ould temporally integrate the output of tilt-selective cells into a tilt position signal.

76 sed motion responses in downstream direction-selective cells.

77 In conscious rats, selective chemogenetic activation of SubM neurons specif

78 ids to the corresponding organic halides via selective cleavage of a carbon-carbon bond between the s

79 ioorthogonal utility was demonstrated by the selective cleavage of a tetrazine-linked antibody-drug c

80 schemic HF were randomized to routine versus selective CMR.

81 eceptor genes also displayed a relaxation of selective constraints consistent with greater redundancy

82 olution, pachytene piRNA genes are under few selective constraints.

83 ered protocol, we found that TMS over object-selective cortex (lateral occipital complex) selectively

84 red object recognition, while TMS over scene-selective cortex (occipital place area) selectively impa

85 t becomes accessible upon pocket opening for selective covalent attachment of electrophilic ligands i

86 idine reactive group with the discovery of a selective covalent modifier of adenosine deaminase (ADA)

87 Finally, we demonstrate selective covalent targeting of cellular Hsp90, which re

88 Acalabrutinib is a selective, covalent Bruton tyrosine-kinase inhibitor wit

89 SA and beta-gal, respectively) attributed to selective crystallization of disodium hydrogen phosphate

90 le using isolation-based methods, indicating selective culturability for some members of the species.

91 ions" in cancer-related genes and implicated selective culture conditions.

92 Our results provide a structural basis for selective CYP3A5 inhibition, along with mechanistic insi

93 JAs possess selective cytotoxicity in mixed populations of cancer an

94 s suggest that ML417 is a novel and uniquely selective D3R agonist that may serve as both a research

95 We recently described the first selective DCLK1/2 inhibitor, DCLK1-IN-1, developed to ai

96 in early amyloid pathology and reveal that a selective decrease in excitatory synaptic drive to PV ba

97 e analysis of Hh-deficient mesoderm revealed selective deficits in anterior mesoderm populations, cul

98 nery, thus providing the molecular basis for selective degradation of sizable cytosolic components.

99 ns to lymph nodes for processing by cDC2, as selective deletion of major histocompatibility class II

100 We show that the selective deletion of OXT receptors from MCH neurons inc

101 m(-1)K(-1)) based on a process of spatially selective delignification and epoxy infiltration.

102 he obese/diabetic environment confers cancer-selective dependencies that can be therapeutically explo

103 f the Ag reference electrode and enabled the selective detection in spiked plasma as well as in whole

104 are specifically designed for sensitive and selective detection of arsenite.

105 The selective detection of carbon particles in the presence

106 GCs (thereby also reinforcing the notion of selective DG vulnerability).

107 hat employs machine learning to automate the selective discovery and isolation of novel RiPPs.

108 Through the selective DOC of SASFs with a range of dipoles and cycli

109 se units were recorded deeper than direction selective (DS) ones and at the same depth where response

110 rt we describe the discovery of a potent and selective DYRK1A inhibitor GNF2133, which was identified

111 mperatures suggests redundancy of their size-selective effects, meaning that warming will lessen the

112 Selective, efficient electrocatalysts that operate at lo

113 Here we report selective electrochemical oxidation of CH(4) to methyl b

114 Each ion-selective electrode functions in an equilibrium mode, he

115 mical cell composed of several identical ion-selective electrodes immersed into separate sample solut

116 H(+)- and K(+)-selective electrodes thus prepared exhibit highly select

117 s that 1) preferentially expose the CD4bs by selective elimination of glycosylation sites flanking th

118 This demonstrates that selective engagement and activation of FZD7 signaling is

119 ar polarisation studies of batteries and the selective enhancement of metal-solid interfaces in a wid

120 dified sialosides, through the use of highly selective enzyme cascades.

121 PH and the therapeutic potential of isoform-selective enzyme modulation are lacking.

122 ctly from biomass carbohydrates through site-selective epimerization reactions.

123 Tamoxifen is the most prescribed selective estrogen receptor (ER) modulator in patients w

124 hatchlings in most nautilids may explain the selective extinction of ammonoids as a consequence of lo

125 g in significantly reduced proliferation and selective failure to regenerate cone photoreceptors.

126 which can be synthesized in a scalable, size-selective fashion.

127 em duplication AML cells with quizartinib, a selective FLT3 inhibitor, upregulates inflammatory genes

128 lated peptides provide a new handle for site-selective fluorination of peptides, thus installing a sp

129 Although SH53d-ester is only moderately selective for alpha5-subunit-containing GABA(A) receptor

130 he Na(2)CO(3) solution is significantly less selective for HNO(3(g)) collection than the NaCl solutio

131 ET inhibition, the development of inhibitors selective for individual, or sets of, bromodomains withi

132 These monobodies are highly selective for STAT3 and bind with nanomolar affinity to

133 how that these main-group cations are highly selective for the fluoride anion, which is transported m

134 tion of the unactivated alkene is completely selective for the formation of the quaternary center, al

135 onvenient and highly effective precursor for selective formation of bromo-substituted B,N,B-benzo[4]h

136 s specific function is related to the tissue-selective functionality of SERMs.

