ライフサイエンスコーパス: selective pressure

1 tedly test diverse sequences with a designed selective pressure.

2 play critical functional roles and are under selective pressure.

3 aclovinus, showing limited impact of relaxed selective pressure.

4 spatio-temporal expression modes affected by selective pressure.

5 d efficiency and is presumed to be under the selective pressure.

6 ation of regions that may be under different selective pressure.

7 dence that the tet(W) gene is under positive selective pressure.

8 benefit relationship during times of intense selective pressure.

9 may not be well maintained in the absence of selective pressure.

10 asing copy number, may be sites of secondary selective pressure.

11 rge in genetic sequences of HIV through drug-selective pressure.

12 and to identify the corresponding phenotypic selective pressure.

13 r mutation rates as a response to changes in selective pressure.

14 vaccine candidates in the context of strong selective pressure.

15 t capsid residues not being under any strong selective pressure.

16 CENP-B favors neocentromere formation under selective pressure.

17 also limit possible structural solutions to selective pressures.

18 ddition microcosms, suggesting deterministic selective pressures.

19 environments seem to have created important selective pressures.

20 ed-associated behaviors resulting from human selective pressures.

21 courtship behavior, which is under different selective pressures.

22 rtality, continuously evolves in response to selective pressures.

23 , suggesting the need to consider additional selective pressures.

24 r addition to natural systems results in new selective pressures.

25 tries might be explained by local antibiotic-selective pressures.

26 unctions, to generate variation and adapt to selective pressures.

27 drug concentration, and (d) the strength of selective pressures.

28 ersity, recombination, allele frequency, and selective pressures.

29 pread throughout the lung, suggesting global selective pressures.

30 fferent environments, which impose different selective pressures.

31 tion, rapid demographic changes, and ongoing selective pressures.

32 netic responses of the two species to recent selective pressures.

33 configuration that reflects context-specific selective pressures.

34 balance between the levels of mutations and selective pressures.

35 ong oceanographic gradients and hence strong selective pressures.

36 temporal variability in recruitment or local selective pressures.

37 lity to quickly adapt in the face of extreme selective pressures.

38 breeding population may experience different selective pressures.

39 ed predators, which may impose contradictory selective pressures.

40 bservations indicate that genes under weaker selective pressure accumulate more maladaptive substitut

41 ctionally similar genes can suggest a common selective pressure across a group of species.

42 rt a direct role for IFN-lambda4 in exerting selective pressure across the viral genome, possibly by

43 y use in other functions, leading to complex selective pressures across space and time.

44 iched for transposable elements suggesting a selective pressure acting on lncRNAs length and composit

45 he stasis is likely to be due principally to selective pressure acting on pollen morphogenesis becaus

46 formed support the presence of long-standing selective pressures acting against ADHD-associated allel

47 n dynamics is relatively unexplored, and the selective pressures acting on CVB3 in the intestine are

48 olate traits, likely as a result of specific selective pressures acting on each defense.

49 regulation of 3' UTR isoforms is a proxy for selective pressures acting upon APA usage and consequent

50 of immune surveillance resulting in negative selective pressure against gene fusion-derived neoantige

51 Selective pressure against immune escape by pathogens ca

52 duals in the population experience different selective pressures along that gradient and quantify var

53 Darwinian selective pressures alter L1 genomic distributions durin

54 and cardiovascular systems, and suggest that selective pressure altered haemostasis genes to help Kom

55 ss populations to explore the differences in selective pressures among the three regions sampled.

56 milar taxa suggested dispersal and/or common selective pressures among zones.

57 Additionally, since cancer cells are under selective pressure and are prone to adaptation, particul

58 Harboring EGFR mutations is critical to the selective pressure and further impacts the prognosis.

59 mans and chimpanzees; the former are free of selective pressure and may thus include both neutral and

60 This has resulted in a selective pressure and opportunity to reduce the levels

61 ciations, suggesting they are under negative selective pressure and providing a basis for investigati

62 Selective pressures and competition between yeasts influ

63 torical function or if the intense divergent selective pressures and geographical barriers have creat

64 These results indicate that selective pressures and PRDM9 function contribute to var

65 nition-which can address questions about the selective pressures and proximate mechanisms driving cog

66 contribute to a better understanding of the selective pressures and rates of molecular evolution in

67 nd adaptive evolutionary response to a novel selective pressure, and that explicitly (quantitative) g

68 Thus, selective pressure appears to conserve the distribution

69 Instead we hypothesized that the selective pressure applied during the establishment of [

70 Self-replication and evolution under selective pressure are inherent phenomena in life, and b

71 These selective pressures are associated with the quality of o

72 ntial for trap function, suggesting that key selective pressures are in action.

