ライフサイエンスコーパス: selective toxicity

1 e a new group of anticancer drugs with tumor selective toxicity.

2 evaluated in cell culture to delineate their selective toxicity.

3 ine atovaquone-binding affinity, and thereby selective toxicity.

4 noline-derived Mannich bases with robust MDR-selective toxicity.

5 ent a new class of anticancer agents showing selective toxicity against cancer cells.

6 ions include: (a) tirapazamine having a high selective toxicity against hypoxic cells; (b) the nature

7 inhibitors (BXI-61 and BXI-72) that exhibit selective toxicity against lung cancer cells compared wi

8 t disulfiram (DSF) is shown to have a highly selective toxicity against melanoma in culture, inducing

9 a new avenue to defeat cancer by exploiting selective toxicity against multidrug-resistant (MDR) can

10 XII inhibitors were also screened for their selective toxicity against non tumoral primary cells (fi

11 humans, inhibitors that target DapE may have selective toxicity against only bacteria.

12 inhibitor does not consistently produce the selective toxicity and pathological hallmarks characteri

13 may be the fundamental mechanism conferring selective toxicity and therapeutic effectiveness in OGG1

14 ecificity for insect nicotinic receptors and selective toxicity as insecticides.

15 cations for insecticide cross-resistance and selective toxicity between insects and mammals.

16 ical screen and discovered compounds showing selective toxicity for breast CSCs.

17 Biliatresone has selective toxicity for extrahepatic cholangiocytes (EHCs

18 The complex displays selective toxicity for HMLER breast cancer cells enriche

19 n-binding drug combretastatin A-4 exhibits a selective toxicity for proliferating endothelial cells i

20 ative, the antimalaria drug quinacrine, have selective toxicity for tumor cells and can simultaneousl

21 o spinal mitochondria as the basis for their selective toxicity in ALS.

22 ent of a DNA-alkylating compound that showed selective toxicity in breast cancer cells.

23 has focused on genomic expression related to selective toxicity in chiral pesticide, nor on epigeneti

24 ition of KSR1 or EPHB4 effectors may lead to selective toxicity in colorectal tumors.

25 We confirm that the compounds show selective toxicity in ERa-expressing cells, induce ERa l

26 e (GSH) depletion induces ROS production and selective toxicity in HL60 cells that overexpress Bcl-2

27 ur cell-based platform for facile testing of selective toxicity in MSI versus MSS cell lines.

28 This type of selective toxicity might be potentially important in the

29 ytotoxic drug cargo, exhibited M2 macrophage-selective toxicity not observed in monovalent M2pep trea

30 d patterns of Htt proteolysis leading to the selective toxicity observed in HD striatum.

31 Although the selective toxicity of 5,7-dihydroxytryptamine (5,7-DHT)

32 This study reported the selective toxicity of 6PPD-Q and pinpointed the possibil

33 The structurally selective toxicity of 6PPD-Q was also observed in a coho

34 umulation levels were not the reason for the selective toxicity of 6PPD-Q.

35 The cell-selective toxicity of Abeta resembles the selective dama

36 important implications for understanding the selective toxicity of anti-cancer drugs in tumor cells.

37 nderstanding of the structural basis for the selective toxicity of atovaquone could help in designing

38 We nonetheless suggest that the selective toxicity of BCL-X(L) antagonists to HIV-infect

39 il, a P-gp inhibitor, partially reversed the selective toxicity of both 1 and 10.

40 therapeutic intent as well as to promote the selective toxicity of cancer cells.

41 The selective toxicity of chemicals to lung tissues is predo

42 The exact mechanisms for the selective toxicity of chemotherapeutic drugs against tum

43 Cell proliferation assays demonstrated selective toxicity of combination bicalutamide-(18)F-FDG

44 The selective toxicity of DEP for DA neurons was demonstrate

45 To investigate the selective toxicity of emodepside, we performed transgeni

46 Selective toxicity of full-length human mutant HTT (fl-m

47 We describe a novel strategy to increase the selective toxicity of genotoxic compounds.

48 Mechanistic studies indicated that the selective toxicity of miR-17 approximately 92 polycistro

49 ition alone is not sufficient to explain the selective toxicity of MPP(+) to dopaminergic neurons.

50 , 88-amino acid protein that may mediate the selective toxicity of organotins.

51 abotropic glutamate receptors attenuates the selective toxicity of rotenone on DA neurons by activati

52 nase kinases (MKK) significantly reduced the selective toxicity of rotenone or colchicine.

53 Here we show a completely new mechanism of selective toxicity of superparamagnetic nanoparticles (S

54 ysis of Msh2+/+ and Msh2-/- cells shows that selective toxicity of the halogenated nucleotide analogu

55 Several models could explain the selective toxicity of the mustard-phenylindole compounds

56 gases and is responsible for determining the selective toxicity of these compounds in mammals.

57 Specifically, selective toxicity of tiopronin toward MDR cells is achi

58 The selective toxicity of WL-276 against drug-resistant PC-3

59 ity of rotenone plays a critical role in its selective toxicity on DA neurons.

60 ity of rotenone plays a critical role in its selective toxicity on tyrosine hydroxylase-positive (TH+

61 2; however, the mechanism(s) for cancer cell-selective toxicity remain unknown.

62 experiments indicate hydrogel surfaces show selective toxicity to bacterial versus mammalian cells.

63 M2pep]4-Biotin and [M2pep]2-[KLA]2 exhibited selective toxicity to both M2-like TAMs and malignant ce

64 ygen species drive pharmacologic ascorbate's selective toxicity to cancer cells in vitro, in mice, an

65 rough to using genes to mediate powerful and selective toxicity to cancer cells.

66 Mutant alpha-synuclein also causes selective toxicity to catecholaminergic neurons in prima

67 Hence, we hypothesized that HNO can exert selective toxicity to cells subjected to acidosis.

68 otenone, another complex I inhibitor, causes selective toxicity to dopamine neurons, and Ndufs4 inact

69 Selective toxicity to PDD00017273 was associated with po

70 n of BPNT-1 in the nervous system, can cause selective toxicity to specific neurons, resulting in cor

71 poxic cytotoxic agent tirapazamine exhibited selective toxicity to the primitive stem cell subset.

72 essed in HIV-infected cells, and demonstrate selective toxicity to these cells by BCL-X(L) antagonist

73 al injection of 6-hydroxydopamine results in selective toxicity to these neurons.

74 clinical trials demonstrate the feasibility, selective toxicity, tolerability, and potential efficacy

75 l cell-based Gli1-mediated transcription and selective toxicity toward cancer cells.

76 offer a promising therapeutic strategy with selective toxicity toward malignant but not normal cells

77 These compounds show a selective toxicity toward MOLT-4 compared to HeLa cells

78 ssociated with personalized drug therapy and selective toxicity toward specific microbial species are

79 The molecule's selective toxicity toward the beetle's fungal antagonist

80 allowed facile screening for compounds with selective toxicity toward the mutant Ras genotype.

81 or related compounds, might exhibit greater selective toxicity toward tumor cells that overexpress t

82 inuclear platinum(II) complex, Pt-3 exhibits selective toxicity towards breast CSCs over bulk breast

83 anti-cancer drugs due to their demonstrated selective toxicity towards cancer cells relative to norm

84 They exhibit selective toxicity towards cancer cells while sparing no

85 Genotype-selective toxicity was first determined through short-te