137 sults allowed the identification of a highly selective G-quadruplex ligand that, when studied in huma

138 ze the current state of the field of subtype-selective GABA(A)R modulators acting via the BZD binding

139 pharmacology of BZDs indicates that subtype-selective GABA(A)R modulators will have novel pharmacolo

140 re-based drug design to develop more subtype-selective GPCR ligands with potentially reduced side eff

141 rated safety profile driven by significantly selective (>100-fold) inhibition of a subset of the eigh

142 Isoform-selective HDAC inhibition is a viable approach to circum

143 ignaling was unaffected by global or HDAC3/6-selective HDACi, and new protein synthesis was not requi

144 logues, thereby identifying 8 and 9 as novel selective hOAT time-dependent inhibitors.

145 he naturally occurring estrogen estetrol and Selective Human Estrogen-Receptor Partial Agonists are b

146 encoded in oligomers to be retrieved through selective hybridization with complementary, mass-labeled

147 ly available magnesium catalysts achieve the selective hydroboration of a wide range of epoxides and

148 sible reaction with dihydrogen, resulting in selective hydrogenolysis of the C-C sigma-bond.

149 rthermore, this poisoning may be cancer cell selective if this pathway is overactive in a cancer cell

150 Conversely, selective IFN receptor blockade effectively diminished t

151 on assays need to be extremely sensitive and selective in small value of intricate RNA samples.

152 ly regulated silencing of ESRRB triggers the selective inactivation of these units within SEs.

153 ct conversion to memory is associated with a selective increase in TCR sensitivity to self-peptide MH

154 s, a rapid, mostly transient upregulation of selective inflammatory markers including IL-6, CXCL10, C

155 ion of cyclin-dependent kinase 12 (CDK12) or selective inhibition of an analog-sensitive CDK12 reduce

156 duces DNA damage repair gene expression, but selective inhibition of endogenous CDK12 is difficult.

157 ght the discovery of IACS-13909 as a potent, selective inhibitor of SHP2 with drug-like properties, a

158 GSK789, a potent, cell-permeable, and highly selective inhibitor of the first bromodomains of the BET

159 PDE10A deficiency or inhibiting PDE10A with selective inhibitor TP-10, attenuated cardiac myocyte pa

160 further developments toward more potent and selective inhibitors for the tumor-expressed CA IX.

161 3 decades with an emphasis on the design of selective inhibitors that discriminate between the 11 hu

162 his work shows that Ponatinib and BRAF dimer selective inhibitors will be useful in treating BRAF-dep

163 mutations may derive benefit from p110alpha-selective inhibitors, including the recently FDA-approve

164 e design of high-affinity and enzyme isoform-selective inhibitors, we applied an approach of augmenti

165 the basis for the development of potent and selective inhibitors.

166 mpounds showed to be endowed with potent and selective inhibitory activity against the cancer-related

167 The selective insertion of the probe into a microtubule trig

168 bing their biological function, enabling the selective installation of an analysis tag for downstream

169 ified WNT proteins and by their apparent non-selective interactions with the FZD receptors.

170 Our initial results suggest that selective intra-arterial embolization is a safe and pain

171 ecipes, while concurrently subject to looped selective inversion or selective saturation procedures.

172 venue to develop functional MOF channels for selective ion conduction and efficient ion separation.

173 ation (BDI) systems because they can achieve selective ion removal and low energy deionization.

174 ness of IECs to type III IFN in vivo enables selective ISG expression during infection that confers a

175 Abrocitinib, an oral selective Janus kinase 1 inhibitor, was effective and we

176 we report the discovery of a series of JAK1-selective kinase inhibitors with high potency and excell

177 vely turns the macropores into a charged ion-selective layer and thus increases the conductivity of m

178 via structural optimization: first, a smooth selective layer should be maintained to ensure uniform f

179 ionization behavior of nanoporous polyamide selective layers in state-of-the-art nanofiltration (NF)

180 ctosyl-carborane building blocks to the GRPR-selective ligand [d-Phe(6), beta-Ala(11), Ala(13), Nle(1

181 ox protein 2 (SPSB2) that binds to iNOS, and selective ligands for AGRP-binding melanocortin (MC) rec

182 Compound 5 represents a new class of selective ligands with antileishmanial activity.

183 se binding properties were exploited for the selective liquid-liquid extraction of primary ammonium s