73 ; an African ancestral variant adopted under selective pressure as protection against malaria) was as

74 nt subpopulations adapt to location-specific selective pressures as they migrate and evolve across sp

75 o in extant land plants reflects more recent selective pressures associated with improved diffusive s

76 rther elucidated adaptations, responses, and selective pressures associated with the semi-terrestrial

77 about the origin and timing of the onset of selective pressures associated with, for example, the co

78 fic sequence analysis reveals no evidence of selective pressure at this region of the molecule, sugge

79 d ARGs, exemplifying the potential impact of selective pressures at both low (10 mug/L) and high (250

80 mechanisms, in combination with differential selective pressures at the population level, resulted in

81 to climate and are likely to be under strong selective pressure, but their macro-evolutionary history

82 Thus, selective pressure by ssNAbs to maintain the N332 glycan

83 cific retrovirus-receptor interactions under selective pressure by the host results in the emergence

84 We then introduced a second selective pressure by transferring chloramphenicol-resis

85 Here, we probe ancient selective pressures by computing %GC-corrected rates of

86 udy highlights how independent and divergent selective pressures can alter allometry.

87 demographic features, spatial processes, and selective pressures can result in the accumulation and e

88 ells, where co-occurring mutations and tumor selective pressures complicate the influence of NRF2 on

89 volve independently in response to different selective pressures corresponding to their distinct func

90 Novel selective pressures derived from human activities challe

91 Biotic selective pressures dominate explanations for the evolut

92 secondary resistance often occurs as immune selective pressure drives outgrowth of resistant tumor c

93 riation in breeding season length is a major selective pressure driving life-history variation along

94 We thus reveal the underlying selective pressures driving morphological diversity in a

95 e effects of germline genetic context on the selective pressures driving somatic clonal evolution are

96 When strain BQ11 was exposed to meropenem, selective pressure drove amplification of the transposon

97 ent in class A beta-lactamases that is under selective pressure due to antibiotic use.

98 In order to better understand shifts in selective pressure due to stewardship, we use publicly a

99 n humans, and they likely experienced strong selective pressures due to their unique lifestyle in the

100 bitual vertical support use exerted a strong selective pressure during crown primate origins.

101 tic marine species are potentially born from selective pressures during Cenozoic global cooling and e

102 traits may experience long periods of stable selective pressures, during which the stochastic forces

103 f SPI-2 T3SS effectors in the context of the selective pressures encountered by S. enterica in vivo.

104 cuity is a trait whose value would depend on selective pressures, even during prebiotic evolution.

105 Selective pressure exerted by HIV-1 protease inhibitors,

106 ded evolution approach that does not require selective pressure exerted by NAbs.

107 rum transmission was used to investigate the selective pressure exerted on parasite populations by us

108 re found between HCV quasispecies diversity, selective pressure exerted on the HCV E2 envelope protei

109 Although selective pressures exerted by different activity patter

110 ortance in a range of species as well as the selective pressures exerted on viruses to antagonize it.

111 symmetric division in female meiosis creates selective pressure favoring selfish centromeres that bia

112 Selective pressure favoring the Cys529 codon may have co

113 We discovered that exposure to phage selective pressure favors mutation in nonconserved epa g

114 ing population use of 4C antibiotics reduced selective pressures favouring multidrug-resistant epidem

115 ing population use of 4C antibiotics reduced selective pressures favouring multidrug-resistant epidem

116 pidly evolve their phenotypes in response to selective pressures follow short-term optima, with the r

117 the orthosteric site, further motivating the selective pressure for additional modes of selectivity.

118 ed camouflage pattern, suggesting a possible selective pressure for animals to orient themselves appr

119 nction alterations in BRCA1/2, respectively, selective pressure for biallelic inactivation, zygosity-

120 ns are one of the novel approaches with less selective pressure for developing resistance than tradit

121 of CycA conservation, highlighting a strong selective pressure for functionality.

122 rent Biology, Grawunder et al.[4] argue that selective pressure for higher f(0) has led to the evolut

123 that in rhesus monkeys, there is independent selective pressure for loss of babA and for overexpressi

124 pread of MDROs include oversight to decrease selective pressure for MDROs by promoting appropriate an

125 use of antibiotics with the aim to decrease selective pressure for multidrug-resistant organisms in

126 stable Mre11-Nbn(mid8) interaction, and that selective pressure for overexpression reflects the essen

127 domain and trimerization interface are under selective pressure for PG16 binding.