184 Review and synthesis of selective literature, with interpretation and perspectiv

185 Selective logging is the dominant form of human disturba

186 e conditions are associated with a rapid and selective loss of BBB transcripts and chromatin features

187 The cause of this selective loss of beta cells needs to be further elucida

188 rexpression culminating in extensive, highly selective loss of DG GCs (thereby also reinforcing the n

189 of MPTP resulted in severe motor impairment, selective loss of dopamine neurons and increased astrocy

190 ceptor-ligand crosstalk in cancer, including selective loss of function for tumor-associated mutation

191 UCM-05194) stands out as the most potent and selective LPA(1) receptor agonist described so far (E(ma

192 development of robust, efficient and highly selective LRSPR based biosensors with SiO(2) as tunable

193 iscovery of a novel series of reversible and selective LSDl inhibitors.

194 galactose could represent novel targets for selective manipulation of CD11b function and reduction o

195 ng, including brightness(2), low cost(3) and selective manipulation of their emission(4).

196 n onto OFC pyramidal neurons in a regionally selective manner.

197 s unusually long (9-29 ns), facilitating its selective measurement in complex media using a lifetime-

198 heterokaryotic transformant was observed on selective medium containing hygromycin B, neither germin

199 ng of ion-transfer (IT) processes across ion-selective membranes (ISMs) with thicknesses in the nanom

200 her that cathode coatings composed of cation selective membranes provide a straightforward method for

201 We report a versatile and selective method to functionalize peptides and proteins

202 ikely targets the receptor complex in ligand-selective modes.

203 Molecular tagging involves the selective modification of particular functional groups,

204 nt a single-step, versatile strategy for the selective modification of protein N-termini with mass bo

205 We used [(11)C]carfentanil, a selective MOR agonist positron emission tomography (PET)

206 esses drive the disease process resulting in selective motor neuron degeneration in different disease

207 cales present in the low-dimensional orbital-selective Mott phase (OSMP) induce an exotic magnetic or

208 ploited to achieve visual memory, wavelength-selective multibit programming, and erasing functions, w

209 ectures, which allows for engineering such a selective multivalent metal ion binding site into target

210 nalysis of VirChR1 shows that it is a highly selective, Na(+)/K(+)-conducting channel and, in contras

211 ally hazardous substances, and sensitive and selective nanomaterials represent only a few of these po

212 Although we found no fully invariant OMA-selective neuron, we discovered a population code that a

213 mune populations and may enable discovery of selective neuroprotective strategies.

214 Selective nitrogen substitution into the ortho positions

215 the discovery of second-generation GluN2C/D-selective NMDAR-positive allosteric modulators (PAMs) wi

216 These species-independent A(3)AR-selective nucleosides are low efficacy partial agonists

217 and symmetry are simultaneously achieved by selective, 'one-pot' coordination of soft and hard metal

218 Further, within the PVN, selective optogenetic stimulation of afferents that aris

219 y led to the discovery of the potent, highly selective, orally available ATR inhibitor BAY 1895344, w

220 piro[4.5]decan-4-amine (1), a highly potent, selective, orally efficacious, and first-in-class SHP2 i

221 he same depth where responses of orientation selective (OS) GCs were recorded.

222 displayed marked global hypomethylation and selective overexpression of histone genes.

223 We show that SST interneuron-selective overexpression of Lypd6, an endogenous nicotin

224 Subtype-selective OX1R antagonists are valuable tools to further

225 em, giving rise to an ideal platform for the selective oxidation of anthracene.

226 Selective oxidative deamination has long been considered

227 d by surface adsorbed iodide enable the site-selective oxidative etching of Au(0), which leads to non

228 esis in response to elevated glucose and the selective P2Y(11) agonist NF546 is blocked by disruption

229 Selective partial oxidation of methane to methanol suffe

230 OM) of Gram-negative bacteria functions as a selective permeability barrier to the environment.

231 In mice, genetic ablation or selective pharmacological inhibition of FAAH bidirection

232 and provide new mechanistic insights on the selective poor response of SCC-TAFs to nintedanib.

233 ng, completely stereo-, regio- and furanosyl-selective prebiotic synthesis of the purine deoxyribonuc

234 of CycA conservation, highlighting a strong selective pressure for functionality.

235 In social organisms, this may include selective pressure from the social environment.

236 The selective pressure imposed by extrinsic death signals an

237 rowing body of literature showing that phage selective pressure promotes mutations in bacteria that a

238 conditions to evaluate support for different selective pressures in driving the evolution of glucocor

239 tment during tumor progression and under the selective pressures of immune surveillance, remain unkno

240 Japanese and European populations differ in selective pressures on clones long before the developmen

241 luences upon the environment, creating novel selective pressures to which organisms must adapt.

242 est suited for organisms evolving under weak selective pressures, such as animals and plants.

243 lity to quickly adapt in the face of extreme selective pressures.

244 However, evidence for selective proactive control before stopping was manifest

245 d found reduced fluorescence of a superoxide-selective probe within the primordia of tt7-2 compared w

246 However, highly selective probes for individual SHs are scarce because p

247 ne into liquid chemicals, whereas an ambient selective process with minimal infrastructure support re

248 ve been considerable efforts to develop more selective processes for less constrained substrates.

249 phenotypic divergence even in the absence of selective processes.

250 tude, establishing a functional link between selective processing and gamma-activity.SIGNIFICANCE STA

251 Finally, we demonstrate selective promotion of the Au-C bond formation by contro

252 drug molecules is demonstrated through site-selective protein modification and incorporation into ki

253 (14) can mimic membrane proteins and exhibit selective proton transport across lipid bilayers at a ra

254 ow-cost (~0.03 $ per sweat patch), portable, selective, rapid, and non-invasive healthcare monitoring

255 to the laser-irradiated region, leads to the selective reaction of graphene, thereby completing direc

256 incorporation of chemical groups with highly selective reactivity into small molecules or protein mod

257 hemical sensor, confirming the sensitive and selective readings of the bio (sensing) imprinted film.

258 rimary ammonium salts from water and for the selective recognition of lysine-containing peptides, ope

259 between inner and outer photoreceptors using selective recovery of activity in photoreceptor pairs.

260 ion) were evaluated and compared towards the selective recovery of bioactive compounds.

261 9%), and PGD development was associated with selective reduction of the ILC2 subset after reperfusion

262 tive electrodes thus prepared exhibit highly selective responses with the theoretically expected (Ner

263 ery and clinical validation of highly potent selective RET inhibitors (pralsetinib, selpercatinib) de

264 Here an alternative approach to the existing selective reverse INEPT FESTA (SRI-FESTA) experiment is

265 These recordings revealed a critical and selective role for K(v)1 channel inactivation in synapti

266 Together, our findings provide evidence for selective SARS-CoV-2 neurotropism and support the use of

267 tly subject to looped selective inversion or selective saturation procedures.

268 cular dynamics modeling, we show that mildly selective self-assembled monolayers can influence the st

269 action), between F(-) and MOF host, a highly selective, sensitive, and reliable fluoride sensor was t

270 Selective serotonin reuptake inhibitors (SSRIs) constitu

271 Most antidepressants, including selective serotonin reuptake inhibitors (SSRIs), initiat

272 between HC organization and function, these selective shifts are likely to have played a significant

273 alogenation constitutes the first example of selective, single-site halide doping of homometallic met

274 results demonstrate that targeting FPR1 by a selective small molecule antagonist, such as ICT12035, c

275 th this, inhibition of FGFR1 function by the selective small-molecule inhibitor BGJ398 enhanced EGFR

276 The NPT2a-selective small-molecule inhibitor PF-06869206 was previ

277 In this work, a selective sorbent for carbendazim was prepared by the th

278 tween MHC and antigenic peptides is the most selective step in the antigen presentation pathway.

279 Selective stimulation of cholinergic axons was sufficien

280 Sulfamethazine (NAT2-selective substrate) and NAT2 protein expression differe

281 esponse to the face and was expressed as the selective suppression of sustained responses to low-iden

282 Phase separation is crucial for selective surfactant formation as well as autocatalytic

283 Selective sweeps are thought to play a significant role

284 The ability to achieve chirality-selective synthesis (chiral induction) is of great impor

285 ompound for structural optimization aimed at selective targeting of ClpB and/or DnaK.

286 Selective targeting of cyst cell proliferation is an eff

287 al therapeutic target in pediatric B-ALL and selective targeting of Plk1 can be achieved by the use o

288 naptic network embedded through acoustically selective TeA neurons that help link the calls to a disc

289 Some cortical neurons receive highly selective thalamocortical (TC) input, but others do not.

290 t that targeting mortalin has potential as a selective therapeutic strategy in B-Raf-mutant or MEK-ER

291 ty of CRLF2-rearranged Ph-like ALL following selective TKI pressure, which occurs in the absence of g

292 sfunctional immune response, and therefore a selective TLR8 agonist may be an effective treatment opt

293 osols from the tank experiments-suggesting a selective transfer of organic compounds from seawater in

294 o break the energetic degeneracy and provide selective transformations.

295 y filter (SF) disrupts inactivation and K(+)-selective transport in hERG1, leading to arrhythmogenic

296 Interestingly, selective uptake can also be achieved in CA IX overexpre

297 Selective use of race-specific algorithms for workers' c

298 , demonstrations of information covering and selective visualization are successfully implemented wit

299 hanisms and causal determinants of cell type-selective vulnerability and to identify therapeutic targ

300 erted interplay during development specifies selective wiring and transmission of cone signals.