128 These results indicate selective pressure for production of GA4 in the distinct

129 t do not affect growth, resulting in reduced selective pressure for resistance.

130 ad to decreased pesticide use and reduce the selective pressure for resistant pathogens.

131 cted typhoid might therefore be an important selective pressure for the emergence and spread of antim

132 nst HlyU-harboring Vibrio species with a low selective pressure for the emergence of resistance.

133 atmospheric oxygen (O(2) ) levels provided a selective pressure for the evolution of O(2) -dependent

134 ults provide compelling evidence that strong selective pressures for high vocal efficiency may have b

135 Our results demonstrate that the selective pressures for organisms within a single water

136 cape mutants that might arise in response to selective pressure from a single-antibody treatment.

137 Understanding how selective pressure from chemotherapy directs the evoluti

138 Viruses are under relentless selective pressure from host immune defenses.

139 In social organisms, this may include selective pressure from the social environment.

140 nt mechanism used by organisms to respond to selective pressures from the environment.

141 troller described here, it seems likely that selective pressures from the humoral immune system were

142 in cold climates, while a range of competing selective pressures further influence eggshell colours i

143 uppressors, tumor evolution may react to the selective pressure generated by inflammation to globally

144 accumulated in recent years [1-14], but the selective pressures governing the evolutionary fate of t

145 29; we also provide an overview of potential selective pressures guiding both Shigella phage and host

146 To investigate how this selective pressure has affected the genetic regulation o

147 eral defenses will reveal the interbacterial selective pressures impacting bacterial survival in natu

148 nce mutations responding to antibody-induced selective pressure.IMPORTANCE Influenza A virus is a pub

149 The selective pressure imposed by extrinsic death signals an

150 Our data suggests that the continuous selective pressure imposed by widespread Carbapenem util

151 a structure-enabled history of evolutionary selective pressure imposed on the human proteome.

152 th a high mutation rate enables HIV to evade selective pressures imposed by host immune responses.

153 Selective pressures imposed by pathogens have varied amo

154 of spread among metastases, the extent that selective pressures imposed by treatments cause bottlene

155 these sutures under tension, is the driving selective pressure in the evolution of the female Curcul

156 via the transfer of mobile genetic elements, selective pressure in vivo resulting in gene mutations,

157 of agriculture imposed radically heightened selective pressures in agriculturalist populations.

158 To assess the possible role of different selective pressures in determining Native American HLA d

159 conditions to evaluate support for different selective pressures in driving the evolution of glucocor

160 the need to investigate interactions between selective pressures in other cases of puzzling adaptive

161 tterns of plant diversity by imposing strong selective pressures in species-rich areas across the glo

162 encing gut microbiome dynamics under extreme selective pressures in the clinical context of HCT.

163 isolated from mopane trees, to determine how selective pressures in the environment coincidentally ad

164 e was largely consistent with increased drug-selective pressures in the plasma, overrepresentation of

165 ion rates that allow for rapid adaptation to selective pressures in their environment.

166 ion intolerant genes, supporting the role of selective pressures in this early-onset phenotype.

167 ough investigation of the impacts of diverse selective pressures including genetic alterations, thera

168 bsequently mineral-interacting functions via selective-pressure incorporation and click chemistry, re

169 tend these cavities have recently been under selective pressure, indicating that larger charged pocke

170 ny variables, potentially involving external selective pressures induced by therapies.

171 e of four subjects on ART to investigate the selective pressures influencing the dynamics of the trea

172 nary perspective to understand the principal selective pressures involved in stomatal evolution, thus

173 orphism N86 by IPTp-MQ highlights the strong selective pressure IPTp can exert and the opportunity fo

174 However, their genetic stability under selective pressure is largely unknown.

175 nvironments and are exposed to a plethora of selective pressures, leading to multiple genetic adaptat

176 n of this strategy, it has been unclear what selective pressure maintains the fitness of this develop

177 Different selective pressures may also promote different rates of

178 These countervailing selective pressures may explain why a breadth of sizes e

179 eed traits illustrates how a wide variety of selective pressures may influence the function and physi

180 s populations, the specific loci affected by selective pressures more often vary across populations.

181 vely, our results suggest that the strongest selective pressures occur during early glioma developmen

182 osis provides insight into the mutations and selective pressures occurring over the course of an infe

183 Cancer aggressiveness may result from the selective pressure of a harsh nutrient-deprived microenv

184 assessment and how groups are shaped by the selective pressure of contests.

185 that these mutations were acquired under the selective pressure of ER-directed therapy.

186 nd S. aureus that has evolved under the dual selective pressure of host immune responses and antibiot

187 te and whale sharks may reflect the combined selective pressure of large genome sizes, high repeat co

188 with hyperactivated RAS signaling escape the selective pressure of MEK inhibition via YAP1-mediated t

189 tDNA demonstrated tumour evolution under the selective pressure of NAC e.g. in one case, urine analys

190 Thus, we hypothesized that a selective pressure of plant-based diets on fish gut micr

191 to muscle repair and niche repopulation upon selective pressure of radiation stress, consistent with

192 own that the same mutation emerged under the selective pressure of small-molecule antiviral treatment

193 tment during tumor progression and under the selective pressures of immune surveillance, remain unkno

194 enesis in humans results from the cumulative selective pressures of multiple amoebal hosts in the env

195 land exploration, stabilized by the opposing selective pressures of their amphibious habits.

196 ich the chromatin state is altered under the selective pressures of therapy is unknown.

197 The selective pressures of widespread macrolide use and PCV7

198 ericidal or bacteriostatic agents that place selective pressure on bacteria, leading to the expansion

199 ions in individual conditions, the long-term selective pressure on Hsp90 may have been that of fluctu

200 senic at a high concentration imposes strong selective pressure on microbes, various microbes have be

201 We speculated that altering the selective pressure on mutant cell populations may cause

202 The host immune response can exert strong selective pressure on pathogen virulence, particularly w

203 h as nutrient availability has a significant selective pressure on the biodiversity of microorganisms

204 ls in typhoid-endemic settings has increased selective pressure on the development of antimicrobial-r

205 eated reactivation events, suggesting strong selective pressure on the viral genome to maintain seque

206 have virus restriction mechanisms that exert selective pressure on the viruses during sexual transmis

207 harsh northern conditions may impose greater selective pressure on timing of growth cessation, and th

208 in natural populations might be an important selective pressure on traits of bacteria that facilitate

209 al lesions, imposing a distinct and profound selective pressure on tumour cells that, in turn, shapes

210 imate change is exerting increasingly strong selective pressures on a myriad of fitness traits that a

211 rical environments might have imposed strong selective pressures on BMR to compensate for increased r

212 We suggest that selective pressures on clones are modulated by factors t

213 Japanese and European populations differ in selective pressures on clones long before the developmen

214 These responses exert strong selective pressures on different parts of HIV's genome,

215 constant cold has apparently not relaxed the selective pressures on maintaining HSF1 and HSEs in Anta

216 sition, illustrating the effect of different selective pressures on the core.

217 t with this hypothesis but implies different selective pressures on the immune system due to contrast

218 We take advantage of the intense selective pressures on the major malaria vector Anophele

219 iversity of environments has placed variable selective pressures on the populations living in each re

220 tumor-type specific, suggesting differential selective pressures on the two tumor cell types.

221 therapeutic strategies that combine opposing selective pressures on this parasite transporter as an a

222 immune modulation, through differing immune selective pressures, on viral evolutionary behavior in a

223 pism was observed, and there was no apparent selective pressure or constraint of emm types.

224 ce-based discovery of polymorphisms under co-selective pressure or epistasis has received considerabl

225 l genes, which are likely targets of greater selective pressure (p = 0.006, for the 22 autosomes).

226 ed in the Southern Ocean suggests that other selective pressures, particularly food availability and

227 rowing body of literature showing that phage selective pressure promotes mutations in bacteria that a

228 administration early in life exerts a strong selective pressure, providing mutants with a growth adva

229 e influences evolutionary rates by modifying selective pressures rather than through its effect on en

230 tionary rate estimates, inference of natural selective pressures, recombination and reassortment, and

231 indicating that carnivores are under strong selective pressure related to diet.

232 unction with high photorespiratory flux as a selective pressure relevant to the evolution of C4.

233 However, much is unknown about how selective pressures resulting from nutrient limitation s

234 etic variants and exposing these variants to selective pressure, resulting in the survival of the fit

235 ntergenerational plasticity and sex-specific selective pressures, sexual conflict and sexual selectio

236 that both hydrologic connectivity and local selective pressures shape microbial communities in the G

237 The selective pressures shaping its mutational spectrum, dom

238 etic signal, partly related to environmental selective pressures shaping lineage evolution.

239 itro models are a powerful tool to study the selective pressures shaping the viral landscape.

240 tionships of obligate mutualists may lead to selective pressures similar to those seen in parasites,

241 est suited for organisms evolving under weak selective pressures, such as animals and plants.

242 of proteins to respond rapidly to divergent selective pressures, such as sexual conflict or reproduc

243 tic tumor- and tissue-specific variations in selective pressures suggest that cancer cells with advan

244 d in this battlefield points to a reciprocal selective pressure suggesting a coevolutionary arms race

245 e thought to be evolving under much stronger selective pressures, suggesting that forward-in-time sim

246 and proximal duplicates experienced stronger selective pressure than genes formed by other modes and

247 e lectin and CD2v may experience substantial selective pressure than previously thought.

248 mber variants (CNVs) are subject to stronger selective pressure than single-nucleotide variants, but

249 that TRmIND is under different evolutionary selective pressures than TRmD.

250 neous delivery of dual Ags may alleviate the selective pressure that is thought to potentiate antigen

251 ase the use of antibiotics, thereby reducing selective pressure that leads to antibiotic resistance m

252 Predation is hypothesized as one selective pressure that may have driven the evolution of

253 The disturbance imposed a strong selective pressure that persisted for up to 10 days, aft

254 r active TGFbeta represents an unappreciated selective pressure that promotes the accumulation and pe

255 that arise from context- and allele-specific selective pressures that are dependent in part on gene a

256 Caves offer selective pressures that are distinct from the surface.

257 ange their environment, thereby imposing new selective pressures that can modify their biological tra

258 ase environments and are subject to shifting selective pressures that can result in pathoadaptation o

259 nsporters is needed to identify the types of selective pressures that contribute to this process.

260 These may impose selective pressures that drive genomic diversification a

261 er the negative evolutionary change, nor the selective pressures that drive it, are apparent on the p

262 We propose the possibility that selective pressures that favor more synchronizable subgr

263 widespread use of antibiotics has generated selective pressures that have driven the emergence of re

264 nge for most applications is the presence of selective pressures that lead to high mutation rates for

265 ally and together, in order to elucidate the selective pressures that maintain multi-modal defence me

266 These responses reflect the selective pressures that these fungi have faced relative

267 lly and reversibly, and in the presence of a selective pressure the advantageous phenotype(s) predomi

268 es (TCVs) in these settings may relieve this selective pressure, thereby reducing resistant infection

269 ast number of these ancient variants and the selective pressures they survived yield insights into ge

270 lished a permanent presence and have altered selective pressures through influences such as invasive

271 pecies are likely to experience more dynamic selective pressures through ontogeny compared with speci

272 vative floral morphologies even under strong selective pressure to change from their environments.

273 The selective pressure to decrease gene expression due to th

274 ween otherwise related orthologs, suggesting selective pressure to diversify PAM recognition and supp

275 result, the mosaics are not under long-term selective pressure to encode a functional protein; conse

276 n and therefore place microbes under extreme selective pressure to evolve resistance.

277 In particular, in SDS there is enormous selective pressure to expand TP53-mutated HSPCs, suggest

278 he mitochondrial division machinery provides selective pressure to identify dysfunctional organelles

279 ividuals (i.e., potential leaders) are under selective pressure to maintain group cohesion, favoring

280 te cis and trans acting functions, providing selective pressure to maintain multiple copies of 3B.

281 biofilm-associated infection there is a high selective pressure to maintain QS control.

282 ance may release former constraints on other selective pressures to breed early, such as seasonal dec

283 cence, which is under identical age-specific selective pressures to fertility.

284 It may arise from selective pressures to infer and avoid social threats, p

285 This implies that selective pressures to modulate such pathways operate du

286 luences upon the environment, creating novel selective pressures to which organisms must adapt.

287 Our results can explain the strong selective pressure towards the evolution of sexual cell

288 explain the uniqueness of our brain and the selective pressures under which it evolves.

289 rch, we synthesise current literature on the selective pressures underlying the evolution of MLSs and

290 often occurred in the distant past, and the selective pressures underlying these ancient events have

291 Contrasting emergent soil structures exert selective pressures upon the microbiome metagenome.

292 agents of natural selection, producing acute selective pressures very different from the everyday pre

293 fer and more stable than strains obtained by selective pressure via mutagenic nucleotides or adaptati

294 Applying differential selective pressure, we identified the three strongest vi

295 ary processes by allowing the examination of selective pressures which lead to particular optimal sol

296 ions in each receptor subunit that are under selective pressure, which has focused research efforts a

297 ias for pMHC molecules in the absence of any selective pressure, which is further strengthened in the

298 to genotypes that remain fit across diverse selective pressures; while multi-drug resistant microbes

299 stead, we found HSF1 experienced intensified selective pressure, with conserved sequence changes in A

300 c evolutionary pattern mediated by intrahost selective pressure, with important nucleotide substituti